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Items: 14


Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter.

Kusakizako T, Claxton DP, Tanaka Y, Maturana AD, Kuroda T, Ishitani R, Mchaourab HS, Nureki O.

Structure. 2019 Feb 5;27(2):293-301.e3. doi: 10.1016/j.str.2018.10.004. Epub 2018 Nov 15.


Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA.

Phulera S, Zhu H, Yu J, Claxton DP, Yoder N, Yoshioka C, Gouaux E.

Elife. 2018 Jul 25;7. pii: e39383. doi: 10.7554/eLife.39383.


Expression and purification of a functional heteromeric GABAA receptor for structural studies.

Claxton DP, Gouaux E.

PLoS One. 2018 Jul 20;13(7):e0201210. doi: 10.1371/journal.pone.0201210. eCollection 2018.


Engineering of a Polydisperse Small Heat-Shock Protein Reveals Conserved Motifs of Oligomer Plasticity.

Mishra S, Chandler SA, Williams D, Claxton DP, Koteiche HA, Stewart PL, Benesch JLP, Mchaourab HS.

Structure. 2018 Aug 7;26(8):1116-1126.e4. doi: 10.1016/j.str.2018.05.015. Epub 2018 Jul 5.


Sodium and proton coupling in the conformational cycle of a MATE antiporter from Vibrio cholerae.

Claxton DP, Jagessar KL, Steed PR, Stein RA, Mchaourab HS.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6182-E6190. doi: 10.1073/pnas.1802417115. Epub 2018 Jun 18.


Conformational transitions of the sodium-dependent sugar transporter, vSGLT.

Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2742-E2751. doi: 10.1073/pnas.1718451115. Epub 2018 Mar 5.


Alternating access mechanisms of LeuT-fold transporters: trailblazing towards the promised energy landscapes.

Kazmier K, Claxton DP, Mchaourab HS.

Curr Opin Struct Biol. 2017 Aug;45:100-108. doi: 10.1016/ Epub 2016 Dec 30. Review.


Navigating Membrane Protein Structure, Dynamics, and Energy Landscapes Using Spin Labeling and EPR Spectroscopy.

Claxton DP, Kazmier K, Mishra S, Mchaourab HS.

Methods Enzymol. 2015;564:349-87. doi: 10.1016/bs.mie.2015.07.026. Epub 2015 Aug 29.


Species-Specific Structural and Functional Divergence of α-Crystallins: Zebrafish αBa- and Rodent αA(ins)-Crystallin Encode Activated Chaperones.

Koteiche HA, Claxton DP, Mishra S, Stein RA, McDonald ET, Mchaourab HS.

Biochemistry. 2015 Sep 29;54(38):5949-58. doi: 10.1021/acs.biochem.5b00678. Epub 2015 Sep 17.


Screening and large-scale expression of membrane proteins in mammalian cells for structural studies.

Goehring A, Lee CH, Wang KH, Michel JC, Claxton DP, Baconguis I, Althoff T, Fischer S, Garcia KC, Gouaux E.

Nat Protoc. 2014 Nov;9(11):2574-85. doi: 10.1038/nprot.2014.173. Epub 2014 Oct 9.


Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters.

Claxton DP, Quick M, Shi L, de Carvalho FD, Weinstein H, Javitch JA, McHaourab HS.

Nat Struct Mol Biol. 2010 Jul;17(7):822-9. doi: 10.1038/nsmb.1854. Epub 2010 Jun 20.


Disulfide cross-links in the interaction of a cataract-linked alphaA-crystallin mutant with betaB1-crystallin.

Kumar MS, Koteiche HA, Claxton DP, Mchaourab HS.

FEBS Lett. 2009 Jan 5;583(1):175-9. doi: 10.1016/j.febslet.2008.11.047. Epub 2008 Dec 9.


Structure and orientation of T4 lysozyme bound to the small heat shock protein alpha-crystallin.

Claxton DP, Zou P, Mchaourab HS.

J Mol Biol. 2008 Jan 25;375(4):1026-39. Epub 2007 Nov 13.


Purification, crystallization and preliminary X-ray analysis of Caenorhabditis elegans ubiquitin-conjugation enzyme M7.1.

Gavira J JA, Claxton DP, Wang JH, Toh D, Meehan EJ, DiGiammarino EL.

Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):544-6. Epub 2003 Feb 21.


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