Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 117

1.

Predicting the Conformational Variability of Abl Tyrosine Kinase using Molecular Dynamics Simulations and Markov State Models.

Meng Y, Gao C, Clawson DK, Atwell S, Russell M, Vieth M, Roux B.

J Chem Theory Comput. 2018 May 8;14(5):2721-2732. doi: 10.1021/acs.jctc.7b01170. Epub 2018 Apr 3.

2.

Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor.

Yingling JM, McMillen WT, Yan L, Huang H, Sawyer JS, Graff J, Clawson DK, Britt KS, Anderson BD, Beight DW, Desaiah D, Lahn MM, Benhadji KA, Lallena MJ, Holmgaard RB, Xu X, Zhang F, Manro JR, Iversen PW, Iyer CV, Brekken RA, Kalos MD, Driscoll KE.

Oncotarget. 2017 Dec 31;9(6):6659-6677. doi: 10.18632/oncotarget.23795. eCollection 2018 Jan 23.

3.

Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist.

Monn JA, Henry SS, Massey SM, Clawson DK, Chen Q, Diseroad BA, Bhardwaj RM, Atwell S, Lu F, Wang J, Russell M, Heinz BA, Wang XS, Carter JH, Getman BG, Adragni K, Broad LM, Sanger HE, Ursu D, Catlow JT, Swanson S, Johnson BG, Shaw DB, McKinzie DL, Hao J.

J Med Chem. 2018 Mar 22;61(6):2303-2328. doi: 10.1021/acs.jmedchem.7b01481. Epub 2018 Feb 6.

PMID:
29350927
4.

Initial planning benefits complex prospective memory at a cost.

Settle JR, Clawson DM, Sebrechts MM.

Q J Exp Psychol (Hove). 2017 Aug;70(8):1700-1712. doi: 10.1080/17470218.2016.1204326. Epub 2016 Jul 12.

PMID:
27328201
5.

Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.

Monn JA, Prieto L, Taboada L, Hao J, Reinhard MR, Henry SS, Beadle CD, Walton L, Man T, Rudyk H, Clark B, Tupper D, Baker SR, Lamas C, Montero C, Marcos A, Blanco J, Bures M, Clawson DK, Atwell S, Lu F, Wang J, Russell M, Heinz BA, Wang X, Carter JH, Getman BG, Catlow JT, Swanson S, Johnson BG, Shaw DB, McKinzie DL.

J Med Chem. 2015 Sep 24;58(18):7526-48. doi: 10.1021/acs.jmedchem.5b01124.

PMID:
26313429
6.

Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site.

Luz JG, Carson MW, Condon B, Clawson D, Pustilnik A, Kohlman DT, Barr RJ, Bean JS, Dill MJ, Sindelar DK, Maletic M, Coghlan MJ.

J Med Chem. 2015 Aug 27;58(16):6607-18. doi: 10.1021/acs.jmedchem.5b00736. Epub 2015 Aug 7.

PMID:
26218343
7.

Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.

Henry JR, Kaufman MD, Peng SB, Ahn YM, Caldwell TM, Vogeti L, Telikepalli H, Lu WP, Hood MM, Rutkoski TJ, Smith BD, Vogeti S, Miller D, Wise SC, Chun L, Zhang X, Zhang Y, Kays L, Hipskind PA, Wrobleski AD, Lobb KL, Clay JM, Cohen JD, Walgren JL, McCann D, Patel P, Clawson DK, Guo S, Manglicmot D, Groshong C, Logan C, Starling JJ, Flynn DL.

J Med Chem. 2015 May 28;58(10):4165-79. doi: 10.1021/acs.jmedchem.5b00067. Epub 2015 May 12.

PMID:
25965804
8.

Class advantage and the gender divide: flexibility on the job and at home.

Gerstel N, Clawson D.

AJS. 2014 Sep;120(2):395-431.

PMID:
25811068
9.

Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound human mGlu2 and mGlu3 amino terminal domain structures.

Monn JA, Prieto L, Taboada L, Pedregal C, Hao J, Reinhard MR, Henry SS, Goldsmith PJ, Beadle CD, Walton L, Man T, Rudyk H, Clark B, Tupper D, Baker SR, Lamas C, Montero C, Marcos A, Blanco J, Bures M, Clawson DK, Atwell S, Lu F, Wang J, Russell M, Heinz BA, Wang X, Carter JH, Xiang C, Catlow JT, Swanson S, Sanger H, Broad LM, Johnson MP, Knopp KL, Simmons RM, Johnson BG, Shaw DB, McKinzie DL.

J Med Chem. 2015 Feb 26;58(4):1776-94. doi: 10.1021/jm501612y. Epub 2015 Feb 5.

PMID:
25602126
10.

Effects of management strategies on glucocorticoids and behavior in Indian rhinoceros (Rhinoceros unicornis): translocation and operant conditioning.

Capiro JM, Stoops MA, Freeman EW, Clawson D, Schook MW.

Zoo Biol. 2014 Mar-Apr;33(2):131-43. doi: 10.1002/zoo.21119. Epub 2014 Feb 13.

PMID:
24523250
11.

Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design.

Carson MW, Luz JG, Suen C, Montrose C, Zink R, Ruan X, Cheng C, Cole H, Adrian MD, Kohlman DT, Mabry T, Snyder N, Condon B, Maletic M, Clawson D, Pustilnik A, Coghlan MJ.

J Med Chem. 2014 Feb 13;57(3):849-60. doi: 10.1021/jm401616g. Epub 2014 Feb 4.

PMID:
24446728
12.

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.

Martinez-Perez JA, Iyengar S, Shannon HE, Bleakman D, Alt A, Clawson DK, Arnold BM, Bell MG, Bleisch TJ, Castaño AM, Del Prado M, Dominguez E, Escribano AM, Filla SA, Ho KH, Hudziak KJ, Jones CK, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6463-6. doi: 10.1016/j.bmcl.2013.09.045. Epub 2013 Sep 24.

PMID:
24140446
13.

Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor.

King C, Diaz H, Barnard D, Barda D, Clawson D, Blosser W, Cox K, Guo S, Marshall M.

Invest New Drugs. 2014 Apr;32(2):213-26. doi: 10.1007/s10637-013-0036-7. Epub 2013 Oct 10.

PMID:
24114124
14.

Quantification of HSV-1-mediated expression of the ferritin MRI reporter in the mouse brain.

Iordanova B, Goins WF, Clawson DS, Hitchens TK, Ahrens ET.

Gene Ther. 2013 Jun;20(6):589-96. doi: 10.1038/gt.2012.70. Epub 2012 Sep 20.

15.

Adenoviruses in fecal samples from asymptomatic rhesus macaques, United States.

Roy S, Sandhu A, Medina A, Clawson DS, Wilson JM.

Emerg Infect Dis. 2012 Jul;18(7):1081-8. doi: 10.3201/eid1807.111665.

16.

Regional brain atrophy and impaired decision making on the balloon analog risk task in behavioral variant frontotemporal dementia.

Strenziok M, Pulaski S, Krueger F, Zamboni G, Clawson D, Grafman J.

Cogn Behav Neurol. 2011 Jun;24(2):59-67. doi: 10.1097/WNN.0b013e3182255a7c.

PMID:
21697710
17.

Construction of gene transfer vectors based on simian adenovirus 7.

Roy S, Clawson DS, Adam VS, Medina A, Wilson JM.

J Gen Virol. 2011 Aug;92(Pt 8):1749-53. doi: 10.1099/vir.0.032300-0. Epub 2011 May 11.

PMID:
21562118
18.

Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model.

Burkholder TP, Clayton JR, Rempala ME, Henry JR, Knobeloch JM, Mendel D, McLean JA, Hao Y, Barda DA, Considine EL, Uhlik MT, Chen Y, Ma L, Bloem LJ, Akunda JK, McCann DJ, Sanchez-Felix M, Clawson DK, Lahn MM, Starling JJ.

Invest New Drugs. 2012 Jun;30(3):936-49. doi: 10.1007/s10637-011-9640-6. Epub 2011 Mar 1. Erratum in: Invest New Drugs. 2012 Jun;30(3):1270-1.

PMID:
21360050
19.

Infrastructure. Tenure and the future of the university.

Clawson D.

Science. 2009 May 29;324(5931):1147-8. doi: 10.1126/science.1172995. No abstract available.

PMID:
19478168
20.

Prospective memory and the efficacy of a memory strategy in multiple sclerosis.

Kardiasmenos KS, Clawson DM, Wilken JA, Wallin MT.

Neuropsychology. 2008 Nov;22(6):746-54. doi: 10.1037/a0013211.

PMID:
18999348
21.

Optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type I receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type I inhibitor as antitumor agent.

Li HY, McMillen WT, Heap CR, McCann DJ, Yan L, Campbell RM, Mundla SR, King CH, Dierks EA, Anderson BD, Britt KS, Huss KL, Voss MD, Wang Y, Clawson DK, Yingling JM, Sawyer JS.

J Med Chem. 2008 Apr 10;51(7):2302-6. doi: 10.1021/jm701199p. Epub 2008 Mar 4.

PMID:
18314943
22.
23.

Rescue of chimeric adenoviral vectors to expand the serotype repertoire.

Roy S, Clawson DS, Lavrukhin O, Sandhu A, Miller J, Wilson JM.

J Virol Methods. 2007 Apr;141(1):14-21. Epub 2007 Jan 2.

24.

The history of fracture fixation of the hand and wrist.

Clawson DK.

Clin Orthop Relat Res. 2006 Oct;451:293; author reply 294. No abstract available.

PMID:
16936592
25.

Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7.

Li HY, Wang Y, Heap CR, King CH, Mundla SR, Voss M, Clawson DK, Yan L, Campbell RM, Anderson BD, Wagner JR, Britt K, Lu KX, McMillen WT, Yingling JM.

J Med Chem. 2006 Mar 23;49(6):2138-42.

PMID:
16539403
26.

Use of chimeric adenoviral vectors to assess capsid neutralization determinants.

Roy S, Clawson DS, Calcedo R, Lebherz C, Sanmiguel J, Wu D, Wilson JM.

Virology. 2005 Mar 15;333(2):207-14.

27.

Complete nucleotide sequences and genome organization of four chimpanzee adenoviruses.

Roy S, Gao G, Clawson DS, Vandenberghe LH, Farina SF, Wilson JM.

Virology. 2004 Jul 1;324(2):361-72.

28.

Pharmacology of nuclear receptor-coregulator recognition.

Savkur RS, Bramlett KS, Clawson D, Burris TP.

Vitam Horm. 2004;68:145-83. Review.

PMID:
15193454
29.

Enhancing entrepreneurship and professionalism in medical informatics instruction: a collaborative training model.

Carroll CA, Rychlewski W, Teat M, Clawson D.

J Am Med Inform Assoc. 2004 Jul-Aug;11(4):317-9. Epub 2004 Apr 2.

30.

Health visitor risk assessment for preventing falls in elderly people.

Kinn S, Clawson D.

Br J Nurs. 2002 Mar 14-27;11(5):316-21.

PMID:
11904560
31.

Closed intramedullary nailing of femoral fractures. A report of five hundred and twenty cases. 1984.

Winquist RA, Hansen ST Jr, Clawson DK.

J Bone Joint Surg Am. 2001 Dec;83-A(12):1912. No abstract available.

PMID:
11741073
32.

Major surface protein 1a effects tick infection and transmission of Anaplasma marginale.

de la Fuente J, Garcia-Garcia JC, Blouin EF, McEwen BR, Clawson D, Kocan KM.

Int J Parasitol. 2001 Dec;31(14):1705-14.

PMID:
11730800
33.

Cultivating a valuable hybrid: the orthopaedic clinician-scientist.

Clawson DK.

J Bone Joint Surg Am. 2001 Sep;83-A(9):1432-3. No abstract available.

PMID:
11568215
34.

Retention and transfer of morse code reception skill by novices: part-whole training.

Clawson DM, Healy AF, Ericsson KA, Bourne LE Jr.

J Exp Psychol Appl. 2001 Jun;7(2):129-42.

PMID:
11477980
35.

It's past time to reform the musculoskeletal curriculum.

Clawson DK, Jackson DW, Ostergaard DJ.

Acad Med. 2001 Jul;76(7):709-10. No abstract available.

PMID:
11448825
36.

Orthopaedic manpower: an overview.

Clawson DK.

Clin Orthop Relat Res. 2001 Apr;(385):7-12.

PMID:
11302329
37.

Orthopedic manpower.

Clawson DK, Denton TJ.

Clin Orthop Relat Res. 2001 Apr;(385):3-6. No abstract available.

PMID:
11302323
38.

Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.

Jin L, Briggs SL, Chandrasekhar S, Chirgadze NY, Clawson DK, Schevitz RW, Smiley DL, Tashjian AH, Zhang F.

J Biol Chem. 2000 Sep 1;275(35):27238-44.

39.
40.

The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element.

Wiley MR, Weir LC, Briggs SL, Chirgadze NY, Clawson D, Gifford-Moore DS, Schacht AL, Smith GF, Vasudevan V, Zornes LL, Klimkowski VJ.

Bioorg Med Chem Lett. 1999 Sep 20;9(18):2767-72.

PMID:
10509932
41.

Challenges and opportunities of racial diversity in medical education.

Clawson DK.

Clin Orthop Relat Res. 1999 May;(362):34-9.

PMID:
10335275
42.

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy.

Zhang M, Bailey DL, Bastian JA, Briggs SL, Chirgadze NY, Clawson DK, Denney ML, Gifford-Moore DS, Harper RW, Johnson LM, Klimkowski VJ, Kohn TJ, Lin HS, McCowan JR, Richett ME, Sall DJ, Smith AJ, Smith GF, Snyder DW, Takeuchi K, Utterback BG, Yan SC.

Bioorg Med Chem Lett. 1999 Mar 8;9(5):775-80.

PMID:
10201846
43.

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal (S2) binding site.

Sall DJ, Briggs SL, Chirgadze NY, Clawson DK, Gifford-Moore DS, Klimkowski VJ, McCowan JR, Smith GF, Wikel JH.

Bioorg Med Chem Lett. 1998 Sep 22;8(18):2527-32.

PMID:
9873574
44.

Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms.

Barnard D, Diaz B, Clawson D, Marshall M.

Oncogene. 1998 Sep 24;17(12):1539-47.

45.

Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease.

Kaldor SW, Kalish VJ, Davies JF 2nd, Shetty BV, Fritz JE, Appelt K, Burgess JA, Campanale KM, Chirgadze NY, Clawson DK, Dressman BA, Hatch SD, Khalil DA, Kosa MB, Lubbehusen PP, Muesing MA, Patick AK, Reich SH, Su KS, Tatlock JH.

J Med Chem. 1997 Nov 21;40(24):3979-85.

PMID:
9397180
46.

Dibasic benzo[b]thiophene derivatives as a novel class of active site-directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation.

Sall DJ, Bastian JA, Briggs SL, Buben JA, Chirgadze NY, Clawson DK, Denney ML, Giera DD, Gifford-Moore DS, Harper RW, Hauser KL, Klimkowski VJ, Kohn TJ, Lin HS, McCowan JR, Palkowitz AD, Smith GF, Takeuchi K, Thrasher KJ, Tinsley JM, Utterback BG, Yan SC, Zhang M.

J Med Chem. 1997 Oct 24;40(22):3489-93. No abstract available.

PMID:
9357512
47.

Proteinase-free myeloperoxidase increases airway epithelial permeability in a whole trachea model.

Regelmann WE, Schneider LA, Fahrenkrug SC, Gray BH, Johnson S, Herron JM, Clawson CC, Clawson DJ, Wangensteen OD.

Pediatr Pulmonol. 1997 Jul;24(1):29-34.

PMID:
9261850
48.

The crystal structure of human alpha-thrombin complexed with LY178550, a nonpeptidyl, active site-directed inhibitor.

Chirgadze NY, Sall DJ, Klimkowski VJ, Clawson DK, Briggs SL, Hermann R, Smith GF, Gifford-Moore DS, Wery JP.

Protein Sci. 1997 Jul;6(7):1412-7.

49.

Crystal structure of the obese protein leptin-E100.

Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW.

Nature. 1997 May 8;387(6629):206-9.

PMID:
9144295
50.

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 1. Indole-3-acetamides.

Dillard RD, Bach NJ, Draheim SE, Berry DR, Carlson DG, Chirgadze NY, Clawson DK, Hartley LW, Johnson LM, Jones ND, McKinney ER, Mihelich ED, Olkowski JL, Schevitz RW, Smith AC, Snyder DW, Sommers CD, Wery JP.

J Med Chem. 1996 Dec 20;39(26):5119-36.

PMID:
9005255

Supplemental Content

Loading ...
Support Center