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Items: 1 to 50 of 438

1.

Current Technologies for Complex Glycoproteomics and Their Applications to Biology/Disease-Driven Glycoproteomics.

Narimatsu H, Kaji H, Vakhrushev SY, Clausen H, Zhang H, Noro E, Togayachi A, Nagai-Okatani C, Kuno A, Zou X, Cheng L, Tao SC, Sun Y.

J Proteome Res. 2018 Oct 25. doi: 10.1021/acs.jproteome.8b00515. [Epub ahead of print]

PMID:
30359034
2.

Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4.

de Las Rivas M, Paul Daniel EJ, Coelho H, Lira-Navarrete E, Raich L, Compañón I, Diniz A, Lagartera L, Jiménez-Barbero J, Clausen H, Rovira C, Marcelo F, Corzana F, Gerken TA, Hurtado-Guerrero R.

ACS Cent Sci. 2018 Sep 26;4(9):1274-1290. doi: 10.1021/acscentsci.8b00488. Epub 2018 Sep 14.

3.

Expression of the O-Glycosylation Enzyme GalNAc-T3 in the Equatorial Segment Correlates with the Quality of Spermatozoa.

Nygaard MB, Herlihy AS, Jeanneau C, Nielsen JE, Bennett EP, Jørgensen N, Clausen H, Mandel U, Rajpert-De Meyts E, Almstrup K.

Int J Mol Sci. 2018 Sep 27;19(10). pii: E2949. doi: 10.3390/ijms19102949.

4.

Targeted Analysis of Lysosomal Directed Proteins and Their Sites of Mannose-6-phosphate Modification.

Čaval T, Zhu J, Tian W, Remmelzwaal S, Yang Z, Clausen H, Heck AJR.

Mol Cell Proteomics. 2019 Jan;18(1):16-27. doi: 10.1074/mcp.RA118.000967. Epub 2018 Sep 20.

PMID:
30237200
5.

Direct quality control of glycoengineered erythropoietin variants.

Čaval T, Tian W, Yang Z, Clausen H, Heck AJR.

Nat Commun. 2018 Aug 21;9(1):3342. doi: 10.1038/s41467-018-05536-3.

6.

The GAGOme: a cell-based library of displayed glycosaminoglycans.

Chen YH, Narimatsu Y, Clausen TM, Gomes C, Karlsson R, Steentoft C, Spliid CB, Gustavsson T, Salanti A, Persson A, Malmström A, Willén D, Ellervik U, Bennett EP, Mao Y, Clausen H, Yang Z.

Nat Methods. 2018 Nov;15(11):881-888. doi: 10.1038/s41592-018-0086-z. Epub 2018 Aug 13.

PMID:
30104636
7.

EDEM1's mannosidase-like domain binds ERAD client proteins in a redox-sensitive manner and possesses catalytic activity.

Lamriben L, Oster ME, Tamura T, Tian W, Yang Z, Clausen H, Hebert DN.

J Biol Chem. 2018 Sep 7;293(36):13932-13945. doi: 10.1074/jbc.RA118.004183. Epub 2018 Jul 18.

PMID:
30021839
8.

Mucins and Truncated O-Glycans Unveil Phenotypic Discrepancies between Serous Ovarian Cancer Cell Lines and Primary Tumours.

Coelho R, Marcos-Silva L, Mendes N, Pereira D, Brito C, Jacob F, Steentoft C, Mandel U, Clausen H, David L, Ricardo S.

Int J Mol Sci. 2018 Jul 13;19(7). pii: E2045. doi: 10.3390/ijms19072045.

9.

Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts.

de Las Rivas M, Coelho H, Diniz A, Lira-Navarrete E, Compañón I, Jiménez-Barbero J, Schjoldager KT, Bennett EP, Vakhrushev SY, Clausen H, Corzana F, Marcelo F, Hurtado-Guerrero R.

Chemistry. 2018 Jun 12;24(33):8382-8392. doi: 10.1002/chem.201800701. Epub 2018 May 16.

PMID:
29601100
10.

Glycoengineering design options for IgG1 in CHO cells using precise gene editing.

Schulz MA, Tian W, Mao Y, Van Coillie J, Sun L, Larsen JS, Chen YH, Kristensen C, Vakhrushev SY, Clausen H, Yang Z.

Glycobiology. 2018 Jul 1;28(7):542-549. doi: 10.1093/glycob/cwy022.

PMID:
29596681
11.

Glycosyltransferase genes that cause monogenic congenital disorders of glycosylation are distinct from glycosyltransferase genes associated with complex diseases.

Joshi HJ, Hansen L, Narimatsu Y, Freeze HH, Henrissat B, Bennett E, Wandall HH, Clausen H, Schjoldager KT.

Glycobiology. 2018 May 1;28(5):284-294. doi: 10.1093/glycob/cwy015.

PMID:
29579191
12.

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions.

Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H.

J Biol Chem. 2018 May 11;293(19):7408-7422. doi: 10.1074/jbc.M117.817981. Epub 2018 Mar 20.

PMID:
29559555
13.

Fine-Tuning Limited Proteolysis: A Major Role for Regulated Site-Specific O-Glycosylation.

Goth CK, Vakhrushev SY, Joshi HJ, Clausen H, Schjoldager KT.

Trends Biochem Sci. 2018 Apr;43(4):269-284. doi: 10.1016/j.tibs.2018.02.005. Epub 2018 Mar 2. Review.

PMID:
29506880
14.

SnapShot: O-Glycosylation Pathways across Kingdoms.

Joshi HJ, Narimatsu Y, Schjoldager KT, Tytgat HLP, Aebi M, Clausen H, Halim A.

Cell. 2018 Jan 25;172(3):632-632.e2. doi: 10.1016/j.cell.2018.01.016. Review.

15.

A validated gRNA library for CRISPR/Cas9 targeting of the human glycosyltransferase genome.

Narimatsu Y, Joshi HJ, Yang Z, Gomes C, Chen YH, Lorenzetti FC, Furukawa S, Schjoldager KT, Hansen L, Clausen H, Bennett EP, Wandall HH.

Glycobiology. 2018 May 1;28(5):295-305. doi: 10.1093/glycob/cwx101.

PMID:
29315387
16.

GlycoDomainViewer: a bioinformatics tool for contextual exploration of glycoproteomes.

Joshi HJ, Jørgensen A, Schjoldager KT, Halim A, Dworkin LA, Steentoft C, Wandall HH, Clausen H, Vakhrushev SY.

Glycobiology. 2018 Mar 1;28(3):131-136. doi: 10.1093/glycob/cwx104.

PMID:
29267884
17.

The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences.

de Las Rivas M, Lira-Navarrete E, Daniel EJP, Compañón I, Coelho H, Diniz A, Jiménez-Barbero J, Peregrina JM, Clausen H, Corzana F, Marcelo F, Jiménez-Osés G, Gerken TA, Hurtado-Guerrero R.

Nat Commun. 2017 Dec 5;8(1):1959. doi: 10.1038/s41467-017-02006-0.

18.

Site-specific O-glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human δ-opioid receptor turnover at the plasma membrane.

Lackman JJ, Goth CK, Halim A, Vakhrushev SY, Clausen H, Petäjä-Repo UE.

Cell Signal. 2018 Jan;42:184-193. doi: 10.1016/j.cellsig.2017.10.016. Epub 2017 Oct 31.

PMID:
29097258
19.

Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins.

Larsen ISB, Narimatsu Y, Joshi HJ, Siukstaite L, Harrison OJ, Brasch J, Goodman KM, Hansen L, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11163-11168. doi: 10.1073/pnas.1708319114. Epub 2017 Oct 2.

20.

Glycosylation Engineering.

Clausen H, Wandall HH, Steentoft C, Stanley P, Schnaar RL.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 56.
2017.

21.

Spatial separation of the cyanogenic β-glucosidase ZfBGD2 and cyanogenic glucosides in the haemolymph of Zygaena larvae facilitates cyanide release.

Pentzold S, Jensen MK, Matthes A, Olsen CE, Petersen BL, Clausen H, Møller BL, Bak S, Zagrobelny M.

R Soc Open Sci. 2017 Jun 28;4(6):170262. doi: 10.1098/rsos.170262. eCollection 2017 Jun.

22.

Generation and characterization of a monoclonal antibody to the cytoplasmic tail of MUC16.

Gipson IK, Mandel U, Menon B, Michaud S, Tisdale A, Campos D, Clausen H.

Glycobiology. 2017 Oct 1;27(10):920-926. doi: 10.1093/glycob/cwx054.

23.

Corrigendum: Identification and evolution of a plant cell wall specific glycoprotein glycosyl transferase, ExAD.

Møller SR, Yi X, Velásquez SM, Gille S, Hansen PLM, Poulsen CP, Olsen CE, Rejzek M, Parsons H, Yang Z, Wandall HH, Clausen H, Field RA, Pauly M, Estevez JM, Harholt J, Ulvskov P, Petersen BL.

Sci Rep. 2017 May 23;7:46774. doi: 10.1038/srep46774.

24.

NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity.

El Qaidi S, Chen K, Halim A, Siukstaite L, Rueter C, Hurtado-Guerrero R, Clausen H, Hardwidge PR.

J Biol Chem. 2017 Jul 7;292(27):11423-11430. doi: 10.1074/jbc.M117.790675. Epub 2017 May 18.

25.

Mammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2.

Larsen ISB, Narimatsu Y, Joshi HJ, Yang Z, Harrison OJ, Brasch J, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A.

J Biol Chem. 2017 Jul 7;292(27):11586-11598. doi: 10.1074/jbc.M117.794487. Epub 2017 May 16.

26.

Effects of liraglutide on ovarian dysfunction in polycystic ovary syndrome: a randomized clinical trial.

Nylander M, Frøssing S, Clausen HV, Kistorp C, Faber J, Skouby SO.

Reprod Biomed Online. 2017 Jul;35(1):121-127. doi: 10.1016/j.rbmo.2017.03.023. Epub 2017 Apr 24.

PMID:
28479118
27.

Identification and evolution of a plant cell wall specific glycoprotein glycosyl transferase, ExAD.

Møller SR, Yi X, Velásquez SM, Gille S, Hansen PL, Poulsen CP, Olsen CE, Rejzek M, Parsons H, Yang Z, Wandall HH, Clausen H, Field RA, Pauly M, Estevez JM, Harholt J, Ulvskov P, Petersen BL.

Sci Rep. 2017 Mar 30;7:45341. doi: 10.1038/srep45341. Erratum in: Sci Rep. 2017 May 23;7:46774. Zhang, Yang [corrected to Yang, Zhang].

28.

Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis.

Lonowski LA, Narimatsu Y, Riaz A, Delay CE, Yang Z, Niola F, Duda K, Ober EA, Clausen H, Wandall HH, Hansen SH, Bennett EP, Frödin M.

Nat Protoc. 2017 Mar;12(3):581-603. doi: 10.1038/nprot.2016.165. Epub 2017 Feb 16.

PMID:
28207001
29.

Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β1-Adrenergic Receptor N-terminal Cleavage.

Goth CK, Tuhkanen HE, Khan H, Lackman JJ, Wang S, Narimatsu Y, Hansen LH, Overall CM, Clausen H, Schjoldager KT, Petäjä-Repo UE.

J Biol Chem. 2017 Mar 17;292(11):4714-4726. doi: 10.1074/jbc.M116.730614. Epub 2017 Feb 6.

30.

Revisiting the human polypeptide GalNAc-T1 and T13 paralogs.

Festari MF, Trajtenberg F, Berois N, Pantano S, Revoredo L, Kong Y, Solari-Saquieres P, Narimatsu Y, Freire T, Bay S, Robello C, Bénard J, Gerken TA, Clausen H, Osinaga E.

Glycobiology. 2017 Jan;27(2):140-153. doi: 10.1093/glycob/cww111. Epub 2016 Nov 22.

31.

Distinguishing Truncated and Normal MUC1 Glycoform Targeting from Tn-MUC1-Specific CAR T Cells: Specificity Is the Key to Safety.

Posey AD Jr, Clausen H, June CH.

Immunity. 2016 Nov 15;45(5):947-948. doi: 10.1016/j.immuni.2016.10.015.

32.

Extrinsic Functions of Lectin Domains in O-N-Acetylgalactosamine Glycan Biosynthesis.

Lorenz V, Ditamo Y, Cejas RB, Carrizo ME, Bennett EP, Clausen H, Nores GA, Irazoqui FJ.

J Biol Chem. 2016 Dec 2;291(49):25339-25350. Epub 2016 Oct 13.

33.

Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.

Khetarpal SA, Schjoldager KT, Christoffersen C, Raghavan A, Edmondson AC, Reutter HM, Ahmed B, Ouazzani R, Peloso GM, Vitali C, Zhao W, Somasundara AV, Millar JS, Park Y, Fernando G, Livanov V, Choi S, Noé E, Patel P, Ho SP; Myocardial Infarction Exome Sequencing Study, Kirchgessner TG, Wandall HH, Hansen L, Bennett EP, Vakhrushev SY, Saleheen D, Kathiresan S, Brown CD, Abou Jamra R, LeGuern E, Clausen H, Rader DJ.

Cell Metab. 2016 Aug 9;24(2):234-45. doi: 10.1016/j.cmet.2016.07.012.

34.

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.

Posey AD Jr, Schwab RD, Boesteanu AC, Steentoft C, Mandel U, Engels B, Stone JD, Madsen TD, Schreiber K, Haines KM, Cogdill AP, Chen TJ, Song D, Scholler J, Kranz DM, Feldman MD, Young R, Keith B, Schreiber H, Clausen H, Johnson LA, June CH.

Immunity. 2016 Jun 21;44(6):1444-54. doi: 10.1016/j.immuni.2016.05.014.

35.

Hospitalisation of severely mentally ill patients with and without problematic substance use before and during Assertive Community Treatment: an observational cohort study.

Clausen H, Ruud T, Odden S, Šaltytė Benth J, Heiervang KS, Stuen HK, Killaspy H, Drake RE, Landheim A.

BMC Psychiatry. 2016 May 4;16:125. doi: 10.1186/s12888-016-0826-5.

36.

Lepidopteran defence droplets - a composite physical and chemical weapon against potential predators.

Pentzold S, Zagrobelny M, Khakimov B, Engelsen SB, Clausen H, Petersen BL, Borch J, Møller BL, Bak S.

Sci Rep. 2016 Mar 4;6:22407. doi: 10.1038/srep22407.

37.

Hospitalization of high and low inpatient service users before and after enrollment into Assertive Community Treatment teams: a naturalistic observational study.

Clausen H, Landheim A, Odden S, Šaltytė Benth J, Heiervang KS, Stuen HK, Killaspy H, Ruud T.

Int J Ment Health Syst. 2016 Feb 29;10:14. doi: 10.1186/s13033-016-0052-z. eCollection 2016.

38.

Mucins and associated glycan signatures in colon adenoma-carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer.

Krishn SR, Kaur S, Smith LM, Johansson SL, Jain M, Patel A, Gautam SK, Hollingsworth MA, Mandel U, Clausen H, Lo WC, Fan WT, Manne U, Batra SK.

Cancer Lett. 2016 May 1;374(2):304-14. doi: 10.1016/j.canlet.2016.02.016. Epub 2016 Feb 16.

39.

Are Users Satisfied with Assertive Community Treatment in Spite of Personal Restrictions?

Lofthus AM, Westerlund H, Bjørgen D, Lindstrøm JC, Lauveng A, Clausen H, Ruud T, Heiervang KS.

Community Ment Health J. 2016 Nov;52(8):891-897. Epub 2016 Feb 11.

PMID:
26868646
40.

Mapping the O-Mannose Glycoproteome in Saccharomyces cerevisiae.

Neubert P, Halim A, Zauser M, Essig A, Joshi HJ, Zatorska E, Larsen IS, Loibl M, Castells-Ballester J, Aebi M, Clausen H, Strahl S.

Mol Cell Proteomics. 2016 Apr;15(4):1323-37. doi: 10.1074/mcp.M115.057505. Epub 2016 Jan 13.

41.

Ovarian morphology in polycystic ovary syndrome: estimates from 2D and 3D ultrasound and magnetic resonance imaging and their correlation to anti-Müllerian hormone.

Nylander M, Frøssing S, Bjerre AH, Chabanova E, Clausen HV, Faber J, Skouby SO.

Acta Radiol. 2017 Aug;58(8):997-1004. doi: 10.1177/0284185116676656. Epub 2016 Nov 13.

PMID:
28273731
42.

Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.

Halim A, Larsen IS, Neubert P, Joshi HJ, Petersen BL, Vakhrushev SY, Strahl S, Clausen H.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15648-53. doi: 10.1073/pnas.1511743112. Epub 2015 Dec 7.

43.

Mucin-type O-glycosylation is controlled by short- and long-range glycopeptide substrate recognition that varies among members of the polypeptide GalNAc transferase family.

Revoredo L, Wang S, Bennett EP, Clausen H, Moremen KW, Jarvis DL, Ten Hagen KG, Tabak LA, Gerken TA.

Glycobiology. 2016 Apr;26(4):360-76. doi: 10.1093/glycob/cwv108. Epub 2015 Nov 26.

44.

Deconstruction of O-glycosylation--GalNAc-T isoforms direct distinct subsets of the O-glycoproteome.

Schjoldager KT, Joshi HJ, Kong Y, Goth CK, King SL, Wandall HH, Bennett EP, Vakhrushev SY, Clausen H.

EMBO Rep. 2015 Dec;16(12):1713-22. doi: 10.15252/embr.201540796. Epub 2015 Nov 13.

45.

A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation.

Goth CK, Halim A, Khetarpal SA, Rader DJ, Clausen H, Schjoldager KT.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14623-8. doi: 10.1073/pnas.1511175112. Epub 2015 Nov 9.

46.

Fucosylation and protein glycosylation create functional receptors for cholera toxin.

Wands AM, Fujita A, McCombs JE, Cervin J, Dedic B, Rodriguez AC, Nischan N, Bond MR, Mettlen M, Trudgian DC, Lemoff A, Quiding-Järbrink M, Gustavsson B, Steentoft C, Clausen H, Mirzaei H, Teneberg S, Yrlid U, Kohler JJ.

Elife. 2015 Oct 29;4:e09545. doi: 10.7554/eLife.09545.

47.

Molecular logic of neuronal self-recognition through protocadherin domain interactions.

Rubinstein R, Thu CA, Goodman KM, Wolcott HN, Bahna F, Mannepalli S, Ahlsen G, Chevee M, Halim A, Clausen H, Maniatis T, Shapiro L, Honig B.

Cell. 2015 Oct 22;163(3):629-42. doi: 10.1016/j.cell.2015.09.026. Epub 2015 Oct 17.

48.

Cognitive and physical symptoms of concussive injury in children: a detailed longitudinal recovery study.

Crowe L, Collie A, Hearps S, Dooley J, Clausen H, Maddocks D, McCrory P, Davis G, Anderson V.

Br J Sports Med. 2016 Mar;50(5):311-6. doi: 10.1136/bjsports-2015-094663. Epub 2015 Oct 1.

PMID:
26429808
49.

Associations Between Quality of Life and Functioning in an Assertive Community Treatment Population.

Clausen H, Landheim A, Odden S, Heiervang KS, Stuen HK, Killaspy H, Šaltytė Benth J, Ruud T.

Psychiatr Serv. 2015 Nov;66(11):1249-52. doi: 10.1176/appi.ps.201400376. Epub 2015 Aug 3.

PMID:
26234328
50.

A novel monoclonal antibody to a defined peptide epitope in MUC16.

Marcos-Silva L, Ricardo S, Chen K, Blixt O, Arigi E, Pereira D, Høgdall E, Mandel U, Bennett EP, Vakhrushev SY, David L, Clausen H.

Glycobiology. 2015 Nov;25(11):1172-82. doi: 10.1093/glycob/cwv056. Epub 2015 Jul 22.

PMID:
26201951

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