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Items: 1 to 50 of 453

1.

Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell.

He Y, Schreiber K, Wolf SP, Wen F, Steentoft C, Zerweck J, Steiner M, Sharma P, Shepard HM, Posey A, June CH, Mandel U, Clausen H, Leisegang M, Meredith SC, Kranz DM, Schreiber H.

JCI Insight. 2019 Dec 5;4(23). pii: 135306. doi: 10.1172/jci.insight.135306. No abstract available.

2.

Correction: Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor.

Hansen LH, Madsen TD, Goth CK, Clausen H, Chen Y, Dzoyashvili N, Iyer SR, Sangaralingham SJ, Burnett JC Jr, Rehfeld JF, Vakhrushev SY, Schjoldager KT, Goetze JP.

J Biol Chem. 2019 Nov 29;294(48):18516. doi: 10.1074/jbc.AAC119.011661. No abstract available.

3.

Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell.

He Y, Schreiber K, Wolf SP, Wen F, Steentoft C, Zerweck J, Steiner M, Sharma P, Shepard HM, Posey A, June CH, Mandel U, Clausen H, Leisegang M, Meredith SC, Kranz DM, Schreiber H.

JCI Insight. 2019 Nov 1;4(21). pii: 130416. doi: 10.1172/jci.insight.130416.

4.

Model fidelity and team members' experiences of assertive community treatment in Norway: a sequential mixed-methods study.

Odden S, Landheim A, Clausen H, Stuen HK, Heiervang KS, Ruud T.

Int J Ment Health Syst. 2019 Oct 16;13:65. doi: 10.1186/s13033-019-0321-8. eCollection 2019.

5.

Towards universally acceptable blood.

Clausen H, Olsson ML.

Nat Microbiol. 2019 Sep;4(9):1426-1427. doi: 10.1038/s41564-019-0548-9. No abstract available.

PMID:
31439931
6.

Glyco-DIA: a method for quantitative O-glycoproteomics with in silico-boosted glycopeptide libraries.

Ye Z, Mao Y, Clausen H, Vakhrushev SY.

Nat Methods. 2019 Sep;16(9):902-910. doi: 10.1038/s41592-019-0504-x. Epub 2019 Aug 5.

PMID:
31384044
7.

An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells.

Narimatsu Y, Joshi HJ, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen YH, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, Büll C, Adema GJ, Mandel U, Hansen L, Bennett EP, Varki A, Vakhrushev SY, Yang Z, Clausen H.

Mol Cell. 2019 Jul 25;75(2):394-407.e5. doi: 10.1016/j.molcel.2019.05.017. Epub 2019 Jun 18.

PMID:
31227230
8.

Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor.

Hansen LH, Madsen TD, Goth CK, Clausen H, Chen Y, Dzhoyashvili N, Iyer SR, Sangaralingham SJ, Burnett JC Jr, Rehfeld JF, Vakhrushev SY, Schjoldager KT, Goetze JP.

J Biol Chem. 2019 Aug 23;294(34):12567-12578. doi: 10.1074/jbc.RA119.008102. Epub 2019 Jun 11. Erratum in: J Biol Chem. 2019 Nov 29;294(48):18516.

9.

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions.

Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H.

J Biol Chem. 2019 May 24;294(21):8349. doi: 10.1074/jbc.AAC119.009121. No abstract available.

10.

Activity of N-acylneuraminate-9-phosphatase (NANP) is not essential for de novo sialic acid biosynthesis.

Willems AP, Sun L, Schulz MA, Tian W, Ashikov A, van Scherpenzeel M, Hermans E, Clausen H, Yang Z, Lefeber DJ.

Biochim Biophys Acta Gen Subj. 2019 Oct;1863(10):1471-1479. doi: 10.1016/j.bbagen.2019.05.011. Epub 2019 May 20.

PMID:
31121216
11.

The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells.

Tian W, Ye Z, Wang S, Schulz MA, Van Coillie J, Sun L, Chen YH, Narimatsu Y, Hansen L, Kristensen C, Mandel U, Bennett EP, Jabbarzadeh-Tabrizi S, Schiffmann R, Shen JS, Vakhrushev SY, Clausen H, Yang Z.

Nat Commun. 2019 Apr 30;10(1):1785. doi: 10.1038/s41467-019-09809-3.

12.

Exploring Regulation of Protein O-Glycosylation in Isogenic Human HEK293 Cells by Differential O-Glycoproteomics.

Narimatsu Y, Joshi HJ, Schjoldager KT, Hintze J, Halim A, Steentoft C, Nason R, Mandel U, Bennett EP, Clausen H, Vakhrushev SY.

Mol Cell Proteomics. 2019 Jul;18(7):1396-1409. doi: 10.1074/mcp.RA118.001121. Epub 2019 Apr 30.

PMID:
31040225
13.

Multiple distinct O-Mannosylation pathways in eukaryotes.

Larsen ISB, Narimatsu Y, Clausen H, Joshi HJ, Halim A.

Curr Opin Struct Biol. 2019 Jun;56:171-178. doi: 10.1016/j.sbi.2019.03.003. Epub 2019 Apr 15. Review.

PMID:
30999272
14.

A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion.

Valoskova K, Biebl J, Roblek M, Emtenani S, Gyoergy A, Misova M, Ratheesh A, Reis-Rodrigues P, Shkarina K, Larsen ISB, Vakhrushev SY, Clausen H, Siekhaus DE.

Elife. 2019 Mar 26;8. pii: e41801. doi: 10.7554/eLife.41801.

15.

Current Technologies for Complex Glycoproteomics and Their Applications to Biology/Disease-Driven Glycoproteomics.

Narimatsu H, Kaji H, Vakhrushev SY, Clausen H, Zhang H, Noro E, Togayachi A, Nagai-Okatani C, Kuno A, Zou X, Cheng L, Tao SC, Sun Y.

J Proteome Res. 2018 Dec 7;17(12):4097-4112. doi: 10.1021/acs.jproteome.8b00515. Epub 2018 Oct 25. Review.

PMID:
30359034
16.

Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4.

de Las Rivas M, Paul Daniel EJ, Coelho H, Lira-Navarrete E, Raich L, Compañón I, Diniz A, Lagartera L, Jiménez-Barbero J, Clausen H, Rovira C, Marcelo F, Corzana F, Gerken TA, Hurtado-Guerrero R.

ACS Cent Sci. 2018 Sep 26;4(9):1274-1290. doi: 10.1021/acscentsci.8b00488. Epub 2018 Sep 14.

17.

Expression of the O-Glycosylation Enzyme GalNAc-T3 in the Equatorial Segment Correlates with the Quality of Spermatozoa.

Nygaard MB, Herlihy AS, Jeanneau C, Nielsen JE, Bennett EP, Jørgensen N, Clausen H, Mandel U, Rajpert-De Meyts E, Almstrup K.

Int J Mol Sci. 2018 Sep 27;19(10). pii: E2949. doi: 10.3390/ijms19102949.

18.

Targeted Analysis of Lysosomal Directed Proteins and Their Sites of Mannose-6-phosphate Modification.

Čaval T, Zhu J, Tian W, Remmelzwaal S, Yang Z, Clausen H, Heck AJR.

Mol Cell Proteomics. 2019 Jan;18(1):16-27. doi: 10.1074/mcp.RA118.000967. Epub 2018 Sep 20.

PMID:
30237200
19.

Direct quality control of glycoengineered erythropoietin variants.

Čaval T, Tian W, Yang Z, Clausen H, Heck AJR.

Nat Commun. 2018 Aug 21;9(1):3342. doi: 10.1038/s41467-018-05536-3.

20.

The GAGOme: a cell-based library of displayed glycosaminoglycans.

Chen YH, Narimatsu Y, Clausen TM, Gomes C, Karlsson R, Steentoft C, Spliid CB, Gustavsson T, Salanti A, Persson A, Malmström A, Willén D, Ellervik U, Bennett EP, Mao Y, Clausen H, Yang Z.

Nat Methods. 2018 Nov;15(11):881-888. doi: 10.1038/s41592-018-0086-z. Epub 2018 Aug 13.

PMID:
30104636
21.

EDEM1's mannosidase-like domain binds ERAD client proteins in a redox-sensitive manner and possesses catalytic activity.

Lamriben L, Oster ME, Tamura T, Tian W, Yang Z, Clausen H, Hebert DN.

J Biol Chem. 2018 Sep 7;293(36):13932-13945. doi: 10.1074/jbc.RA118.004183. Epub 2018 Jul 18.

22.

Mucins and Truncated O-Glycans Unveil Phenotypic Discrepancies between Serous Ovarian Cancer Cell Lines and Primary Tumours.

Coelho R, Marcos-Silva L, Mendes N, Pereira D, Brito C, Jacob F, Steentoft C, Mandel U, Clausen H, David L, Ricardo S.

Int J Mol Sci. 2018 Jul 13;19(7). pii: E2045. doi: 10.3390/ijms19072045.

23.

Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts.

de Las Rivas M, Coelho H, Diniz A, Lira-Navarrete E, Compañón I, Jiménez-Barbero J, Schjoldager KT, Bennett EP, Vakhrushev SY, Clausen H, Corzana F, Marcelo F, Hurtado-Guerrero R.

Chemistry. 2018 Jun 12;24(33):8382-8392. doi: 10.1002/chem.201800701. Epub 2018 May 16.

PMID:
29601100
24.

Glycoengineering design options for IgG1 in CHO cells using precise gene editing.

Schulz MA, Tian W, Mao Y, Van Coillie J, Sun L, Larsen JS, Chen YH, Kristensen C, Vakhrushev SY, Clausen H, Yang Z.

Glycobiology. 2018 Jul 1;28(7):542-549. doi: 10.1093/glycob/cwy022.

PMID:
29596681
25.

Glycosyltransferase genes that cause monogenic congenital disorders of glycosylation are distinct from glycosyltransferase genes associated with complex diseases.

Joshi HJ, Hansen L, Narimatsu Y, Freeze HH, Henrissat B, Bennett E, Wandall HH, Clausen H, Schjoldager KT.

Glycobiology. 2018 May 1;28(5):284-294. doi: 10.1093/glycob/cwy015.

26.

Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions.

Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H.

J Biol Chem. 2018 May 11;293(19):7408-7422. doi: 10.1074/jbc.M117.817981. Epub 2018 Mar 20. Erratum in: J Biol Chem. 2019 May 24;294(21):8349.

27.

Fine-Tuning Limited Proteolysis: A Major Role for Regulated Site-Specific O-Glycosylation.

Goth CK, Vakhrushev SY, Joshi HJ, Clausen H, Schjoldager KT.

Trends Biochem Sci. 2018 Apr;43(4):269-284. doi: 10.1016/j.tibs.2018.02.005. Epub 2018 Mar 2. Review.

PMID:
29506880
28.

SnapShot: O-Glycosylation Pathways across Kingdoms.

Joshi HJ, Narimatsu Y, Schjoldager KT, Tytgat HLP, Aebi M, Clausen H, Halim A.

Cell. 2018 Jan 25;172(3):632-632.e2. doi: 10.1016/j.cell.2018.01.016. Review.

29.

A validated gRNA library for CRISPR/Cas9 targeting of the human glycosyltransferase genome.

Narimatsu Y, Joshi HJ, Yang Z, Gomes C, Chen YH, Lorenzetti FC, Furukawa S, Schjoldager KT, Hansen L, Clausen H, Bennett EP, Wandall HH.

Glycobiology. 2018 May 1;28(5):295-305. doi: 10.1093/glycob/cwx101.

PMID:
29315387
30.

GlycoDomainViewer: a bioinformatics tool for contextual exploration of glycoproteomes.

Joshi HJ, Jørgensen A, Schjoldager KT, Halim A, Dworkin LA, Steentoft C, Wandall HH, Clausen H, Vakhrushev SY.

Glycobiology. 2018 Mar 1;28(3):131-136. doi: 10.1093/glycob/cwx104.

PMID:
29267884
31.

The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences.

de Las Rivas M, Lira-Navarrete E, Daniel EJP, Compañón I, Coelho H, Diniz A, Jiménez-Barbero J, Peregrina JM, Clausen H, Corzana F, Marcelo F, Jiménez-Osés G, Gerken TA, Hurtado-Guerrero R.

Nat Commun. 2017 Dec 5;8(1):1959. doi: 10.1038/s41467-017-02006-0.

32.

Site-specific O-glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human δ-opioid receptor turnover at the plasma membrane.

Lackman JJ, Goth CK, Halim A, Vakhrushev SY, Clausen H, Petäjä-Repo UE.

Cell Signal. 2018 Jan;42:184-193. doi: 10.1016/j.cellsig.2017.10.016. Epub 2017 Oct 31.

PMID:
29097258
33.

Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins.

Larsen ISB, Narimatsu Y, Joshi HJ, Siukstaite L, Harrison OJ, Brasch J, Goodman KM, Hansen L, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11163-11168. doi: 10.1073/pnas.1708319114. Epub 2017 Oct 2.

34.

Glycosylation Engineering.

Clausen H, Wandall HH, Steentoft C, Stanley P, Schnaar RL.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 56.
2017.

35.

Spatial separation of the cyanogenic β-glucosidase ZfBGD2 and cyanogenic glucosides in the haemolymph of Zygaena larvae facilitates cyanide release.

Pentzold S, Jensen MK, Matthes A, Olsen CE, Petersen BL, Clausen H, Møller BL, Bak S, Zagrobelny M.

R Soc Open Sci. 2017 Jun 28;4(6):170262. doi: 10.1098/rsos.170262. eCollection 2017 Jun.

36.

Generation and characterization of a monoclonal antibody to the cytoplasmic tail of MUC16.

Gipson IK, Mandel U, Menon B, Michaud S, Tisdale A, Campos D, Clausen H.

Glycobiology. 2017 Oct 1;27(10):920-926. doi: 10.1093/glycob/cwx054.

37.

Corrigendum: Identification and evolution of a plant cell wall specific glycoprotein glycosyl transferase, ExAD.

Møller SR, Yi X, Velásquez SM, Gille S, Hansen PLM, Poulsen CP, Olsen CE, Rejzek M, Parsons H, Yang Z, Wandall HH, Clausen H, Field RA, Pauly M, Estevez JM, Harholt J, Ulvskov P, Petersen BL.

Sci Rep. 2017 May 23;7:46774. doi: 10.1038/srep46774.

38.

Erratum: Corrigendum: Identification and evolution of a plant cell wall specific glycoprotein glycosyl transferase, ExAD.

Møller SR, Yi X, Velásquez SM, Gille S, Hansen PLM, Poulsen CP, Olsen CE, Rejzek M, Parsons H, Yang Z, Wandall HH, Clausen H, Field RA, Pauly M, Estevez JM, Harholt J, Ulvskov P, Petersen BL.

Sci Rep. 2017 May 23;7(1):46774. doi: 10.1038/srep46774.

39.

NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity.

El Qaidi S, Chen K, Halim A, Siukstaite L, Rueter C, Hurtado-Guerrero R, Clausen H, Hardwidge PR.

J Biol Chem. 2017 Jul 7;292(27):11423-11430. doi: 10.1074/jbc.M117.790675. Epub 2017 May 18.

40.

Mammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2.

Larsen ISB, Narimatsu Y, Joshi HJ, Yang Z, Harrison OJ, Brasch J, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A.

J Biol Chem. 2017 Jul 7;292(27):11586-11598. doi: 10.1074/jbc.M117.794487. Epub 2017 May 16.

41.

Effects of liraglutide on ovarian dysfunction in polycystic ovary syndrome: a randomized clinical trial.

Nylander M, Frøssing S, Clausen HV, Kistorp C, Faber J, Skouby SO.

Reprod Biomed Online. 2017 Jul;35(1):121-127. doi: 10.1016/j.rbmo.2017.03.023. Epub 2017 Apr 24.

PMID:
28479118
42.

Identification and evolution of a plant cell wall specific glycoprotein glycosyl transferase, ExAD.

Møller SR, Yi X, Velásquez SM, Gille S, Hansen PLM, Poulsen CP, Olsen CE, Rejzek M, Parsons H, Yang Z, Wandall HH, Clausen H, Field RA, Pauly M, Estevez JM, Harholt J, Ulvskov P, Petersen BL.

Sci Rep. 2017 Mar 30;7:45341. doi: 10.1038/srep45341. Erratum in: Sci Rep. 2017 May 23;7:46774. Zhang, Yang [corrected to Yang, Zhang]. Sci Rep. 2017 May 23;7(1):46774.

43.

Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis.

Lonowski LA, Narimatsu Y, Riaz A, Delay CE, Yang Z, Niola F, Duda K, Ober EA, Clausen H, Wandall HH, Hansen SH, Bennett EP, Frödin M.

Nat Protoc. 2017 Mar;12(3):581-603. doi: 10.1038/nprot.2016.165. Epub 2017 Feb 16.

PMID:
28207001
44.

Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β1-Adrenergic Receptor N-terminal Cleavage.

Goth CK, Tuhkanen HE, Khan H, Lackman JJ, Wang S, Narimatsu Y, Hansen LH, Overall CM, Clausen H, Schjoldager KT, Petäjä-Repo UE.

J Biol Chem. 2017 Mar 17;292(11):4714-4726. doi: 10.1074/jbc.M116.730614. Epub 2017 Feb 6.

45.

Revisiting the human polypeptide GalNAc-T1 and T13 paralogs.

Festari MF, Trajtenberg F, Berois N, Pantano S, Revoredo L, Kong Y, Solari-Saquieres P, Narimatsu Y, Freire T, Bay S, Robello C, Bénard J, Gerken TA, Clausen H, Osinaga E.

Glycobiology. 2017 Jan;27(2):140-153. doi: 10.1093/glycob/cww111. Epub 2016 Nov 22.

46.

Distinguishing Truncated and Normal MUC1 Glycoform Targeting from Tn-MUC1-Specific CAR T Cells: Specificity Is the Key to Safety.

Posey AD Jr, Clausen H, June CH.

Immunity. 2016 Nov 15;45(5):947-948. doi: 10.1016/j.immuni.2016.10.015.

47.

Extrinsic Functions of Lectin Domains in O-N-Acetylgalactosamine Glycan Biosynthesis.

Lorenz V, Ditamo Y, Cejas RB, Carrizo ME, Bennett EP, Clausen H, Nores GA, Irazoqui FJ.

J Biol Chem. 2016 Dec 2;291(49):25339-25350. Epub 2016 Oct 13.

48.

Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.

Khetarpal SA, Schjoldager KT, Christoffersen C, Raghavan A, Edmondson AC, Reutter HM, Ahmed B, Ouazzani R, Peloso GM, Vitali C, Zhao W, Somasundara AV, Millar JS, Park Y, Fernando G, Livanov V, Choi S, Noé E, Patel P, Ho SP; Myocardial Infarction Exome Sequencing Study, Kirchgessner TG, Wandall HH, Hansen L, Bennett EP, Vakhrushev SY, Saleheen D, Kathiresan S, Brown CD, Abou Jamra R, LeGuern E, Clausen H, Rader DJ.

Cell Metab. 2016 Aug 9;24(2):234-45. doi: 10.1016/j.cmet.2016.07.012.

49.

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.

Posey AD Jr, Schwab RD, Boesteanu AC, Steentoft C, Mandel U, Engels B, Stone JD, Madsen TD, Schreiber K, Haines KM, Cogdill AP, Chen TJ, Song D, Scholler J, Kranz DM, Feldman MD, Young R, Keith B, Schreiber H, Clausen H, Johnson LA, June CH.

Immunity. 2016 Jun 21;44(6):1444-54. doi: 10.1016/j.immuni.2016.05.014.

50.

Hospitalisation of severely mentally ill patients with and without problematic substance use before and during Assertive Community Treatment: an observational cohort study.

Clausen H, Ruud T, Odden S, Šaltytė Benth J, Heiervang KS, Stuen HK, Killaspy H, Drake RE, Landheim A.

BMC Psychiatry. 2016 May 4;16:125. doi: 10.1186/s12888-016-0826-5.

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