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Items: 1 to 50 of 98

1.

IL-10 signaling prevents gluten-dependent intraepithelial CD4+ cytotoxic T lymphocyte infiltration and epithelial damage in the small intestine.

Costes LMM, Lindenbergh-Kortleve DJ, van Berkel LA, Veenbergen S, Raatgeep HRC, Simons-Oosterhuis Y, van Haaften DH, Karrich JJ, Escher JC, Groeneweg M, Clausen BE, Cupedo T, Samsom JN.

Mucosal Immunol. 2019 Mar;12(2):479-490. doi: 10.1038/s41385-018-0118-0. Epub 2018 Dec 12.

PMID:
30542112
2.

Production of Extracellular Adenosine by CD73+ Dendritic Cells Is Crucial for Induction of Tolerance in Contact Hypersensitivity Reactions.

Silva-Vilches C, Ring S, Schrader J, Clausen BE, Probst HC, Melchior F, Schild H, Enk A, Mahnke K.

J Invest Dermatol. 2018 Oct 28. pii: S0022-202X(18)32708-8. doi: 10.1016/j.jid.2018.10.016. [Epub ahead of print]

PMID:
30393085
3.

Antagonization of IL-17A Attenuates Skin Inflammation and Vascular Dysfunction in Mouse Models of Psoriasis.

Schüler R, Brand A, Klebow S, Wild J, Veras FP, Ullmann E, Roohani S, Kolbinger F, Kossmann S, Wohn C, Daiber A, Münzel T, Wenzel P, Waisman A, Clausen BE, Karbach S.

J Invest Dermatol. 2018 Oct 24. pii: S0022-202X(18)32690-3. doi: 10.1016/j.jid.2018.09.021. [Epub ahead of print]

PMID:
30367871
4.

Dermal CD207-Negative Migratory Dendritic Cells Are Fully Competent to Prime Protective, Skin Homing Cytotoxic T-Lymphocyte Responses.

Hain T, Melchior F, Kamenjarin N, Muth S, Weslati H, Clausen BE, Mahnke K, Silva-Vilches C, Schütze K, Sohl J, Radsak MP, Bündgen G, Bopp T, Danckwardt S, Schild H, Probst HC.

J Invest Dermatol. 2019 Feb;139(2):422-429. doi: 10.1016/j.jid.2018.08.022. Epub 2018 Oct 6.

PMID:
30296420
5.

Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection.

Sparber F, Dolowschiak T, Mertens S, Lauener L, Clausen BE, Joller N, Stoitzner P, Tussiwand R, LeibundGut-Landmann S.

PLoS Pathog. 2018 May 21;14(5):e1007069. doi: 10.1371/journal.ppat.1007069. eCollection 2018 May.

6.

Sequential BMP7/TGF-β1 signaling and microbiota instruct mucosal Langerhans cell differentiation.

Capucha T, Koren N, Nassar M, Heyman O, Nir T, Levy M, Zilberman-Schapira G, Zelentova K, Eli-Berchoer L, Zenke M, Hieronymus T, Wilensky A, Bercovier H, Elinav E, Clausen BE, Hovav AH.

J Exp Med. 2018 Feb 5;215(2):481-500. doi: 10.1084/jem.20171508. Epub 2018 Jan 17.

7.

Langerhans Cells Prevent Autoimmunity via Expansion of Keratinocyte Antigen-Specific Regulatory T Cells.

Kitashima DY, Kobayashi T, Woodring T, Idouchi K, Doebel T, Voisin B, Adachi T, Ouchi T, Takahashi H, Nishifuji K, Kaplan DH, Clausen BE, Amagai M, Nagao K.

EBioMedicine. 2018 Jan;27:293-303. doi: 10.1016/j.ebiom.2017.12.022. Epub 2017 Dec 20.

8.

TGFβR signalling controls CD103+CD11b+ dendritic cell development in the intestine.

Bain CC, Montgomery J, Scott CL, Kel JM, Girard-Madoux MJH, Martens L, Zangerle-Murray TFP, Ober-Blöbaum J, Lindenbergh-Kortleve D, Samsom JN, Henri S, Lawrence T, Saeys Y, Malissen B, Dalod M, Clausen BE, Mowat AM.

Nat Commun. 2017 Sep 20;8(1):620. doi: 10.1038/s41467-017-00658-6.

9.

In cutaneous leishmaniasis, induction of retinoic acid in skin-derived Langerhans cells is not sufficient for induction of parasite persistence-mediating regulatory T cells.

Dietze-Schwonberg K, Kautz-Neu K, Lorenz B, Clausen BE, von Stebut E.

J Dermatol Sci. 2017 Sep;87(3):307-309. doi: 10.1016/j.jdermsci.2017.06.014. Epub 2017 Jun 17. No abstract available.

PMID:
28823643
10.

Langerhans cells and NK cells cooperate in the inhibition of chemical skin carcinogenesis.

Ortner D, Tripp CH, Komenda K, Dubrac S, Zelger B, Hermann M, Doppler W, Tymoszuk PZ, Boon L, Clausen BE, Stoitzner P.

Oncoimmunology. 2016 Nov 18;6(2):e1260215. doi: 10.1080/2162402X.2016.1260215. eCollection 2017.

11.

TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity.

Lukas D, Yogev N, Kel JM, Regen T, Mufazalov IA, Tang Y, Wanke F, Reizis B, Müller W, Kurschus FC, Prinz M, Kleiter I, Clausen BE, Waisman A.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1480-E1489. doi: 10.1073/pnas.1615065114. Epub 2017 Feb 6.

12.

Monitoring Skin Dendritic Cells in Steady State and Inflammation by Immunofluorescence Microscopy and Flow Cytometry.

Ober-Blöbaum JL, Ortner D, Haid B, Brand A, Tripp C, Clausen BE, Stoitzner P.

Methods Mol Biol. 2017;1559:37-52. doi: 10.1007/978-1-4939-6786-5_3.

PMID:
28063035
13.

Reproducibility Issues: Avoiding Pitfalls in Animal Inflammation Models.

Laman JD, Kooistra SM, Clausen BE.

Methods Mol Biol. 2017;1559:1-17. doi: 10.1007/978-1-4939-6786-5_1. Review.

PMID:
28063033
14.

Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation.

Singh TP, Zhang HH, Borek I, Wolf P, Hedrick MN, Singh SP, Kelsall BL, Clausen BE, Farber JM.

Nat Commun. 2016 Dec 16;7:13581. doi: 10.1038/ncomms13581.

15.

IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively.

Sichien D, Scott CL, Martens L, Vanderkerken M, Van Gassen S, Plantinga M, Joeris T, De Prijck S, Vanhoutte L, Vanheerswynghels M, Van Isterdael G, Toussaint W, Madeira FB, Vergote K, Agace WW, Clausen BE, Hammad H, Dalod M, Saeys Y, Lambrecht BN, Guilliams M.

Immunity. 2016 Sep 20;45(3):626-640. doi: 10.1016/j.immuni.2016.08.013. Epub 2016 Sep 13.

16.

Dendritic cells as gatekeepers of tolerance.

Waisman A, Lukas D, Clausen BE, Yogev N.

Semin Immunopathol. 2017 Feb;39(2):153-163. doi: 10.1007/s00281-016-0583-z. Epub 2016 Jul 25. Review.

PMID:
27456849
17.

IL-10 control of CD11c+ myeloid cells is essential to maintain immune homeostasis in the small and large intestine.

Girard-Madoux MJ, Ober-Blöbaum JL, Costes LM, Kel JM, Lindenbergh-Kortleve DJ, Brouwers-Haspels I, Heikema AP, Samsom JN, Clausen BE.

Oncotarget. 2016 May 31;7(22):32015-30. doi: 10.18632/oncotarget.8337.

18.

Atopic dermatitis induces the expansion of thymus-derived regulatory T cells exhibiting a Th2-like phenotype in mice.

Moosbrugger-Martinz V, Tripp CH, Clausen BE, Schmuth M, Dubrac S.

J Cell Mol Med. 2016 May;20(5):930-8. doi: 10.1111/jcmm.12806. Epub 2016 Mar 2.

19.

Gradual development of psoriatic skin lesions by constitutive low-level expression of IL-17A.

Wohn C, Brand A, van Ettinger K, Brouwers-Haspels I, Waisman A, Laman JD, Clausen BE.

Cell Immunol. 2016 Oct;308:57-65. doi: 10.1016/j.cellimm.2015.11.006. Epub 2015 Nov 26.

PMID:
26653007
20.

Dendritic Cell-Specific Deletion of β-Catenin Results in Fewer Regulatory T-Cells without Exacerbating Autoimmune Collagen-Induced Arthritis.

Alves CH, Ober-Blöbaum JL, Brouwers-Haspels I, Asmawidjaja PS, Mus AM, Razawy W, Molendijk M, Clausen BE, Lubberts E.

PLoS One. 2015 Nov 20;10(11):e0142972. doi: 10.1371/journal.pone.0142972. eCollection 2015.

21.

Functional Specialization of Skin Dendritic Cell Subsets in Regulating T Cell Responses.

Clausen BE, Stoitzner P.

Front Immunol. 2015 Oct 22;6:534. doi: 10.3389/fimmu.2015.00534. eCollection 2015. Review.

22.

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.

Croxford AL, Lanzinger M, Hartmann FJ, Schreiner B, Mair F, Pelczar P, Clausen BE, Jung S, Greter M, Becher B.

Immunity. 2015 Sep 15;43(3):502-14. doi: 10.1016/j.immuni.2015.08.010. Epub 2015 Sep 1.

23.

IL-10 signaling in dendritic cells attenuates anti-Leishmania major immunity without affecting protective memory responses.

Girard-Madoux MJH, Kautz-Neu K, Lorenz B, Ober-Blöbaum JL, von Stebut E, Clausen BE.

J Invest Dermatol. 2015 Nov;135(11):2890-2894. doi: 10.1038/jid.2015.236. Epub 2015 Jun 22. No abstract available.

24.

Cutaneous RANK-RANKL Signaling Upregulates CD8-Mediated Antiviral Immunity during Herpes simplex Virus Infection by Preventing Virus-Induced Langerhans Cell Apoptosis.

Klenner L, Hafezi W, Clausen BE, Lorentzen EU, Luger TA, Beissert S, Kühn JE, Loser K.

J Invest Dermatol. 2015 Nov;135(11):2676-2687. doi: 10.1038/jid.2015.225. Epub 2015 Jun 15.

25.

Surmounting limited gene delivery into primary immune cell populations: Efficient cell type-specific adenoviral transduction by CAR.

Clausen BE, Brand A, Karram K.

Eur J Immunol. 2015 Jun;45(6):1596-9. doi: 10.1002/eji.201545685. Epub 2015 May 12.

26.

Multifaceted contributions of epidermal langerhans cells to cutaneous carcinogenesis.

Clausen BE, Grabbe S.

J Invest Dermatol. 2015 May;135(5):1218-1220. doi: 10.1038/jid.2014.520.

27.

β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10.

Fu C, Liang X, Cui W, Ober-Blöbaum JL, Vazzana J, Shrikant PA, Lee KP, Clausen BE, Mellman I, Jiang A.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2823-8. doi: 10.1073/pnas.1414167112. Epub 2015 Feb 17.

28.

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.

Berres ML, Lim KP, Peters T, Price J, Takizawa H, Salmon H, Idoyaga J, Ruzo A, Lupo PJ, Hicks MJ, Shih A, Simko SJ, Abhyankar H, Chakraborty R, Leboeuf M, Beltrão M, Lira SA, Heym KM, Clausen BE, Bigley V, Collin M, Manz MG, McClain K, Merad M, Allen CE.

J Exp Med. 2015 Feb 9;212(2):281. doi: 10.1084/jem.2013097701202015c. Epub 2015 Feb 2. No abstract available.

29.

Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells.

Cohen SB, Smith NL, McDougal C, Pepper M, Shah S, Yap GS, Acha-Orbea H, Jiang A, Clausen BE, Rudd BD, Denkers EY.

J Immunol. 2015 Jan 1;194(1):210-22.

30.

Dermal dendritic cells, but not Langerhans cells, are critical in murine single epicutaneous sensitization.

Lee CH, Chen JS, Chiu HC, Hong CH, Liu CY, Ta YC, Clausen BE, Ho JC, Wang LF.

Exp Dermatol. 2015 Jan;24(1):67-9. doi: 10.1111/exd.12583. Epub 2014 Dec 8.

PMID:
25363677
31.

Aldara-induced psoriasis-like skin inflammation: isolation and characterization of cutaneous dendritic cells and innate lymphocytes.

Wohn CT, Pantelyushin S, Ober-Blöbaum JL, Clausen BE.

Methods Mol Biol. 2014;1193:171-85. doi: 10.1007/978-1-4939-1212-4_16.

PMID:
25151006
32.

Classical Flt3L-dependent dendritic cells control immunity to protein vaccine.

Anandasabapathy N, Feder R, Mollah S, Tse SW, Longhi MP, Mehandru S, Matos I, Cheong C, Ruane D, Brane L, Teixeira A, Dobrin J, Mizenina O, Park CG, Meredith M, Clausen BE, Nussenzweig MC, Steinman RM.

J Exp Med. 2014 Aug 25;211(9):1875-91. doi: 10.1084/jem.20131397. Epub 2014 Aug 18.

33.

The late endosomal adaptor molecule p14 (LAMTOR2) regulates TGFβ1-mediated homeostasis of Langerhans cells.

Sparber F, Tripp CH, Komenda K, Scheffler JM, Clausen BE, Huber LA, Romani N, Stoitzner P.

J Invest Dermatol. 2015 Jan;135(1):119-129. doi: 10.1038/jid.2014.324. Epub 2014 Jul 31.

34.

Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity.

Breuer J, Schwab N, Schneider-Hohendorf T, Marziniak M, Mohan H, Bhatia U, Gross CC, Clausen BE, Weishaupt C, Luger TA, Meuth SG, Loser K, Wiendl H.

Ann Neurol. 2014 May;75(5):739-58. doi: 10.1002/ana.24165. Epub 2014 May 13.

PMID:
24771567
35.

Second-generation Langerhans cells originating from epidermal precursors are essential for CD8+ T cell priming.

Elnekave M, Furmanov K, Shaul Y, Capucha T, Eli-Berchoer L, Zelentsova K, Clausen BE, Hovav AH.

J Immunol. 2014 Feb 15;192(4):1395-403. doi: 10.4049/jimmunol.1301143. Epub 2014 Jan 13.

36.

The late endosomal adaptor molecule p14 (LAMTOR2) represents a novel regulator of Langerhans cell homeostasis.

Sparber F, Scheffler JM, Amberg N, Tripp CH, Heib V, Hermann M, Zahner SP, Clausen BE, Reizis B, Huber LA, Stoitzner P, Romani N.

Blood. 2014 Jan 9;123(2):217-27. doi: 10.1182/blood-2013-08-518555. Epub 2013 Oct 3.

37.

β-catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8⁺ T cells.

Liang X, Fu C, Cui W, Ober-Blöbaum JL, Zahner SP, Shrikant PA, Clausen BE, Flavell RA, Mellman I, Jiang A.

J Leukoc Biol. 2014 Jan;95(1):179-90. doi: 10.1189/jlb.0613330. Epub 2013 Sep 10.

PMID:
24023259
38.

Multicolor fate mapping of Langerhans cell homeostasis.

Ghigo C, Mondor I, Jorquera A, Nowak J, Wienert S, Zahner SP, Clausen BE, Luche H, Malissen B, Klauschen F, Bajénoff M.

J Exp Med. 2013 Aug 26;210(9):1657-64. doi: 10.1084/jem.20130403. Epub 2013 Aug 12.

39.

IL-10 control of dendritic cells in the skin.

Clausen BE, Girard-Madoux MJ.

Oncoimmunology. 2013 Mar 1;2(3):e23186.

40.

Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice.

Wohn C, Ober-Blöbaum JL, Haak S, Pantelyushin S, Cheong C, Zahner SP, Onderwater S, Kant M, Weighardt H, Holzmann B, Reizis B, Becher B, Prens EP, Clausen BE.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10723-8. doi: 10.1073/pnas.1307569110. Epub 2013 Jun 10.

41.

Alveolar epithelial cells orchestrate DC function in murine viral pneumonia.

Unkel B, Hoegner K, Clausen BE, Lewe-Schlosser P, Bodner J, Gattenloehner S, Janßen H, Seeger W, Lohmeyer J, Herold S.

J Clin Invest. 2012 Oct;122(10):3652-64. doi: 10.1172/JCI62139. Epub 2012 Sep 10.

42.

IL-10 suppression of NK/DC crosstalk leads to poor priming of MCMV-specific CD4 T cells and prolonged MCMV persistence.

Mandaric S, Walton SM, Rülicke T, Richter K, Girard-Madoux MJ, Clausen BE, Zurunic A, Kamanaka M, Flavell RA, Jonjic S, Oxenius A.

PLoS Pathog. 2012;8(8):e1002846. doi: 10.1371/journal.ppat.1002846. Epub 2012 Aug 2.

43.

1,25-dihydroxyvitamin D exerts similar immunosuppressive effects as UVR but is dispensable for local UVR-induced immunosuppression.

Schwarz A, Navid F, Sparwasser T, Clausen BE, Schwarz T.

J Invest Dermatol. 2012 Dec;132(12):2762-9. doi: 10.1038/jid.2012.238. Epub 2012 Aug 2.

44.

Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin.

Nagao K, Kobayashi T, Moro K, Ohyama M, Adachi T, Kitashima DY, Ueha S, Horiuchi K, Tanizaki H, Kabashima K, Kubo A, Cho YH, Clausen BE, Matsushima K, Suematsu M, Furtado GC, Lira SA, Farber JM, Udey MC, Amagai M.

Nat Immunol. 2012 Jun 24;13(8):744-52. doi: 10.1038/ni.2353.

45.

Langerhans cells down-regulate inflammation-driven alveolar bone loss.

Arizon M, Nudel I, Segev H, Mizraji G, Elnekave M, Furmanov K, Eli-Berchoer L, Clausen BE, Shapira L, Wilensky A, Hovav AH.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):7043-8. doi: 10.1073/pnas.1116770109. Epub 2012 Apr 16.

46.

Arsenic mobilizes Langerhans cell migration and induces Th1 response in epicutaneous protein sensitization via CCL21: a plausible cause of decreased Langerhans cells in arsenic-induced intraepithelial carcinoma.

Lee CH, Hong CH, Yu CL, Wang LF, Clausen BE, Liao WT, Huang SK, Chen GS, Yu HS.

Biochem Pharmacol. 2012 May 1;83(9):1290-9. doi: 10.1016/j.bcp.2012.01.028. Epub 2012 Feb 1.

PMID:
22321510
47.

Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome.

Ouchi T, Kubo A, Yokouchi M, Adachi T, Kobayashi T, Kitashima DY, Fujii H, Clausen BE, Koyasu S, Amagai M, Nagao K.

J Exp Med. 2011 Dec 19;208(13):2607-13. doi: 10.1084/jem.20111718. Epub 2011 Dec 5.

48.

Conditional deletion of TGF-βR1 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity.

Zahner SP, Kel JM, Martina CA, Brouwers-Haspels I, van Roon MA, Clausen BE.

J Immunol. 2011 Nov 15;187(10):5069-76. doi: 10.4049/jimmunol.1101880. Epub 2011 Oct 12.

49.

IL-10 controls dendritic cell-induced T-cell reactivation in the skin to limit contact hypersensitivity.

Girard-Madoux MJ, Kel JM, Reizis B, Clausen BE.

J Allergy Clin Immunol. 2012 Jan;129(1):143-50.e1-10. doi: 10.1016/j.jaci.2011.08.032. Epub 2011 Oct 5.

PMID:
21975175
50.

Aryl hydrocarbon receptor is critical for homeostasis of invariant gammadelta T cells in the murine epidermis.

Kadow S, Jux B, Zahner SP, Wingerath B, Chmill S, Clausen BE, Hengstler J, Esser C.

J Immunol. 2011 Sep 15;187(6):3104-10. doi: 10.4049/jimmunol.1100912. Epub 2011 Aug 15.

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