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Items: 36

1.

Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies.

Parada-Kusz M, Penaranda C, Hagedorn EJ, Clatworthy A, Nair AV, Henninger JE, Ernst C, Li B, Riquelme R, Jijon H, Villablanca EJ, Zon LI, Hung D, Allende ML.

Dis Model Mech. 2018 Nov 5;11(11). pii: dmm034876. doi: 10.1242/dmm.034876.

2.

Whole-organism phenotypic screening for anti-infectives promoting host health.

Clatworthy AE, Romano KP, Hung DT.

Nat Chem Biol. 2018 Apr;14(4):331-341. doi: 10.1038/s41589-018-0018-3. Epub 2018 Mar 19. Review.

PMID:
29556098
3.

A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.

Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, Hung DT.

Nat Chem Biol. 2017 Sep;13(9):943-950. doi: 10.1038/nchembio.2420. Epub 2017 Jul 3.

PMID:
28671682
4.

Bacterial toxins and small molecules elucidate endosomal trafficking.

Slater LH, Clatworthy AE, Hung DT.

Trends Microbiol. 2014 Feb;22(2):53-5. doi: 10.1016/j.tim.2013.12.002. Epub 2013 Dec 23.

PMID:
24370463
5.

Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32.

Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Grant SS, Rubin EJ, Hung DT.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11565-70. doi: 10.1073/pnas.1302114110. Epub 2013 Jun 24.

6.

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.

Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9932-7. doi: 10.1073/pnas.1302257110. Epub 2013 May 28.

7.

The two-component sensor KinB acts as a phosphatase to regulate Pseudomonas aeruginosa Virulence.

Chand NS, Clatworthy AE, Hung DT.

J Bacteriol. 2012 Dec;194(23):6537-47. doi: 10.1128/JB.01168-12. Epub 2012 Sep 28.

8.

The sensor kinase KinB regulates virulence in acute Pseudomonas aeruginosa infection.

Chand NS, Lee JS, Clatworthy AE, Golas AJ, Smith RS, Hung DT.

J Bacteriol. 2011 Jun;193(12):2989-99. doi: 10.1128/JB.01546-10. Epub 2011 Apr 22.

9.

Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.

Gomez JE, Clatworthy A, Hung DT.

Crit Rev Biochem Mol Biol. 2011 Feb;46(1):41-66. doi: 10.3109/10409238.2010.538663. Review.

PMID:
21250782
10.

Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants.

Clatworthy AE, Lee JS, Leibman M, Kostun Z, Davidson AJ, Hung DT.

Infect Immun. 2009 Apr;77(4):1293-303. doi: 10.1128/IAI.01181-08. Epub 2009 Jan 21.

11.

Targeting virulence: a new paradigm for antimicrobial therapy.

Clatworthy AE, Pierson E, Hung DT.

Nat Chem Biol. 2007 Sep;3(9):541-8. Review.

PMID:
17710100
12.

The MRE11-RAD50-XRS2 complex, in addition to other non-homologous end-joining factors, is required for V(D)J joining in yeast.

Clatworthy AE, Valencia-Burton MA, Haber JE, Oettinger MA.

J Biol Chem. 2005 May 27;280(21):20247-52. Epub 2005 Mar 9.

13.

V(D)J recombination and RAG-mediated transposition in yeast.

Clatworthy AE, Valencia MA, Haber JE, Oettinger MA.

Mol Cell. 2003 Aug;12(2):489-99.

14.

Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs.

Melián A, Watts GF, Shamshiev A, De Libero G, Clatworthy A, Vincent M, Brenner MB, Behar S, Niazi K, Modlin RL, Almo S, Ostrov D, Nathenson SG, Porcelli SA.

J Immunol. 2000 Oct 15;165(8):4494-504.

15.

Ionizing radiation-induced alterations in the electrophysiological properties of Aplysia sensory neurons.

Clatworthy AL, Noel F, Grose E, Cui M, Tofilon PJ.

Neurosci Lett. 1999 Jun 11;268(1):45-8.

PMID:
10400074
16.

Expression and alternate splicing of apolipoprotein E receptor 2 in brain.

Clatworthy AE, Stockinger W, Christie RH, Schneider WJ, Nimpf J, Hyman BT, Rebeck GW.

Neuroscience. 1999 Mar;90(3):903-11.

PMID:
10218790
17.

Immune-mediated alterations in nociceptive sensory function in Aplysia californica.

Clatworthy AL, Grose E.

J Exp Biol. 1999 Mar;202(Pt 5):623-30.

18.

Lack of association of presenilin-1 intron-8 polymorphism with neuropathological features of Alzheimer's disease.

Liao A, Gómez-Isla T, Clatworthy A, Hyman BT.

Brain Res. 1999 Jan 23;816(2):295-8.

PMID:
9878795
19.

Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.

Liao A, Nitsch RM, Greenberg SM, Finckh U, Blacker D, Albert M, Rebeck GW, Gomez-Isla T, Clatworthy A, Binetti G, Hock C, Mueller-Thomsen T, Mann U, Zuchowski K, Beisiegel U, Staehelin H, Growdon JH, Tanzi RE, Hyman BT.

Hum Mol Genet. 1998 Nov;7(12):1953-6.

PMID:
9811940
20.

Neural-immune interactions--an evolutionary perspective.

Clatworthy AL.

Neuroimmunomodulation. 1998 May-Aug;5(3-4):136-42. Review.

PMID:
9730679
21.

Association of apolipoprotein E epsilon2 and vasculopathy in cerebral amyloid angiopathy.

Greenberg SM, Vonsattel JP, Segal AZ, Chiu RI, Clatworthy AE, Liao A, Hyman BT, Rebeck GW.

Neurology. 1998 Apr;50(4):961-5.

PMID:
9566379
22.

Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease.

Clatworthy AE, Gomez-Isla T, Rebeck GW, Wallace RB, Hyman BT.

Arch Neurol. 1997 Oct;54(10):1289-92.

PMID:
9341576
23.

A simple systems approach to neural-immune communication.

Clatworthy AL.

Comp Biochem Physiol A Physiol. 1996 Sep;115(1):1-10. Review.

PMID:
8858835
24.

Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain.

Clatworthy AL, Illich PA, Castro GA, Walters ET.

Neurosci Lett. 1995 Jan 16;184(1):5-8.

PMID:
7739805
25.

Induction of a cellular defense reaction is accompanied by an increase in sensory neuron excitability in Aplysia.

Clatworthy AL, Castro GA, Budelmann BU, Walters ET.

J Neurosci. 1994 May;14(5 Pt 2):3263-70.

27.

Induction of a cellular defense reaction is accompanied by an increase in sensory neuron excitability in Aplysia.

Clatworthy AL, Castro GA, Walters ET.

Ann N Y Acad Sci. 1994 Apr 15;712:335-7. No abstract available.

PMID:
8192342
28.

Activity-dependent depression of mechanosensory discharge in Aplysia.

Clatworthy AL, Walters ET.

J Neurophysiol. 1993 Sep;70(3):1195-209.

PMID:
8229168
29.

Rapid amplification and facilitation of mechanosensory discharge in Aplysia by noxious stimulation.

Clatworthy AL, Walters ET.

J Neurophysiol. 1993 Sep;70(3):1181-94.

PMID:
8229167
30.

Urinary cannabinoid analysis: comparison of four immunoassays with gas chromatography-mass spectrometry.

Altunkaya D, Clatworthy AJ, Smith RN, Start IJ.

Forensic Sci Int. 1991 Jul-Aug;50(1):15-22.

PMID:
1937304
31.

Gas chromatographic-mass spectrometric confirmation of radioimmunoassay results for cannabinoids in blood and urine.

Clatworthy AJ, Oon MC, Smith RN, Whitehouse MJ.

Forensic Sci Int. 1990 Jul;46(3):219-30.

PMID:
2376363
35.

Dopamine receptor-mediated spinal antinociception in the normal and haloperidol pretreated rat: effects of sulpiride and SCH 23390.

Barasi S, Ben-Sreti MM, Clatworthy AL, Duggal KN, Gonzalez JP, Robertson J, Rooney KF, Sewell RD.

Br J Pharmacol. 1987 Jan;90(1):15-22.

36.

The gas chromatography mass spectrometry of the major metabolites of flurazepam.

Clatworthy AJ, Jones LV, Whitehouse MJ.

Biomed Mass Spectrom. 1977 Aug;4(4):248-54.

PMID:
21004

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