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Items: 1 to 50 of 53

1.

Polyamine-regulated translation of spermidine/spermine-N1-acetyltransferase.

Perez-Leal O, Barrero CA, Clarkson AB, Casero RA Jr, Merali S.

Mol Cell Biol. 2012 Apr;32(8):1453-67. doi: 10.1128/MCB.06444-11. Epub 2012 Feb 21.

2.

Pneumocystis S-adenosylmethionine transport: a potential drug target.

Perez-Leal O, Moncada C, Clarkson AB, Merali S.

Am J Respir Cell Mol Biol. 2011 Dec;45(6):1142-6. doi: 10.1165/rcmb.2011-0009OC. Epub 2011 Jun 3.

3.

Pneumocystis pneumonia and S-adenosylmethionine plasma levels.

Skelly M, Merali S, Clarkson AB.

J Infect. 2011 Jun;62(6):490-2; author reply 493-5. doi: 10.1016/j.jinf.2011.04.012. Epub 2011 May 1. No abstract available.

PMID:
21605909
4.

SILAC analysis of oxidative stress-mediated proteins in human pneumocytes: new role for treacle.

Duan X, Kelsen SG, Clarkson AB Jr, Ji R, Merali S.

Proteomics. 2010 Jun;10(11):2165-74. doi: 10.1002/pmic.201000020.

5.

Kupffer cells are obligatory for Plasmodium yoelii sporozoite infection of the liver.

Baer K, Roosevelt M, Clarkson AB Jr, van Rooijen N, Schnieder T, Frevert U.

Cell Microbiol. 2007 Feb;9(2):397-412. Epub 2006 Aug 31.

PMID:
16953803
6.

Effect of nicotine on lung S-adenosylmethionine and development of Pneumocystis pneumonia.

Shivji M, Burger S, Moncada CA, Clarkson AB Jr, Merali S.

J Biol Chem. 2005 Apr 15;280(15):15219-28. Epub 2005 Jan 24.

7.

S-adenosylmethionine and Pneumocystis.

Merali S, Clarkson AB Jr.

FEMS Microbiol Lett. 2004 Aug 15;237(2):179-86. Review.

8.

S-adenosylmethionine concentrations in diagnosis of Pneumocystis carinii pneumonia.

Skelly M, Hoffman J, Fabbri M, Holzman RS, Clarkson AB Jr, Merali S.

Lancet. 2003 Apr 12;361(9365):1267-8.

PMID:
12699956
9.

Action of deferoxamine against Pneumocystis carinii.

Clarkson AB Jr, Turkel-Parrella D, Williams JH, Chen LC, Gordon T, Merali S.

Antimicrob Agents Chemother. 2001 Dec;45(12):3560-5.

10.

S-adenosylmethionine and Pneumocystis carinii.

Merali S, Vargas D, Franklin M, Clarkson AB Jr.

J Biol Chem. 2000 May 19;275(20):14958-63.

11.

Effect of a bis-benzyl polyamine analogue on Pneumocystis carinii.

Merali S, Saric M, Chin K, Clarkson AB Jr.

Antimicrob Agents Chemother. 2000 Feb;44(2):337-43.

12.

Continuous axenic cultivation of Pneumocystis carinii.

Merali S, Frevert U, Williams JH, Chin K, Bryan R, Clarkson AB Jr.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2402-7.

13.

Continuous infusion of DL-alpha-difluoromethylornithine and improved efficacy against a rat model of Pneumocystis carinii pneumonia.

Chin K, Merali S, Sarić M, Clarkson AB Jr.

Antimicrob Agents Chemother. 1996 Oct;40(10):2318-20.

14.

Subpopulations of Pneumocystis carinii separated by a Percoll gradient.

Chin K, Merali S, Shaw MM, Bartlett MS, Clarkson AB Jr.

J Eukaryot Microbiol. 1996 Sep-Oct;43(5):53S. No abstract available.

PMID:
8822855
15.

Clinically achievable plasma deferoxamine concentrations eliminate Pneumocystis carinii trophozoites in a rat model.

Merali S, Chin K, Grady RW, Clarkson AB Jr.

J Eukaryot Microbiol. 1996 Sep-Oct;43(5):52S. No abstract available.

PMID:
8822854
16.

Trophozoite elimination in a rat model of Pneumocystis carinii pneumonia by clinically achievable plasma deferoxamine concentrations.

Merali S, Chin K, Grady RW, Clarkson AB Jr.

Antimicrob Agents Chemother. 1996 May;40(5):1298-300.

17.
18.

Polyamine analysis using N-hydroxysuccinimidyl-6-aminoquinoyl carbamate for pre-column derivatization.

Merali S, Clarkson AB Jr.

J Chromatogr B Biomed Appl. 1996 Jan 26;675(2):321-6.

PMID:
8852721
19.

Competition between inhibitors of the trypanosome alternative oxidase (TAO) and reduced coenzyme Q9.

Pollakis G, Grady RW, Dieck HA, Clarkson AB Jr.

Biochem Pharmacol. 1995 Oct 12;50(8):1207-10.

PMID:
7488235
20.

Clinically achievable plasma deferoxamine concentrations are therapeutic in a rat model of Pneumocystis carinii pneumonia.

Merali S, Chin K, Del Angel L, Grady RW, Armstrong M, Clarkson AB Jr.

Antimicrob Agents Chemother. 1995 Sep;39(9):2023-6.

21.

Response of rat model of Pneumocystis carinii pneumonia to continuous infusion of deferoxamine.

Merali S, Chin K, Grady RW, Weissberger L, Clarkson AB Jr.

Antimicrob Agents Chemother. 1995 Jul;39(7):1442-4.

22.

Ornithine decarboxylase in Pneumocystis carinii and implications for therapy.

Sarić M, Clarkson AB Jr.

Antimicrob Agents Chemother. 1994 Nov;38(11):2545-52.

23.

Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides.

Bacchi CJ, Nathan HC, Yarlett N, Goldberg B, McCann PP, Sjoerdsma A, Saric M, Clarkson AB Jr.

Antimicrob Agents Chemother. 1994 Mar;38(3):563-9.

24.

Non-cytochrome mediated mitochondrial ATP production in bloodstream form Trypanosoma brucei brucei.

Bienen EJ, Maturi RK, Pollakis G, Clarkson AB Jr.

Eur J Biochem. 1993 Aug 15;216(1):75-80.

25.

N-n-alkyl-3,4-dihydroxybenzamides as inhibitors of the trypanosome alternative oxidase: activity in vitro and in vivo.

Grady RW, Bienen EJ, Dieck HA, Saric M, Clarkson AB Jr.

Antimicrob Agents Chemother. 1993 May;37(5):1082-5.

26.

Minorities in science: the dialogue.

Clarkson AB Jr.

Science. 1993 Feb 19;259(5098):1106. No abstract available.

PMID:
17794367
27.

Characterization of a novel trans-sialidase of Trypanosoma brucei procyclic trypomastigotes and identification of procyclin as the main sialic acid acceptor.

Pontes de Carvalho LC, Tomlinson S, Vandekerckhove F, Bienen EJ, Clarkson AB, Jiang MS, Hart GW, Nussenzweig V.

J Exp Med. 1993 Feb 1;177(2):465-74.

28.

Mitochondrial development in Trypanosoma brucei brucei transitional bloodstream forms.

Bienen EJ, Saric M, Pollakis G, Grady RW, Clarkson AB Jr.

Mol Biochem Parasitol. 1991 Apr;45(2):185-92.

PMID:
1645458
29.

Deferoxamine and eflornithine (DL-alpha-difluoromethylornithine) in a rat model of Pneumocystis carinii pneumonia.

Clarkson AB Jr, Sarić M, Grady RW.

Antimicrob Agents Chemother. 1990 Sep;34(9):1833-5.

30.

Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase.

Bitonti AJ, Byers TL, Bush TL, Casara PJ, Bacchi CJ, Clarkson AB Jr, McCann PP, Sjoerdsma A.

Antimicrob Agents Chemother. 1990 Aug;34(8):1485-90.

31.

Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense.

Bacchi CJ, Nathan HC, Livingston T, Valladares G, Saric M, Sayer PD, Njogu AR, Clarkson AB Jr.

Antimicrob Agents Chemother. 1990 Jun;34(6):1183-8.

32.

Respiration of bloodstream forms of the parasite Trypanosoma brucei brucei is dependent on a plant-like alternative oxidase.

Clarkson AB Jr, Bienen EJ, Pollakis G, Grady RW.

J Biol Chem. 1989 Oct 25;264(30):17770-6.

33.

Trypanocidal CoQ analogues: their effect on other mitochondrial systems.

Clarkson AB Jr, Bienen EJ, Pollakis G, Grady RW.

Comp Biochem Physiol B. 1989;94(2):245-51.

PMID:
2591192
34.

Efficacy of DL-alpha-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia.

Clarkson AB Jr, Williams DE, Rosenberg C.

Antimicrob Agents Chemother. 1988 Aug;32(8):1158-63.

35.

Use of difluoromethylornithine (DFMO, eflornithine) for late-stage African trypanosomiasis.

McCann PP, Bitonti AJ, Bacchi CJ, Clarkson AB Jr.

Trans R Soc Trop Med Hyg. 1987;81(4):701-2. No abstract available.

PMID:
3127968
37.

Inhibition of polyamine biosynthesis by alpha-difluoromethylornithine in African trypanosomes and Pneumocystis carinii as a basis of chemotherapy: biochemical and clinical aspects.

McCann PP, Bacchi CJ, Clarkson AB Jr, Bey P, Sjoerdsma A, Schecter PJ, Walzer PD, Barlow JL.

Am J Trop Med Hyg. 1986 Nov;35(6):1153-6.

PMID:
3098121
38.
39.

p-Alkyloxybenzhydroxamic acids, effective inhibitors of the trypanosome glycerol-3-phosphate oxidase.

Grady RW, Bienen EJ, Clarkson AB Jr.

Mol Biochem Parasitol. 1986 Jun;19(3):231-40.

PMID:
3736594
40.

New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin.

Clarkson AB Jr, Bienen EJ, Bacchi CJ, McCann PP, Nathan HC, Hutner SH, Sjoerdsma A.

Am J Trop Med Hyg. 1984 Nov;33(6):1073-7.

PMID:
6439061
41.

Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.

Clarkson AB Jr, Bacchi CJ, Mellow GH, Nathan HC, McCann PP, Sjoerdsma A.

Proc Natl Acad Sci U S A. 1983 Sep;80(18):5729-33.

42.

Rheumatoid factors and Chagas' disease.

Clarkson AB Jr, Mellow GH.

Science. 1983 Mar 11;219(4589):1238-9. No abstract available.

PMID:
6402816
43.

Role of calcium in trypanocidal drug action.

Clarkson AB Jr, Amole BO.

Science. 1982 Jun 18;216(4552):1321-3.

PMID:
6805075
44.

Pathogenesis of anemia in Trypanosoma brucei-infected mice.

Amole BO, Clarkson AB Jr, Shear HL.

Infect Immun. 1982 Jun;36(3):1060-8.

45.

Trypanosoma lewisi: enhanced resistance in naive lactating rats and their suckling pups.

Mellow GH, Clarkson AB Jr.

Exp Parasitol. 1982 Apr;53(2):217-28. No abstract available.

PMID:
7037439
46.

Further studies on difluoromethylornithine in African trypanosomes.

McCann PP, Bacchi CJ, Clarkson AB Jr, Seed JR, Nathan HC, Amole BO, Hutner SH, Sjoerdsma A.

Med Biol. 1981 Dec;59(5-6):434-40.

PMID:
6175860
47.
48.

Trypanosoma brucei brucei: a systematic screening for alternatives to the salicylhydroxamic acid-glycerol combination.

Clarkson AB Jr, Grady RW, Grossman SA, McCallum RJ, Brohn FH.

Mol Biochem Parasitol. 1981 Sep;3(5):271-91.

PMID:
6795501
49.

Trypanosoma brucei: host parasite interaction in parasite destruction by salicylhydroxamic acid and glycerol in mice.

Amole BO, Clarkson AB Jr.

Exp Parasitol. 1981 Feb;51(1):133-40. No abstract available.

PMID:
6109641
50.

Trypanosoma lewisi: avidity and adsorbability of ablastin, the rat antibody inhibiting parasite reproduction.

D'Alesandro PA, Clarkson AB Jr.

Exp Parasitol. 1980 Dec;50(3):384-96. No abstract available.

PMID:
7000542

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