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Risk factor profiles and clinical outcomes for children and adults with pneumococcal infections in Singapore: A need to expand vaccination policy?

Martinez-Vega R, Jauneikaite E, Thoon KC, Chua HY, Huishi Chua A, Khong WX, Tan BH, Low Guek Hong J, Venkatachalam I, Anantharajah Tambyah P, Hibberd ML, Clarke SC, Ng OT.

PLoS One. 2019 Oct 16;14(10):e0220951. doi: 10.1371/journal.pone.0220951. eCollection 2019.


Microbial epidemiology and carriage studies for the evaluation of vaccines.

Coughtrie AL, Jefferies JM, Cleary DW, Doncaster CP, Faust SN, Kraaijeveld AR, Moore MV, Mullee MA, Roderick PJ, Webb JS, Yuen HM, Clarke SC.

J Med Microbiol. 2019 Oct;68(10):1408-1418. doi: 10.1099/jmm.0.001046. Review.


The role of Glucagon-Like Peptide 1 Loading on periprocedural myocardial infarction During elective PCI (GOLD-PCI study): A randomized, placebo-controlled trial.

Giblett JP, Clarke S, Zhao T, McCormick LM, Braganza DM, Densem CG, O'Sullivan M, Adlam D, Clarke SC, Steele J, Fielding S, West NEJ, Villar SS, Hoole SP.

Am Heart J. 2019 Sep;215:41-51. doi: 10.1016/j.ahj.2019.05.013. Epub 2019 Jun 9.


Serotype distribution of disease-causing Streptococcus pneumoniae in Thailand: A systematic review.

Hocknell RE, Cleary DW, Srifeungfung S, Clarke SC.

Vaccine. 2019 May 27;37(24):3159-3166. doi: 10.1016/j.vaccine.2019.04.085. Epub 2019 May 3. Review.


Drivers of year-to-year variation in exacerbation frequency of COPD: analysis of the AERIS cohort.

Wilkinson TMA, Aris E, Bourne SC, Clarke SC, Peeters M, Pascal TG, Taddei L, Tuck AC, Kim VL, Ostridge KK, Staples KJ, Williams NP, Williams AP, Wootton SA, Devaster JM.

ERJ Open Res. 2019 Feb 25;5(1). pii: 00248-2018. doi: 10.1183/23120541.00248-2018. eCollection 2019 Feb. Erratum in: ERJ Open Res. 2019 Jul 29;5(3):.


Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies.

Trinklein ND, Pham D, Schellenberger U, Buelow B, Boudreau A, Choudhry P, Clarke SC, Dang K, Harris KE, Iyer S, Jorgensen B, Pratap PP, Rangaswamy US, Ugamraj HS, Vafa O, Wiita AP, van Schooten W, Buelow R, Force Aldred S.

MAbs. 2019 May/Jun;11(4):639-652. doi: 10.1080/19420862.2019.1574521. Epub 2019 Feb 20.


Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies.

Clarke SC, Ma B, Trinklein ND, Schellenberger U, Osborn MJ, Ouisse LH, Boudreau A, Davison LM, Harris KE, Ugamraj HS, Balasubramani A, Dang KH, Jorgensen B, Ogana HAN, Pham DT, Pratap PP, Sankaran P, Anegon I, van Schooten WC, Brüggemann M, Buelow R, Force Aldred S.

Front Immunol. 2019 Jan 7;9:3037. doi: 10.3389/fimmu.2018.03037. eCollection 2018.


Global emergence and population dynamics of divergent serotype 3 CC180 pneumococci.

Azarian T, Mitchell PK, Georgieva M, Thompson CM, Ghouila A, Pollard AJ, von Gottberg A, du Plessis M, Antonio M, Kwambana-Adams BA, Clarke SC, Everett D, Cornick J, Sadowy E, Hryniewicz W, Skoczynska A, Moïsi JC, McGee L, Beall B, Metcalf BJ, Breiman RF, Ho PL, Reid R, O'Brien KL, Gladstone RA, Bentley SD, Hanage WP.

PLoS Pathog. 2018 Nov 26;14(11):e1007438. doi: 10.1371/journal.ppat.1007438. eCollection 2018 Nov.


Elucidating the survival and response of carbapenem resistant Klebsiella pneumoniae after exposure to imipenem at sub-lethal concentrations.

Low YM, Chong CW, Yap IKS, Chai LC, Clarke SC, Ponnampalavanar S, Abdul Jabar K, Md Yusof MY, Teh CSJ.

Pathog Glob Health. 2018 Oct;112(7):378-386. doi: 10.1080/20477724.2018.1538281. Epub 2018 Oct 31.


Patients with Chronic Obstructive Pulmonary Disease harbour a variation of Haemophilus species.

Osman KL, Jefferies JMC, Woelk CH, Devos N, Pascal TG, Mortier MC, Devaster JM, Wilkinson TMA, Cleary DW, Clarke SC; AERIS Study Group.

Sci Rep. 2018 Oct 3;8(1):14734. doi: 10.1038/s41598-018-32973-3.


Prevalence and antimicrobial susceptibilities of Acinetobacter baumannii and non-baumannii Acinetobacters from Terengganu, Malaysia and their carriage of carbapenemase genes.

Mohd Rani F, A Rahman NI, Ismail S, Abdullah FH, Othman N, Alattraqchi AG, Cleary DW, Clarke SC, Yeo CC.

J Med Microbiol. 2018 Nov;67(11):1538-1543. doi: 10.1099/jmm.0.000844. Epub 2018 Sep 25.


Cognitive Interpretation Bias: The Effect of a Single Session Moderate Exercise Protocol on Anxiety and Depression.

Clarke SC, Cooper NR, Rana M, Mackintosh B.

Front Psychol. 2018 Aug 8;9:1363. doi: 10.3389/fpsyg.2018.01363. eCollection 2018.


Impact of radiologically stratified exacerbations: insights into pneumonia aetiology in COPD.

Williams NP, Ostridge K, Devaster JM, Kim V, Coombs NA, Bourne S, Clarke SC, Harden S, Abbas A, Aris E, Lambert C, Tuck A, Williams A, Wootton S, Staples KJ, Wilkinson TMA; AERIS Study Group.

Respir Res. 2018 Jul 28;19(1):143. doi: 10.1186/s12931-018-0842-8.


Ecology and diversity in upper respiratory tract microbial population structures from a cross-sectional community swabbing study.

Coughtrie AL, Morris DE, Anderson R, Begum N, Cleary DW, Faust SN, Jefferies JM, Kraaijeveld AR, Moore MV, Mullee MA, Roderick PJ, Tuck A, Whittaker RN, Yuen HM, Doncaster CP, Clarke SC.

J Med Microbiol. 2018 Aug;67(8):1096-1108. doi: 10.1099/jmm.0.000773. Epub 2018 Jun 21.


Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies.

Harris KE, Aldred SF, Davison LM, Ogana HAN, Boudreau A, Brüggemann M, Osborn M, Ma B, Buelow B, Clarke SC, Dang KH, Iyer S, Jorgensen B, Pham DT, Pratap PP, Rangaswamy US, Schellenberger U, van Schooten WC, Ugamraj HS, Vafa O, Buelow R, Trinklein ND.

Front Immunol. 2018 Apr 24;9:889. doi: 10.3389/fimmu.2018.00889. eCollection 2018.


Global Distribution of Invasive Serotype 35D Streptococcus pneumoniae Isolates following Introduction of 13-Valent Pneumococcal Conjugate Vaccine.

Lo SW, Gladstone RA, van Tonder AJ, Hawkins PA, Kwambana-Adams B, Cornick JE, Madhi SA, Nzenze SA, du Plessis M, Kandasamy R, Carter PE, Eser ÖK, Ho PL, Elmdaghri N, Shakoor S, Clarke SC, Antonio M, Everett DB, von Gottberg A, Klugman KP, McGee L, Breiman RF, Bentley SD.

J Clin Microbiol. 2018 Jun 25;56(7). pii: e00228-18. doi: 10.1128/JCM.00228-18. Print 2018 Jul.


Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD.

Ostridge K, Williams NP, Kim V, Harden S, Bourne S, Clarke SC, Aris E, Mesia-Vela S, Devaster JM, Tuck A, Williams A, Wootton S, Staples KJ, Wilkinson TMA; AERIS Study Group.

Respir Res. 2018 Feb 20;19(1):31. doi: 10.1186/s12931-018-0734-y.


The adhesins of non-typeable Haemophilus influenzae.

Osman KL, Jefferies JM, Woelk CH, Cleary DW, Clarke SC.

Expert Rev Anti Infect Ther. 2018 Mar;16(3):187-196. doi: 10.1080/14787210.2018.1438263. Epub 2018 Feb 21. Review.


Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations.

Mayhew D, Devos N, Lambert C, Brown JR, Clarke SC, Kim VL, Magid-Slav M, Miller BE, Ostridge KK, Patel R, Sathe G, Simola DF, Staples KJ, Sung R, Tal-Singer R, Tuck AC, Van Horn S, Weynants V, Williams NP, Devaster JM, Wilkinson TMA; AERIS Study Group.

Thorax. 2018 May;73(5):422-430. doi: 10.1136/thoraxjnl-2017-210408. Epub 2018 Jan 31.


Acinetobacter spp. Infections in Malaysia: A Review of Antimicrobial Resistance Trends, Mechanisms and Epidemiology.

Mohd Rani F, A Rahman NI, Ismail S, Alattraqchi AG, Cleary DW, Clarke SC, Yeo CC.

Front Microbiol. 2017 Dec 12;8:2479. doi: 10.3389/fmicb.2017.02479. eCollection 2017. Review.


Research investments for UK infectious disease research 1997-2013: A systematic analysis of awards to UK institutions alongside national burden of disease.

Head MG, Brown RJ, Clarke SC.

J Infect. 2018 Jan;76(1):11-19. doi: 10.1016/j.jinf.2017.10.006. Epub 2017 Oct 20.


Pre-vaccine serotype composition within a lineage signposts its serotype replacement - a carriage study over 7 years following pneumococcal conjugate vaccine use in the UK.

Gladstone RA, Devine V, Jones J, Cleary D, Jefferies JM, Bentley SD, Faust SN, Clarke SC.

Microb Genom. 2017 Jun 9;3(6):e000119. doi: 10.1099/mgen.0.000119. eCollection 2017 Jun 30.


Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort.

Kim VL, Coombs NA, Staples KJ, Ostridge KK, Williams NP, Wootton SA, Devaster JM, Aris E, Clarke SC, Tuck AC, Bourne SC, Wilkinson TMA; AERIS Study Group.

Eur Respir J. 2017 Oct 12;50(4). pii: 1700853. doi: 10.1183/13993003.00853-2017. Print 2017 Oct.


Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study.

de Graaf H, Sukhtankar P, Arch B, Ahmad N, Lees A, Bennett A, Spowart C, Hickey H, Jeanes A, Armon K, Riordan A, Herberg J, Hackett S, Gamble C, Shingadia D, Pallett A, Clarke SC, Henman P, Emonts M, Sharland M, Finn A, Pollard AJ, Powell C, Marsh P, Ballinger C, Williamson PR, Clarke NM, Faust SN.

Health Technol Assess. 2017 Sep;21(48):1-164. doi: 10.3310/hta21480.


Low-Dose Nitric Oxide as Targeted Anti-biofilm Adjunctive Therapy to Treat Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis.

Howlin RP, Cathie K, Hall-Stoodley L, Cornelius V, Duignan C, Allan RN, Fernandez BO, Barraud N, Bruce KD, Jefferies J, Kelso M, Kjelleberg S, Rice SA, Rogers GB, Pink S, Smith C, Sukhtankar PS, Salib R, Legg J, Carroll M, Daniels T, Feelisch M, Stoodley P, Clarke SC, Connett G, Faust SN, Webb JS.

Mol Ther. 2017 Sep 6;25(9):2104-2116. doi: 10.1016/j.ymthe.2017.06.021. Epub 2017 Jul 24.


Pneumococcal conjugate vaccine implementation in middle-income countries.

Tricarico S, McNeil HC, Cleary DW, Head MG, Lim V, Yap IKS, Wie CC, Tan CS, Norazmi MN, Aziah I, Cheah ESG, Faust SN, Jefferies JMC, Roderick PJ, Moore M, Yuen HM, Newell ML, McGrath N, Doncaster CP, Kraaijeveld AR, Webb JS, Clarke SC.

Pneumonia (Nathan). 2017 Mar 25;9:6. doi: 10.1186/s41479-017-0030-5. eCollection 2017. Review.


Secondary Bacterial Infections Associated with Influenza Pandemics.

Morris DE, Cleary DW, Clarke SC.

Front Microbiol. 2017 Jun 23;8:1041. doi: 10.3389/fmicb.2017.01041. eCollection 2017. Review.


Global funding trends for malaria research in sub-Saharan Africa: a systematic analysis.

Head MG, Goss S, Gelister Y, Alegana V, Brown RJ, Clarke SC, Fitchett JRA, Atun R, Scott JAG, Newell ML, Padmadas SS, Tatem AJ.

Lancet Glob Health. 2017 Aug;5(8):e772-e781. doi: 10.1016/S2214-109X(17)30245-0. Epub 2017 Jun 28.


Correction: Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD.

Staples KJ, Taylor S, Thomas S, Leung S, Cox K, Pascal TG, Ostridge K, Welch L, Tuck AC, Clarke SC, Gorringe A, Wilkinson TMA.

PLoS One. 2017 Apr 25;12(4):e0176749. doi: 10.1371/journal.pone.0176749. eCollection 2017.


A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD.

Wilkinson TMA, Aris E, Bourne S, Clarke SC, Peeters M, Pascal TG, Schoonbroodt S, Tuck AC, Kim V, Ostridge K, Staples KJ, Williams N, Williams A, Wootton S, Devaster JM; AERIS Study Group.

Thorax. 2017 Oct;72(10):919-927. doi: 10.1136/thoraxjnl-2016-209023. Epub 2017 Apr 21.


Informing pneumococcal conjugate vaccine policy in middle-income countries: The case of Malaysia.

Tricarico S, McNeil HC, Head MG, Cleary DW, Clarke SC; MYCarriage.

Vaccine. 2017 Apr 25;35(18):2288-2290. doi: 10.1016/j.vaccine.2017.03.053. Epub 2017 Mar 24. No abstract available.


Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam-mediated activity against Streptococcus pneumoniae biofilms.

Allan RN, Kelso MJ, Rineh A, Yepuri NR, Feelisch M, Soren O, Brito-Mutunayagam S, Salib RJ, Stoodley P, Clarke SC, Webb JS, Hall-Stoodley L, Faust SN.

Nitric Oxide. 2017 May 1;65:43-49. doi: 10.1016/j.niox.2017.02.006. Epub 2017 Feb 21.


The rise and fall of pneumococcal serotypes carried in the PCV era.

Devine VT, Cleary DW, Jefferies JM, Anderson R, Morris DE, Tuck AC, Gladstone RA, O'Doherty G, Kuruparan P, Bentley SD, Faust SN, Clarke SC.

Vaccine. 2017 Mar 1;35(9):1293-1298. doi: 10.1016/j.vaccine.2017.01.035. Epub 2017 Feb 1.


Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence.

Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS.

PLoS Pathog. 2016 Dec 15;12(12):e1006051. doi: 10.1371/journal.ppat.1006051. eCollection 2016 Dec.


Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD.

Staples KJ, Taylor S, Thomas S, Leung S, Cox K, Pascal TG, Ostridge K, Welch L, Tuck AC, Clarke SC, Gorringe A, Wilkinson TM.

PLoS One. 2016 Nov 29;11(11):e0167250. doi: 10.1371/journal.pone.0167250. eCollection 2016. Erratum in: PLoS One. 2017 Apr 25;12 (4):e0176749.


The state of ESKAPE in Malaysia.

McNeil HC, Lean SS, Lim V, Clarke SC.

Int J Antimicrob Agents. 2016 Nov;48(5):578-579. doi: 10.1016/j.ijantimicag.2016.08.011. Epub 2016 Sep 29. No abstract available.


Development of X-ray micro-focus computed tomography to image and quantify biofilms in central venous catheter models in vitro.

Niehaus WL, Howlin RP, Johnston DA, Bull DJ, Jones GL, Calton E, Mavrogordato MN, Clarke SC, Thurner PJ, Faust SN, Stoodley P.

Microbiology. 2016 Sep;162(9):1629-1640. doi: 10.1099/mic.0.000334. Epub 2016 Jul 6.


Intracellular Action of a Secreted Peptide Required for Fungal Virulence.

Homer CM, Summers DK, Goranov AI, Clarke SC, Wiesner DL, Diedrich JK, Moresco JJ, Toffaletti D, Upadhya R, Caradonna I, Petnic S, Pessino V, Cuomo CA, Lodge JK, Perfect J, Yates JR 3rd, Nielsen K, Craik CS, Madhani HD.

Cell Host Microbe. 2016 Jun 8;19(6):849-64. doi: 10.1016/j.chom.2016.05.001. Epub 2016 May 19.


Navigating Optimal Revascularization for Unprotected Left Main Disease in Changing Interventional Seas.

Hoole SP, Clarke SC.

JACC Cardiovasc Interv. 2016 May 23;9(10):1008-10. doi: 10.1016/j.jcin.2016.03.019. No abstract available.


Parallel Evolution in Streptococcus pneumoniae Biofilms.

Churton NW, Misra RV, Howlin RP, Allan RN, Jefferies J, Faust SN, Gharbia SE, Edwards RJ, Clarke SC, Webb JS.

Genome Biol Evol. 2016 May 9;8(5):1316-26. doi: 10.1093/gbe/evw072.


Comparative Genomics of Carriage and Disease Isolates of Streptococcus pneumoniae Serotype 22F Reveals Lineage-Specific Divergence and Niche Adaptation.

Cleary DW, Devine VT, Jefferies JM, Webb JS, Bentley SD, Gladstone RA, Faust SN, Clarke SC.

Genome Biol Evol. 2016 Apr 21;8(4):1243-51. doi: 10.1093/gbe/evw066.


Low Concentrations of Nitric Oxide Modulate Streptococcus pneumoniae Biofilm Metabolism and Antibiotic Tolerance.

Allan RN, Morgan S, Brito-Mutunayagam S, Skipp P, Feelisch M, Hayes SM, Hellier W, Clarke SC, Stoodley P, Burgess A, Ismail-Koch H, Salib RJ, Webb JS, Faust SN, Hall-Stoodley L.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2456-66. doi: 10.1128/AAC.02432-15. Print 2016 Apr.


Evolutionary Selection on Barrier Activity: Bar1 Is an Aspartyl Protease with Novel Substrate Specificity.

Jones SK Jr, Clarke SC, Craik CS, Bennett RJ.

MBio. 2015 Nov 24;6(6):e01604-15. doi: 10.1128/mBio.01604-15.


Challenges in mapping research investments for treatments against pneumonia.

Head MG, Fitchett JR, Clarke SC.

Lancet Infect Dis. 2015 Nov;15(11):1262. doi: 10.1016/S1473-3099(15)00351-5. No abstract available.


Mapping pneumonia research: A systematic analysis of UK investments and published outputs 1997-2013.

Head MG, Fitchett JR, Newell ML, Scott JA, Harris JN, Clarke SC, Atun R.

EBioMedicine. 2015 Jul 4;2(9):1193-9. doi: 10.1016/j.ebiom.2015.06.024. eCollection 2015 Sep.


Phylogenetic relationship of non-typeable Haemophilus influenzae isolated in Malaysia.

Mohd-Zain Z, Kamsani NH, Ahmad N, Clarke SC.

Infect Genet Evol. 2015 Dec;36:240-243. doi: 10.1016/j.meegid.2015.09.017. Epub 2015 Sep 21.


Nasopharyngeal Bacterial Carriage in the Conjugate Vaccine Era with a Focus on Pneumococci.

Devine VT, Jefferies JM, Clarke SC, Faust SN.

J Immunol Res. 2015;2015:394368. doi: 10.1155/2015/394368. Epub 2015 Aug 16. Review.


Interpretation of fractional flow reserve in ST-elevation myocardial infarction culprit lesions.

Hoole SP, Brown AJ, Jaworski C, McCormick LM, Clarke SC, West NE.

Coron Artery Dis. 2015 Sep;26(6):495-502. doi: 10.1097/MCA.0000000000000278.


Serial assessment of the index of microcirculatory resistance during primary percutaneous coronary intervention comparing manual aspiration catheter thrombectomy with balloon angioplasty (IMPACT study): a randomised controlled pilot study.

Hoole SP, Jaworski C, Brown AJ, McCormick LM, Agrawal B, Clarke SC, West NE.

Open Heart. 2015 May 16;2(1):e000238. doi: 10.1136/openhrt-2015-000238. eCollection 2015.

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