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Items: 1 to 50 of 121

1.

Atypical APC/C-dependent degradation of Mcl-1 provides an apoptotic timer during mitotic arrest.

Allan LA, Skowyra A, Rogers KI, Zeller D, Clarke PR.

EMBO J. 2018 Jul 9. pii: e96831. doi: 10.15252/embj.201796831. [Epub ahead of print]

2.

USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability.

Skowyra A, Allan LA, Saurin AT, Clarke PR.

Cell Rep. 2018 Apr 17;23(3):852-865. doi: 10.1016/j.celrep.2018.03.100.

3.

Phosphorylation of XIAP by CDK1-cyclin-B1 controls mitotic cell death.

Hou Y, Allan LA, Clarke PR.

J Cell Sci. 2017 Jan 15;130(2):502-511. doi: 10.1242/jcs.192310. Epub 2016 Dec 7.

4.

Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival.

Hain KO, Colin DJ, Rastogi S, Allan LA, Clarke PR.

Sci Rep. 2016 May 27;6:26766. doi: 10.1038/srep26766.

5.

Genomics reveals historic and contemporary transmission dynamics of a bacterial disease among wildlife and livestock.

Kamath PL, Foster JT, Drees KP, Luikart G, Quance C, Anderson NJ, Clarke PR, Cole EK, Drew ML, Edwards WH, Rhyan JC, Treanor JJ, Wallen RL, White PJ, Robbe-Austerman S, Cross PC.

Nat Commun. 2016 May 11;7:11448. doi: 10.1038/ncomms11448.

6.

Comparison of Buffered, Acidified Plate Antigen to Standard Serologic Tests for the Detection of Serum Antibodies to Brucella abortus in Elk (Cervus canadensis).

Clarke PR, Edwards WH, Hennager SG, Block JF, Yates AM, Ebel E, Knopp DJ, Fuentes-Sanchez A, Jennings-Gaines J, Kientz RL, Simunich M.

J Wildl Dis. 2015 Jul;51(3):764-8. doi: 10.7589/2014-06-154. Epub 2015 May 18.

PMID:
25984771
7.

OA34 Forum on end of life: working to influence policy.

McGuinness C, Murphy S, Clarke PR.

BMJ Support Palliat Care. 2015 Apr;5 Suppl 1:A11. doi: 10.1136/bmjspcare-2015-000906.34.

PMID:
25960456
8.

Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins.

Colin DJ, Hain KO, Allan LA, Clarke PR.

Open Biol. 2015 Mar;5(3):140156. doi: 10.1098/rsob.140156.

9.

Evaluation of bison (Bison bison) semen from Yellowstone National Park, Montana, USA, bulls for Brucella abortus shedding.

Frey RK, Clarke PR, McCollum MP, Nol P, Johnson KR, Thompson BD, Ramsey JM, Anderson NJ, Rhyan JC.

J Wildl Dis. 2013 Jul;49(3):714-7. doi: 10.7589/2012-04-118.

PMID:
23778628
10.

Phosphorylation of Crm1 by CDK1-cyclin-B promotes Ran-dependent mitotic spindle assembly.

Wu Z, Jiang Q, Clarke PR, Zhang C.

J Cell Sci. 2013 Aug 1;126(Pt 15):3417-28. doi: 10.1242/jcs.126854. Epub 2013 May 31.

11.

Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-α/β.

Lu Q, Lu Z, Liu Q, Guo L, Ren H, Fu J, Jiang Q, Clarke PR, Zhang C.

Cell Res. 2012 Nov;22(11):1562-75. doi: 10.1038/cr.2012.113. Epub 2012 Jul 31.

12.

Shared Bacterial and Viral Respiratory Agents in Bighorn Sheep (Ovis canadensis), Domestic Sheep (Ovis aries), and Goats (Capra hircus) in Montana.

Miller DS, Weiser GC, Aune K, Roeder B, Atkinson M, Anderson N, Roffe TJ, Keating KA, Chapman PL, Kimberling C, Rhyan J, Clarke PR.

Vet Med Int. 2011;2011:162520. doi: 10.4061/2011/162520. Epub 2011 Nov 16.

13.

Destruction's our delight: controlling apoptosis during mitotic arrest.

Clarke PR, Allan LA.

Cell Cycle. 2010 Oct 15;9(20):4035-6. Epub 2010 Oct 2. No abstract available.

PMID:
20935484
14.

Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment.

Fu W, Tao W, Zheng P, Fu J, Bian M, Jiang Q, Clarke PR, Zhang C.

J Cell Sci. 2010 Nov 1;123(Pt 21):3645-51. doi: 10.1242/jcs.075911. Epub 2010 Oct 5.

15.

The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells.

Hitakomate E, Hood FE, Sanderson HS, Clarke PR.

BMC Cell Biol. 2010 Jun 21;11:43. doi: 10.1186/1471-2121-11-43.

16.

Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.

Harley ME, Allan LA, Sanderson HS, Clarke PR.

EMBO J. 2010 Jul 21;29(14):2407-20. doi: 10.1038/emboj.2010.112. Epub 2010 Jun 4.

17.

Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP.

Dikovskaya D, Li Z, Newton IP, Davidson I, Hutchins JR, Kalab P, Clarke PR, Näthke IS.

J Cell Sci. 2010 Mar 1;123(Pt 5):736-46. doi: 10.1242/jcs.060806. Epub 2010 Feb 9.

18.

Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation.

Allan LA, Clarke PR.

FEBS J. 2009 Nov;276(21):6063-73. doi: 10.1111/j.1742-4658.2009.07330.x. Epub 2009 Sep 29. Review.

19.

Dynamic localisation of Ran GTPase during the cell cycle.

Hutchins JR, Moore WJ, Clarke PR.

BMC Cell Biol. 2009 Sep 18;10:66. doi: 10.1186/1471-2121-10-66.

20.

p38alpha- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress.

Seifert A, Clarke PR.

Cell Signal. 2009 Nov;21(11):1626-33. doi: 10.1016/j.cellsig.2009.06.009. Epub 2009 Jul 5.

PMID:
19586613
21.

hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks.

Berglund FM, Clarke PR.

Biochem Biophys Res Commun. 2009 Mar 27;381(1):59-64. doi: 10.1016/j.bbrc.2009.02.019. Epub 2009 Feb 11.

PMID:
19351595
22.

Cell-cycle control in the face of damage--a matter of life or death.

Clarke PR, Allan LA.

Trends Cell Biol. 2009 Mar;19(3):89-98. doi: 10.1016/j.tcb.2008.12.003. Epub 2009 Jan 23. Review.

PMID:
19168356
23.

DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine.

Seifert A, Allan LA, Clarke PR.

FEBS J. 2008 Dec;275(24):6268-80. doi: 10.1111/j.1742-4658.2008.06751.x. Epub 2008 Nov 7.

24.

Spatial and temporal coordination of mitosis by Ran GTPase.

Clarke PR, Zhang C.

Nat Rev Mol Cell Biol. 2008 Jun;9(6):464-77. doi: 10.1038/nrm2410. Epub 2008 May 14. Review.

PMID:
18478030
25.

To the centre of the volcano. Workshop on the mechanisms of nucleocytoplasmic transport.

Fornerod M, Clarke PR.

EMBO Rep. 2008 May;9(5):419-24. doi: 10.1038/embor.2008.51. Epub 2008 Apr 11. No abstract available.

26.

A mechanism coupling cell division and the control of apoptosis.

Allan LA, Clarke PR.

SEB Exp Biol Ser. 2008;59:257-65.

PMID:
18368928
27.

Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1.

Bennett LN, Larkin C, Gillespie DA, Clarke PR.

Biochem Biophys Res Commun. 2008 May 9;369(3):973-6. doi: 10.1016/j.bbrc.2008.02.154. Epub 2008 Mar 10.

PMID:
18331829
28.

Signaling to nuclear transport.

Clarke PR.

Dev Cell. 2008 Mar;14(3):316-8. doi: 10.1016/j.devcel.2008.02.005.

29.

Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis.

Chen Q, Zhang X, Jiang Q, Clarke PR, Zhang C.

Cell Res. 2008 Feb;18(2):268-80. doi: 10.1038/cr.2008.11.

30.

The docking interaction of caspase-9 with ERK2 provides a mechanism for the selective inhibitory phosphorylation of caspase-9 at threonine 125.

Martin MC, Allan LA, Mancini EJ, Clarke PR.

J Biol Chem. 2008 Feb 15;283(7):3854-65. Epub 2007 Dec 14.

31.

RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation.

Hood FE, Clarke PR.

J Cell Sci. 2007 Oct 1;120(Pt 19):3436-45. Epub 2007 Sep 12.

32.

Mitosis: ran scales the alps of spindle formation.

Clarke PR, Sazer S.

Curr Biol. 2007 Aug 21;17(16):R643-5.

33.

Anchoring RCC1 by the tail.

Clarke PR.

Nat Cell Biol. 2007 May;9(5):485-7. No abstract available.

PMID:
17473856
34.
35.

A mitotic role for BRCA1/BARD1 in tumor suppression?

Clarke PR, Sanderson HS.

Cell. 2006 Nov 3;127(3):453-5.

36.
37.

Cell biology: Ran, mitosis and the cancer connection.

Sanderson HS, Clarke PR.

Curr Biol. 2006 Jun 20;16(12):R466-8.

38.
39.

Cell biology. A gradient signal orchestrates the mitotic spindle.

Clarke PR.

Science. 2005 Aug 26;309(5739):1334-5. No abstract available.

PMID:
16123292
40.

Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway.

Clarke CA, Bennett LN, Clarke PR.

J Biol Chem. 2005 Oct 21;280(42):35337-45. Epub 2005 Aug 25.

41.

The Crm de la crème of mitosis.

Clarke PR.

Nat Cell Biol. 2005 Jun;7(6):551-2. No abstract available.

PMID:
15928702
42.

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.

Clarke CA, Clarke PR.

Biochem J. 2005 Jun 1;388(Pt 2):705-12.

43.

Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c.

Martin MC, Allan LA, Lickrish M, Sampson C, Morrice N, Clarke PR.

J Biol Chem. 2005 Apr 15;280(15):15449-55. Epub 2005 Feb 9.

44.

Spatial and temporal control of nuclear envelope assembly by Ran GTPase.

Clarke PR, Zhang C.

Symp Soc Exp Biol. 2004;(56):193-204. Review.

PMID:
15565882
45.

Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis.

Hutchins JR, Moore WJ, Hood FE, Wilson JS, Andrews PD, Swedlow JR, Clarke PR.

Curr Biol. 2004 Jun 22;14(12):1099-104.

46.

Nuclear pores: sowing the seeds of assembly on the chromatin landscape.

Wozniak R, Clarke PR.

Curr Biol. 2003 Dec 16;13(24):R970-2. Review. No abstract available.

47.

Many fingers on the mitotic trigger: post-translational regulation of the Cdc25C phosphatase.

Hutchins JR, Clarke PR.

Cell Cycle. 2004 Jan;3(1):41-5. Review.

PMID:
14657664
48.

Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.

Hutchins JR, Dikovskaya D, Clarke PR.

Mol Biol Cell. 2003 Oct;14(10):4003-14. Epub 2003 Jul 11. Erratum in: Mol Biol Cell. 2005 Mar;16(3):1568.

49.

Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.

Allan LA, Morrice N, Brady S, Magee G, Pathak S, Clarke PR.

Nat Cell Biol. 2003 Jul;5(7):647-54.

PMID:
12792650
50.

Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly.

Zhang C, Goldberg MW, Moore WJ, Allen TD, Clarke PR.

Eur J Cell Biol. 2002 Nov;81(11):623-33.

PMID:
12494999

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