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Complement C5a Induces Renal Injury in Diabetic Kidney Disease Via Disruption in Mitochondrial Metabolic Agility.

Tan SM, Ziemann M, Thallas-Bonke V, Snelson M, Kumar V, Laskowski A, Nguyen TV, Huynh K, Clarke MV, Libianto R, Baker ST, Skene A, Power DA, MacIsaac RJ, Henstridge DC, Wetsel RA, El-Osta A, Meikle PJ, Wilson SG, Forbes JM, Cooper ME, Ekinci EI, Woodruff TM, Coughlan MT.

Diabetes. 2019 Oct 17. pii: db190043. doi: 10.2337/db19-0043. [Epub ahead of print]


Surfactant plus budesonide decreases lung and systemic responses to injurious ventilation in preterm sheep.

Hillman NH, Kothe TB, Schmidt AF, Kemp MW, Royse E, Fee E, Salomone F, Clarke MW, Musk GC, Jobe AH.

Am J Physiol Lung Cell Mol Physiol. 2019 Oct 16. doi: 10.1152/ajplung.00203.2019. [Epub ahead of print]


Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling.

Kreuzaler P, Clarke MA, Brown EJ, Wilson CH, Kortlever RM, Piterman N, Littlewood T, Evan GI, Fisher J.

Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201903485. doi: 10.1073/pnas.1903485116. [Epub ahead of print]


Reply to M. Schlumbrecht et al.

Clarke MA, Devesa SS, Wentzensen N.

J Clin Oncol. 2019 Oct 2:JCO1902109. doi: 10.1200/JCO.19.02109. [Epub ahead of print] No abstract available.


A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations.

George SL, Izquierdo E, Campbell J, Koutroumanidou E, Proszek P, Jamal S, Hughes D, Yuan L, Marshall LV, Carceller F, Chisholm JC, Vaidya S, Mandeville H, Angelini P, Wasti A, Bexelius T, Thway K, Gatz SA, Clarke M, Al-Lazikani B, Barone G, Anderson J, Tweddle DA, Gonzalez D, Walker BA, Barton J, Depani S, Eze J, Ahmed SW, Moreno L, Pearson A, Shipley J, Jones C, Hargrave D, Jacques TS, Hubank M, Chesler L.

Eur J Cancer. 2019 Sep 11. pii: S0959-8049(19)30446-0. doi: 10.1016/j.ejca.2019.07.027. [Epub ahead of print]


Oral dosing for antenatal corticosteroids in the Rhesus macaque.

Schmidt AF, Kemp MW, Milad M, Miller LA, Bridges JP, Clarke MW, Kannan PS, Jobe AH.

PLoS One. 2019 Sep 19;14(9):e0222817. doi: 10.1371/journal.pone.0222817. eCollection 2019.


Recast type, repair, and acquisition in AAC mediated interaction.

Soto G, Clarke MT, Nelson K, Starowicz R, Savaldi-Harussi G.

J Child Lang. 2019 Sep 16:1-15. doi: 10.1017/S0305000919000436. [Epub ahead of print]


Simultaneous quantification of dopamine, serotonin, their metabolites and amino acids by LC-MS/MS in mouse brain following repetitive transcranial magnetic stimulation.

Poh EZ, Hahne D, Moretti J, Harvey AR, Clarke MW, Rodger J.

Neurochem Int. 2019 Sep 10;131:104546. doi: 10.1016/j.neuint.2019.104546. [Epub ahead of print]


Assessing the impact of a research funder's recommendation to consider core outcome sets.

Hughes KL, Kirkham JJ, Clarke M, Williamson PR.

PLoS One. 2019 Sep 13;14(9):e0222418. doi: 10.1371/journal.pone.0222418. eCollection 2019.


Psychotic experiences in childhood are associated with increased structural integrity of the left arcuate fasciculus - A population-based case-control study.

Dooley N, O'Hanlon E, Healy C, Adair A, McCandless C, Coppinger D, Kelleher I, Clarke M, Leemans A, Frodl T, Cannon M.

Schizophr Res. 2019 Sep 5. pii: S0920-9964(19)30377-9. doi: 10.1016/j.schres.2019.08.022. [Epub ahead of print]


Patient satisfaction with treatment outcomes after surgery and/or radiotherapy for spinal metastases.

Versteeg AL, Sahgal A, Kawahara N, Rhines LD, Sciubba DM, Weber MH, Lazary Á, Fehlings MG, Schuster JM, Clarke MJ, Arnold PM, Boriani S, Bettegowda C, Gokaslan ZL, Fisher CG; AOSpine Knowledge Forum Tumor.

Cancer. 2019 Sep 6. doi: 10.1002/cncr.32465. [Epub ahead of print]


The role of prenatal stress as a pathway to personality disorder: longitudinal birth cohort study.

Brannigan R, Tanskanen A, Huttunen MO, Cannon M, Leacy FP, Clarke MC.

Br J Psychiatry. 2019 Sep 6:1-5. doi: 10.1192/bjp.2019.190. [Epub ahead of print]


Clinical and Therapeutic Implications of Cancer Stem Cells. Reply.

Clarke MF.

N Engl J Med. 2019 Sep 5;381(10):e19. doi: 10.1056/NEJMc1908886. No abstract available.


Social network interventions for health behaviours and outcomes: A systematic review and meta-analysis.

Hunter RF, de la Haye K, Murray JM, Badham J, Valente TW, Clarke M, Kee F.

PLoS Med. 2019 Sep 3;16(9):e1002890. doi: 10.1371/journal.pmed.1002890. eCollection 2019 Sep.


Maternal vitamin D deficiency during rat gestation elicits a milder phenotype compared to the mouse model: Implications for the placental glucocorticoid barrier.

Crew RC, Rakonjac A, Tesic D, Clarke MW, Yates NJ, Wyrwoll CS.

Placenta. 2019 Aug;83:5-7. doi: 10.1016/j.placenta.2019.06.001. Epub 2019 Jun 4.


Dominant inhibition of awn development by a putative zinc-finger transcriptional repressor expressed at the B1 locus in wheat.

Huang D, Zheng Q, Melchkart T, Bekkaoui Y, Konkin DJF, Kagale S, Martucci M, You FM, Clarke M, Adamski NM, Chinoy C, Steed A, McCartney CA, Cutler AJ, Nicholson P, Feurtado JA.

New Phytol. 2019 Aug 30. doi: 10.1111/nph.16154. [Epub ahead of print]


Longitudinal (18F)AV-1451 PET imaging in a patient with frontotemporal dementia due to a Q351R MAPT mutation.

Convery RS, Jiao J, Clarke MTM, Moore KM, Koriath CAM, Woollacott IOC, Weston PSJ, Gunn R, Rabiner I, Cash DM, Rossor MN, Warren JD, Fox NC, Ourselin S, Bocchetta M, Rohrer JD.

J Neurol Neurosurg Psychiatry. 2019 Aug 22. pii: jnnp-2019-320904. doi: 10.1136/jnnp-2019-320904. [Epub ahead of print] No abstract available.


Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis.

Sinnecker T, Clarke MA, Meier D, Enzinger C, Calabrese M, De Stefano N, Pitiot A, Giorgio A, Schoonheim MM, Paul F, Pawlak MA, Schmidt R, Kappos L, Montalban X, Rovira À, Evangelou N, Wuerfel J; MAGNIMS Study Group.

JAMA Neurol. 2019 Aug 19. doi: 10.1001/jamaneurol.2019.2478. [Epub ahead of print]


Reporting stAndards for research in PedIatric Dentistry (RAPID): A development protocol.

Jayaraman J, Dhar V, Donly KJ, Priya E, Innes NPT, Clarkson J, Raggio DP, Childers N, Wright T, King N, Nagendrababu V, Clarke M.

Int J Paediatr Dent. 2019 Aug 14. doi: 10.1111/ipd.12569. [Epub ahead of print] Review.


Association of neurologic deficits with surgical outcomes and health-related quality of life after treatment for metastatic epidural spinal cord compression.

Barzilai O, Versteeg AL, Goodwin CR, Sahgal A, Rhines LD, Sciubba DM, Schuster JM, Weber MH, Lazary A, Fehlings MG, Clarke MJ, Arnold PM, Boriani S, Bettegowda C, Gokaslan ZL, Fisher CG, Laufer I; AOSpine Knowledge Forum Tumor.

Cancer. 2019 Aug 13. doi: 10.1002/cncr.32420. [Epub ahead of print]


Evidence for public health on novel psychoactive substance use: a mixed-methods study.

Higgins K, O’Neill N, O’Hara L, Jordan JA, McCann M, O’Neill T, Clarke M, O’Neill T, Campbell A.

Southampton (UK): NIHR Journals Library; 2019 Aug.


An external quality assurance trial to assess mass spectrometry protein testing facilities for identifying multiple human peptides.

Horan MP, Hoffmann P, Briggs MT, Condina M, Herbert S, Ito J, Rodger A, McKay M, Maltby D, Crossett B, Abudulai LN, Clarke MW, Badrick T.

Anal Bioanal Chem. 2019 Oct;411(25):6575-6581. doi: 10.1007/s00216-019-02047-y. Epub 2019 Aug 5.


Vitamin D metabolites are lower with active Crohn's disease and spontaneously recover with development of remission.

Haifer C, Lawrance IC, Center JR, Clarke MW, Hart PH, Eisman JA, Lucas R, Ghaly S.

Therap Adv Gastroenterol. 2019 Jul 26;12:1756284819865144. doi: 10.1177/1756284819865144. eCollection 2019.


Spinal Cord Ependymomas With MYCN Amplification Show Aggressive Clinical Behavior.

Swanson AA, Raghunathan A, Jenkins RB, Messing-Jünger M, Pietsch T, Clarke MJ, Kaufmann TJ, Giannini C.

J Neuropathol Exp Neurol. 2019 Sep 1;78(9):791-797. doi: 10.1093/jnen/nlz064.


Oral antenatal corticosteroids evaluated in fetal sheep.

Schmidt AF, Jobe AH, Kannan PS, Bridges JP, Newnham JP, Saito M, Usuda H, Kumagai Y, Fee EL, Clarke M, Kemp MW.

Pediatr Res. 2019 Jul 31. doi: 10.1038/s41390-019-0519-0. [Epub ahead of print]


A Core Outcome Set for Critical Care Ventilation Trials.

Blackwood B, Ringrow S, Clarke M, Marshall JC, Connolly B, Rose L, McAuley DF.

Crit Care Med. 2019 Oct;47(10):1324-1331. doi: 10.1097/CCM.0000000000003904.


The challenges of developing and optimising an assay to measure 25-hydroxyvitamin D in saliva.

Clarke MW, Black LJ, Hart PH, Jones AP, Palmer DJ, Siafarikas A, Lucas RM, Gorman S.

J Steroid Biochem Mol Biol. 2019 Jul 25;194:105437. doi: 10.1016/j.jsbmb.2019.105437. [Epub ahead of print]


Food matrix and co-presence of turmeric compounds influence bioavailability of curcumin in healthy humans.

Ahmed Nasef N, Loveday SM, Golding M, Martins RN, Shah TM, Clarke M, Coad J, Moughan PJ, Garg ML, Singh H.

Food Funct. 2019 Aug 1;10(8):4584-4592. doi: 10.1039/c9fo01063g. Epub 2019 Jul 26.


Early intervention in psychosis: health economic evaluation using the net benefit approach in a real-world setting.

Behan C, Kennelly B, Roche E, Renwick L, Masterson S, Lyne J, O'Donoghue B, Waddington J, McDonough C, McCrone P, Clarke M.

Br J Psychiatry. 2019 Jul 24:1-7. doi: 10.1192/bjp.2019.126. [Epub ahead of print]


Pharmacy Students' Reflections on an Experiential Learning Visit to a Psychiatric Hospital.

Keating D, McWilliams S, Hynes C, Clarke M, Strawbridge J.

Am J Pharm Educ. 2019 Jun;83(5):6784. doi: 10.5688/ajpe6784.


Modeling variability in the fire response of an endangered bird to improve fire-management.

James Verdon S, Watson SJ, Clarke MF.

Ecol Appl. 2019 Jul 22:e01980. doi: 10.1002/eap.1980. [Epub ahead of print]


Industry funding was associated with increased use of core outcome sets.

Kirkham JJ, Bracken M, Hind L, Pennington K, Clarke M, Williamson PR.

J Clin Epidemiol. 2019 Jul 18;115:90-97. doi: 10.1016/j.jclinepi.2019.07.007. [Epub ahead of print]


EXPRESS: Rates of Hospitalization Associated with the use of Aldosterone Receptor Antagonists in Patients with Pulmonary Arterial Hypertension.

Corkish M, Devine L, Clarke M, Murray B, Rose-Jones L.

Pulm Circ. 2019 Jul 18:2045894019868422. doi: 10.1177/2045894019868422. [Epub ahead of print] No abstract available.


Frequency and clinical outcomes of CYP2C19 genotype-guided escalation and de-escalation of antiplatelet therapy in a real-world clinical setting.

Martin J, Williams AK, Klein MD, Sriramoju VB, Madan S, Rossi JS, Clarke M, Cicci JD, Cavallari LH, Weck KE, Stouffer GA, Lee CR.

Genet Med. 2019 Jul 18. doi: 10.1038/s41436-019-0611-1. [Epub ahead of print]


Early risk and protective factors and young adult outcomes in a longitudinal sample of young people with a history of psychotic-like experiences.

Coughlan H, Healy C, Ní Sheaghdha Á, Murray G, Humphries N, Clarke M, Cannon M.

Early Interv Psychiatry. 2019 Jul 16. doi: 10.1111/eip.12855. [Epub ahead of print]


Examining constipation assessment and management of patients with advanced cancer receiving specialist palliative care: a multi-site retrospective case note review of clinical practice.

McIlfatrick S, Muldrew DHL, Beck E, Carduff E, Clarke M, Finucane A, Graham-Wisener L, Larkin P, McCorry NK, Slater P, Hasson F.

BMC Palliat Care. 2019 Jul 15;18(1):57. doi: 10.1186/s12904-019-0436-3.


A systematic review of feasibility studies promoting the use of mobile technologies in clinical research.

Bakker JP, Goldsack JC, Clarke M, Coravos A, Geoghegan C, Godfrey A, Heasley MG, Karlin DR, Manta C, Peterson B, Ramirez E, Sheth N, Bruno A, Bullis E, Wareham K, Zimmerman N, Forrest A, Wood WA.

NPJ Digit Med. 2019 Jun 6;2:47. doi: 10.1038/s41746-019-0125-x. eCollection 2019.


Clinical presentation, management and outcomes of sacral metastases: a multicenter, retrospective cohort study.

Charest-Morin R, Fisher CG, Versteeg AL, Sahgal A, Varga PP, Sciubba DM, Schuster JM, Weber MH, Clarke MJ, Rhines LD, Boriani S, Bettegowda C, Fehlings MG, Arnold PM, Gokaslan ZL, Dea N.

Ann Transl Med. 2019 May;7(10):214. doi: 10.21037/atm.2019.04.88.


Key Worker-Mediated Enhancement of Physical Health in First Episode Psychosis: Protocol For a Feasibility Study in Primary Care.

McCombe G, Harrold A, Brown K, Hennessy L, Clarke M, Hanlon D, O'Brien S, Lyne J, Corcoran C, McGorry P, Cullen W.

JMIR Res Protoc. 2019 Jul 10;8(7):e13115. doi: 10.2196/13115.


Prioritization of Outcomes in Efficacy and Effectiveness of Alcohol Brief Intervention Trials: International Multi-Stakeholder e-Delphi Consensus Study to Inform a Core Outcome Set.

Shorter GW, Heather N, Bray JW, Berman AH, Giles EL, O'Donnell AJ, Barbosa C, Clarke M, Holloway A, Newbury-Birch D.

J Stud Alcohol Drugs. 2019 May;80(3):299-309.


The Variability of Outcomes Used in Efficacy and Effectiveness Trials of Alcohol Brief Interventions: A Systematic Review.

Shorter GW, Bray JW, Giles EL, O'Donnell AJ, Berman AH, Holloway A, Heather N, Barbosa C, Stockdale KJ, Scott SJ, Clarke M, Newbury-Birch D.

J Stud Alcohol Drugs. 2019 May;80(3):286-298.


Vascular smooth muscle cells in atherosclerosis.

Basatemur GL, Jørgensen HF, Clarke MCH, Bennett MR, Mallat Z.

Nat Rev Cardiol. 2019 Jun 26. doi: 10.1038/s41569-019-0227-9. [Epub ahead of print] Review.


Pulpotomy for mature carious teeth with symptoms of irreversible pulpitis: A systematic review.

Cushley S, Duncan HF, Lappin MJ, Tomson PL, Lundy FT, Cooper P, Clarke M, El Karim IA.

J Dent. 2019 Sep;88:103158. doi: 10.1016/j.jdent.2019.06.005. Epub 2019 Jun 20. Review.


Death Is Coming and the Clot Thickens, as Pyroptosis Feeds the Fire.

Burzynski LC, Clarke MCH.

Immunity. 2019 Jun 18;50(6):1339-1341. doi: 10.1016/j.immuni.2019.05.015.


How Effective Is the Multidisciplinary Team Approach in Bariatric Surgery?

Bullen NL, Parmar J, Gilbert J, Clarke M, Cota A, Finlay IG.

Obes Surg. 2019 Oct;29(10):3232-3238. doi: 10.1007/s11695-019-03975-5.


Senescence utilises inflammatory caspases to drive the SASP.

Wiggins KA, Clarke MC.

Aging (Albany NY). 2019 Jun 17;11(12):3891-3892. doi: 10.18632/aging.102031. No abstract available.


Overlooked Minorities: The Intersection of Cancer in Lesbian, Gay, Bisexual, Transgender, and/or Intersex Adolescents and Young Adults.

Clarke M, Lewin J, Lazarakis S, Thompson K.

J Adolesc Young Adult Oncol. 2019 Oct;8(5):525-528. doi: 10.1089/jayao.2019.0021. Epub 2019 Jun 14. No abstract available.


A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks-results from the Lassa fever pilot.

Sigfrid L, Moore C, Salam AP, Maayan N, Hamel C, Garritty C, Lutje V, Buckley B, Soares-Weiser K, Marshall R, Clarke M, Horby P.

BMC Med. 2019 Jun 11;17(1):107. doi: 10.1186/s12916-019-1338-1.


Clinical and Therapeutic Implications of Cancer Stem Cells.

Clarke MF.

N Engl J Med. 2019 Jun 6;380(23):2237-2245. doi: 10.1056/NEJMra1804280. Review. No abstract available.


Molecular biomarkers and precision medicine in colorectal cancer: a systematic review of health economic analyses.

Henderson R, French D, Sullivan R, Maughan T, Clarke M, Lawler M.

Oncotarget. 2019 May 21;10(36):3408-3423. doi: 10.18632/oncotarget.26909. eCollection 2019 May 21. Review.

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