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Items: 1 to 50 of 137

1.

Gene-by-Environment Interaction of Bcrp-/- and Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition.

Toth EL, Li H, Dzierlenga AL, Clarke JD, Vildhede A, Goedken M, Cherrington NJ.

Drug Metab Dispos. 2018 Nov;46(11):1478-1486. doi: 10.1124/dmd.118.082081. Epub 2018 Aug 30.

PMID:
30166404
2.

Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice.

Beaver LM, Lӧhr CV, Clarke JD, Glasser ST, Watson GW, Wong CP, Zhang Z, Williams DE, Dashwood RH, Shannon J, Thuillier P, Ho E.

Curr Dev Nutr. 2017 Dec 26;2(3):nzy002. doi: 10.1093/cdn/nzy002. eCollection 2018 Mar.

3.

Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis.

Li H, Canet MJ, Clarke JD, Billheimer D, Xanthakos SA, Lavine JE, Erickson RP, Cherrington NJ.

Drug Metab Dispos. 2017 Dec;45(12):1317-1325. doi: 10.1124/dmd.117.077644. Epub 2017 Oct 6.

PMID:
28986475
4.

Increased Ca buffering underpins remodelling of Ca2+ handling in old sheep atrial myocytes.

Clarke JD, Caldwell JL, Pearman CM, Eisner DA, Trafford AW, Dibb KM.

J Physiol. 2017 Oct 1;595(19):6263-6279. doi: 10.1113/JP274053. Epub 2017 Sep 11.

5.

Spatial distribution and characterization of non-apical progenitors in the zebrafish embryo central nervous system.

McIntosh R, Norris J, Clarke JD, Alexandre P.

Open Biol. 2017 Feb;7(2). pii: 160312. doi: 10.1098/rsob.160312.

6.

Impaired N-linked glycosylation of uptake and efflux transporters in human non-alcoholic fatty liver disease.

Clarke JD, Novak P, Lake AD, Hardwick RN, Cherrington NJ.

Liver Int. 2017 Jul;37(7):1074-1081. doi: 10.1111/liv.13362. Epub 2017 Feb 7.

7.

In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice.

Li H, Clarke JD, Dzierlenga AL, Bear J, Goedken MJ, Cherrington NJ.

J Biochem Mol Toxicol. 2017 Feb;31(2). doi: 10.1002/jbt.21840. Epub 2016 Oct 6.

8.

Nonalcoholic Steatohepatitis Modulates Membrane Protein Retrieval and Insertion Processes.

Dzierlenga AL, Clarke JD, Cherrington NJ.

Drug Metab Dispos. 2016 Nov;44(11):1799-1807. Epub 2016 Sep 7.

9.

Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir.

Laho T, Clarke JD, Dzierlenga AL, Li H, Klein DM, Goedken M, Micuda S, Cherrington NJ.

Biochem Pharmacol. 2016 Sep 1;115:144-51. doi: 10.1016/j.bcp.2016.07.001. Epub 2016 Jul 2.

10.

Biliary Elimination of Pemetrexed Is Dependent on Mrp2 in Rats: Potential Mechanism of Variable Response in Nonalcoholic Steatohepatitis.

Dzierlenga AL, Clarke JD, Klein DM, Anumol T, Snyder SA, Li H, Cherrington NJ.

J Pharmacol Exp Ther. 2016 Aug;358(2):246-53. doi: 10.1124/jpet.116.234310. Epub 2016 May 27.

11.

Extracellular matrix couples the convergence movements of mesoderm and neural plate during the early stages of neurulation.

Araya C, Carmona-Fontaine C, Clarke JD.

Dev Dyn. 2016 May;245(5):580-9. doi: 10.1002/dvdy.24401. Epub 2016 Apr 6.

12.

Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo.

Buckley CE, Moore RE, Reade A, Goldberg AR, Weiner OD, Clarke JDW.

Dev Cell. 2016 Jan 11;36(1):117-126. doi: 10.1016/j.devcel.2015.12.011.

13.

Erratum to: Morphogenesis underlying the development of the everted teleost telencephalon.

Folgueira M, Bayley P, Navratilova P, Becker TS, Wilson SW, Clarke JD.

Neural Dev. 2015 Oct 2;10:22. doi: 10.1186/s13064-015-0048-4. No abstract available.

14.

Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis.

Clarke JD, Dzierlenga AL, Nelson NR, Li H, Werts S, Goedken MJ, Cherrington NJ.

Diabetes. 2015 Sep;64(9):3305-13. doi: 10.2337/db14-1947. Epub 2015 May 27.

15.

Nonalcoholic steatohepatitis in precision medicine: Unraveling the factors that contribute to individual variability.

Clarke JD, Cherrington NJ.

Pharmacol Ther. 2015 Jul;151:99-106. doi: 10.1016/j.pharmthera.2015.03.005. Epub 2015 Mar 21. Review.

16.

Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis.

Dzierlenga AL, Clarke JD, Hargraves TL, Ainslie GR, Vanderah TW, Paine MF, Cherrington NJ.

J Pharmacol Exp Ther. 2015 Mar;352(3):462-70. doi: 10.1124/jpet.114.220764. Epub 2014 Dec 15.

17.

Renal xenobiotic transporter expression is altered in multiple experimental models of nonalcoholic steatohepatitis.

Canet MJ, Hardwick RN, Lake AD, Dzierlenga AL, Clarke JD, Goedken MJ, Cherrington NJ.

Drug Metab Dispos. 2015 Feb;43(2):266-72. doi: 10.1124/dmd.114.060574. Epub 2014 Dec 8.

18.

Perturbed atrial calcium handling in an ovine model of heart failure: potential roles for reductions in the L-type calcium current.

Clarke JD, Caldwell JL, Horn MA, Bode EF, Richards MA, Hall MC, Graham HK, Briston SJ, Greensmith DJ, Eisner DA, Dibb KM, Trafford AW.

J Mol Cell Cardiol. 2015 Feb;79:169-79. doi: 10.1016/j.yjmcc.2014.11.017. Epub 2014 Nov 22.

19.

Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis.

Hardwick RN, Clarke JD, Lake AD, Canet MJ, Anumol T, Street SM, Merrell MD, Goedken MJ, Snyder SA, Cherrington NJ.

Toxicol Sci. 2014 Nov;142(1):45-55. doi: 10.1093/toxsci/kfu156. Epub 2014 Jul 31.

20.

Mesoderm is required for coordinated cell movements within zebrafish neural plate in vivo.

Araya C, Tawk M, Girdler GC, Costa M, Carmona-Fontaine C, Clarke JD.

Neural Dev. 2014 Apr 23;9:9. doi: 10.1186/1749-8104-9-9.

21.

Synergistic interaction between genetics and disease on pravastatin disposition.

Clarke JD, Hardwick RN, Lake AD, Lickteig AJ, Goedken MJ, Klaassen CD, Cherrington NJ.

J Hepatol. 2014 Jul;61(1):139-47. doi: 10.1016/j.jhep.2014.02.021. Epub 2014 Mar 5.

22.

Experimental nonalcoholic steatohepatitis increases exposure to simvastatin hydroxy acid by decreasing hepatic organic anion transporting polypeptide expression.

Clarke JD, Hardwick RN, Lake AD, Canet MJ, Cherrington NJ.

J Pharmacol Exp Ther. 2014 Mar;348(3):452-8. doi: 10.1124/jpet.113.211284. Epub 2014 Jan 8.

23.

Modeling human nonalcoholic steatohepatitis-associated changes in drug transporter expression using experimental rodent models.

Canet MJ, Hardwick RN, Lake AD, Dzierlenga AL, Clarke JD, Cherrington NJ.

Drug Metab Dispos. 2014 Apr;42(4):586-95. doi: 10.1124/dmd.113.055996. Epub 2014 Jan 2.

24.

Selective and cytokine-dependent regulation of hepatic transporters and bile acid homeostasis during infectious colitis in mice.

Merrell MD, Nyagode BA, Clarke JD, Cherrington NJ, Morgan ET.

Drug Metab Dispos. 2014 Apr;42(4):596-602. doi: 10.1124/dmd.113.055525. Epub 2013 Dec 30.

25.

Circulating microRNA 122 in the methionine and choline-deficient mouse model of non-alcoholic steatohepatitis.

Clarke JD, Sharapova T, Lake AD, Blomme E, Maher J, Cherrington NJ.

J Appl Toxicol. 2014 Jun;34(6):726-32. doi: 10.1002/jat.2960. Epub 2013 Nov 12.

26.

Assessment of genetically modified soybean in relation to natural variation in the soybean seed metabolome.

Clarke JD, Alexander DC, Ward DP, Ryals JA, Mitchell MW, Wulff JE, Guo L.

Sci Rep. 2013 Oct 30;3:3082. doi: 10.1038/srep03082. Erratum in: Sci Rep. 2014;4:3871.

27.

Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease.

Clarke JD, Novak P, Lake AD, Shipkova P, Aranibar N, Robertson D, Severson PL, Reily MD, Futscher BW, Lehman-McKeeman LD, Cherrington NJ.

Dig Dis Sci. 2014 Feb;59(2):365-74. doi: 10.1007/s10620-013-2873-9. Epub 2013 Sep 19.

28.

Developmental time rather than local environment regulates the schedule of epithelial polarization in the zebrafish neural rod.

Girdler GC, Araya C, Ren X, Clarke JD.

Neural Dev. 2013 Mar 24;8:5. doi: 10.1186/1749-8104-8-5.

29.

Calcium signalling microdomains and the t-tubular system in atrial mycoytes: potential roles in cardiac disease and arrhythmias.

Trafford AW, Clarke JD, Richards MA, Eisner DA, Dibb KM.

Cardiovasc Res. 2013 May 1;98(2):192-203. doi: 10.1093/cvr/cvt018. Epub 2013 Feb 5.

PMID:
23386275
30.

Can early second-look tympanoplasty reduce the rate of conversion to modified radical mastoidectomy?

Stew BT, Fishpool SJ, Clarke JD, Johnson PM.

Acta Otolaryngol. 2013 Jun;133(6):590-3. doi: 10.3109/00016489.2012.762116. Epub 2013 Feb 5.

PMID:
23379759
31.

Mirror-symmetric microtubule assembly and cell interactions drive lumen formation in the zebrafish neural rod.

Buckley CE, Ren X, Ward LC, Girdler GC, Araya C, Green MJ, Clark BS, Link BA, Clarke JD.

EMBO J. 2013 Jan 9;32(1):30-44. doi: 10.1038/emboj.2012.305. Epub 2012 Nov 30.

32.

A functional role for transverse (t-) tubules in the atria.

Dibb KM, Clarke JD, Eisner DA, Richards MA, Trafford AW.

J Mol Cell Cardiol. 2013 May;58:84-91. doi: 10.1016/j.yjmcc.2012.11.001. Epub 2012 Nov 9. Review.

PMID:
23147188
33.

In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.

Reese MJ, Savina PM, Generaux GT, Tracey H, Humphreys JE, Kanaoka E, Webster LO, Harmon KA, Clarke JD, Polli JW.

Drug Metab Dispos. 2013 Feb;41(2):353-61. doi: 10.1124/dmd.112.048918. Epub 2012 Nov 6.

34.

Morphogenesis underlying the development of the everted teleost telencephalon.

Folgueira M, Bayley P, Navratilova P, Becker TS, Wilson SW, Clarke JD.

Neural Dev. 2012 Sep 18;7:32. doi: 10.1186/1749-8104-7-32. Erratum in: Neural Dev. 2015;10:22.

35.

Age-related divergent remodeling of the cardiac extracellular matrix in heart failure: collagen accumulation in the young and loss in the aged.

Horn MA, Graham HK, Richards MA, Clarke JD, Greensmith DJ, Briston SJ, Hall MC, Dibb KM, Trafford AW.

J Mol Cell Cardiol. 2012 Jul;53(1):82-90. doi: 10.1016/j.yjmcc.2012.03.011. Epub 2012 Mar 30.

36.

Genetics or environment in drug transport: the case of organic anion transporting polypeptides and adverse drug reactions.

Clarke JD, Cherrington NJ.

Expert Opin Drug Metab Toxicol. 2012 Mar;8(3):349-60. doi: 10.1517/17425255.2012.656087. Epub 2012 Jan 27. Review.

37.

A large maize (Zea mays L.) SNP genotyping array: development and germplasm genotyping, and genetic mapping to compare with the B73 reference genome.

Ganal MW, Durstewitz G, Polley A, Bérard A, Buckler ES, Charcosset A, Clarke JD, Graner EM, Hansen M, Joets J, Le Paslier MC, McMullen MD, Montalent P, Rose M, Schön CC, Sun Q, Walter H, Martin OC, Falque M.

PLoS One. 2011;6(12):e28334. doi: 10.1371/journal.pone.0028334. Epub 2011 Dec 8.

38.

An extensive phase space for the potential martian biosphere.

Jones EG, Lineweaver CH, Clarke JD.

Astrobiology. 2011 Dec;11(10):1017-33. doi: 10.1089/ast.2011.0660. Epub 2011 Dec 9.

PMID:
22149914
39.

Light splitting in nanoporous gold and silver.

Bosman M, Anstis GR, Keast VJ, Clarke JD, Cortie MB.

ACS Nano. 2012 Jan 24;6(1):319-26. doi: 10.1021/nn203600n. Epub 2011 Dec 30.

PMID:
22148628
40.

GNC and CGA1 modulate chlorophyll biosynthesis and glutamate synthase (GLU1/Fd-GOGAT) expression in Arabidopsis.

Hudson D, Guevara D, Yaish MW, Hannam C, Long N, Clarke JD, Bi YM, Rothstein SJ.

PLoS One. 2011;6(11):e26765. doi: 10.1371/journal.pone.0026765. Epub 2011 Nov 10.

41.

Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement.

Clarke JD, Riedl K, Bella D, Schwartz SJ, Stevens JF, Ho E.

J Agric Food Chem. 2011 Oct 26;59(20):10955-63. doi: 10.1021/jf202887c. Epub 2011 Sep 30.

42.

Transverse tubules are a common feature in large mammalian atrial myocytes including human.

Richards MA, Clarke JD, Saravanan P, Voigt N, Dobrev D, Eisner DA, Trafford AW, Dibb KM.

Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1996-2005. doi: 10.1152/ajpheart.00284.2011. Epub 2011 Aug 12.

43.

Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design.

Clarke JD, Hsu A, Riedl K, Bella D, Schwartz SJ, Stevens JF, Ho E.

Pharmacol Res. 2011 Nov;64(5):456-63. doi: 10.1016/j.phrs.2011.07.005. Epub 2011 Jul 26.

44.

Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice.

Clarke JD, Hsu A, Williams DE, Dashwood RH, Stevens JF, Yamamoto M, Ho E.

Pharm Res. 2011 Dec;28(12):3171-9. doi: 10.1007/s11095-011-0500-z. Epub 2011 Jun 17.

45.

Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells.

Clarke JD, Hsu A, Yu Z, Dashwood RH, Ho E.

Mol Nutr Food Res. 2011 Jul;55(7):999-1009. doi: 10.1002/mnfr.201000547. Epub 2011 Mar 4.

46.

Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure.

Briston SJ, Caldwell JL, Horn MA, Clarke JD, Richards MA, Greensmith DJ, Graham HK, Hall MC, Eisner DA, Dibb KM, Trafford AW.

J Physiol. 2011 Mar 15;589(Pt 6):1367-82. doi: 10.1113/jphysiol.2010.203984. Epub 2011 Jan 17.

47.

A polarised population of dynamic microtubules mediates homeostatic length control in animal cells.

Picone R, Ren X, Ivanovitch KD, Clarke JD, McKendry RA, Baum B.

PLoS Biol. 2010 Nov 16;8(11):e1000542. doi: 10.1371/journal.pbio.1000542.

48.

Evaluation of treatment with a combination of azathioprine and prednisone in dogs with meningoencephalomyelitis of undetermined etiology: 40 cases (2000-2007).

Wong MA, Hopkins AL, Meeks JC, Clarke JD.

J Am Vet Med Assoc. 2010 Oct 15;237(8):929-35. doi: 10.2460/javma.237.8.929.

PMID:
20946080
49.

Neurons derive from the more apical daughter in asymmetric divisions in the zebrafish neural tube.

Alexandre P, Reugels AM, Barker D, Blanc E, Clarke JD.

Nat Neurosci. 2010 Jun;13(6):673-9. doi: 10.1038/nn.2547. Epub 2010 May 9.

PMID:
20453852
50.

Phenotypic analysis of Arabidopsis mutants: diaminobenzidine stain for hydrogen peroxide.

Clarke JD.

Cold Spring Harb Protoc. 2009 Jun;2009(6):pdb.prot4981. doi: 10.1101/pdb.prot4981. No abstract available.

PMID:
20147180

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