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Evaluating the impact of healthcare interventions using routine data.

Clarke GM, Conti S, Wolters AT, Steventon A.

BMJ. 2019 Jun 20;365:l2239. doi: 10.1136/bmj.l2239. No abstract available.


Methodological challenges in European ethics approvals for a genetic epidemiology study in critically ill patients: the GenOSept experience.

Tridente A, Holloway PAH, Hutton P, Gordon AC, Mills GH, Clarke GM, Chiche JD, Stuber F, Garrard C, Hinds C, Bion J; GenOSept National Coordinators, European Society of Intensive Care Medicine.

BMC Med Ethics. 2019 May 7;20(1):30. doi: 10.1186/s12910-019-0370-1.


Three-dimensional tumor visualization of invasive breast carcinomas using whole-mount serial section histopathology: implications for tumor size assessment.

Clarke GM, Holloway CMB, Zubovits JT, Nofech-Mozes S, Murray M, Liu K, Wang D, Kiss A, Yaffe MJ.

Breast Cancer Res Treat. 2019 Apr;174(3):669-677. doi: 10.1007/s10549-018-05122-7. Epub 2019 Jan 5.


Derivation and validation of a prognostic model for postoperative risk stratification of critically ill patients with faecal peritonitis.

Tridente A, Bion J, Mills GH, Gordon AC, Clarke GM, Walden A, Hutton P, Holloway PAH, Chiche JD, Stuber F, Garrard C, Hinds C; GenOSept and GAinS Investigators.

Ann Intensive Care. 2017 Sep 12;7(1):96. doi: 10.1186/s13613-017-0314-1.


Resistance to malaria through structural variation of red blood cell invasion receptors.

Leffler EM, Band G, Busby GBJ, Kivinen K, Le QS, Clarke GM, Bojang KA, Conway DJ, Jallow M, Sisay-Joof F, Bougouma EC, Mangano VD, Modiano D, Sirima SB, Achidi E, Apinjoh TO, Marsh K, Ndila CM, Peshu N, Williams TN, Drakeley C, Manjurano A, Reyburn H, Riley E, Kachala D, Molyneux M, Nyirongo V, Taylor T, Thornton N, Tilley L, Grimsley S, Drury E, Stalker J, Cornelius V, Hubbart C, Jeffreys AE, Rowlands K, Rockett KA, Spencer CCA, Kwiatkowski DP; Malaria Genomic Epidemiology Network.

Science. 2017 Jun 16;356(6343). pii: eaam6393. doi: 10.1126/science.aam6393. Epub 2017 May 18.


SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes.

Mägi R, Suleimanov YV, Clarke GM, Kaakinen M, Fischer K, Prokopenko I, Morris AP.

BMC Bioinformatics. 2017 Jan 11;18(1):25. doi: 10.1186/s12859-016-1437-3.


Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.

Clarke GM, Rockett K, Kivinen K, Hubbart C, Jeffreys AE, Rowlands K, Jallow M, Conway DJ, Bojang KA, Pinder M, Usen S, Sisay-Joof F, Sirugo G, Toure O, Thera MA, Konate S, Sissoko S, Niangaly A, Poudiougou B, Mangano VD, Bougouma EC, Sirima SB, Modiano D, Amenga-Etego LN, Ghansah A, Koram KA, Wilson MD, Enimil A, Evans J, Amodu OK, Olaniyan S, Apinjoh T, Mugri R, Ndi A, Ndila CM, Uyoga S, Macharia A, Peshu N, Williams TN, Manjurano A, Sepúlveda N, Clark TG, Riley E, Drakeley C, Reyburn H, Nyirongo V, Kachala D, Molyneux M, Dunstan SJ, Phu NH, Quyen NN, Thai CQ, Hien TT, Manning L, Laman M, Siba P, Karunajeewa H, Allen S, Allen A, Davis TM, Michon P, Mueller I, Molloy SF, Campino S, Kerasidou A, Cornelius VJ, Hart L, Shah SS, Band G, Spencer CC, Agbenyega T, Achidi E, Doumbo OK, Farrar J, Marsh K, Taylor T, Kwiatkowski DP; MalariaGEN Consortium.

Elife. 2017 Jan 9;6. pii: e15085. doi: 10.7554/eLife.15085.


Cost-effectiveness analysis of whole-mount pathology processing for patients with early breast cancer undergoing breast conservation.

Hong NJ, Clarke GM, Yaffe MJ, Holloway CM.

Curr Oncol. 2016 Feb;23(Suppl 1):S23-31. doi: 10.3747/co.23.2917. Epub 2016 Feb 29.


Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study.

Uyoga S, Ndila CM, Macharia AW, Nyutu G, Shah S, Peshu N, Clarke GM, Kwiatkowski DP, Rockett KA, Williams TN; MalariaGEN Consortium.

Lancet Haematol. 2015 Oct;2(10):e437-44. doi: 10.1016/S2352-3026(15)00152-0. Epub 2015 Sep 22.


Whole-mount pathology of breast lumpectomy specimens improves detection of tumour margins and focality.

Clarke GM, Holloway CM, Zubovits JT, Nofech-Mozes S, Liu K, Murray M, Wang D, Yaffe MJ.

Histopathology. 2016 Jul;69(1):35-44. doi: 10.1111/his.12912. Epub 2016 Jan 19.


Genetic determinants of anti-malarial acquired immunity in a large multi-centre study.

Shelton JM, Corran P, Risley P, Silva N, Hubbart C, Jeffreys A, Rowlands K, Craik R, Cornelius V, Hensmann M, Molloy S, Sepulveda N, Clark TG, Band G, Clarke GM, Spencer CC, Kerasidou A, Campino S, Auburn S, Tall A, Ly AB, Mercereau-Puijalon O, Sakuntabhai A, Djimdé A, Maiga B, Touré O, Doumbo OK, Dolo A, Troye-Blomberg M, Mangano VD, Verra F, Modiano D, Bougouma E, Sirima SB, Ibrahim M, Hussain A, Eid N, Elzein A, Mohammed H, Elhassan A, Elhassan I, Williams TN, Ndila C, Macharia A, Marsh K, Manjurano A, Reyburn H, Lemnge M, Ishengoma D, Carter R, Karunaweera N, Fernando D, Dewasurendra R, Drakeley CJ, Riley EM, Kwiatkowski DP, Rockett KA; MalariaGEN Consortium.

Malar J. 2015 Aug 28;14:333. doi: 10.1186/s12936-015-0833-x.


Ki-67 Membranous Staining: Biologically Relevant or an Artifact of Multiplexed Immunofluorescent Staining.

Wang D, Pang Z, Clarke GM, Nofech-Mozes S, Liu K, Cheung AM, Filkins RJ, Yaffe MJ.

Appl Immunohistochem Mol Morphol. 2016 Jul;24(6):447-52. doi: 10.1097/PAI.0000000000000202.


Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort.

Tridente A, Clarke GM, Walden A, Gordon AC, Hutton P, Chiche JD, Holloway PA, Mills GH, Bion J, Stüber F, Garrard C, Hinds C; GenOSept Investigators.

Crit Care. 2015 May 5;19:210. doi: 10.1186/s13054-015-0931-8.


Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study.

Langenberg C, Sharp SJ, Franks PW, Scott RA, Deloukas P, Forouhi NG, Froguel P, Groop LC, Hansen T, Palla L, Pedersen O, Schulze MB, Tormo MJ, Wheeler E, Agnoli C, Arriola L, Barricarte A, Boeing H, Clarke GM, Clavel-Chapelon F, Duell EJ, Fagherazzi G, Kaaks R, Kerrison ND, Key TJ, Khaw KT, Kröger J, Lajous M, Morris AP, Navarro C, Nilsson PM, Overvad K, Palli D, Panico S, Quirós JR, Rolandsson O, Sacerdote C, Sánchez MJ, Slimani N, Spijkerman AM, Tumino R, van der A DL, van der Schouw YT, Barroso I, McCarthy MI, Riboli E, Wareham NJ.

PLoS Med. 2014 May 20;11(5):e1001647. doi: 10.1371/journal.pmed.1001647. eCollection 2014 May.


Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort.

Walden AP, Clarke GM, McKechnie S, Hutton P, Gordon AC, Rello J, Chiche JD, Stueber F, Garrard CS, Hinds CJ; ESICM/ECCRN GenOSept Investigators.

Crit Care. 2014 Apr 1;18(2):R58. doi: 10.1186/cc13812.


A novel, automated technology for multiplex biomarker imaging and application to breast cancer.

Clarke GM, Zubovits JT, Shaikh KA, Wang D, Dinn SR, Corwin AD, Santamaria-Pang A, Li Q, Nofech-Mozes S, Liu K, Pang Z, Filkins RJ, Yaffe MJ.

Histopathology. 2014 Jan;64(2):242-55. doi: 10.1111/his.12240. Epub 2013 Nov 5.


Patients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort.

Tridente A, Clarke GM, Walden A, McKechnie S, Hutton P, Mills GH, Gordon AC, Holloway PA, Chiche JD, Bion J, Stuber F, Garrard C, Hinds CJ; GenOSept Investigators.

Intensive Care Med. 2014 Feb;40(2):202-10. doi: 10.1007/s00134-013-3158-7. Epub 2013 Dec 4.


A flexible approach for the analysis of rare variants allowing for a mixture of effects on binary or quantitative traits.

Clarke GM, Rivas MA, Morris AP.

PLoS Genet. 2013;9(8):e1003694. doi: 10.1371/journal.pgen.1003694. Epub 2013 Aug 15.


3D Pathology Volumetric Technique: A Method for Calculating Breast Tumour Volume from Whole-Mount Serial Section Images.

Clarke GM, Murray M, Holloway CM, Liu K, Zubovits JT, Yaffe MJ.

Int J Breast Cancer. 2012;2012:691205. doi: 10.1155/2012/691205. Epub 2012 Dec 23.


Pain and sleep-wake disturbances in adolescents with depressive disorders.

Murray CB, Murphy LK, Palermo TM, Clarke GM.

J Clin Child Adolesc Psychol. 2012;41(4):482-90. doi: 10.1080/15374416.2012.658613. Epub 2012 Mar 16.


Development and evaluation of a robust algorithm for computer-assisted detection of sentinel lymph node micrometastases.

Clarke GM, Peressotti C, Holloway CM, Zubovits JT, Liu K, Yaffe MJ.

Histopathology. 2011 Jul;59(1):116-28. doi: 10.1111/j.1365-2559.2011.03896.x.


Increasing specimen coverage using digital whole-mount breast pathology: implementation, clinical feasibility and application in research.

Clarke GM, Peressotti C, Constantinou P, Hosseinzadeh D, Martel A, Yaffe MJ.

Comput Med Imaging Graph. 2011 Oct-Dec;35(7-8):531-41. doi: 10.1016/j.compmedimag.2011.05.002. Epub 2011 Jun 11.


Basic statistical analysis in genetic case-control studies.

Clarke GM, Anderson CA, Pettersson FH, Cardon LR, Morris AP, Zondervan KT.

Nat Protoc. 2011 Feb;6(2):121-33. doi: 10.1038/nprot.2010.182. Epub 2011 Feb 3.


Data quality control in genetic case-control association studies.

Anderson CA, Pettersson FH, Clarke GM, Cardon LR, Morris AP, Zondervan KT.

Nat Protoc. 2010 Sep;5(9):1564-73. doi: 10.1038/nprot.2010.116. Epub 2010 Aug 26.


A comparison of sample size and power in case-only association studies of gene-environment interaction.

Clarke GM, Morris AP.

Am J Epidemiol. 2010 Feb 15;171(4):498-505. doi: 10.1093/aje/kwp398. Epub 2010 Jan 4.


Genome-wide association analysis and replication of coronary artery disease in South Korea suggests a causal variant common to diverse populations.

Cho EY, Jang Y, Shin ES, Jang HY, Yoo YK, Kim S, Jang JH, Lee JY, Yun MH, Park MY, Chae JS, Lim JW, Shin DJ, Park S, Lee JH, Han BG, Rae KH, Cardon LR, Morris AP, Lee JE, Clarke GM.

Heart Asia. 2010 Sep 18;2(1):104-8. doi: 10.1136/ha.2009.001370. eCollection 2010.


Aspects of observing and claiming allele flips in association studies.

Clarke GM, Cardon LR.

Genet Epidemiol. 2010 Apr;34(3):266-74. doi: 10.1002/gepi.20458.


The challenge of detecting epistasis (G x G interactions): Genetic Analysis Workshop 16.

An P, Mukherjee O, Chanda P, Yao L, Engelman CD, Huang CH, Zheng T, Kovac IP, Dubé MP, Liang X, Li J, de Andrade M, Culverhouse R, Malzahn D, Manning AK, Clarke GM, Jung J, Province MA.

Genet Epidemiol. 2009;33 Suppl 1:S58-67. doi: 10.1002/gepi.20474.


Marker selection for genetic case-control association studies.

Pettersson FH, Anderson CA, Clarke GM, Barrett JC, Cardon LR, Morris AP, Zondervan KT.

Nat Protoc. 2009;4(5):743-52. doi: 10.1038/nprot.2009.38. Epub 2009 Apr 23.


An improved processing method for breast whole-mount serial sections for three-dimensional histopathology imaging.

Sun L, Wang D, Zubovits JT, Yaffe MJ, Clarke GM.

Am J Clin Pathol. 2009 Mar;131(3):383-92. doi: 10.1309/AJCPVBZZ4IKJHY3U.


Developmental stability and fitness: the evidence is not quite so clear.

Clarke GM.

Am Nat. 1998 Nov;152(5):762-6. doi: 10.1086/286207. No abstract available.


Fine mapping versus replication in whole-genome association studies.

Clarke GM, Carter KW, Palmer LJ, Morris AP, Cardon LR.

Am J Hum Genet. 2007 Nov;81(5):995-1005. Epub 2007 Sep 19.


Spatial resolution requirements for acquisition of the virtual screening slide for digital whole-specimen breast histopathology.

Clarke GM, Zubovits JT, Katic M, Peressotti C, Yaffe MJ.

Hum Pathol. 2007 Dec;38(12):1764-71. Epub 2007 Aug 17.


Recent human effective population size estimated from linkage disequilibrium.

Tenesa A, Navarro P, Hayes BJ, Duffy DL, Clarke GM, Goddard ME, Visscher PM.

Genome Res. 2007 Apr;17(4):520-6. Epub 2007 Mar 9.


Whole-specimen histopathology: a method to produce whole-mount breast serial sections for 3-D digital histopathology imaging.

Clarke GM, Eidt S, Sun L, Mawdsley G, Zubovits JT, Yaffe MJ.

Histopathology. 2007 Jan;50(2):232-42.


Design and characterization of a digital image acquisition system for whole-specimen breast histopathology.

Clarke GM, Peressotti C, Mawdsley GE, Yaffe MJ.

Phys Med Biol. 2006 Oct 21;51(20):5089-103. Epub 2006 Sep 22.


Pulmonary artery catheter versus new technology.

Clarke GM.

Crit Care Resusc. 2000 Jun;2(2):103-4. No abstract available.


"You See but you do Not Observe, Watson".

Clarke GM.

Crit Care Resusc. 2005 Sep;7(3):158. No abstract available.


Disentangling linkage disequilibrium and linkage from dense single-nucleotide polymorphism trio data.

Clarke GM, Cardon LR.

Genetics. 2005 Dec;171(4):2085-95. Epub 2005 Aug 22.


Disseminated Saccharomyces cerevisiae infection following polymicrobial hepatobiliary sepsis.

Heath CH, Jaksic A, McKerracher D, Clarke GM.

Aust N Z J Med. 2000 Aug;30(4):521-2. No abstract available.


A case of beta thalassemia major detected using HPLC in a child of Chinese ancestry.

Berendt HL, Blakney GB, Clarke GM, Higgins TN.

Clin Biochem. 2000 Jun;33(4):311-3. No abstract available.


Laboratory investigation of hemoglobinopathies and thalassemias: review and update.

Clarke GM, Higgins TN.

Clin Chem. 2000 Aug;46(8 Pt 2):1284-90. Review.


A Comment on In-Group/Out-Group Comparisons for Fluctuating Asymmetry Based on Trait Values from the Left or Right Sides of an Individual.

Hoffmann AA, Woods RE, Clarke GM.

Am Nat. 1999 Jan;153(1):140-142. doi: 10.1086/303152. No abstract available.



Clarke GM.

Evolution. 1997 Dec;51(6):2021-2028. doi: 10.1111/j.1558-5646.1997.tb05124.x. No abstract available.


The genetic and molecular basis of developmental stability: the Lucilia story.

Clarke GM.

Trends Ecol Evol. 1997 Mar;12(3):89-91. No abstract available.


Acute renal failure in cardiac surgical patients, potentiated by gentamicin and calcium.

Schneider M, Valentine S, Clarke GM, Newman MA, Peacock J.

Anaesth Intensive Care. 1996 Dec;24(6):647-50.


Proximally delivered dilute heparin does not improve circuit life in continuous venovenous haemodiafiltration.

Leslie GD, Jacobs IG, Clarke GM.

Intensive Care Med. 1996 Nov;22(11):1261-4.


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