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Evaluating the impact of healthcare interventions using routine data.

Clarke GM, Conti S, Wolters AT, Steventon A.

BMJ. 2019 Jun 20;365:l2239. doi: 10.1136/bmj.l2239. No abstract available.


Computational modeling of human left ventricle to assess the role of trabeculae carneae on the diastolic and systolic functions.

Fatemifar F, Feldman M, Clarke G, Finol EA, Han HC.

J Biomech Eng. 2019 May 22. doi: 10.1115/1.4043831. [Epub ahead of print]


Gut microbiome patterns depending on children's psychosocial stress: Reports versus biomarkers.

Michels N, Van de Wiele T, Fouhy F, O'Mahony S, Clarke G, Keane J.

Brain Behav Immun. 2019 May 18. pii: S0889-1591(18)31214-5. doi: 10.1016/j.bbi.2019.05.024. [Epub ahead of print]


Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome.

Boehme M, van de Wouw M, Bastiaanssen TFS, Olavarría-Ramírez L, Lyons K, Fouhy F, Golubeva AV, Moloney GM, Minuto C, Sandhu KV, Scott KA, Clarke G, Stanton C, Dinan TG, Schellekens H, Cryan JF.

Mol Psychiatry. 2019 May 16. doi: 10.1038/s41380-019-0425-1. [Epub ahead of print]


The gut microbiome and pharmacology: a prescription for therapeutic targeting of the gut-brain axis.

Leprun PMB, Clarke G.

Curr Opin Pharmacol. 2019 May 9;49:17-23. doi: 10.1016/j.coph.2019.04.007. [Epub ahead of print] Review.


Methodological challenges in European ethics approvals for a genetic epidemiology study in critically ill patients: the GenOSept experience.

Tridente A, Holloway PAH, Hutton P, Gordon AC, Mills GH, Clarke GM, Chiche JD, Stuber F, Garrard C, Hinds C, Bion J; GenOSept National Coordinators, European Society of Intensive Care Medicine.

BMC Med Ethics. 2019 May 7;20(1):30. doi: 10.1186/s12910-019-0370-1.


Cervical syphilitic lymphadenitis causing fever of unknown origin followed by rash of secondary syphilis.

Mahapatra R, Clarke G, Lobo Z, Psevdos G.

Indian J Pathol Microbiol. 2019 Apr-Jun;62(2):339-340. doi: 10.4103/IJPM.IJPM_188_18. No abstract available.


Cost-Effectiveness of Preventing Depression Among At-Risk Youths: Postintervention and 2-Year Follow-Up.

Lynch FL, Dickerson JF, Clarke GN, Beardslee WR, Weersing VR, Gladstone TRG, Porta G, Brent DA, Mark TL, DeBar LL, Hollon SD, Garber J.

Psychiatr Serv. 2019 Apr 1;70(4):279-286. doi: 10.1176/ Epub 2019 Jan 3.


Manipulation of gut microbiota blunts the ventilatory response to hypercapnia in adult rats.

O'Connor KM, Lucking EF, Golubeva AV, Strain CR, Fouhy F, Cenit MC, Dhaliwal P, Bastiaanssen TFS, Burns DP, Stanton C, Clarke G, Cryan JF, O'Halloran KD.

EBioMedicine. 2019 Mar 18. pii: S2352-3964(19)30169-0. doi: 10.1016/j.ebiom.2019.03.029. [Epub ahead of print]


Gut Reactions: Breaking Down Xenobiotic-Microbiome Interactions.

Clarke G, Sandhu KV, Griffin BT, Dinan TG, Cryan JF, Hyland NP.

Pharmacol Rev. 2019 Apr;71(2):198-224. doi: 10.1124/pr.118.015768. Review.


Impaired left ventricular diastolic function in T2DM patients is closely related to glycemic control.

Clarke GD, Molina-Wilkins M, Solis-Herrera C, Mendez V, Monroy A, Cersosimo E, Chilton RJ, Abdul-Ghani M, DeFronzo RA.

Endocrinol Diabetes Metab. 2018 Apr 6;1(2):e00014. doi: 10.1002/edm2.14. eCollection 2018 Apr.


Psychotropics and the Microbiome: a Chamber of Secrets….

Cussotto S, Clarke G, Dinan TG, Cryan JF.

Psychopharmacology (Berl). 2019 Feb 26. doi: 10.1007/s00213-019-5185-8. [Epub ahead of print] Review.


epiCaPture: A Urine DNA Methylation Test for Early Detection of Aggressive Prostate Cancer.

O'Reilly E, Tuzova AV, Walsh AL, Russell NM, O'Brien O, Kelly S, Dhomhnallain ON, DeBarra L, Dale CM, Brugman R, Clarke G, Schmidt O, O'Meachair S, Patil D, Pellegrini KL, Fleshner N, Garcia J, Zhao F, Finn S, Mills R, Hanna MY, Hurst R, McEvoy E, Gallagher WM, Manecksha RP, Cooper CS, Brewer DS, Bapat B, Sanda MG, Clark J, Perry AS.

JCO Precis Oncol. 2019;2019. doi: 10.1200/PO.18.00134. Epub 2019 Jan 14.


Individual Response to Standardized Exercise: Total and Abdominal Adipose Tissue.

Brennan AM, Day AG, Cowan TE, Clarke GJ, Lamarche B, Ross R.

Med Sci Sports Exerc. 2019 Feb 15. doi: 10.1249/MSS.0000000000001930. [Epub ahead of print]


Aortic Root Abscess in a Patient with Marfan's Syndrome.

McCarron EP, Clarke G, Sreenivasan S, Monaghan M.

Am J Med. 2019 Jun;132(6):e585-e586. doi: 10.1016/j.amjmed.2019.01.009. Epub 2019 Jan 30. No abstract available.


Insomnia is associated with an increased risk of type 2 diabetes in the clinical setting.

LeBlanc ES, Smith NX, Nichols GA, Allison MJ, Clarke GN.

BMJ Open Diabetes Res Care. 2018 Dec 26;6(1):e000604. doi: 10.1136/bmjdrc-2018-000604. eCollection 2018.


Three-dimensional tumor visualization of invasive breast carcinomas using whole-mount serial section histopathology: implications for tumor size assessment.

Clarke GM, Holloway CMB, Zubovits JT, Nofech-Mozes S, Murray M, Liu K, Wang D, Kiss A, Yaffe MJ.

Breast Cancer Res Treat. 2019 Apr;174(3):669-677. doi: 10.1007/s10549-018-05122-7. Epub 2019 Jan 5.


Validation of Altered Umbilical Cord Blood MicroRNA Expression in Neonatal Hypoxic-Ischemic Encephalopathy.

O'Sullivan MP, Looney AM, Moloney GM, Finder M, Hallberg B, Clarke G, Boylan GB, Murray DM.

JAMA Neurol. 2018 Dec 28. doi: 10.1001/jamaneurol.2018.4182. [Epub ahead of print]


Lung Cancer Screening Reveals a Nonspiculated Nodule: Histoplasmosis.

Khoo T, Clarke G, Psevdos G.

J Glob Infect Dis. 2018 Oct-Dec;10(4):226-227. doi: 10.4103/jgid.jgid_92_18.


Modeling rare blood in Canada.

Blake JT, Clarke G.

Transfusion. 2019 Feb;59(2):582-592. doi: 10.1111/trf.15027. Epub 2018 Nov 19.


Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs.

Lucking EF, O'Connor KM, Strain CR, Fouhy F, Bastiaanssen TFS, Burns DP, Golubeva AV, Stanton C, Clarke G, Cryan JF, O'Halloran KD.

EBioMedicine. 2018 Dec;38:191-205. doi: 10.1016/j.ebiom.2018.11.010. Epub 2018 Nov 13.


Placental FKBP51 mediates a link between second trimester maternal anxiety and birthweight in female infants.

Togher KL, O'Keeffe GW, Khashan AS, Clarke G, Kenny LC.

Sci Rep. 2018 Oct 11;8(1):15151. doi: 10.1038/s41598-018-33357-3.


Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer's patches of mice.

Di Paola M, Bonechi E, Provensi G, Costa A, Clarke G, Ballerini C, De Filippo C, Passani MB.

Sci Rep. 2018 Oct 5;8(1):14881. doi: 10.1038/s41598-018-32925-x.


Severe hemolytic disease of the fetus and newborn due to allo-anti-D in a patient with a partial DEL phenotype arising from the variant allele described as RHD*148+1T (RHD*01EL.31).

Turley E, McGowan EC, Hyland CA, Schoeman EM, Flower RL, Skoll A, Delisle MF, Nelson T, Clarke G, Au N.

Transfusion. 2018 Oct;58(10):2260-2264. doi: 10.1111/trf.14944. Epub 2018 Sep 17.


Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function.

Cussotto S, Strain CR, Fouhy F, Strain RG, Peterson VL, Clarke G, Stanton C, Dinan TG, Cryan JF.

Psychopharmacology (Berl). 2018 Aug 28. doi: 10.1007/s00213-018-5006-5. [Epub ahead of print]


Ageing changes in biventricular cardiac function in male and female baboons (Papio spp.).

Kuo AH, Li C, Huber HF, Nathanielsz PW, Clarke GD.

J Physiol. 2018 Nov;596(21):5083-5098. doi: 10.1113/JP276338. Epub 2018 Sep 19.


Dimensional thinking in psychiatry in the era of the Research Domain Criteria (RDoC).

Kelly JR, Clarke G, Cryan JF, Dinan TG.

Ir J Psychol Med. 2018 Jun;35(2):89-94. doi: 10.1017/ipm.2017.7.


Planning for an uncertain future in progressive neurological disease: a qualitative study of patient and family decision-making with a focus on eating and drinking.

Clarke G, Fistein E, Holland A, Tobin J, Barclay S, Barclay S.

BMC Neurol. 2018 Aug 16;18(1):115. doi: 10.1186/s12883-018-1112-6.


Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations.

van de Wouw M, Boehme M, Lyte JM, Wiley N, Strain C, O'Sullivan O, Clarke G, Stanton C, Dinan TG, Cryan JF.

J Physiol. 2018 Oct;596(20):4923-4944. doi: 10.1113/JP276431. Epub 2018 Aug 28.


Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease.

Codagnone MG, Spichak S, O'Mahony SM, O'Leary OF, Clarke G, Stanton C, Dinan TG, Cryan JF.

Biol Psychiatry. 2019 Jan 15;85(2):150-163. doi: 10.1016/j.biopsych.2018.06.014. Epub 2018 Jun 27. Review.


Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study.

Ndila CM, Uyoga S, Macharia AW, Nyutu G, Peshu N, Ojal J, Shebe M, Awuondo KO, Mturi N, Tsofa B, Sepúlveda N, Clark TG, Band G, Clarke G, Rowlands K, Hubbart C, Jeffreys A, Kariuki S, Marsh K, Mackinnon M, Maitland K, Kwiatkowski DP, Rockett KA, Williams TN; MalariaGEN Consortium.

Lancet Haematol. 2018 Aug;5(8):e333-e345. doi: 10.1016/S2352-3026(18)30107-8. Epub 2018 Jul 20.


Bench to bedside: Current advances in regenerative medicine.

Clarke G, Harley P, Hubber EL, Manea T, Manuelli L, Read E, Watt FM.

Curr Opin Cell Biol. 2018 Dec;55:59-66. doi: 10.1016/ Epub 2018 Jul 11. Review.


Preparation from a revisited wet chemical route of phase-pure, monocrystalline and SHG-efficient BiFeO3 nanoparticles for harmonic bio-imaging.

Clarke G, Rogov A, McCarthy S, Bonacina L, Gun'ko Y, Galez C, Le Dantec R, Volkov Y, Mugnier Y, Prina-Mello A.

Sci Rep. 2018 Jul 11;8(1):10473. doi: 10.1038/s41598-018-28557-w.


Characterisation of the cellular and proteomic response of Galleria mellonella larvae to the development of invasive aspergillosis.

Sheehan G, Clarke G, Kavanagh K.

BMC Microbiol. 2018 Jun 28;18(1):63. doi: 10.1186/s12866-018-1208-6.


A Microbial Drugstore for Motility.

Cryan JF, Clarke G, Dinan TG, Schellekens H.

Cell Host Microbe. 2018 Jun 13;23(6):691-692. doi: 10.1016/j.chom.2018.05.020.


Spring warming in Yukon mountains is not amplified by the snow albedo feedback.

Williamson SN, Anslow FS, Clarke GKC, Gamon JA, Jarosch AH, Hik DS.

Sci Rep. 2018 Jun 13;8(1):9000. doi: 10.1038/s41598-018-27348-7.


Antenatal Synthetic Glucocorticoid Exposure at Human Therapeutic Equivalent Doses Predisposes Middle-Age Male Offspring Baboons to an Obese Phenotype That Emerges With Aging.

Huber HF, Kuo AH, Li C, Jenkins SL, Gerow KG, Clarke GD, Nathanielsz PW.

Reprod Sci. 2019 May;26(5):591-599. doi: 10.1177/1933719118778794. Epub 2018 Jun 5.


Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice.

Stilling RM, Moloney GM, Ryan FJ, Hoban AE, Bastiaanssen TF, Shanahan F, Clarke G, Claesson MJ, Dinan TG, Cryan JF.

Elife. 2018 May 29;7. pii: e33070. doi: 10.7554/eLife.33070.


Drug-gut microbiota interactions: implications for neuropharmacology.

Walsh J, Griffin BT, Clarke G, Hyland NP.

Br J Pharmacol. 2018 Dec;175(24):4415-4429. doi: 10.1111/bph.14366. Epub 2018 Jun 28. Review.


Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts.

Michels N, Clarke G, Olavarria-Ramirez L, Gómez-Martínez S, Díaz LE, Marcos A, Widhalm K, Carvalho LA.

Psychoneuroendocrinology. 2018 Aug;94:104-111. doi: 10.1016/j.psyneuen.2018.05.013. Epub 2018 May 21.


The difficulties of discharging hospice patients to care homes at the end of life: A focus group study.

Thomas T, Clarke G, Barclay S.

Palliat Med. 2018 Jul;32(7):1267-1274. doi: 10.1177/0269216318772735. Epub 2018 Apr 30.


Tryptophan metabolic profile in term and preterm breast milk: implications for health.

O'Rourke L, Clarke G, Nolan A, Watkins C, Dinan TG, Stanton C, Ross RP, Ryan CA.

J Nutr Sci. 2018 Apr 4;7:e13. doi: 10.1017/jns.2017.69. eCollection 2018.


'Stiffening the sinews of the heart'.

Clarke GD, Nathanielsz PW.

J Physiol. 2018 Jun;596(12):2279-2280. doi: 10.1113/JP276234. Epub 2018 May 10. No abstract available.


Efficacy and safety of antenatal steroids.

Kemp MW, Jobe AH, Usuda H, Nathanielsz PW, Li C, Kuo A, Huber HF, Clarke GD, Saito M, Newnham JP, Stock SJ.

Am J Physiol Regul Integr Comp Physiol. 2018 Oct 1;315(4):R825-R839. doi: 10.1152/ajpregu.00193.2017. Epub 2018 Apr 11.


Near Real-time Surveillance for Consequences of Health Policies Using Sequential Analysis.

Lu CY, Penfold RB, Toh S, Sturtevant JL, Madden JM, Simon G, Ahmedani BK, Clarke G, Coleman KJ, Copeland LA, Daida YG, Davis RL, Hunkeler EM, Owen-Smith A, Raebel MA, Rossom R, Soumerai SB, Kulldorff M.

Med Care. 2018 May;56(5):365-372. doi: 10.1097/MLR.0000000000000893.


The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial.

Patel NR, Cunoosamy DM, Fagerås M, Taib Z, Asimus S, Hegelund-Myrbäck T, Lundin S, Pardali K, Kurian N, Ersdal E, Kristensson C, Korsback K, Palmér R, Brown MN, Greenaway S, Siew L, Clarke GW, Rennard SI, Make BJ, Wise RA, Jansson P.

Int J Chron Obstruct Pulmon Dis. 2018 Mar 27;13:1009-1019. doi: 10.2147/COPD.S150576. eCollection 2018.


Neurocognitive Effects of Repetitive Transcranial Magnetic Stimulation With a 2-Coil Device in Treatment-Resistant Major Depressive Disorder.

Kavanaugh BC, Aaronson ST, Clarke GN, Holtzheimer PE, Johnson CW, McDonald WM, Schneider MB, Carpenter LL.

J ECT. 2018 Dec;34(4):258-265. doi: 10.1097/YCT.0000000000000494.


Reduced skeletal muscle phosphocreatine concentration in type 2 diabetic patients: a quantitative image-based phosphorus-31 MR spectroscopy study.

Ripley EM, Clarke GD, Hamidi V, Martinez RA, Settles FD, Solis C, Deng S, Abdul-Ghani M, Tripathy D, DeFronzo RA.

Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E229-E239. doi: 10.1152/ajpendo.00426.2017. Epub 2018 Mar 6.


Digital IAPT: the effectiveness & cost-effectiveness of internet-delivered interventions for depression and anxiety disorders in the Improving Access to Psychological Therapies programme: study protocol for a randomised control trial.

Richards D, Duffy D, Blackburn B, Earley C, Enrique A, Palacios J, Franklin M, Clarke G, Sollesse S, Connell S, Timulak L.

BMC Psychiatry. 2018 Mar 2;18(1):59. doi: 10.1186/s12888-018-1639-5.

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