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Items: 31

1.

Injuries among Artisanal and Small-Scale Gold Miners in Ghana.

Kyeremateng-Amoah E, Clarke EE.

Int J Environ Res Public Health. 2015 Sep 2;12(9):10886-96. doi: 10.3390/ijerph120910886.

2.

Health risks of using mothballs in Greater Accra, Ghana.

Soghoian S, Nyadedzor C, Ed Nignpense B, Clarke EE, Hoffman RS.

Trop Med Int Health. 2012 Jan;17(1):135-8. doi: 10.1111/j.1365-3156.2011.02885.x. Epub 2011 Oct 4.

3.

Acceptability of PrEP for HIV prevention among women at high risk for HIV.

Guest G, Shattuck D, Johnson L, Akumatey B, Clarke EE, Chen PL, Macqueen KM.

J Womens Health (Larchmt). 2010 Apr;19(4):791-8. doi: 10.1089/jwh.2009.1576.

PMID:
20210540
4.

Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity.

Keown LE, Collins I, Cooper LC, Harrison T, Madin A, Mistry J, Reilly M, Shaimi M, Welch CJ, Clarke EE, Lewis HD, Wrigley JD, Best JD, Murray F, Shearman MS.

J Med Chem. 2009 Jun 11;52(11):3441-4. doi: 10.1021/jm900056p.

PMID:
19432431
5.

Changes in sexual risk behavior among participants in a PrEP HIV prevention trial.

Guest G, Shattuck D, Johnson L, Akumatey B, Clarke EE, Chen PL, MacQueen KM.

Sex Transm Dis. 2008 Dec;35(12):1002-8.

PMID:
19051397
6.

Tenofovir disoproxil fumarate for prevention of HIV infection in women: a phase 2, double-blind, randomized, placebo-controlled trial.

Peterson L, Taylor D, Roddy R, Belai G, Phillips P, Nanda K, Grant R, Clarke EE, Doh AS, Ridzon R, Jaffe HS, Cates W.

PLoS Clin Trials. 2007 May 25;2(5):e27.

7.

Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes.

Clarke EE, Churcher I, Ellis S, Wrigley JD, Lewis HD, Harrison T, Shearman MS, Beher D.

J Biol Chem. 2006 Oct 20;281(42):31279-89. Epub 2006 Aug 9.

8.

3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.

Jelley RA, Elliott J, Gibson KR, Harrison T, Beher D, Clarke EE, Lewis HD, Shearman M, Wrigley JD.

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3839-42. Epub 2006 May 6.

PMID:
16682202
9.

4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.

Churcher I, Beher D, Best JD, Castro JL, Clarke EE, Gentry A, Harrison T, Hitzel L, Kay E, Kerrad S, Lewis HD, Morentin-Gutierrez P, Mortishire-Smith R, Oakley PJ, Reilly M, Shaw DE, Shearman MS, Teall MR, Williams S, Wrigley JD.

Bioorg Med Chem Lett. 2006 Jan 15;16(2):280-4. Epub 2005 Nov 3.

PMID:
16275079
10.

Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.

Wrigley JD, Schurov I, Nunn EJ, Martin AC, Clarke EE, Ellis S, Bonnert TP, Shearman MS, Beher D.

J Biol Chem. 2005 Apr 1;280(13):12523-35. Epub 2004 Dec 21.

11.

Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.

Wrigley JD, Nunn EJ, Nyabi O, Clarke EE, Hunt P, Nadin A, De Strooper B, Shearman MS, Beher D.

J Neurochem. 2004 Sep;90(6):1312-20.

12.

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

Beher D, Clarke EE, Wrigley JD, Martin AC, Nadin A, Churcher I, Shearman MS.

J Biol Chem. 2004 Oct 15;279(42):43419-26. Epub 2004 Aug 10.

13.

The experience of starting a poison control centre in Africa--the Ghana experience.

Clarke EE.

Toxicology. 2004 May 20;198(1-3):267-72.

PMID:
15138051
14.

High affinity, bioavailable 3-amino-1,4-benzodiazepine-based gamma-secretase inhibitors.

Owens AP, Nadin A, Talbot AC, Clarke EE, Harrison T, Lewis HD, Reilly M, Wrigley JD, Castro JL.

Bioorg Med Chem Lett. 2003 Nov 17;13(22):4143-5.

PMID:
14592525
15.

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

Beher D, Fricker M, Nadin A, Clarke EE, Wrigley JD, Li YM, Culvenor JG, Masters CL, Harrison T, Shearman MS.

Biochemistry. 2003 Jul 15;42(27):8133-42.

PMID:
12846562
17.

A new series of potent benzodiazepine gamma-secretase inhibitors.

Churcher I, Ashton K, Butcher JW, Clarke EE, Harrison T, Lewis HD, Owens AP, Teall MR, Williams S, Wrigley JD.

Bioorg Med Chem Lett. 2003 Jan 20;13(2):179-83.

PMID:
12482419
18.
19.

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity.

Shearman MS, Beher D, Clarke EE, Lewis HD, Harrison T, Hunt P, Nadin A, Smith AL, Stevenson G, Castro JL.

Biochemistry. 2000 Aug 1;39(30):8698-704.

PMID:
10913280
20.

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.

Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S, Nicholson DW.

Cell. 1999 Apr 30;97(3):395-406.

21.

The problems associated with pesticide use by irrigation workers in Ghana.

Clarke EE, Levy LS, Spurgeon A, Calvert IA.

Occup Med (Lond). 1997 Jul;47(5):301-8.

PMID:
9302813
22.

Characterization of the ecdysteroid UDP-glucosyltransferase gene from Mamestra brassicae nucleopolyhedrovirus.

Clarke EE, Tristem M, Cory JS, O'Reilly DR.

J Gen Virol. 1996 Nov;77 ( Pt 11):2865-71.

PMID:
8922482
23.

Altered in vitro adaptive responses of lymphocyte Na+,K(+)-ATPase in patients with manic depressive psychosis.

Wood AJ, Smith CE, Clarke EE, Cowen PJ, Aronson JK, Grahame-Smith DG.

J Affect Disord. 1991 Mar;21(3):199-206.

PMID:
1648581
24.

Precise determination of 5-hydroxytryptamine in platelets and platelet-poor plasma.

Molyneux SG, Clarke EE.

Clin Chem. 1985 Sep;31(9):1573-4. No abstract available.

25.
26.

An interesting experiment.

Clarke EE.

J Pract Nurs. 1968 Mar;18(3):36-7. No abstract available.

PMID:
5184038
27.

An evaluation of treatments; the Brandon Hospital for Mental Diseases Brandon, Manitoba; 1928-1932 and 1943-1947.

SCHULTZ S, HENDERSON AL, CLARKE EE, FISHER JW.

Med Serv J Can. 1958 Apr;14(4):243-62. No abstract available.

PMID:
13540587
28.

The metabolism of melanomas in platyfish-swordtail hybrids.

HUMM DG, CLARKE EE.

J Natl Cancer Inst. 1955 Dec;16(3):741-61. No abstract available.

PMID:
13272028
29.

A small hospital plans for rooming-in.

CLARKE EE.

Am J Nurs. 1953 May;53(5):570-1. No abstract available.

PMID:
13050623
30.

The premature infant goes home.

CLARKE EE.

Am J Nurs. 1952 Jul;52(7):882. No abstract available.

PMID:
12976475
31.

Work simplification in the nursery.

CLARKE EE.

Am J Nurs. 1951 Sep;51(9):541. No abstract available.

PMID:
14868694

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