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Items: 1 to 50 of 148

1.

Thermal stability of dialkylimidazolium tetrafluoroborate and hexafluorophosphate ionic liquids: ex situ bulk heating to complement in situ mass spectrometry.

Clarke CJ, Puttick S, Sanderson TJ, Taylor AW, Bourne RA, Lovelock KRJ, Licence P.

Phys Chem Chem Phys. 2018 Jun 20;20(24):16786-16800. doi: 10.1039/c8cp01090k.

PMID:
29888367
2.

Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5.

Newcomb B, Rhein C, Mileva I, Ahmad R, Clarke CJ, Snider J, Obeid LM, Hannun YA.

J Lipid Res. 2018 Jul;59(7):1219-1229. doi: 10.1194/jlr.M084202. Epub 2018 May 3.

PMID:
29724781
3.

hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival.

Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A, Abraham SA, Hair A, Helgason GV, Aspinall-O'Dea M, Bhatia R, Leone G, Kranc KR, Whetton AD, Holyoake TL.

Blood. 2018 Apr 5;131(14):1532-1544. doi: 10.1182/blood-2017-05-783845. Epub 2018 Feb 5.

PMID:
29437554
4.

An intrinsic lipid-binding interface controls sphingosine kinase 1 function.

Pulkoski-Gross MJ, Jenkins ML, Truman JP, Salama MF, Clarke CJ, Burke JE, Hannun YA, Obeid LM.

J Lipid Res. 2018 Mar;59(3):462-474. doi: 10.1194/jlr.M081307. Epub 2018 Jan 11.

PMID:
29326159
5.

Green and Sustainable Solvents in Chemical Processes.

Clarke CJ, Tu WC, Levers O, Bröhl A, Hallett JP.

Chem Rev. 2018 Jan 24;118(2):747-800. doi: 10.1021/acs.chemrev.7b00571. Epub 2018 Jan 4.

PMID:
29300087
6.

Underutilization of Aldosterone Antagonists in Heart Failure.

Patterson SJ, Reaves AB, Tolley EA, Ulrich D, Hilty C, Clarke CJ, Self TH.

Hosp Pharm. 2017 Nov;52(10):698-703. doi: 10.1177/0018578717724886. Epub 2017 Aug 20.

PMID:
29276242
7.

Sphingosine 1-phosphate activation of ERM contributes to vascular calcification.

Morris TG, Borland SJ, Clarke CJ, Wilson C, Hannun YA, Ohanian V, Canfield AE, Ohanian J.

J Lipid Res. 2018 Jan;59(1):69-78. doi: 10.1194/jlr.M079731. Epub 2017 Nov 22.

PMID:
29167409
8.

Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation.

Liu M, Clarke CJ, Salama MF, Choi YJ, Obeid LM, Hannun YA.

PLoS One. 2017 Sep 19;12(9):e0184818. doi: 10.1371/journal.pone.0184818. eCollection 2017.

9.

Activation of tissue plasminogen activator by metastasis-inducing S100P protein.

Clarke CJ, Gross SR, Ismail TM, Rudland PS, Al-Medhtiy M, Santangeli M, Barraclough R.

Biochem J. 2017 Sep 12;474(19):3227-3240. doi: 10.1042/BCJ20170578.

PMID:
28798096
10.

Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.

Dupre TV, Doll MA, Shah PP, Sharp CN, Siow D, Megyesi J, Shayman J, Bielawska A, Bielawski J, Beverly LJ, Hernandez-Corbacho M, Clarke CJ, Snider AJ, Schnellmann RG, Obeid LM, Hannun YA, Siskind LJ.

J Lipid Res. 2017 Jul;58(7):1439-1452. doi: 10.1194/jlr.M076745. Epub 2017 May 10.

11.

Preclinical approaches in chronic myeloid leukemia: from cells to systems.

Clarke CJ, Holyoake TL.

Exp Hematol. 2017 Mar;47:13-23. doi: 10.1016/j.exphem.2016.11.005. Epub 2016 Dec 23. Review.

12.

Role of neutral ceramidase in colon cancer.

García-Barros M, Coant N, Kawamori T, Wada M, Snider AJ, Truman JP, Wu BX, Furuya H, Clarke CJ, Bialkowska AB, Ghaleb A, Yang VW, Obeid LM, Hannun YA.

FASEB J. 2016 Dec;30(12):4159-4171. Epub 2016 Sep 8.

13.

The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma.

Birch J, Clarke CJ, Campbell AD, Campbell K, Mitchell L, Liko D, Kalna G, Strathdee D, Sansom OJ, Neilson M, Blyth K, Norman JC.

Biol Open. 2016 Oct 15;5(10):1371-1379. doi: 10.1242/bio.019075.

14.

Constitutive IFNα/β signaling maintains expression of signaling intermediaries for efficient cytokine responses.

Messina NL, Clarke CJ, Johnstone RW.

JAKSTAT. 2016 May 18;5(1):e1173804. doi: 10.1080/21623996.2016.1173804. eCollection 2016.

15.

Collision velocity of dust grains in self-gravitating protoplanetary discs.

Booth RA, Clarke CJ.

Mon Not R Astron Soc. 2016 Mar 3;458(3):2676-2693. eCollection 2016 May 21.

16.

Neuralgic amyotrophy is not the most common neurologic disorder of the shoulder: a 78-month prospective study of 60 neurologic shoulder patients in a specialist shoulder clinic.

Clarke CJ, Torrance E, McIntosh J, Funk L.

J Shoulder Elbow Surg. 2016 Dec;25(12):1997-2004. doi: 10.1016/j.jse.2016.04.005. Epub 2016 Jun 6.

PMID:
27282731
17.

The minimum mass of detectable planets in protoplanetary discs and the derivation of planetary masses from high-resolution observations.

Rosotti GP, Juhasz A, Booth RA, Clarke CJ.

Mon Not R Astron Soc. 2016 May 4;459(3):2790-2805. eCollection 2016 Jul 1.

PMID:
27279783
18.

Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation.

Arecco N, Clarke CJ, Jones FK, Simpson DM, Mason D, Beynon RJ, Pisconti A.

Sci Rep. 2016 May 31;6:24708. doi: 10.1038/srep24708.

19.

ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation.

Clarke CJ, Shamseddine AA, Jacob JJ, Khalife G, Burns TA, Hannun YA.

J Lipid Res. 2016 May;57(5):868-81. doi: 10.1194/jlr.M067447. Epub 2016 Mar 24.

20.

The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis.

Clarke CJ, Berg TJ, Birch J, Ennis D, Mitchell L, Cloix C, Campbell A, Sumpton D, Nixon C, Campbell K, Bridgeman VL, Vermeulen PB, Foo S, Kostaras E, Jones JL, Haywood L, Pulleine E, Yin H, Strathdee D, Sansom O, Blyth K, McNeish I, Zanivan S, Reynolds AR, Norman JC.

Curr Biol. 2016 Mar 21;26(6):755-65. doi: 10.1016/j.cub.2016.01.045. Epub 2016 Mar 3.

21.

New insights into the phenotype of human dendritic cell populations.

Clark GJ, Kupresanin F, Fromm PD, Ju X, Muusers L, Silveira PA, Elgundi Z, Gasiorowski RE, Papadimitrious MS, Bryant C, Lee KM, Clarke CJ, Young JW, Chan A, Harman A, Botting R, Cabezón R, Benitez-Ribas D, Brooks AE, Dunbar PR, Hart DN.

Clin Transl Immunology. 2016 Jan 29;5(1):e61. doi: 10.1038/cti.2015.40. eCollection 2016 Jan.

22.

Lactosylceramide contributes to mitochondrial dysfunction in diabetes.

Novgorodov SA, Riley CL, Yu J, Keffler JA, Clarke CJ, Van Laer AO, Baicu CF, Zile MR, Gudz TI.

J Lipid Res. 2016 Apr;57(4):546-62. doi: 10.1194/jlr.M060061. Epub 2016 Feb 21.

23.

The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD.

Russell KE, Chung KF, Clarke CJ, Durham AL, Mallia P, Footitt J, Johnston SL, Barnes PJ, Hall SR, Simpson KD, Starkey MR, Hansbro PM, Adcock IM, Wiegman CH.

PLoS One. 2016 Jan 11;11(1):e0146102. doi: 10.1371/journal.pone.0146102. eCollection 2016.

24.

P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest.

Shamseddine AA, Clarke CJ, Carroll B, Airola MV, Mohammed S, Rella A, Obeid LM, Hannun YA.

Cell Death Dis. 2015 Oct 29;6:e1947. doi: 10.1038/cddis.2015.268.

25.

Hydration Strategy for Endurance Running in an Athlete Requiring Home Parenteral Nutrition.

Tillman EM, Killmeier G, Opilla M, Clarke CJ, Nishikawa RA.

Nutr Clin Pract. 2016 Apr;31(2):191-4. doi: 10.1177/0884533615591603. Epub 2015 Jul 6.

PMID:
26150104
26.

Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease.

Wiegman CH, Michaeloudes C, Haji G, Narang P, Clarke CJ, Russell KE, Bao W, Pavlidis S, Barnes PJ, Kanerva J, Bittner A, Rao N, Murphy MP, Kirkham PA, Chung KF, Adcock IM; COPDMAP.

J Allergy Clin Immunol. 2015 Sep;136(3):769-80. doi: 10.1016/j.jaci.2015.01.046. Epub 2015 Mar 29.

27.

Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis.

Rachidi S, Sun S, Wu BX, Jones E, Drake RR, Ogretmen B, Cowart LA, Clarke CJ, Hannun YA, Chiosis G, Liu B, Li Z.

J Hepatol. 2015 Apr;62(4):879-88. doi: 10.1016/j.jhep.2014.11.010. Epub 2014 Nov 22.

28.

Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.

Bai A, Szulc ZM, Bielawski J, Pierce JS, Rembiesa B, Terzieva S, Mao C, Xu R, Wu B, Clarke CJ, Newcomb B, Liu X, Norris J, Hannun YA, Bielawska A.

Bioorg Med Chem. 2014 Dec 15;22(24):6933-44. doi: 10.1016/j.bmc.2014.10.025. Epub 2014 Oct 22.

29.

Emotion differentiation and alcohol-related problems: the mediating role of urgency.

Emery NN, Simons JS, Clarke CJ, Gaher RM.

Addict Behav. 2014 Oct;39(10):1459-63. doi: 10.1016/j.addbeh.2014.05.004. Epub 2014 May 27.

30.

Further evidence for the effectiveness of PCV10 against Streptococcus pneumoniae serotype 19A.

Clarke CJ, Hausdorff WP.

Lancet Respir Med. 2014 Jun;2(6):e7. doi: 10.1016/S2213-2600(14)70128-6. No abstract available.

PMID:
24899371
31.

Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation.

Wei J, Ferron M, Clarke CJ, Hannun YA, Jiang H, Blaner WS, Karsenty G.

J Clin Invest. 2014 Apr;124(4):1-13. doi: 10.1172/JCI72323. Epub 2014 Mar 18.

32.

Isometric hip and knee torque measurements as an outcome measure in robot assisted gait training.

Galen SS, Clarke CJ, McLean AN, Allan DB, Conway BA.

NeuroRehabilitation. 2014;34(2):287-95. doi: 10.3233/NRE-131042.

PMID:
24419018
33.

Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor.

Liu M, Idkowiak-Baldys J, Roddy PL, Baldys A, Raymond J, Clarke CJ, Hannun YA.

PLoS One. 2013 Nov 11;8(11):e80721. doi: 10.1371/journal.pone.0080721. eCollection 2013.

34.

Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner.

El Osta M, Liu M, Adada M, Senkal CE, Idkowiak-Baldys J, Obeid LM, Clarke CJ, Hannun YA.

FASEB J. 2014 Jan;28(1):495-505. doi: 10.1096/fj.13-230557. Epub 2013 Oct 11.

35.

Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities.

Newbold A, Matthews GM, Bots M, Cluse LA, Clarke CJ, Banks KM, Cullinane C, Bolden JE, Christiansen AJ, Dickins RA, Miccolo C, Chiocca S, Kral AM, Ozerova ND, Miller TA, Methot JL, Richon VM, Secrist JP, Minucci S, Johnstone RW.

Mol Cancer Ther. 2013 Dec;12(12):2709-21. doi: 10.1158/1535-7163.MCT-13-0626. Epub 2013 Oct 3.

36.

A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model.

Wiegman CH, Li F, Clarke CJ, Jazrawi E, Kirkham P, Barnes PJ, Adcock IM, Chung KF.

Clin Sci (Lond). 2014 Mar;126(6):425-40. doi: 10.1042/CS20130039.

PMID:
24040961
37.

Modulation of antitumour immune responses by intratumoural Stat1 expression.

Messina NL, Banks KM, Vidacs E, Martin BP, Long F, Christiansen AJ, Smyth MJ, Clarke CJ, Johnstone RW.

Immunol Cell Biol. 2013 Oct;91(9):556-67. doi: 10.1038/icb.2013.41. Epub 2013 Aug 20.

PMID:
23958683
38.

Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation.

Adada MM, Orr-Gandy KA, Snider AJ, Canals D, Hannun YA, Obeid LM, Clarke CJ.

J Biol Chem. 2013 Sep 20;288(38):27667-79. doi: 10.1074/jbc.M113.489443. Epub 2013 Aug 9.

39.

Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis.

Jenkins RW, Clarke CJ, Lucas JT Jr, Shabbir M, Wu BX, Simbari F, Mueller J, Hannun YA, Lazarchick J, Shirai K.

Am J Hematol. 2013 Nov;88(11):E265-72. doi: 10.1002/ajh.23535. Epub 2013 Aug 30.

40.

Supratherapeutic international normalized ratio due to reduced vitamin K intake secondary to prolonged vomiting in a patient on warfarin.

Reaves AB, Clarke CJ, Tillman EM.

Ann Pharmacother. 2013 Jun;47(6):e28. doi: 10.1345/aph.1R688.

PMID:
23719786
41.

Wall-motion based analysis of global and regional left atrial mechanics.

Moyer CB, Helm PA, Clarke CJ, Budge LP, Kramer CM, Ferguson JD, Norton PT, Holmes JW.

IEEE Trans Med Imaging. 2013 Oct;32(10):1765-76. doi: 10.1109/TMI.2013.2264062. Epub 2013 May 20.

42.

Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1.

Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, DePinho RA, Guo XE, Mann JJ, Karsenty G.

Cell Metab. 2013 Jun 4;17(6):901-15. doi: 10.1016/j.cmet.2013.04.009. Epub 2013 May 16. Erratum in: Cell Metab. 2014 May 6;19(5):891. Guo, Edward X [corrected to Guo, X Edward].

43.

Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain.

Salegio EA, Samaranch L, Jenkins RW, Clarke CJ, Lamarre C, Beyer J, Kells AP, Bringas J, Sebastian WS, Richardson RM, Rosenbluth KH, Hannun YA, Bankiewicz KS, Forsayeth J.

Hum Gene Ther. 2012 Aug;23(8):891-902. doi: 10.1089/hum.2012.052.

44.

Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction.

Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B.

Mol Cancer Ther. 2012 May;11(5):1092-102. doi: 10.1158/1535-7163.MCT-11-0705. Epub 2012 Mar 27.

45.

Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis.

Chipuk JE, McStay GP, Bharti A, Kuwana T, Clarke CJ, Siskind LJ, Obeid LM, Green DR.

Cell. 2012 Mar 2;148(5):988-1000. doi: 10.1016/j.cell.2012.01.038.

46.

Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells.

Spassieva SD, Rahmaniyan M, Bielawski J, Clarke CJ, Kraveka JM, Obeid LM.

J Lipid Res. 2012 May;53(5):918-28. doi: 10.1194/jlr.M019075. Epub 2012 Feb 29.

47.

Constitutive type I interferon modulates homeostatic balance through tonic signaling.

Gough DJ, Messina NL, Clarke CJ, Johnstone RW, Levy DE.

Immunity. 2012 Feb 24;36(2):166-74. doi: 10.1016/j.immuni.2012.01.011. Review.

48.

Assessment of the accuracy and reproducibility of RV volume measurements by CMR in congenital heart disease.

Clarke CJ, Gurka MJ, Norton PT, Kramer CM, Hoyer AW.

JACC Cardiovasc Imaging. 2012 Jan;5(1):28-37. doi: 10.1016/j.jcmg.2011.05.007.

49.

A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization.

Khavandgar Z, Poirier C, Clarke CJ, Li J, Wang N, McKee MD, Hannun YA, Murshed M.

J Cell Biol. 2011 Jul 25;194(2):277-89. doi: 10.1083/jcb.201102051.

50.

Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.

Hernández-Corbacho MJ, Jenkins RW, Clarke CJ, Hannun YA, Obeid LM, Snider AJ, Siskind LJ.

PLoS One. 2011;6(6):e20411. doi: 10.1371/journal.pone.0020411. Epub 2011 Jun 8.

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