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Anti-Hu limbic encephalitis preceding the appearance of mediastinal germinoma by 9 years.

Silsby M, Clarke CJ, Lee K, Sharpe D.

Neurol Neuroimmunol Neuroinflamm. 2020 Feb 21;7(3). pii: e685. doi: 10.1212/NXI.0000000000000685. Print 2020 May. No abstract available.


Correction: CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy.

Kinstrie R, Horne GA, Morrison H, Irvine D, Munje C, Castañeda EG, Moka HA, Dunn K, Cassels JE, Parry N, Clarke CJ, Scott MT, Clark RE, Holyoake TL, Wheadon H, Copland M.

Leukemia. 2020 Jan 31. doi: 10.1038/s41375-020-0721-4. [Epub ahead of print]


A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer.

Madigan JP, Robey RW, Poprawski JE, Huang H, Clarke CJ, Gottesman MM, Cabot MC, Rosenberg DW.

Exp Cell Res. 2020 Jan 20:111860. doi: 10.1016/j.yexcr.2020.111860. [Epub ahead of print]


CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy.

Kinstrie R, Horne GA, Morrison H, Irvine D, Munje C, Castañeda EG, Moka HA, Dunn K, Cassels JE, Parry N, Clarke CJ, Scott MT, Clark RE, Holyoake TL, Wheadon H, Copland M.

Leukemia. 2020 Jan 2. doi: 10.1038/s41375-019-0684-5. [Epub ahead of print] Erratum in: Leukemia. 2020 Jan 31;:.


Zinc 1s Valence-to-Core X-ray Emission Spectroscopy of Halozincate Complexes.

Clarke CJ, Hayama S, Hawes A, Hallett JP, Chamberlain TW, Lovelock KRJ, Besley NA.

J Phys Chem A. 2019 Nov 7;123(44):9552-9559. doi: 10.1021/acs.jpca.9b08037. Epub 2019 Oct 28.


Correction: PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation.

Salama MF, Liu M, Clarke CJ, Espaillat MP, Haley JD, Jin T, Wang D, Obeid LM, Hannun YA.

Oncogene. 2019 Nov;38(48):7366. doi: 10.1038/s41388-019-1019-8.


Strong anion exchange-mediated phosphoproteomics reveals extensive human non-canonical phosphorylation.

Hardman G, Perkins S, Brownridge PJ, Clarke CJ, Byrne DP, Campbell AE, Kalyuzhnyy A, Myall A, Eyers PA, Jones AR, Eyers CE.

EMBO J. 2019 Oct 4;38(21):e100847. doi: 10.15252/embj.2018100847. Epub 2019 Aug 21.


PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation.

Salama MF, Liu M, Clarke CJ, Espaillat MP, Haley JD, Jin T, Wang D, Obeid LM, Hannun YA.

Oncogene. 2019 Nov;38(48):7311-7328. doi: 10.1038/s41388-019-0950-z. Epub 2019 Aug 16. Erratum in: Oncogene. 2019 Oct 1;:.


Meeting Report - The 2019 FEBS special meeting on sphingolipid biology: sphingolipids in physiology and pathology.

D'Angelo G, Clarke CJ, Silva LC.

J Cell Sci. 2019 Jul 31;132(15). pii: jcs235705. doi: 10.1242/jcs.235705. Review.


Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases.

Sakamoto W, Canals D, Salamone S, Allopenna J, Clarke CJ, Snider J, Obeid LM, Hannun YA.

J Lipid Res. 2019 Nov;60(11):1841-1850. doi: 10.1194/jlr.M094722. Epub 2019 Jun 26.


Protocol for a prospective, longitudinal, cohort study of recovery pathways, acute biomarkers and cost for children with persistent postconcussion symptoms: the Take CARe Biomarkers study.

Takagi M, Babl FE, Anderson N, Bressan S, Clarke CJ, Crichton A, Dalziel K, Davis GA, Doyle M, Dunne K, Godfrey C, Hearps SJC, Ignjatovic V, Parkin G, Rausa V, Seal M, Thompson EJ, Truss K, Anderson V.

BMJ Open. 2019 Feb 24;9(2):e022098. doi: 10.1136/bmjopen-2018-022098.


Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis.

Snider JM, Trayssac M, Clarke CJ, Schwartz N, Snider AJ, Obeid LM, Luberto C, Hannun YA.

J Lipid Res. 2019 Apr;60(4):819-831. doi: 10.1194/jlr.M089714. Epub 2018 Dec 20.


Resolving X-ray photoelectron spectra of ionic liquids with difference spectroscopy.

Clarke CJ, Maxwell-Hogg S, Smith EF, Hawker RR, Harper JB, Licence P.

Phys Chem Chem Phys. 2018 Dec 19;21(1):114-123. doi: 10.1039/c8cp06701e.


The choice of analytical methodology can alter conclusions regarding herd effects of paediatric pneumococcal vaccination programmes.

Pirçon JY, Talarico CA, Bollaerts K, Hausdorff WP, Clarke CJ.

Vaccine. 2018 Nov 12;36(46):6933-6943. doi: 10.1016/j.vaccine.2018.10.003. Epub 2018 Oct 11.


Genomic Deletion of BAP1 and CDKN2A Are Useful Markers for Quality Control of Malignant Pleural Mesothelioma (MPM) Primary Cultures.

Sarun KH, Lee K, Williams M, Wright CM, Clarke CJ, Cheng NC, Takahashi K, Cheng YY.

Int J Mol Sci. 2018 Oct 7;19(10). pii: E3056. doi: 10.3390/ijms19103056.


Recurrence After Arthroscopic Labral Repair for Traumatic Anterior Instability in Adolescent Rugby and Contact Athletes.

Torrance E, Clarke CJ, Monga P, Funk L, Walton MJ.

Am J Sports Med. 2018 Oct;46(12):2969-2974. doi: 10.1177/0363546518794673. Epub 2018 Sep 10.


Neutral Sphingomyelinases in Cancer: Friend or Foe?

Clarke CJ.

Adv Cancer Res. 2018;140:97-119. doi: 10.1016/bs.acr.2018.04.010. Epub 2018 May 28. Review.


Thermal stability of dialkylimidazolium tetrafluoroborate and hexafluorophosphate ionic liquids: ex situ bulk heating to complement in situ mass spectrometry.

Clarke CJ, Puttick S, Sanderson TJ, Taylor AW, Bourne RA, Lovelock KRJ, Licence P.

Phys Chem Chem Phys. 2018 Jun 20;20(24):16786-16800. doi: 10.1039/c8cp01090k.


Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5.

Newcomb B, Rhein C, Mileva I, Ahmad R, Clarke CJ, Snider J, Obeid LM, Hannun YA.

J Lipid Res. 2018 Jul;59(7):1219-1229. doi: 10.1194/jlr.M084202. Epub 2018 May 3.


hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival.

Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A, Abraham SA, Hair A, Helgason GV, Aspinall-O'Dea M, Bhatia R, Leone G, Kranc KR, Whetton AD, Holyoake TL.

Blood. 2018 Apr 5;131(14):1532-1544. doi: 10.1182/blood-2017-05-783845. Epub 2018 Feb 5.


An intrinsic lipid-binding interface controls sphingosine kinase 1 function.

Pulkoski-Gross MJ, Jenkins ML, Truman JP, Salama MF, Clarke CJ, Burke JE, Hannun YA, Obeid LM.

J Lipid Res. 2018 Mar;59(3):462-474. doi: 10.1194/jlr.M081307. Epub 2018 Jan 11.


Green and Sustainable Solvents in Chemical Processes.

Clarke CJ, Tu WC, Levers O, Bröhl A, Hallett JP.

Chem Rev. 2018 Jan 24;118(2):747-800. doi: 10.1021/acs.chemrev.7b00571. Epub 2018 Jan 4.


Underutilization of Aldosterone Antagonists in Heart Failure.

Patterson SJ, Reaves AB, Tolley EA, Ulrich D, Hilty C, Clarke CJ, Self TH.

Hosp Pharm. 2017 Nov;52(10):698-703. doi: 10.1177/0018578717724886. Epub 2017 Aug 20.


Sphingosine 1-phosphate activation of ERM contributes to vascular calcification.

Morris TG, Borland SJ, Clarke CJ, Wilson C, Hannun YA, Ohanian V, Canfield AE, Ohanian J.

J Lipid Res. 2018 Jan;59(1):69-78. doi: 10.1194/jlr.M079731. Epub 2017 Nov 22.


Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation.

Liu M, Clarke CJ, Salama MF, Choi YJ, Obeid LM, Hannun YA.

PLoS One. 2017 Sep 19;12(9):e0184818. doi: 10.1371/journal.pone.0184818. eCollection 2017.


Activation of tissue plasminogen activator by metastasis-inducing S100P protein.

Clarke CJ, Gross SR, Ismail TM, Rudland PS, Al-Medhtiy M, Santangeli M, Barraclough R.

Biochem J. 2017 Sep 12;474(19):3227-3240. doi: 10.1042/BCJ20170578.


Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.

Dupre TV, Doll MA, Shah PP, Sharp CN, Siow D, Megyesi J, Shayman J, Bielawska A, Bielawski J, Beverly LJ, Hernandez-Corbacho M, Clarke CJ, Snider AJ, Schnellmann RG, Obeid LM, Hannun YA, Siskind LJ.

J Lipid Res. 2017 Jul;58(7):1439-1452. doi: 10.1194/jlr.M076745. Epub 2017 May 10.


Preclinical approaches in chronic myeloid leukemia: from cells to systems.

Clarke CJ, Holyoake TL.

Exp Hematol. 2017 Mar;47:13-23. doi: 10.1016/j.exphem.2016.11.005. Epub 2016 Dec 23. Review.


Role of neutral ceramidase in colon cancer.

García-Barros M, Coant N, Kawamori T, Wada M, Snider AJ, Truman JP, Wu BX, Furuya H, Clarke CJ, Bialkowska AB, Ghaleb A, Yang VW, Obeid LM, Hannun YA.

FASEB J. 2016 Dec;30(12):4159-4171. Epub 2016 Sep 8.


The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma.

Birch J, Clarke CJ, Campbell AD, Campbell K, Mitchell L, Liko D, Kalna G, Strathdee D, Sansom OJ, Neilson M, Blyth K, Norman JC.

Biol Open. 2016 Oct 15;5(10):1371-1379. doi: 10.1242/bio.019075.


Constitutive IFNα/β signaling maintains expression of signaling intermediaries for efficient cytokine responses.

Messina NL, Clarke CJ, Johnstone RW.

JAKSTAT. 2016 May 18;5(1):e1173804. doi: 10.1080/21623996.2016.1173804. eCollection 2016.


Collision velocity of dust grains in self-gravitating protoplanetary discs.

Booth RA, Clarke CJ.

Mon Not R Astron Soc. 2016 Mar 3;458(3):2676-2693. eCollection 2016 May 21.


Neuralgic amyotrophy is not the most common neurologic disorder of the shoulder: a 78-month prospective study of 60 neurologic shoulder patients in a specialist shoulder clinic.

Clarke CJ, Torrance E, McIntosh J, Funk L.

J Shoulder Elbow Surg. 2016 Dec;25(12):1997-2004. doi: 10.1016/j.jse.2016.04.005. Epub 2016 Jun 6.


The minimum mass of detectable planets in protoplanetary discs and the derivation of planetary masses from high-resolution observations.

Rosotti GP, Juhasz A, Booth RA, Clarke CJ.

Mon Not R Astron Soc. 2016 May 4;459(3):2790-2805. eCollection 2016 Jul 1.


Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation.

Arecco N, Clarke CJ, Jones FK, Simpson DM, Mason D, Beynon RJ, Pisconti A.

Sci Rep. 2016 May 31;6:24708. doi: 10.1038/srep24708.


ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation.

Clarke CJ, Shamseddine AA, Jacob JJ, Khalife G, Burns TA, Hannun YA.

J Lipid Res. 2016 May;57(5):868-81. doi: 10.1194/jlr.M067447. Epub 2016 Mar 24.


The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis.

Clarke CJ, Berg TJ, Birch J, Ennis D, Mitchell L, Cloix C, Campbell A, Sumpton D, Nixon C, Campbell K, Bridgeman VL, Vermeulen PB, Foo S, Kostaras E, Jones JL, Haywood L, Pulleine E, Yin H, Strathdee D, Sansom O, Blyth K, McNeish I, Zanivan S, Reynolds AR, Norman JC.

Curr Biol. 2016 Mar 21;26(6):755-65. doi: 10.1016/j.cub.2016.01.045. Epub 2016 Mar 3.


New insights into the phenotype of human dendritic cell populations.

Clark GJ, Kupresanin F, Fromm PD, Ju X, Muusers L, Silveira PA, Elgundi Z, Gasiorowski RE, Papadimitrious MS, Bryant C, Lee KM, Clarke CJ, Young JW, Chan A, Harman A, Botting R, Cabezón R, Benitez-Ribas D, Brooks AE, Dunbar PR, Hart DN.

Clin Transl Immunology. 2016 Jan 29;5(1):e61. doi: 10.1038/cti.2015.40. eCollection 2016 Jan.


Lactosylceramide contributes to mitochondrial dysfunction in diabetes.

Novgorodov SA, Riley CL, Yu J, Keffler JA, Clarke CJ, Van Laer AO, Baicu CF, Zile MR, Gudz TI.

J Lipid Res. 2016 Apr;57(4):546-62. doi: 10.1194/jlr.M060061. Epub 2016 Feb 21.


The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD.

Russell KE, Chung KF, Clarke CJ, Durham AL, Mallia P, Footitt J, Johnston SL, Barnes PJ, Hall SR, Simpson KD, Starkey MR, Hansbro PM, Adcock IM, Wiegman CH.

PLoS One. 2016 Jan 11;11(1):e0146102. doi: 10.1371/journal.pone.0146102. eCollection 2016.


P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest.

Shamseddine AA, Clarke CJ, Carroll B, Airola MV, Mohammed S, Rella A, Obeid LM, Hannun YA.

Cell Death Dis. 2015 Oct 29;6:e1947. doi: 10.1038/cddis.2015.268.


Hydration Strategy for Endurance Running in an Athlete Requiring Home Parenteral Nutrition.

Tillman EM, Killmeier G, Opilla M, Clarke CJ, Nishikawa RA.

Nutr Clin Pract. 2016 Apr;31(2):191-4. doi: 10.1177/0884533615591603. Epub 2015 Jul 6.


Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease.

Wiegman CH, Michaeloudes C, Haji G, Narang P, Clarke CJ, Russell KE, Bao W, Pavlidis S, Barnes PJ, Kanerva J, Bittner A, Rao N, Murphy MP, Kirkham PA, Chung KF, Adcock IM; COPDMAP.

J Allergy Clin Immunol. 2015 Sep;136(3):769-80. doi: 10.1016/j.jaci.2015.01.046. Epub 2015 Mar 29.


Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis.

Rachidi S, Sun S, Wu BX, Jones E, Drake RR, Ogretmen B, Cowart LA, Clarke CJ, Hannun YA, Chiosis G, Liu B, Li Z.

J Hepatol. 2015 Apr;62(4):879-88. doi: 10.1016/j.jhep.2014.11.010. Epub 2014 Nov 22.


Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.

Bai A, Szulc ZM, Bielawski J, Pierce JS, Rembiesa B, Terzieva S, Mao C, Xu R, Wu B, Clarke CJ, Newcomb B, Liu X, Norris J, Hannun YA, Bielawska A.

Bioorg Med Chem. 2014 Dec 15;22(24):6933-44. doi: 10.1016/j.bmc.2014.10.025. Epub 2014 Oct 22.


Emotion differentiation and alcohol-related problems: the mediating role of urgency.

Emery NN, Simons JS, Clarke CJ, Gaher RM.

Addict Behav. 2014 Oct;39(10):1459-63. doi: 10.1016/j.addbeh.2014.05.004. Epub 2014 May 27.


Further evidence for the effectiveness of PCV10 against Streptococcus pneumoniae serotype 19A.

Clarke CJ, Hausdorff WP.

Lancet Respir Med. 2014 Jun;2(6):e7. doi: 10.1016/S2213-2600(14)70128-6. No abstract available.


Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation.

Wei J, Ferron M, Clarke CJ, Hannun YA, Jiang H, Blaner WS, Karsenty G.

J Clin Invest. 2014 Apr;124(4):1-13. doi: 10.1172/JCI72323. Epub 2014 Mar 18.


Isometric hip and knee torque measurements as an outcome measure in robot assisted gait training.

Galen SS, Clarke CJ, McLean AN, Allan DB, Conway BA.

NeuroRehabilitation. 2014;34(2):287-95. doi: 10.3233/NRE-131042.


Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor.

Liu M, Idkowiak-Baldys J, Roddy PL, Baldys A, Raymond J, Clarke CJ, Hannun YA.

PLoS One. 2013 Nov 11;8(11):e80721. doi: 10.1371/journal.pone.0080721. eCollection 2013.

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