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Development of a High Throughput Screen for the Identification of Inhibitors of Peptidoglycan O-Acetyltransferases, New Potential Antibacterial Targets.

Brott AS, Jones CS, Clarke AJ.

Antibiotics (Basel). 2019 May 27;8(2). pii: E65. doi: 10.3390/antibiotics8020065.


Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus.

Odhams CA, Roberts AL, Vester SK, Duarte CST, Beales CT, Clarke AJ, Lindinger S, Daffern SJ, Zito A, Chen L, Jones LL, Boteva L, Morris DL, Small KS, Fernando MMA, Cunninghame Graham DS, Vyse TJ.

Nat Commun. 2019 May 15;10(1):2164. doi: 10.1038/s41467-019-10106-2.


A case-note review of continued pregnancies found to be at a high risk of Huntington's disease: considerations for clinical practice.

Wadrup F, Holden S, MacLeod R, Miedzybrodzka Z, Németh AH, Owens S, Pasalodos S, Quarrell O, Clarke AJ; UK Huntington’s Disease Predictive Testing Consortium.

Eur J Hum Genet. 2019 Mar 19. doi: 10.1038/s41431-019-0375-8. [Epub ahead of print]


Assays for the Enzymes Catalyzing the O-Acetylation of Bacterial Cell Wall Polysaccharides.

Brott AS, Sychantha D, Clarke AJ.

Methods Mol Biol. 2019;1954:115-136. doi: 10.1007/978-1-4939-9154-9_10.


Ectodermal dysplasias: Classification and organization by phenotype, genotype and molecular pathway.

Wright JT, Fete M, Schneider H, Zinser M, Koster MI, Clarke AJ, Hadj-Rabia S, Tadini G, Pagnan N, Visinoni AF, Bergendal B, Abbott B, Fete T, Stanford C, Butcher C, D'Souza RN, Sybert VP, Morasso MI.

Am J Med Genet A. 2019 Mar;179(3):442-447. doi: 10.1002/ajmg.a.61045. Epub 2019 Jan 31.


Reply to Bombard and Mighton.

Carrieri D, Howard HC, Clarke AJ, Stefansdottir V, Cornel MC, van El CG, Forzano F.

Eur J Hum Genet. 2019 Apr;27(4):507-508. doi: 10.1038/s41431-018-0315-z. Epub 2019 Jan 18. No abstract available.


Autophagy in the renewal, differentiation and homeostasis of immune cells.

Clarke AJ, Simon AK.

Nat Rev Immunol. 2019 Mar;19(3):170-183. doi: 10.1038/s41577-018-0095-2. Review.


Mechanistic Pathways for Peptidoglycan O-Acetylation and De-O-Acetylation.

Sychantha D, Brott AS, Jones CS, Clarke AJ.

Front Microbiol. 2018 Oct 1;9:2332. doi: 10.3389/fmicb.2018.02332. eCollection 2018. Review.


Recontacting patients in clinical genetics services: recommendations of the European Society of Human Genetics.

Carrieri D, Howard HC, Benjamin C, Clarke AJ, Dheensa S, Doheny S, Hawkins N, Halbersma-Konings TF, Jackson L, Kayserili H, Kelly SE, Lucassen AM, Mendes Á, Rial-Sebbag E, Stefánsdóttir V, Turnpenny PD, van El CG, van Langen IM, Cornel MC, Forzano F; European Society of Human Genetics.

Eur J Hum Genet. 2019 Feb;27(2):169-182. doi: 10.1038/s41431-018-0285-1. Epub 2018 Oct 11.


The "hole" story of predatory outer-membrane vesicles.

Clarke AJ.

Can J Microbiol. 2018 Sep;64(9):589-599. doi: 10.1139/cjm-2017-0466. Review.


Ethics in genetic counselling.

Clarke AJ, Wallgren-Pettersson C.

J Community Genet. 2019 Jan;10(1):3-33. doi: 10.1007/s12687-018-0371-7. Epub 2018 Jun 14. Review.


High Throughput Discovery and Design of Strong Multicomponent Metallic Solid Solutions.

Coury FG, Clarke KD, Kiminami CS, Kaufman MJ, Clarke AJ.

Sci Rep. 2018 Jun 5;8(1):8600. doi: 10.1038/s41598-018-26830-6.


Free-living and laboratory gait characteristics in patients with multiple sclerosis.

Storm FA, Nair KPS, Clarke AJ, Van der Meulen JM, Mazzà C.

PLoS One. 2018 May 1;13(5):e0196463. doi: 10.1371/journal.pone.0196463. eCollection 2018.


Recontacting or not recontacting? A survey of current practices in clinical genetics centres in Europe.

Sirchia F, Carrieri D, Dheensa S, Benjamin C, Kayserili H, Cordier C, van El CG, Turnpenny PD, Melegh B, Mendes Á, Halbersma-Konings TF, van Langen IM, Lucassen AM, Clarke AJ, Forzano F, Kelly SE.

Eur J Hum Genet. 2018 Jul;26(7):946-954. doi: 10.1038/s41431-018-0131-5. Epub 2018 Apr 23.


A perspective on "cure" for Rett syndrome.

Clarke AJ, Abdala Sheikh AP.

Orphanet J Rare Dis. 2018 Apr 2;13(1):44. doi: 10.1186/s13023-018-0786-6.


Peptidoglycan Modification by the Catalytic Domain of Streptococcus pneumoniae OatA Follows a Ping-Pong Bi-Bi Mechanism of Action.

Sychantha D, Clarke AJ.

Biochemistry. 2018 Apr 24;57(16):2394-2401. doi: 10.1021/acs.biochem.8b00301. Epub 2018 Apr 5.


Molecular Basis for the Attachment of S-Layer Proteins to the Cell Wall of Bacillus anthracis.

Sychantha D, Chapman RN, Bamford NC, Boons GJ, Howell PL, Clarke AJ.

Biochemistry. 2018 Apr 3;57(13):1949-1953. doi: 10.1021/acs.biochem.8b00060. Epub 2018 Mar 14.


Patients' acceptance of physician associates.

Clarke AJ, Alberti H.

Br J Gen Pract. 2018 Feb;68(667):70. doi: 10.3399/bjgp18X694517. No abstract available.


B1a B cells require autophagy for metabolic homeostasis and self-renewal.

Clarke AJ, Riffelmacher T, Braas D, Cornall RJ, Simon AK.

J Exp Med. 2018 Feb 5;215(2):399-413. doi: 10.1084/jem.20170771. Epub 2018 Jan 11.


Rapid Thermal Processing to Enhance Steel Toughness.

Judge VK, Speer JG, Clarke KD, Findley KO, Clarke AJ.

Sci Rep. 2018 Jan 11;8(1):445. doi: 10.1038/s41598-017-18917-3.


Points to consider for laboratories reporting results from diagnostic genomic sequencing.

Vears DF, Sénécal K, Clarke AJ, Jackson L, Laberge AM, Lovrecic L, Piton A, Van Gassen KLI, Yntema HG, Knoppers BM, Borry P.

Eur J Hum Genet. 2018 Jan;26(1):36-43. doi: 10.1038/s41431-017-0043-9. Epub 2017 Nov 28.


Somatic mutations in salivary duct carcinoma and potential therapeutic targets.

Khoo TK, Yu B, Smith JA, Clarke AJ, Luk PP, Selinger CI, Mahon KL, Kraitsek S, Palme C, Boyer MJ, Dinger ME, Cowley MJ, O'Toole SA, Clark JR, Gupta R.

Oncotarget. 2017 May 25;8(44):75893-75903. doi: 10.18632/oncotarget.18173. eCollection 2017 Sep 29.


Predictive testing of minors for Huntington's disease: The UK and Netherlands experiences.

Quarrell OW, Clarke AJ, Compton C, de Die-Smulders CEM, Fryer A, Jenkins S, Lahiri N, MacLeod R, Miedzybrodzka Z, Morrison PJ, Musgrave H, O'Driscoll M, Strong M, van Belzen MJ, Vermeer S, Verschuuren-Bemelmans CC, Bijlsma EK.

Am J Med Genet B Neuropsychiatr Genet. 2018 Jan;177(1):35-39. doi: 10.1002/ajmg.b.32582. Epub 2017 Nov 2.


PatB1 is an O-acetyltransferase that decorates secondary cell wall polysaccharides.

Sychantha D, Little DJ, Chapman RN, Boons GJ, Robinson H, Howell PL, Clarke AJ.

Nat Chem Biol. 2018 Jan;14(1):79-85. doi: 10.1038/nchembio.2509. Epub 2017 Oct 30.


A Historical and Current Review of Newborn Screening for Neuromuscular Disorders From Around the World: Lessons for the United States.

Ross LF, Clarke AJ.

Pediatr Neurol. 2017 Dec;77:12-22. doi: 10.1016/j.pediatrneurol.2017.08.012. Epub 2017 Aug 25. Review.


In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA).

Sychantha D, Jones CS, Little DJ, Moynihan PJ, Robinson H, Galley NF, Roper DI, Dowson CG, Howell PL, Clarke AJ.

PLoS Pathog. 2017 Oct 27;13(10):e1006667. doi: 10.1371/journal.ppat.1006667. eCollection 2017 Oct.


O-acetylation of the serine-rich repeat glycoprotein GspB is coordinated with accessory Sec transport.

Seepersaud R, Sychantha D, Bensing BA, Clarke AJ, Sullam PM.

PLoS Pathog. 2017 Aug 21;13(8):e1006558. doi: 10.1371/journal.ppat.1006558. eCollection 2017 Aug.


Recontacting in clinical practice: the views and expectations of patients in the United Kingdom.

Carrieri D, Dheensa S, Doheny S, Clarke AJ, Turnpenny PD, Lucassen AM, Kelly SE.

Eur J Hum Genet. 2017 Oct;25(10):1106-1112. doi: 10.1038/ejhg.2017.122. Epub 2017 Aug 2.


Communication of Information about Genetic Risks: Putting Families at the Center.

Mendes Á, Metcalfe A, Paneque M, Sousa L, Clarke AJ, Sequeiros J.

Fam Process. 2018 Sep;57(3):836-846. doi: 10.1111/famp.12306. Epub 2017 Jul 16.


Anterior lumbar discectomy and fusion for acute cauda equina syndrome caused by recurrent disc prolapse: report of 3 cases.

Tan KA, Sewell MD, Markmann Y, Clarke AJ, Stokes OM, Chan D.

J Neurosurg Spine. 2017 Oct;27(4):352-356. doi: 10.3171/2017.1.SPINE16352. Epub 2017 Jul 14.


Peptidoglycan: Another brick in the wall.

Clarke AJ.

Nat Chem Biol. 2017 Jun 20;13(7):695-696. doi: 10.1038/nchembio.2419. No abstract available.


Outcomes of an International Workshop on Preconception Expanded Carrier Screening: Some Considerations for Governments.

Molster CM, Lister K, Metternick-Jones S, Baynam G, Clarke AJ, Straub V, Dawkins HJ, Laing N.

Front Public Health. 2017 Feb 24;5:25. doi: 10.3389/fpubh.2017.00025. eCollection 2017.


The current state of the evidence for the use of drains in spinal surgery: systematic review.

Patel SB, Griffiths-Jones W, Jones CS, Samartzis D, Clarke AJ, Khan S, Stokes OM.

Eur Spine J. 2017 Nov;26(11):2729-2738. doi: 10.1007/s00586-017-4983-0. Epub 2017 Feb 11. Review.


Recontacting in clinical genetics and genomic medicine? We need to talk about it.

Carrieri D, Dheensa S, Doheny S, Clarke AJ, Turnpenny PD, Lucassen AM, Kelly SE.

Eur J Hum Genet. 2017 May;25(5):520-521. doi: 10.1038/ejhg.2017.8. Epub 2017 Feb 8. No abstract available.


Recontacting in clinical practice: an investigation of the views of healthcare professionals and clinical scientists in the United Kingdom.

Carrieri D, Dheensa S, Doheny S, Clarke AJ, Turnpenny PD, Lucassen AM, Kelly SE.

Eur J Hum Genet. 2017 Feb;25(3):275-279. doi: 10.1038/ejhg.2016.188. Epub 2017 Jan 4.


Neurological Injury in Intermediate-Risk Transcatheter Aortic Valve Implantation.

Fanning JP, Wesley AJ, Walters DL, Eeles EM, Barnett AG, Platts DG, Clarke AJ, Wong AA, Strugnell WE, O'Sullivan C, Tronstad O, Fraser JF.

J Am Heart Assoc. 2016 Nov 15;5(11). pii: e004203. Erratum in: J Am Heart Assoc. 2017 Jan 11;6(1):.


Controlling Autolysis During Flagella Insertion in Gram-Negative Bacteria.

Herlihey FA, Clarke AJ.

Adv Exp Med Biol. 2017;925:41-56. doi: 10.1007/5584_2016_52. Review.


Recommendations for Lengthening of Magnetically Controlled Growing Rods in Children With Pacemakers.

Tan KA, Sewell MD, Clarke AJ, Chan D, Stokes OM, Khan SN, Hutton M.

J Pediatr Orthop. 2017 Jun;37(4):e250-e254. doi: 10.1097/BPO.0000000000000872.


Accumulation of Peptidoglycan O-Acetylation Leads to Altered Cell Wall Biochemistry and Negatively Impacts Pathogenesis Factors of Campylobacter jejuni.

Ha R, Frirdich E, Sychantha D, Biboy J, Taveirne ME, Johnson JG, DiRita VJ, Vollmer W, Clarke AJ, Gaynor EC.

J Biol Chem. 2016 Oct 21;291(43):22686-22702. Epub 2016 Jul 29.


Erratum for Herlihey et al., Modulation of the Lytic Activity of the Dedicated Autolysin for Flagellum Formation SltF by Flagellar Rod Proteins FlgB and FlgF.

Herlihey FA, Osorio-Valeriano M, Dreyfus G, Clarke AJ.

J Bacteriol. 2016 Jul 28;198(16):2276. doi: 10.1128/JB.00481-16. Print 2016 Aug 15. No abstract available.


Alternative technique in atypical spinal decompression: the use of the ultrasonic scalpel in paediatric achondroplasia.

Woodacre T, Sewell M, Clarke AJ, Hutton M.

BMJ Case Rep. 2016 Jun 10;2016. pii: bcr2016214565. doi: 10.1136/bcr-2016-214565.


Non-canonical autophagy LAPs lupus.

Simon AK, Clarke AJ.

Cell Death Differ. 2016 Aug;23(8):1267-8. doi: 10.1038/cdd.2016.55. Epub 2016 Jun 10. No abstract available.


Modulation of the Lytic Activity of the Dedicated Autolysin for Flagellum Formation SltF by Flagellar Rod Proteins FlgB and FlgF.

Herlihey FA, Osorio-Valeriano M, Dreyfus G, Clarke AJ.

J Bacteriol. 2016 Jun 13;198(13):1847-56. doi: 10.1128/JB.00203-16. Print 2016 Jul 1. Erratum in: J Bacteriol. 2016 Aug 15;198(16):2276.


Peer tutoring in a medical school: perceptions of tutors and tutees.

Burgess A, Dornan T, Clarke AJ, Menezes A, Mellis C.

BMC Med Educ. 2016 Mar 8;16:85. doi: 10.1186/s12909-016-0589-1.


Recontact in clinical practice: a survey of clinical genetics services in the United Kingdom.

Carrieri D, Lucassen AM, Clarke AJ, Dheensa S, Doheny S, Turnpenny PD, Kelly SE.

Genet Med. 2016 Sep;18(9):876-81. doi: 10.1038/gim.2015.194. Epub 2016 Feb 18.


Peer-assisted learning in medical school: tutees' perspective.

Menezes A, Burgess A, Clarke AJ, Mellis C.

Adv Med Educ Pract. 2016 Jan 18;7:31-8. doi: 10.2147/AMEP.S94570. eCollection 2016.


Actuator pin fracture in magnetically controlled growing rods: two cases.

Jones CS, Stokes OM, Patel SB, Clarke AJ, Hutton M.

Spine J. 2016 Apr;16(4):e287-91. doi: 10.1016/j.spinee.2015.12.020. Epub 2015 Dec 17.


Senior students' experience as tutors of their junior peers in the hospital setting.

Clarke AJ, Burgess A, Menezes A, Mellis C.

BMC Res Notes. 2015 Dec 2;8:743. doi: 10.1186/s13104-015-1729-0.

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