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Early Hyperoxemia and Outcome Among Critically Ill Children.

Ramgopal S, Dezfulian C, Hickey RW, Au AK, Venkataraman S, Clark RSB, Horvat CM.

Pediatr Crit Care Med. 2020 Feb;21(2):e129-e132. doi: 10.1097/PCC.0000000000002203.


Effect of dietary cellulose supplementation on gut barrier function and apoptosis in a murine model of endotoxemia.

Di Caro V, Alcamo AM, Cummings JL, Clark RSB, Novak EA, Mollen KP, Morowitz MJ, Aneja RK.

PLoS One. 2019 Dec 2;14(12):e0224838. doi: 10.1371/journal.pone.0224838. eCollection 2019.


AAOMS Response to Recent Challenges to OMS Office-Based Anesthesia for Pediatric Patients.

Indresano AT, Nannini VL, Tiner BD, Johnson JD Jr, Ferguson BL, Shafer D, Schwartz PJ, Clark RS, Morrison JD, Crago CA, Egbert MA.

J Oral Maxillofac Surg. 2019 Dec;77(12):2372-2376. doi: 10.1016/j.joms.2019.09.002. Epub 2019 Sep 12. No abstract available.


Early Axonal Injury and Delayed Cytotoxic Cerebral Edema are Associated With Microglial Activation in a Mouse Model of Sepsis.

Pang D, Wu YL, Alcamo AM, Cummings J, Di Caro V, Walko T 3rd, Hsue V, Clark RSB, Panigrahy A, Kochanek PM, Aneja RK.

Shock. 2019 Sep 10. doi: 10.1097/SHK.0000000000001446. [Epub ahead of print]


Association of Severe Hyperoxemia Events and Mortality Among Patients Admitted to a Pediatric Intensive Care Unit.

Ramgopal S, Dezfulian C, Hickey RW, Au AK, Venkataraman S, Clark RSB, Horvat CM.

JAMA Netw Open. 2019 Aug 2;2(8):e199812. doi: 10.1001/jamanetworkopen.2019.9812.


Development and Performance of Electronic Pediatric Risk of Mortality and Pediatric Logistic Organ Dysfunction-2 Automated Acuity Scores.

Horvat CM, Ogoe H, Kantawala S, Au AK, Fink EL, Yablonsky E, Kochanek PM, Suresh S, Clark RSB.

Pediatr Crit Care Med. 2019 Aug;20(8):e372-e379. doi: 10.1097/PCC.0000000000001998.


Opioid e-prescribing trends at discharge in a large pediatric health system.

Horvat CM, Martin B, Wu L, Fabio A, Empey PE, Hagos F, Bigelow S, Kantawala S, Au AK, Kochanek PM, Clark RSB.

J Opioid Manag. 2019 Mar/Apr;15(2):119-127. doi: 10.5055/jom.2019.0493.


DNA Viremia Is Associated with Hyperferritinemia in Pediatric Sepsis.

Simon DW, Halstead ES, Davila S, Kernan KF, Clark RSB, Storch G, Carcillo JA.

J Pediatr. 2019 Oct;213:82-87.e2. doi: 10.1016/j.jpeds.2019.06.033. Epub 2019 Jul 11.


Factors Contributing to Fentanyl Pharmacokinetic Variability Among Diagnostically Diverse Critically Ill Children.

Hagos FT, Horvat CM, Au AK, Conley YP, Li L, Poloyac SM, Kochanek PM, Clark RSB, Empey PE.

Clin Pharmacokinet. 2019 Dec;58(12):1567-1576. doi: 10.1007/s40262-019-00773-1.


Detection of brain specific cardiolipins in plasma after experimental pediatric head injury.

Anthonymuthu TS, Kenny EM, Hier ZE, Clark RSB, Kochanek PM, Kagan VE, Bayır H.

Exp Neurol. 2019 Jun;316:63-73. doi: 10.1016/j.expneurol.2019.04.007. Epub 2019 Apr 11.


C-Reactive Protein and Ferritin Are Associated With Organ Dysfunction and Mortality in Hospitalized Children.

Horvat CM, Bell J, Kantawala S, Au AK, Clark RSB, Carcillo JA.

Clin Pediatr (Phila). 2019 Jun;58(7):752-760. doi: 10.1177/0009922819837352. Epub 2019 Mar 31.


Membrane transporters in traumatic brain injury: Pathological, pharmacotherapeutic, and developmental implications.

Hagos FT, Adams SM, Poloyac SM, Kochanek PM, Horvat CM, Clark RSB, Empey PE.

Exp Neurol. 2019 Jul;317:10-21. doi: 10.1016/j.expneurol.2019.02.011. Epub 2019 Feb 21. Review.


Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision.

Kochanek PM, Jackson TC, Jha RM, Clark RSB, Okonkwo DO, Bayır H, Poloyac SM, Wagner AK, Empey PE, Conley YP, Bell MJ, Kline AE, Bondi CO, Simon DW, Carlson SW, Puccio AM, Horvat CM, Au AK, Elmer J, Treble-Barna A, Ikonomovic MD, Shutter LA, Taylor DL, Stern AM, Graham SH, Kagan VE, Jackson EK, Wisniewski SR, Dixon CE.

J Neurotrauma. 2019 Feb 1. doi: 10.1089/neu.2018.6203. [Epub ahead of print]


The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest.

Wallisch JS, Janesko-Feldman K, Alexander H, Jha RM, Farr GW, McGuirk PR, Kline AE, Jackson TC, Pelletier MF, Clark RSB, Kochanek PM, Manole MD.

Pediatr Res. 2019 Mar;85(4):511-517. doi: 10.1038/s41390-018-0215-5. Epub 2018 Oct 26.


Quantitative and qualitative assessment of glymphatic flux using Evans blue albumin.

Wolf MS, Chen Y, Simon DW, Alexander H, Ross M, Gibson GA, Manole MD, Bayır H, Kochanek PM, Clark RSB.

J Neurosci Methods. 2019 Jan 1;311:436-441. doi: 10.1016/j.jneumeth.2018.09.031. Epub 2018 Oct 5.


Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor.

Krainz T, Lamade AM, Du L, Maskrey TS, Calderon MJ, Watkins SC, Epperly MW, Greenberger JS, Bayır H, Wipf P, Clark RSB.

ACS Chem Biol. 2018 Oct 19;13(10):2868-2879. doi: 10.1021/acschembio.8b00423. Epub 2018 Sep 14.


Modeling Health Disparities and Outcomes in Disenfranchised Populations.

Hauenstein EJ, Clark RS, Merwin EI.

Community Ment Health J. 2019 Jan;55(1):9-23. doi: 10.1007/s10597-018-0326-9. Epub 2018 Aug 22.


Dietary Cellulose Supplementation Modulates the Immune Response in a Murine Endotoxemia Model.

Di Caro V, Cummings JL, Alcamo AM, Piganelli JD, Clark RSB, Morowitz MJ, Aneja RK.

Shock. 2019 Apr;51(4):526-534. doi: 10.1097/SHK.0000000000001180.


Aiming for the target: Mitochondrial drug delivery in traumatic brain injury.

Lamade AM, Kenny EM, Anthonymuthu TS, Soysal E, Clark RSB, Kagan VE, Bayır H.

Neuropharmacology. 2019 Feb;145(Pt B):209-219. doi: 10.1016/j.neuropharm.2018.07.014. Epub 2018 Jul 30. Review.


Exploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury.

Hagos FT, Empey PE, Wang P, Ma X, Poloyac SM, Bayir H, Kochanek PM, Bell MJ, Clark RSB.

Crit Care Med. 2018 Sep;46(9):1471-1479. doi: 10.1097/CCM.0000000000003203.


The role of autophagy in acute brain injury: A state of flux?

Wolf MS, Bayır H, Kochanek PM, Clark RSB.

Neurobiol Dis. 2019 Feb;122:9-15. doi: 10.1016/j.nbd.2018.04.018. Epub 2018 Apr 26. Review.


Regionally clustered ABCC8 polymorphisms in a prospective cohort predict cerebral oedema and outcome in severe traumatic brain injury.

Jha RM, Koleck TA, Puccio AM, Okonkwo DO, Park SY, Zusman BE, Clark RSB, Shutter LA, Wallisch JS, Empey PE, Kochanek PM, Conley YP.

J Neurol Neurosurg Psychiatry. 2018 Nov;89(11):1152-1162. doi: 10.1136/jnnp-2017-317741. Epub 2018 Apr 19.


Presenting predictors and temporal trends of treatment-related outcomes in diabetic ketoacidosis.

Horvat CM, Ismail HM, Au AK, Garibaldi L, Siripong N, Kantawala S, Aneja RK, Hupp DS, Kochanek PM, Clark RS.

Pediatr Diabetes. 2018 Aug;19(5):985-992. doi: 10.1111/pedi.12663. Epub 2018 Apr 26.


24 vs. 72 hours of hypothermia for pediatric cardiac arrest: A pilot, randomized controlled trial.

Fink EL, Clark RSB, Berger RP, Fabio A, Angus DC, Watson RS, Gianakas JJ, Panigrahy A, Callaway CW, Bell MJ, Kochanek PM.

Resuscitation. 2018 May;126:14-20. doi: 10.1016/j.resuscitation.2018.02.008. Epub 2018 Feb 14.


Healthcare in the PICU May Be More Complicated Than We Thought-Who Knew?

Horvat CM, Clark RSB.

Pediatr Crit Care Med. 2017 Dec;18(12):1188-1189. doi: 10.1097/PCC.0000000000001356. No abstract available.


Cerebral microcirculatory alterations and the no-reflow phenomenon in vivo after experimental pediatric cardiac arrest.

Li L, Poloyac SM, Watkins SC, St Croix CM, Alexander H, Gibson GA, Loughran PA, Kirisci L, Clark RS, Kochanek PM, Vazquez AL, Manole MD.

J Cereb Blood Flow Metab. 2019 May;39(5):913-925. doi: 10.1177/0271678X17744717. Epub 2017 Dec 1.


Pre-clinical models in pediatric traumatic brain injury-challenges and lessons learned.

Kochanek PM, Wallisch JS, Bayır H, Clark RSB.

Childs Nerv Syst. 2017 Oct;33(10):1693-1701. doi: 10.1007/s00381-017-3474-2. Epub 2017 Sep 6. Review.


The pharmacogenomics of severe traumatic brain injury.

Adams SM, Conley YP, Wagner AK, Jha RM, Clark RS, Poloyac SM, Kochanek PM, Empey PE.

Pharmacogenomics. 2017 Oct;18(15):1413-1425. doi: 10.2217/pgs-2017-0073. Epub 2017 Oct 4. Review.


Paediatric traumatic brain injury: prognostic insights and outlooks.

Au AK, Clark RSB.

Curr Opin Neurol. 2017 Dec;30(6):565-572. doi: 10.1097/WCO.0000000000000504. Review.


Alterations in Cerebral Blood Flow after Resuscitation from Cardiac Arrest.

Iordanova B, Li L, Clark RSB, Manole MD.

Front Pediatr. 2017 Aug 16;5:174. doi: 10.3389/fped.2017.00174. eCollection 2017. Review.


Mixed methods research in tobacco control with youth and young adults: A methodological review of current strategies.

Fryer CS, Seaman EL, Clark RS, Plano Clark VL.

PLoS One. 2017 Aug 25;12(8):e0183471. doi: 10.1371/journal.pone.0183471. eCollection 2017. Review.


The far-reaching scope of neuroinflammation after traumatic brain injury.

Simon DW, McGeachy MJ, Bayır H, Clark RSB, Loane DJ, Kochanek PM.

Nat Rev Neurol. 2017 Sep;13(9):572. doi: 10.1038/nrneurol.2017.116. Epub 2017 Aug 4.


ABCG2 c.421C>A Is Associated with Outcomes after Severe Traumatic Brain Injury.

Adams SM, Conley YP, Ren D, Okonkwo DO, Puccio AM, Dixon CE, Clark RSB, Kochanek PM, Empey PE.

J Neurotrauma. 2018 Jan 1;35(1):48-53. doi: 10.1089/neu.2017.5000. Epub 2017 Sep 19.


Minocycline Attenuates High Mobility Group Box 1 Translocation, Microglial Activation, and Thalamic Neurodegeneration after Traumatic Brain Injury in Post-Natal Day 17 Rats.

Simon DW, Aneja RK, Alexander H, Bell MJ, Bayır H, Kochanek PM, Clark RSB.

J Neurotrauma. 2018 Jan 1;35(1):130-138. doi: 10.1089/neu.2017.5093. Epub 2017 Aug 22.


Detecting and Quantifying pADPr In Vivo.

Lai YC, Aneja RK, Satchell MA, Clark RSB.

Methods Mol Biol. 2017;1608:27-43. doi: 10.1007/978-1-4939-6993-7_3.


Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children.

Clark RSB, Empey PE, Bayır H, Rosario BL, Poloyac SM, Kochanek PM, Nolin TD, Au AK, Horvat CM, Wisniewski SR, Bell MJ.

PLoS One. 2017 Jul 7;12(7):e0180280. doi: 10.1371/journal.pone.0180280. eCollection 2017.


Long-Term Deficits in Cortical Circuit Function after Asphyxial Cardiac Arrest and Resuscitation in Developing Rats.

Middleton JW, Simons DJ, Simmons JW, Clark RSB, Kochanek PM, Shoykhet M.

eNeuro. 2017 Jun 30;4(3). pii: ENEURO.0319-16.2017. doi: 10.1523/ENEURO.0319-16.2017. eCollection 2017 May-Jun.


Brain-Specific Serum Biomarkers Predict Neurological Morbidity in Diagnostically Diverse Pediatric Intensive Care Unit Patients.

Au AK, Bell MJ, Fink EL, Aneja RK, Kochanek PM, Clark RSB.

Neurocrit Care. 2018 Feb;28(1):26-34. doi: 10.1007/s12028-017-0414-7.


The Oral and Maxillofacial Surgery Anesthesia Team Model.

Fain DW, Ferguson BL, Indresano AT, Johnson JD Jr, Rafetto LK, Farrell S, Nelson SR, Nannini VL, Schwartz PJ, Clark RS, Morrison JD Jr, Tiner BD, Egbert MA.

J Oral Maxillofac Surg. 2017 Jun;75(6):1097-1100. doi: 10.1016/j.joms.2017.03.030. Epub 2017 Mar 24.


ABCB1 genotype is associated with fentanyl requirements in critically ill children.

Horvat CM, Au AK, Conley YP, Kochanek PM, Li L, Poloyac SM, Empey PE, Clark RSB.

Pediatr Res. 2017 Jul;82(1):29-35. doi: 10.1038/pr.2017.103. Epub 2017 May 31.


Dietary Supplementation With Nonfermentable Fiber Alters the Gut Microbiota and Confers Protection in Murine Models of Sepsis.

Morowitz MJ, Di Caro V, Pang D, Cummings J, Firek B, Rogers MB, Ranganathan S, Clark RSB, Aneja RK.

Crit Care Med. 2017 May;45(5):e516-e523. doi: 10.1097/CCM.0000000000002291.


Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.

Berger NA, Besson VC, Boulares AH, Bürkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, Salzman AL, Snyder SH, Soriano FG, Strosznajder RP, Sümegi B, Swanson RA, Szabo C.

Br J Pharmacol. 2018 Jan;175(2):192-222. doi: 10.1111/bph.13748. Epub 2017 Mar 26. Review.


International Survey of Critically Ill Children With Acute Neurologic Insults: The Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment Study.

Fink EL, Kochanek PM, Tasker RC, Beca J, Bell MJ, Clark RS, Hutchison J, Vavilala MS, Fabio A, Angus DC, Watson RS; Prevalence of Acute critical Neurological disease in children: A Global Epidemiological Assessment (PANGEA) Investigators.

Pediatr Crit Care Med. 2017 Apr;18(4):330-342. doi: 10.1097/PCC.0000000000001093.


The far-reaching scope of neuroinflammation after traumatic brain injury.

Simon DW, McGeachy MJ, Bayır H, Clark RS, Loane DJ, Kochanek PM.

Nat Rev Neurol. 2017 Mar;13(3):171-191. doi: 10.1038/nrneurol.2017.13. Epub 2017 Feb 10. Review. Erratum in: Nat Rev Neurol. 2017 Aug 04;:.


Cerebrospinal Fluid NLRP3 is Increased After Severe Traumatic Brain Injury in Infants and Children.

Wallisch JS, Simon DW, Bayır H, Bell MJ, Kochanek PM, Clark RSB.

Neurocrit Care. 2017 Aug;27(1):44-50. doi: 10.1007/s12028-017-0378-7.


Autophagy Biomarkers Beclin 1 and p62 are Increased in Cerebrospinal Fluid after Traumatic Brain Injury.

Au AK, Aneja RK, Bayır H, Bell MJ, Janesko-Feldman K, Kochanek PM, Clark RSB.

Neurocrit Care. 2017 Jun;26(3):348-355. doi: 10.1007/s12028-016-0351-x.


Polynitroxylated Pegylated Hemoglobin-A Novel, Small Volume Therapeutic for Traumatic Brain Injury Resuscitation: Comparison to Whole Blood and Dose Response Evaluation.

Brockman EC, Jackson TC, Dixon CE, Bayɪr H, Clark RS, Vagni V, Feldman K, Byrd C, Ma L, Hsia C, Kochanek PM.

J Neurotrauma. 2017 Apr 1;34(7):1337-1350. doi: 10.1089/neu.2016.4656. Epub 2017 Jan 13.


Enduring disturbances in regional cerebral blood flow and brain oxygenation at 24 h after asphyxial cardiac arrest in developing rats.

Foley LM, Clark RS, Vazquez AL, Hitchens TK, Alexander H, Ho C, Kochanek PM, Manole MD.

Pediatr Res. 2017 Jan;81(1-1):94-98. doi: 10.1038/pr.2016.175. Epub 2016 Sep 16.


Mechanistic characterization of nitrite-mediated neuroprotection after experimental cardiac arrest.

Dezfulian C, Kenny E, Lamade A, Misse A, Krehel N, St Croix C, Kelley EE, Jackson TC, Uray T, Rackley J, Kochanek PM, Clark RS, Bayir H.

J Neurochem. 2016 Nov;139(3):419-431. doi: 10.1111/jnc.13764. Epub 2016 Oct 3.


Probenecid and N-Acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro.

Du L, Empey PE, Ji J, Chao H, Kochanek PM, Bayır H, Clark RS.

J Neurotrauma. 2016 Oct 15;33(20):1913-1917. Epub 2016 Mar 22.

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