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Multiple sclerosis, the microbiome, TLR2, and the hygiene hypothesis.

Wasko N, Nichols F, Clark RB.

Autoimmun Rev. 2019 Nov 14:102430. doi: 10.1016/j.autrev.2019.102430. [Epub ahead of print] Review.


Systemic TLR2 tolerance enhances central nervous system remyelination.

Wasko NJ, Kulak MH, Paul D, Nicaise AM, Yeung ST, Nichols FC, Khanna KM, Crocker S, Pachter JS, Clark RB.

J Neuroinflammation. 2019 Jul 27;16(1):158. doi: 10.1186/s12974-019-1540-2.


Current significance of the Mycobacterium chelonae-abscessus group.

Jones RS, Shier KL, Master RN, Bao JR, Clark RB.

Diagn Microbiol Infect Dis. 2019 Jul;94(3):248-254. doi: 10.1016/j.diagmicrobio.2019.01.021. Epub 2019 Feb 10. Review.


The role of phospholipase A2 in multiple Sclerosis: A systematic review and meta-analysis.

Trotter A, Anstadt E, Clark RB, Nichols F, Dwivedi A, Aung K, Cervantes JL.

Mult Scler Relat Disord. 2019 Jan;27:206-213. doi: 10.1016/j.msard.2018.10.115. Epub 2018 Oct 30.


The Resting Potential and K+ Currents in Primary Human Articular Chondrocytes.

Maleckar MM, Clark RB, Votta B, Giles WR.

Front Physiol. 2018 Sep 4;9:974. doi: 10.3389/fphys.2018.00974. eCollection 2018.


Enhanced TLR2 responses in multiple sclerosis.

Fujiwara M, Anstadt EJ, Flynn B, Morse K, Ng C, Paczkowski P, Zhou J, Mackay S, Wasko N, Nichols F, Clark RB.

Clin Exp Immunol. 2018 Sep;193(3):313-326. doi: 10.1111/cei.13150. Epub 2018 Jul 24.


ATP triggers a robust intracellular [Ca2+ ]-mediated signalling pathway in human synovial fibroblasts.

Kondo C, Clark RB, Al‐Jezani N, Kim TY, Belke D, Banderali U, Szerencsei RT, Jalloul AH, Schnetkamp PPM, Spitzer KW, Giles WR.

Exp Physiol. 2018 Aug;103(8):1101-1122. doi: 10.1113/EP086851. Epub 2018 Jul 3. Erratum in: Exp Physiol. 2018 Nov;103(11):1571.


ATP increases [Ca2+ ]i and activates a Ca2+ -dependent Cl- current in rat ventricular fibroblasts.

Hatano N, Ohya S, Imaizumi Y, Clark RB, Belke D, Giles WR.

Exp Physiol. 2018 May 1;103(5):666-682. doi: 10.1113/EP086822. Epub 2018 Apr 15.


Rapid, Accurate Identification of Candida auris by Using a Novel Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) Database (Library).

Bao JR, Master RN, Azad KN, Schwab DA, Clark RB, Jones RS, Moore EC, Shier KL.

J Clin Microbiol. 2018 Mar 26;56(4). pii: e01700-17. doi: 10.1128/JCM.01700-17. Print 2018 Apr. No abstract available.


Deposition and hydrolysis of serine dipeptide lipids of Bacteroidetes bacteria in human arteries: relationship to atherosclerosis.

Nemati R, Dietz C, Anstadt EJ, Cervantes J, Liu Y, Dewhirst FE, Clark RB, Finegold S, Gallagher JJ, Smith MB, Yao X, Nichols FC.

J Lipid Res. 2017 Oct;58(10):1999-2007. doi: 10.1194/jlr.M077792. Epub 2017 Aug 16.


Heterocyclyl tetracyclines. 2. 7-Methoxy-8-pyrrolidinyltetracyclines: discovery of TP-2758, a potent, orally efficacious antimicrobial against Gram-negative pathogens.

Sun C, Deng Y, Hunt DK, Fyfe C, Chen CL, Clark RB, Grossman TH, Sutcliffe JA, Xiao XY.

J Antibiot (Tokyo). 2018 Feb;71(2):287-297. doi: 10.1038/ja.2017.86. Epub 2017 Jul 26.


Acid-fast bacterium detection and identification from paraffin-embedded tissues using a PCR-pyrosequencing method.

Bao JR, Clark RB, Master RN, Shier KL, Eklund LL.

J Clin Pathol. 2018 Feb;71(2):148-153. doi: 10.1136/jclinpath-2016-204128. Epub 2017 Jul 22.


Evaluation of Helping Babies Breathe Quality Improvement Cycle (HBB-QIC) on retention of neonatal resuscitation skills six months after training in Nepal.

Kc A, Wrammert J, Nelin V, Clark RB, Ewald U, Peterson S, Målqvist M.

BMC Pediatr. 2017 Apr 11;17(1):103. doi: 10.1186/s12887-017-0853-5.


Convergent synthesis of a deuterium-labeled serine dipeptide lipid for analysis of biological samples.

Dietz C, Clark RB, Nichols FC, Smith MB.

J Labelled Comp Radiopharm. 2017 May 30;60(6):274-285. doi: 10.1002/jlcr.3498. Epub 2017 Apr 16.


Cbl-b Deficiency Mediates Resistance to Programmed Death-Ligand 1/Programmed Death-1 Regulation.

Fujiwara M, Anstadt EJ, Clark RB.

Front Immunol. 2017 Jan 26;8:42. doi: 10.3389/fimmu.2017.00042. eCollection 2017.


Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation.

Vang AG, Basole C, Dong H, Nguyen RK, Housley W, Guernsey L, Adami AJ, Thrall RS, Clark RB, Epstein PM, Brocke S.

Front Pharmacol. 2016 Aug 23;7:259. doi: 10.3389/fphar.2016.00259. eCollection 2016.


Current-Voltage Relationship for Late Na(+) Current in Adult Rat Ventricular Myocytes.

Clark RB, Giles WR.

Curr Top Membr. 2016;78:451-78. doi: 10.1016/bs.ctm.2016.04.002. Epub 2016 Aug 1.


Incidence of intrapartum stillbirth and associated risk factors in tertiary care setting of Nepal: a case-control study.

Kc A, Wrammert J, Ewald U, Clark RB, Gautam J, Baral G, Baral KP, Målqvist M.

Reprod Health. 2016 Aug 31;13:103. doi: 10.1186/s12978-016-0226-9.


Inadequate fetal heart rate monitoring and poor use of partogram associated with intrapartum stillbirth: a case-referent study in Nepal.

Kc A, Wrammert J, Clark RB, Ewald U, Målqvist M.

BMC Pregnancy Childbirth. 2016 Aug 19;16:233. doi: 10.1186/s12884-016-1034-5.


TLR Tolerance as a Treatment for Central Nervous System Autoimmunity.

Anstadt EJ, Fujiwara M, Wasko N, Nichols F, Clark RB.

J Immunol. 2016 Sep 15;197(6):2110-8. doi: 10.4049/jimmunol.1600876. Epub 2016 Aug 8.


Reducing Perinatal Mortality in Nepal Using Helping Babies Breathe.

Kc A, Wrammert J, Clark RB, Ewald U, Vitrakoti R, Chaudhary P, Pun A, Raaijmakers H, Målqvist M.

Pediatrics. 2016 Jun;137(6). pii: e20150117. doi: 10.1542/peds.2015-0117.


Cellular electrophysiological principles that modulate secretion from synovial fibroblasts.

Clark RB, Schmidt TA, Sachse FB, Boyle D, Firestein GS, Giles WR.

J Physiol. 2017 Feb 1;595(3):635-645. doi: 10.1113/JP270209. Epub 2017 Jan 5. Review.


Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma.

Carson WF 4th, Guernsey LA, Singh A, Secor ER Jr, Wohlfert EA, Clark RB, Schramm CM, Kunkel SL, Thrall RS.

Front Immunol. 2015 Nov 20;6:592. doi: 10.3389/fimmu.2015.00592. eCollection 2015.


Serine dipeptide lipids of Porphyromonas gingivalis inhibit osteoblast differentiation: Relationship to Toll-like receptor 2.

Wang YH, Nemati R, Anstadt E, Liu Y, Son Y, Zhu Q, Yao X, Clark RB, Rowe DW, Nichols FC.

Bone. 2015 Dec;81:654-661. doi: 10.1016/j.bone.2015.09.008. Epub 2015 Sep 25.


Transition from identity to bioactivity-guided proteomics for biomarker discovery with focus on the PF2D platform.

Ménoret A, Crocker SJ, Rodriguez A, Rathinam VA, Clark RB, Vella AT.

Proteomics Clin Appl. 2016 Jan;10(1):8-24. doi: 10.1002/prca.201500029. Epub 2015 Sep 16. Review.


Design, Synthesis, and Biological Evaluation of Hexacyclic Tetracyclines as Potent, Broad Spectrum Antibacterial Agents.

Sun C, Hunt DK, Chen CL, Deng Y, He M, Clark RB, Fyfe C, Grossman TH, Sutcliffe JA, Xiao XY.

J Med Chem. 2015 Jun 11;58(11):4703-12. doi: 10.1021/acs.jmedchem.5b00262. Epub 2015 May 20.


Cbl-b-deficient mice express alterations in trafficking-related molecules but retain sensitivity to the multiple sclerosis therapeutic agent, FTY720.

Fujiwara M, Anstadt EJ, Khanna KM, Clark RB.

Clin Immunol. 2015 May;158(1):103-13. doi: 10.1016/j.clim.2015.03.018. Epub 2015 Mar 28.


Salmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of β2-Adrenergic Receptors.

Gimenez LE, Baameur F, Vayttaden SJ, Clark RB.

Mol Pharmacol. 2015 Jun;87(6):954-64. doi: 10.1124/mol.114.096800. Epub 2015 Mar 17.


Biochemical and Cellular Specificity of Peptide Inhibitors of G Protein-Coupled Receptor Kinases.

Baameur F, Hammitt RA, Friedman J, McMurray JS, Clark RB.

Int J Pept Res Ther. 2014 Mar;20(1):1-12.


Bacterial lipodipeptide, Lipid 654, is a microbiome-associated biomarker for multiple sclerosis.

Farrokhi V, Nemati R, Nichols FC, Yao X, Anstadt E, Fujiwara M, Grady J, Wakefield D, Castro W, Donaldson J, Clark RB.

Clin Transl Immunology. 2013 Nov 15;2(11):e8. doi: 10.1038/cti.2013.11. eCollection 2013 Nov.


Na(+) current expression in human atrial myofibroblasts: identity and functional roles.

Koivumäki JT, Clark RB, Belke D, Kondo C, Fedak PW, Maleckar MM, Giles WR.

Front Physiol. 2014 Aug 7;5:275. doi: 10.3389/fphys.2014.00275. eCollection 2014.


Biologic activity of porphyromonas endodontalis complex lipids.

Mirucki CS, Abedi M, Jiang J, Zhu Q, Wang YH, Safavi KE, Clark RB, Nichols FC.

J Endod. 2014 Sep;40(9):1342-8. doi: 10.1016/j.joen.2014.02.017. Epub 2014 Apr 13.


Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines as α7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders.

Clark RB, Lamppu D, Libertine L, McDonough A, Kumar A, LaRosa G, Rush R, Elbaum D.

J Med Chem. 2014 May 22;57(10):3966-83. doi: 10.1021/jm5004599. Epub 2014 May 9.


Direct detection and identification of acid-fast bacteria from smear-positive broth cultures using a pyrosequencing method.

Bao JR, Clark RB, Master RN, Piscitelli AE, Tummala PR, Eklund LL, Poselero BG, Wright J.

Diagn Microbiol Infect Dis. 2014 Jun;79(2):228-32. doi: 10.1016/j.diagmicrobio.2014.03.003. Epub 2014 Mar 15.


Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts.

Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK.

Diabetes. 2014 Aug;63(8):2676-89. doi: 10.2337/db13-1763. Epub 2014 Mar 27.


Synthesis and biological evaluation of 8-aminomethyltetracycline derivatives as novel antibacterial agents.

Clark RB, He M, Deng Y, Sun C, Chen CL, Hunt DK, O'Brien WJ, Fyfe C, Grossman TH, Sutcliffe JA, Achorn C, Hogan PC, Katz CE, Niu J, Zhang WY, Zhu Z, Ronn M, Xiao XY.

J Med Chem. 2013 Oct 24;56(20):8112-38. doi: 10.1021/jm401211t. Epub 2013 Oct 3.


Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac.

Vang AG, Housley W, Dong H, Basole C, Ben-Sasson SZ, Kream BE, Epstein PM, Clark RB, Brocke S.

Biochem J. 2013 Dec 15;456(3):463-73. doi: 10.1042/BJ20130064.


Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity.

Yin S, Luo J, Qian A, Du J, Yang Q, Zhou S, Yu W, Du G, Clark RB, Walters ET, Carlton SM, Hu H.

J Clin Invest. 2013 Sep;123(9):3941-51. doi: 10.1172/JCI66413. Epub 2013 Aug 8.


Phospholamban knockout breaks arrhythmogenic Ca²⁺ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice.

Bai Y, Jones PP, Guo J, Zhong X, Clark RB, Zhou Q, Wang R, Vallmitjana A, Benitez R, Hove-Madsen L, Semeniuk L, Guo A, Song LS, Duff HJ, Chen SR.

Circ Res. 2013 Aug 16;113(5):517-26. doi: 10.1161/CIRCRESAHA.113.301678. Epub 2013 Jul 15.


Serine lipids of Porphyromonas gingivalis are human and mouse Toll-like receptor 2 ligands.

Clark RB, Cervantes JL, Maciejewski MW, Farrokhi V, Nemati R, Yao X, Anstadt E, Fujiwara M, Wright KT, Riddle C, La Vake CJ, Salazar JC, Finegold S, Nichols FC.

Infect Immun. 2013 Sep;81(9):3479-89. doi: 10.1128/IAI.00803-13. Epub 2013 Jul 8.


A summary of meeting proceedings on addressing variability around the cut point in serial interferon-γ release assay testing.

Daley CL, Reves RR, Beard MA, Boyle J, Clark RB, Beebe JL, Catanzaro A, Chen L, Desmond E, Dorman SE, Hudson TW, Lardizabal AA, Kapoor H, Marder DC, Miranda C, Narita M, Reichman L, Schwab D, Seaworth BJ, Terpeluk P, Thanassi W, Kawamura LM.

Infect Control Hosp Epidemiol. 2013 Jun;34(6):625-30. doi: 10.1086/670635. Epub 2013 Apr 19.


The role of chromogranin B in an animal model of multiple sclerosis.

Mo M, Hoang HT, Schmidt S, Clark RB, Ehrlich BE.

Mol Cell Neurosci. 2013 Sep;56:102-14. doi: 10.1016/j.mcn.2013.04.003. Epub 2013 Apr 24.


Escherichia coli antimicrobial resistance increased faster among geriatric outpatients compared with adult outpatients in the USA, 2000-10.

Sanchez GV, Adams SJ, Baird AM, Master RN, Clark RB, Bordon JM.

J Antimicrob Chemother. 2013 Aug;68(8):1838-41. doi: 10.1093/jac/dkt110. Epub 2013 Apr 4.


Profile of Brian K. Kobilka and Robert J. Lefkowitz, 2012 Nobel laureates in chemistry.

Clark RB.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5274-5. doi: 10.1073/pnas.1221820110. Epub 2013 Feb 14. No abstract available.


Klebsiella pneumoniae antimicrobial drug resistance, United States, 1998-2010.

Sanchez GV, Master RN, Clark RB, Fyyaz M, Duvvuri P, Ekta G, Bordon J.

Emerg Infect Dis. 2013 Jan;19(1):133-6. doi: 10.3201/eid1901.120310.


Legal disputes over duties to disclose treatment risks to patients: a review of negligence claims and complaints in Australia.

Bismark MM, Gogos AJ, Clark RB, Gruen RL, Gawande AA, Studdert DM.

PLoS Med. 2012;9(8):e1001283. doi: 10.1371/journal.pmed.1001283. Epub 2012 Aug 7. Review. No abstract available.


Legal disputes over informed consent for cosmetic procedures: a descriptive study of negligence claims and complaints in Australia.

Bismark MM, Gogos AJ, McCombe D, Clark RB, Gruen RL, Studdert DM.

J Plast Reconstr Aesthet Surg. 2012 Nov;65(11):1506-12. doi: 10.1016/j.bjps.2012.05.004. Epub 2012 May 30.


Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion.

Finol-Urdaneta RK, Remedi MS, Raasch W, Becker S, Clark RB, Strüver N, Pavlov E, Nichols CG, French RJ, Terlau H.

EMBO Mol Med. 2012 May;4(5):424-34. doi: 10.1002/emmm.201200218. Epub 2012 Mar 21.


Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy.

Clark RB, Hunt DK, He M, Achorn C, Chen CL, Deng Y, Fyfe C, Grossman TH, Hogan PC, O'Brien WJ, Plamondon L, Rönn M, Sutcliffe JA, Zhu Z, Xiao XY.

J Med Chem. 2012 Jan 26;55(2):606-22. doi: 10.1021/jm201467r. Epub 2012 Jan 6.


Fluorocyclines. 1. 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: a potent, broad spectrum antibacterial agent.

Xiao XY, Hunt DK, Zhou J, Clark RB, Dunwoody N, Fyfe C, Grossman TH, O'Brien WJ, Plamondon L, Rönn M, Sun C, Zhang WY, Sutcliffe JA.

J Med Chem. 2012 Jan 26;55(2):597-605. doi: 10.1021/jm201465w. Epub 2012 Jan 4.


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