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Just the FACTS: The Role of Diagnostic Blocks in Lumbar Facet Interventions.

Brummett CM, Clark JD.

Anesthesiology. 2018 Jul 12. doi: 10.1097/ALN.0000000000002346. [Epub ahead of print] No abstract available.


Exercise Reverses Nociceptive Sensitization, Upregulated Neuropeptide Signaling, Inflammatory Changes, Anxiety, and Memory Impairment in a Mouse Tibia Fracture Model.

Shi X, Guo TZ, Li W, Sahbaie P, Rice KC, Sulima A, Clark JD, Kingery WS.

Anesthesiology. 2018 Jul 10. doi: 10.1097/ALN.0000000000002332. [Epub ahead of print]


Nociceptive and Cognitive Changes in a Murine Model of Polytrauma.

Sahbaie P, Tajerian M, Yang P, Irvine KA, Huang TT, Luo J, Wyss-Coray T, Clark JD.

J Pain. 2018 Jun 28. pii: S1526-5900(18)30313-4. doi: 10.1016/j.jpain.2018.06.004. [Epub ahead of print]


Fractality of body movements predicts perception of affordances: Evidence from stand-on-ability judgments about slopes.

Hajnal A, Clark JD, Doyon JK, Kelty-Stephen DG.

J Exp Psychol Hum Percept Perform. 2018 Jun;44(6):836-841. doi: 10.1037/xhp0000510.


Reply to Dr Peltz.

Chu LF, Sun J, Clemenson A, Erlendson MJ, Rico T, Cornell E, Obasi H, Sayyid ZN, Encisco EM, Yu J, Gamble JG, Clark JD.

J Addict Med. 2018 May/Jun;12(3):252-253. doi: 10.1097/ADM.0000000000000393. No abstract available.


Community-based pre-pregnancy care programme improves pregnancy preparation in women with pregestational diabetes.

Yamamoto JM, Hughes DJF, Evans ML, Karunakaran V, Clark JDA, Morrish NJ, Rayman GA, Winocour PH, Hambling C, Harries AW, Sampson MJ, Murphy HR.

Diabetologia. 2018 May 9. doi: 10.1007/s00125-018-4613-3. [Epub ahead of print]


Oxidative stress contributes to fracture/cast-induced inflammation and pain in a rat model of complex regional pain syndrome.

Guo TZ, Wei T, Huang TT, Kingery WS, Clark JD.

J Pain. 2018 Apr 28. pii: S1526-5900(18)30156-1. doi: 10.1016/j.jpain.2018.04.006. [Epub ahead of print]


Health Promotion at the Construction Work Site: The Lunch Truck Pilot Study.

Caban-Martinez AJ, Moore KJ, Clarke TC, Davila EP, Clark JD 3rd, Lee DJ, Fleming LE.

Workplace Health Saf. 2018 Apr 1:2165079918764189. doi: 10.1177/2165079918764189. [Epub ahead of print]


Neuropeptide regulation of adaptive immunity in the tibia fracture model of complex regional pain syndrome.

Li WW, Guo TZ, Shi X, Birklein F, Schlereth T, Kingery WS, Clark JD.

J Neuroinflammation. 2018 Apr 11;15(1):105. doi: 10.1186/s12974-018-1145-1.


Reversibility of peripheral blood leukocyte phenotypic and functional changes after exposure to and withdrawal from tofacitinib, a Janus kinase inhibitor, in healthy volunteers.

Weinhold KJ, Bukowski JF, Brennan TV, Noveck RJ, Staats JS, Lin L, Stempora L, Hammond C, Wouters A, Mojcik CF, Cheng J, Collinge M, Jesson MI, Hazra A, Biswas P, Lan S, Clark JD, Hodge JA.

Clin Immunol. 2018 Jun;191:10-20. doi: 10.1016/j.clim.2018.03.002. Epub 2018 Mar 5.


Traumatic Brain Injury Disrupts Pain Signaling in the Brainstem and Spinal Cord.

Irvine KA, Sahbaie P, Liang DY, Clark JD.

J Neurotrauma. 2018 Jul 1;35(13):1495-1509. doi: 10.1089/neu.2017.5411. Epub 2018 Apr 30.


Estimating population extinction thresholds with categorical classification trees for Louisiana black bears.

Laufenberg JS, Clark JD, Chandler RB.

PLoS One. 2018 Jan 23;13(1):e0191435. doi: 10.1371/journal.pone.0191435. eCollection 2018. Erratum in: PLoS One. 2018 May 24;13(5):e0198368.


Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.

Vazquez ML, Kaila N, Strohbach JW, Trzupek JD, Brown MF, Flanagan ME, Mitton-Fry MJ, Johnson TA, TenBrink RE, Arnold EP, Basak A, Heasley SE, Kwon S, Langille J, Parikh MD, Griffin SH, Casavant JM, Duclos BA, Fenwick AE, Harris TM, Han S, Caspers N, Dowty ME, Yang X, Banker ME, Hegen M, Symanowicz PT, Li L, Wang L, Lin TH, Jussif J, Clark JD, Telliez JB, Robinson RP, Unwalla R.

J Med Chem. 2018 Feb 8;61(3):1130-1152. doi: 10.1021/acs.jmedchem.7b01598. Epub 2018 Jan 23.


Ondansetron does not prevent physical dependence in patients taking opioid medications chronically for pain control.

Chu LF, Rico T, Cornell E, Obasi H, Encisco EM, Vertelney H, Gamble JG, Crawford CW, Sun J, Clemenson A, Erlendson MJ, Okada R, Carroll I, Clark JD.

Drug Alcohol Depend. 2018 Feb 1;183:176-183. doi: 10.1016/j.drugalcdep.2017.06.043. Epub 2017 Aug 14.


Nervous system delivery of antilysophosphatidic acid antibody by nasal application attenuates mechanical allodynia after traumatic brain injury in rats.

Eisenried A, Meidahl ACN, Klukinov M, Tzabazis AZ, Sabbadini RA, Clark JD, Yeomans DC.

Pain. 2017 Nov;158(11):2181-2188. doi: 10.1097/j.pain.0000000000001019.


Chronic Pain After Traumatic Brain Injury: Pathophysiology and Pain Mechanisms.

Irvine KA, Clark JD.

Pain Med. 2018 Jul 1;19(7):1315-1333. doi: 10.1093/pm/pnx153.


Passive transfer autoimmunity in a mouse model of complex regional pain syndrome.

Guo TZ, Shi X, Li WW, Wei T, Clark JD, Kingery WS.

Pain. 2017 Dec;158(12):2410-2421. doi: 10.1097/j.pain.0000000000001046.


The Chemokine Receptor CXCR2 Supports Nociceptive Sensitization after Traumatic Brain Injury.

Liang DY, Shi X, Liu P, Sun Y, Sahbaie P, Li WW, Yeomans DC, Clark JD.

Mol Pain. 2017 Jan-Dec;13:1744806917730212. doi: 10.1177/1744806917730212.


Ondansetron Does Not Reduce Withdrawal in Patients With Physical Dependence on Chronic Opioid Therapy.

Chu LF, Sun J, Clemenson A, Erlendson MJ, Rico T, Cornell E, Obasi H, Sayyid ZN, Encisco EM, Yu J, Gamble JG, Carroll I, Clark JD.

J Addict Med. 2017 Sep/Oct;11(5):342-349. doi: 10.1097/ADM.0000000000000321.


Nonpharmacological Interventions in Targeting Pain-Related Brain Plasticity.

Tajerian M, Clark JD.

Neural Plast. 2017;2017:2038573. doi: 10.1155/2017/2038573. Epub 2017 Feb 16. Review.


Corrigendum to "Combined medial canthopexy and lateral tarsal strip for floppy eyelid syndrome" [Am J Otolaryngol 37 (2016) 240-244].

Compton CJ, Melson AT, Clark JD, Shipchandler TZ, Nunery WR, Harold Lee HB.

Am J Otolaryngol. 2017 May - Jun;38(3):370. doi: 10.1016/j.amjoto.2017.01.029. Epub 2017 Feb 2. No abstract available.


Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.

Corder G, Tawfik VL, Wang D, Sypek EI, Low SA, Dickinson JR, Sotoudeh C, Clark JD, Barres BA, Bohlen CJ, Scherrer G.

Nat Med. 2017 Feb;23(2):164-173. doi: 10.1038/nm.4262. Epub 2017 Jan 16.


The inflammasome as a target for pain therapy.

Zhang H, Li F, Li WW, Stary C, Clark JD, Xu S, Xiong X.

Br J Anaesth. 2016 Dec;117(6):693-707.


Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.

Telliez JB, Dowty ME, Wang L, Jussif J, Lin T, Li L, Moy E, Balbo P, Li W, Zhao Y, Crouse K, Dickinson C, Symanowicz P, Hegen M, Banker ME, Vincent F, Unwalla R, Liang S, Gilbert AM, Brown MF, Hayward M, Montgomery J, Yang X, Bauman J, Trujillo JI, Casimiro-Garcia A, Vajdos FF, Leung L, Geoghegan KF, Quazi A, Xuan D, Jones L, Hett E, Wright K, Clark JD, Thorarensen A.

ACS Chem Biol. 2016 Dec 16;11(12):3442-3451. Epub 2016 Nov 10.


Identification of KRT16 as a target of an autoantibody response in complex regional pain syndrome.

Tajerian M, Hung V, Khan H, Lahey LJ, Sun Y, Birklein F, Krämer HH, Robinson WH, Kingery WS, Clark JD.

Exp Neurol. 2017 Jan;287(Pt 1):14-20. doi: 10.1016/j.expneurol.2016.10.011. Epub 2016 Oct 20.


Preclinical Pain Research: Can We Do Better?

Clark JD.

Anesthesiology. 2016 Nov;125(5):846-849. Review.


Palonosetron and hydroxyzine pre-treatment reduces the objective signs of experimentally-induced acute opioid withdrawal in humans: a double-blinded, randomized, placebo-controlled crossover study.

Erlendson MJ, D'Arcy N, Encisco EM, Yu JJ, Rincon-Cruz L, Peltz G, Clark JD, Chu LF.

Am J Drug Alcohol Abuse. 2017 Jan;43(1):78-86. doi: 10.1080/00952990.2016.1210614. Epub 2016 Aug 11.


Bisphosphonates Inhibit Pain, Bone Loss, and Inflammation in a Rat Tibia Fracture Model of Complex Regional Pain Syndrome.

Wang L, Guo TZ, Hou S, Wei T, Li WW, Shi X, Clark JD, Kingery WS.

Anesth Analg. 2016 Oct;123(4):1033-45. doi: 10.1213/ANE.0000000000001518. Erratum in: Anesth Analg. 2017 Mar;124(3):1024.


Network pharmacology of JAK inhibitors.

Moodley D, Yoshida H, Mostafavi S, Asinovski N, Ortiz-Lopez A, Symanowicz P, Telliez JB, Hegen M, Clark JD, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9852-7. doi: 10.1073/pnas.1610253113. Epub 2016 Aug 11.


Combined medial canthopexy and lateral tarsal strip for floppy eyelid syndrome.

Compton CJ, Melson AT, Clark JD, Shipchandler TZ, Nunery WR, Lee HB.

Am J Otolaryngol. 2016 May-Jun;37(3):240-4. doi: 10.1016/j.amjoto.2016.01.007. Epub 2016 Jan 22. Erratum in: Am J Otolaryngol. 2017 May - Jun;38(3):370.


The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1.

Shutov LP, Warwick CA, Shi X, Gnanasekaran A, Shepherd AJ, Mohapatra DP, Woodruff TM, Clark JD, Usachev YM.

J Neurosci. 2016 May 4;36(18):5055-70. doi: 10.1523/JNEUROSCI.3249-15.2016.


The multiple PDZ domain protein Mpdz/MUPP1 regulates opioid tolerance and opioid-induced hyperalgesia.

Donaldson R, Sun Y, Liang DY, Zheng M, Sahbaie P, Dill DL, Peltz G, Buck KJ, Clark JD.

BMC Genomics. 2016 Apr 29;17:313. doi: 10.1186/s12864-016-2634-1.


Epigenetic regulation of spinal cord gene expression contributes to enhanced postoperative pain and analgesic tolerance subsequent to continuous opioid exposure.

Sahbaie P, Liang DY, Shi XY, Sun Y, Clark JD.

Mol Pain. 2016 Apr 18;12. pii: 1744806916641950. doi: 10.1177/1744806916641950. Print 2016.


Time-to-Cessation of Postoperative Opioids: A Population-Level Analysis of the Veterans Affairs Health Care System.

Mudumbai SC, Oliva EM, Lewis ET, Trafton J, Posner D, Mariano ER, Stafford RS, Wagner T, Clark JD.

Pain Med. 2016 Sep;17(9):1732-43. doi: 10.1093/pm/pnw015. Epub 2016 Apr 15.


Orbital cellulitis and corneal ulcer due to Cedecea: First reported case and review of the literature.

Clark JD, Fernandez de Castro JP, Compton C, Lee H, Nunery W.

Orbit. 2016 Jun;35(3):140-3. doi: 10.3109/01676830.2016.1139597. Epub 2016 Apr 12. Review.


Tofacitinib attenuates pathologic immune pathways in patients with psoriasis: A randomized phase 2 study.

Krueger J, Clark JD, Suárez-Fariñas M, Fuentes-Duculan J, Cueto I, Wang CQ, Tan H, Wolk R, Rottinghaus ST, Whitley MZ, Valdez H, von Schack D, O'Neil SP, Reddy PS, Tatulych S; A3921147 Study Investigators.

J Allergy Clin Immunol. 2016 Apr;137(4):1079-1090. doi: 10.1016/j.jaci.2015.12.1318.


Ophthalmic considerations in patients with Pfeiffer syndrome.

Clark JD, Compton CJ, Tahiri Y, Nunery WR, Harold Lee HB.

Am J Ophthalmol Case Rep. 2016 Apr 7;2:1-3. doi: 10.1016/j.ajoc.2016.04.001. eCollection 2016 Jul.


A Pharmacogenetic Discovery: Cystamine Protects Against Haloperidol-Induced Toxicity and Ischemic Brain Injury.

Zhang H, Zheng M, Wu M, Xu D, Nishimura T, Nishimura Y, Giffard R, Xiong X, Xu LJ, Clark JD, Sahbaie P, Dill DL, Peltz G.

Genetics. 2016 May;203(1):599-609. doi: 10.1534/genetics.115.184648. Epub 2016 Mar 18.


Perception of Stand-on-ability: Do Geographical Slants Feel Steeper Than They Look?

Hajnal A, Wagman JB, Doyon JK, Clark JD.

Perception. 2016 Jul;45(7):768-86. doi: 10.1177/0301006616638597. Epub 2016 Mar 14.


The mechanism of action of tofacitinib - an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis.

Hodge JA, Kawabata TT, Krishnaswami S, Clark JD, Telliez JB, Dowty ME, Menon S, Lamba M, Zwillich S.

Clin Exp Rheumatol. 2016 Mar-Apr;34(2):318-28. Epub 2016 Mar 10. Review.


Molecular Interaction between Stress and Pain.

Flood P, Clark JD.

Anesthesiology. 2016 May;124(5):994-5. doi: 10.1097/ALN.0000000000001071. No abstract available.


Parsing the Interferon Transcriptional Network and Its Disease Associations.

Mostafavi S, Yoshida H, Moodley D, LeBoité H, Rothamel K, Raj T, Ye CJ, Chevrier N, Zhang SY, Feng T, Lee M, Casanova JL, Clark JD, Hegen M, Telliez JB, Hacohen N, De Jager PL, Regev A, Mathis D, Benoist C; Immunological Genome Project Consortium.

Cell. 2016 Jan 28;164(3):564-78. doi: 10.1016/j.cell.2015.12.032.


Acute versus chronic phase mechanisms in a rat model of CRPS.

Wei T, Guo TZ, Li WW, Kingery WS, Clark JD.

J Neuroinflammation. 2016 Jan 19;13:14. doi: 10.1186/s12974-015-0472-8.


New Concepts in Complex Regional Pain Syndrome.

Tajerian M, Clark JD.

Hand Clin. 2016 Feb;32(1):41-9. doi: 10.1016/j.hcl.2015.08.003. Review.


DNA Methylation Modulates Nociceptive Sensitization after Incision.

Sun Y, Sahbaie P, Liang D, Li W, Shi X, Kingery P, Clark JD.

PLoS One. 2015 Nov 4;10(11):e0142046. doi: 10.1371/journal.pone.0142046. eCollection 2015.


Differential Efficacy of Ketamine in the Acute versus Chronic Stages of Complex Regional Pain Syndrome in Mice.

Tajerian M, Leu D, Yang P, Huang TT, Kingery WS, Clark JD.

Anesthesiology. 2015 Dec;123(6):1435-47. doi: 10.1097/ALN.0000000000000889.


Novel cytogenic and neurovascular niches due to blood-brain barrier compromise in the chronic pain brain.

Tajerian M, Clark JD.

Mol Pain. 2015 Oct 9;11:63. doi: 10.1186/s12990-015-0066-6.


A Parent's Journey: Incorporating Principles of Palliative Care into Practice for Children with Chronic Neurologic Diseases.

Brown A, Clark JD.

Semin Pediatr Neurol. 2015 Sep;22(3):159-65. doi: 10.1016/j.spen.2015.05.007. Epub 2015 May 12. Review.


Perioperative Surgical Home and the Integral Role of Pain Medicine.

Walters TL, Mariano ER, Clark JD.

Pain Med. 2015 Sep;16(9):1666-72. doi: 10.1111/pme.12796. Epub 2015 Jul 14. No abstract available.


Acute opioid withdrawal is associated with increased neural activity in reward-processing centers in healthy men: A functional magnetic resonance imaging study.

Chu LF, Lin JC, Clemenson A, Encisco E, Sun J, Hoang D, Alva H, Erlendson M, Clark JD, Younger JW.

Drug Alcohol Depend. 2015 Aug 1;153:314-22. doi: 10.1016/j.drugalcdep.2015.04.019. Epub 2015 May 27.

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