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Items: 1 to 50 of 188

1.

Catalytic Enantioselective Synthesis of C1 - and C2 -Symmetric Spirobiindanones through Counterion-Directed Enolate C-Acylation.

Rahemtulla BF, Clark HF, Smith MD.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13180-13183. doi: 10.1002/anie.201607731.

2.

Distribution of rotavirus genotypes causing nosocomial and community-acquired acute gastroenteritis at the Children's Hospital of Philadelphia in the new rotavirus vaccine era.

Clark HF, Lawley D, DiStefano D, Matthijnssens J, Dinubile MJ.

Hum Vaccin. 2011 Nov;7(11):1118-23. doi: 10.4161/hv.7.11.17820. Epub 2011 Nov 1.

PMID:
22048265
3.

Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q.

Pidasheva S, Trifari S, Phillips A, Hackney JA, Ma Y, Smith A, Sohn SJ, Spits H, Little RD, Behrens TW, Honigberg L, Ghilardi N, Clark HF.

PLoS One. 2011;6(10):e25038. doi: 10.1371/journal.pone.0025038. Epub 2011 Oct 12.

4.

Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model.

Abbas AR, Jackman JK, Bullens SL, Davis SM, Choy DF, Fedorowicz G, Tan M, Truong BT, Gloria Meng Y, Diehl L, Miller LA, Schelegle ES, Hyde DM, Clark HF, Modrusan Z, Arron JR, Wu LC.

Am J Pathol. 2011 Oct;179(4):1667-80. doi: 10.1016/j.ajpath.2011.06.009. Epub 2011 Aug 3.

5.

An unusual outbreak of rotavirus genotype G2P[6] during the 2005-2006 epidemic season in Philadelphia.

Clark HF, Lawley D, DiStefano D, Maliga M, Kilby B, Kulnis G, Mallette L, DiNubile MJ.

Diagn Microbiol Infect Dis. 2011 Jun;70(2):218-22. doi: 10.1016/j.diagmicrobio.2010.12.014. Epub 2011 Mar 12.

PMID:
21398071
6.

Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways.

Choy DF, Modrek B, Abbas AR, Kummerfeld S, Clark HF, Wu LC, Fedorowicz G, Modrusan Z, Fahy JV, Woodruff PG, Arron JR.

J Immunol. 2011 Feb 1;186(3):1861-9. doi: 10.4049/jimmunol.1002568. Epub 2010 Dec 27.

7.

Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis.

Noble CL, Abbas AR, Lees CW, Cornelius J, Toy K, Modrusan Z, Clark HF, Arnott ID, Penman ID, Satsangi J, Diehl L.

Inflamm Bowel Dis. 2010 Oct;16(10):1717-28. doi: 10.1002/ibd.21263.

PMID:
20848455
8.

Influence of potential protective mechanisms on the development of live rotavirus vaccines.

Ward RL, Clark HF, Offit PA.

J Infect Dis. 2010 Sep 1;202 Suppl:S72-9. doi: 10.1086/653549. Review.

PMID:
20684721
9.

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.

Ferreira RC, Pan-Hammarström Q, Graham RR, Gateva V, Fontán G, Lee AT, Ortmann W, Urcelay E, Fernández-Arquero M, Núñez C, Jorgensen G, Ludviksson BR, Koskinen S, Haimila K, Clark HF, Klareskog L, Gregersen PK, Behrens TW, Hammarström L.

Nat Genet. 2010 Sep;42(9):777-80. doi: 10.1038/ng.644. Epub 2010 Aug 8.

PMID:
20694011
10.

Sustained decline in cases of rotavirus gastroenteritis presenting to the Children's Hospital of Philadelphia in the new rotavirus vaccine era.

Clark HF, Lawley D, Matthijnssens J, DiNubile MJ, Hodinka RL.

Pediatr Infect Dis J. 2010 Aug;29(8):699-702. doi: 10.1097/INF.0b013e3181d73524.

PMID:
20661099
11.

Unexpectedly high burden of rotavirus gastroenteritis in very young infants.

Clark HF, Marcello AE, Lawley D, Reilly M, DiNubile MJ.

BMC Pediatr. 2010 Jun 11;10:40. doi: 10.1186/1471-2431-10-40.

12.

Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus.

Abbas AR, Wolslegel K, Seshasayee D, Modrusan Z, Clark HF.

PLoS One. 2009 Jul 1;4(7):e6098. doi: 10.1371/journal.pone.0006098.

13.

Current and historic mercury deposition to New Haven Harbor (CT, USA): implications for industrial coastal environments.

Clark HF, Benoit G.

Sci Total Environ. 2009 Jul 15;407(15):4472-9. doi: 10.1016/j.scitotenv.2009.04.003. Epub 2009 May 8.

PMID:
19427674
14.

Decline in cases of rotavirus gastroenteritis presenting to The Children's Hospital of Philadelphia after introduction of a pentavalent rotavirus vaccine.

Clark HF, Lawley D, Mallette LA, DiNubile MJ, Hodinka RL.

Clin Vaccine Immunol. 2009 Mar;16(3):382-6. doi: 10.1128/CVI.00382-08. Epub 2009 Jan 21.

15.

A brief account of experiences leading to RotaTeq vaccine.

Clark HF.

Hum Vaccin. 2008 Jul-Aug;4(4):256-9. No abstract available.

PMID:
18682692
16.

Urban gardens: lead exposure, recontamination mechanisms, and implications for remediation design.

Clark HF, Hausladen DM, Brabander DJ.

Environ Res. 2008 Jul;107(3):312-9. doi: 10.1016/j.envres.2008.03.003. Epub 2008 May 5.

PMID:
18456252
17.

The clinical and molecular epidemiology of community- and healthcare-acquired rotavirus gastroenteritis.

Smith MJ, Clark HF, Lawley D, Bell LM, Hodinka RL, DiStefano DJ, Kulnis G, Zaoutis TE, Coffin SE.

Pediatr Infect Dis J. 2008 Jan;27(1):54-8.

PMID:
18162939
18.

Gene signatures reflect the marked heterogeneity of tissue-resident macrophages.

Gorgani NN, Ma Y, Clark HF.

Immunol Cell Biol. 2008 Mar-Apr;86(3):246-54. Epub 2007 Nov 13.

PMID:
17998916
19.

Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci.

Raelson JV, Little RD, Ruether A, Fournier H, Paquin B, Van Eerdewegh P, Bradley WE, Croteau P, Nguyen-Huu Q, Segal J, Debrus S, Allard R, Rosenstiel P, Franke A, Jacobs G, Nikolaus S, Vidal JM, Szego P, Laplante N, Clark HF, Paulussen RJ, Hooper JW, Keith TP, Belouchi A, Schreiber S.

Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14747-52. Epub 2007 Sep 5.

20.

Sources, sinks, and exposure pathways of lead in urban garden soil.

Clark HF, Brabander DJ, Erdil RM.

J Environ Qual. 2006 Oct 27;35(6):2066-74. Print 2006 Nov-Dec.

PMID:
17071875
21.

The new pentavalent rotavirus vaccine composed of bovine (strain WC3) -human rotavirus reassortants.

Clark HF, Offit PA, Plotkin SA, Heaton PM.

Pediatr Infect Dis J. 2006 Jul;25(7):577-83. Review.

PMID:
16804425
22.

Effects of the potency and composition of the multivalent human-bovine (WC3) reassortant rotavirus vaccine on efficacy, safety and immunogenicity in healthy infants.

Vesikari T, Clark HF, Offit PA, Dallas MJ, DiStefano DJ, Goveia MG, Ward RL, Schödel F, Karvonen A, Drummond JE, DiNubile MJ, Heaton PM.

Vaccine. 2006 May 29;24(22):4821-9. Epub 2006 Mar 31.

PMID:
16621194
23.

RotaTeq: a pentavalent bovine--human reassortant rotavirus vaccine.

Offit PA, Clark HF.

Pediatr Ann. 2006 Jan;35(1):29-34. Review. No abstract available.

PMID:
16466073
24.

Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine.

Vesikari T, Matson DO, Dennehy P, Van Damme P, Santosham M, Rodriguez Z, Dallas MJ, Heyse JF, Goveia MG, Black SB, Shinefield HR, Christie CD, Ylitalo S, Itzler RF, Coia ML, Onorato MT, Adeyi BA, Marshall GS, Gothefors L, Campens D, Karvonen A, Watt JP, O'Brien KL, DiNubile MJ, Clark HF, Boslego JW, Offit PA, Heaton PM; Rotavirus Efficacy and Safety Trial (REST) Study Team.

N Engl J Med. 2006 Jan 5;354(1):23-33.

26.

Development of a pentavalent rotavirus vaccine against prevalent serotypes of rotavirus gastroenteritis.

Heaton PM, Goveia MG, Miller JM, Offit P, Clark HF.

J Infect Dis. 2005 Sep 1;192 Suppl 1:S17-21.

PMID:
16088800
27.

Memory T-cell response to rotavirus detected with a gamma interferon enzyme-linked immunospot assay.

Kaufhold RM, Field JA, Caulfield MJ, Wang S, Joseph H, Wooters MA, Green T, Clark HF, Krah D, Smith JG.

J Virol. 2005 May;79(9):5684-94.

28.

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data.

Abbas AR, Baldwin D, Ma Y, Ouyang W, Gurney A, Martin F, Fong S, van Lookeren Campagne M, Godowski P, Williams PM, Chan AC, Clark HF.

Genes Immun. 2005 Jun;6(4):319-31.

PMID:
15789058
29.

Vaccines for rotavirus gastroenteritis universally needed for infants.

Clark HF, Offit PA.

Pediatr Ann. 2004 Aug;33(8):536-43.

PMID:
15354605
30.
31.

Rotavirus immunoglobulin a responses stimulated by each of 3 doses of a quadrivalent human/bovine reassortant rotavirus vaccine.

Ward RL, Bernstein DI, Smith VE, Sander DS, Shaw A, Eiden JJ, Heaton P, Offit PA, Clark HF.

J Infect Dis. 2004 Jun 15;189(12):2290-3. Epub 2004 May 25.

PMID:
15181577
32.
33.

Infant immune response to human rotavirus serotype G1 vaccine candidate reassortant WI79-9: different dose response patterns to virus surface proteins VP7 and VP4.

Clark HF, Lawley D, Shrager D, Jean-Guillaume D, Offit PA, Whang SY, Eiden JJ, Bennett PS, Kaplan KM, Shaw AR.

Pediatr Infect Dis J. 2004 Mar;23(3):206-11.

PMID:
15014293
34.

Safety, efficacy, and immunogenicity of a live, quadrivalent human-bovine reassortant rotavirus vaccine in healthy infants.

Clark HF, Bernstein DI, Dennehy PH, Offit P, Pichichero M, Treanor J, Ward RL, Krah DL, Shaw A, Dallas MJ, Laura D, Eiden JJ, Ivanoff N, Kaplan KM, Heaton P.

J Pediatr. 2004 Feb;144(2):184-90. Erratum in: J Pediatr. 2004 Apr;144(4):558.

PMID:
14760258
35.

Safety, immunogenicity and efficacy in healthy infants of G1 and G2 human reassortant rotavirus vaccine in a new stabilizer/buffer liquid formulation.

Clark HF, Burke CJ, Volkin DB, Offit P, Ward RL, Bresee JS, Dennehy P, Gooch WM, Malacaman E, Matson D, Walter E, Watson B, Krah DL, Dallas MJ, Schödel F, Kaplan kM, Heaton P.

Pediatr Infect Dis J. 2003 Oct;22(10):914-20.

PMID:
14551493
36.

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A.

Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. Erratum in: Genome Res. 2003 Dec;13(12):2759.

37.

Hypertrophy, hyperplasia, and infectious virus in gut-associated lymphoid tissue of mice after oral inoculation with simian-human or bovine-human reassortant rotaviruses.

Moser CA, Dolfi DV, Di Vietro ML, Heaton PA, Offit PA, Clark HF.

J Infect Dis. 2001 Apr 1;183(7):1108-11. Epub 2001 Mar 8.

PMID:
11237837
38.

Molecular characterization of serotype G9 rotavirus strains from a global collection.

Ramachandran M, Kirkwood CD, Unicomb L, Cunliffe NA, Ward RL, Bhan MK, Clark HF, Glass RI, Gentsch JR.

Virology. 2000 Dec 20;278(2):436-44.

39.

Genetic and antigenic characterization of a serotype P[6]G9 human rotavirus strain isolated in the United States.

Kirkwood CD, Gentsch JR, Hoshino Y, Clark HF, Glass RI.

Virology. 1999 Mar 30;256(1):45-53.

40.

The rotavirus vaccine.

Offit PA, Clark HF.

Curr Opin Pediatr. 1999 Feb;11(1):9-13. Review.

PMID:
10084077
41.

Identification of two lineages (WA-like and F45-like) within the major rotavirus genotype P[8].

Gouvea V, Lima RC, Linhares RE, Clark HF, Nosawa CM, Santos N.

Virus Res. 1999 Feb;59(2):141-7.

PMID:
10082386
42.

Relationship among serotype G3P5A rotavirus strains isolated from different host species.

Santos N, Clark HF, Hoshino Y, Gouvea V.

Mol Cell Probes. 1998 Dec;12(6):379-86.

PMID:
9843655
43.

Relative importance of rotavirus-specific effector and memory B cells in protection against challenge.

Moser CA, Cookinham S, Coffin SE, Clark HF, Offit PA.

J Virol. 1998 Feb;72(2):1108-14. Erratum in: J Virol 1998 Mar;72(3):2564.

44.

Immunologic correlates of protection against rotavirus challenge after intramuscular immunization of mice.

Coffin SE, Moser CA, Cohen S, Clark HF, Offit PA.

J Virol. 1997 Oct;71(10):7851-6.

45.

The development of multivalent bovine rotavirus (strain WC3) reassortant vaccine for infants.

Clark HF, Offit PA, Ellis RW, Eiden JJ, Krah D, Shaw AR, Pichichero M, Treanor JJ, Borian FE, Bell LM, Plotkin SA.

J Infect Dis. 1996 Sep;174 Suppl 1:S73-80. Review.

PMID:
8752294
46.

WC3 reassortant vaccines in children.

Clark HF, Offit PA, Ellis RW, Krah D, Shaw AR, Eiden JJ, Pichichero M, Treanor JJ.

Arch Virol Suppl. 1996;12:187-98. Review.

PMID:
9015115
47.

Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila.

Clark HF, Brentrup D, Schneitz K, Bieber A, Goodman C, Noll M.

Genes Dev. 1995 Jun 15;9(12):1530-42.

48.

Evaluation of the protective efficacy of a serotype 1 bovine-human rotavirus reassortant vaccine in infants.

Treanor JJ, Clark HF, Pichichero M, Christy C, Gouvea V, Shrager D, Palazzo S, Offit P.

Pediatr Infect Dis J. 1995 Apr;14(4):301-7.

PMID:
7603812
49.

Enhancement of rotavirus immunogenicity by microencapsulation.

Offit PA, Khoury CA, Moser CA, Clark HF, Kim JE, Speaker TJ.

Virology. 1994 Aug 15;203(1):134-43.

PMID:
8030269
50.

Comparative analysis of VP8* sequences from rotaviruses possessing M37-like VP4 recovered from children with and without diarrhoea.

Santos N, Gouvea V, Timenetsky MC, Clark HF, Riepenhoff-Talty M, Garbarg-Chenon A.

J Gen Virol. 1994 Jul;75 ( Pt 7):1775-80.

PMID:
8021606

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