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Items: 1 to 50 of 301

1.

Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy.

Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom EH, Rivadeneira A, Sahakian N, Roignot J, Papagregoriou G, Montesinos MS, Clark AR, McKinney D, Gutierrez J, Roth M, Ronco L, Elonga E, Carter TA, Gnirke A, Melanson M, Hartland K, Wieder N, Hsu JC, Deltas C, Hughey R, Bleyer AJ, Kmoch S, Živná M, Barešova V, Kota S, Schlondorff J, Heiman M, Alper SL, Wagner F, Weins A, Golub TR, Lander ES, Greka A.

Cell. 2019 Jul 25;178(3):521-535.e23. doi: 10.1016/j.cell.2019.07.002.

PMID:
31348885
2.

Rapid MALDI mass spectrometry imaging for surgical pathology.

Basu SS, Regan MS, Randall EC, Abdelmoula WM, Clark AR, Gimenez-Cassina Lopez B, Cornett DS, Haase A, Santagata S, Agar NYR.

NPJ Precis Oncol. 2019 Jul 4;3:17. doi: 10.1038/s41698-019-0089-y. eCollection 2019.

3.

Differences in placental capillary shear stress in fetal growth restriction may affect endothelial cell function and vascular network formation.

Tun WM, Yap CH, Saw SN, James JL, Clark AR.

Sci Rep. 2019 Jul 8;9(1):9876. doi: 10.1038/s41598-019-46151-6.

4.

The pore structure of Clostridium perfringens epsilon toxin.

Savva CG, Clark AR, Naylor CE, Popoff MR, Moss DS, Basak AK, Titball RW, Bokori-Brown M.

Nat Commun. 2019 Jun 14;10(1):2641. doi: 10.1038/s41467-019-10645-8.

5.

Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration.

Clark AR, Ohlmeyer M.

Pharmacol Ther. 2019 Jun 1. pii: S0163-7258(19)30099-3. doi: 10.1016/j.pharmthera.2019.05.016. [Epub ahead of print] Review.

6.

Metal Oxide Laser Ionization Mass Spectrometry Imaging (MOLI MSI) Using Cerium(IV) Oxide.

Basu SS, McMinn MH, Giménez-Cassina Lopéz B, Regan MS, Randall EC, Clark AR, Cox CR, Agar NYR.

Anal Chem. 2019 May 21;91(10):6800-6807. doi: 10.1021/acs.analchem.9b00894. Epub 2019 May 8.

PMID:
31025851
7.

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3.

McCarthy PC, Phair IR, Greger C, Pardali K, McGuire VA, Clark AR, Gaestel M, Arthur JSC.

Immunol Cell Biol. 2019 Jan;97(1):54-71. doi: 10.1111/imcb.12200. Epub 2018 Oct 19.

8.

Major Comorbidities of Atopic Dermatitis: Beyond Allergic Disorders.

Paller A, Jaworski JC, Simpson EL, Boguniewicz M, Russell JJ, Block JK, Tofte S, Dunn JD, Feldman SR, Clark AR, Schwartz G, Eichenfield LF.

Am J Clin Dermatol. 2018 Dec;19(6):821-838. doi: 10.1007/s40257-018-0383-4. Review.

PMID:
30168085
9.

Rapid discrimination of pediatric brain tumors by mass spectrometry imaging.

Clark AR, Calligaris D, Regan MS, Pomeranz Krummel D, Agar JN, Kallay L, MacDonald T, Schniederjan M, Santagata S, Pomeroy SL, Agar NYR, Sengupta S.

J Neurooncol. 2018 Nov;140(2):269-279. doi: 10.1007/s11060-018-2978-2. Epub 2018 Aug 20.

10.

Terminal Regions Confer Plasticity to the Tetrameric Assembly of Human HspB2 and HspB3.

Clark AR, Vree Egberts W, Kondrat FDL, Hilton GR, Ray NJ, Cole AR, Carver JA, Benesch JLP, Keep NH, Boelens WC, Slingsby C.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3297-3310. doi: 10.1016/j.jmb.2018.06.047. Epub 2018 Jun 30.

11.

Trophoblast plugs: impact on utero-placental haemodynamics and spiral artery remodelling.

James JL, Saghian R, Perwick R, Clark AR.

Hum Reprod. 2018 Jun 28. doi: 10.1093/humrep/dey225. [Epub ahead of print]

PMID:
29955830
12.

Understanding abnormal uterine artery Doppler waveforms: A novel computational model to explore potential causes within the utero-placental vasculature.

Clark AR, James JL, Stevenson GN, Collins SL.

Placenta. 2018 Jun;66:74-81. doi: 10.1016/j.placenta.2018.05.001. Epub 2018 May 9.

13.

Stroma: the forgotten cells of innate immune memory.

Crowley T, Buckley CD, Clark AR.

Clin Exp Immunol. 2018 Jul;193(1):24-36. doi: 10.1111/cei.13149. Review.

14.

Worldwide Protein Data Bank biocuration supporting open access to high-quality 3D structural biology data.

Young JY, Westbrook JD, Feng Z, Peisach E, Persikova I, Sala R, Sen S, Berrisford JM, Swaminathan GJ, Oldfield TJ, Gutmanas A, Igarashi R, Armstrong DR, Baskaran K, Chen L, Chen M, Clark AR, Di Costanzo L, Dimitropoulos D, Gao G, Ghosh S, Gore S, Guranovic V, Hendrickx PMS, Hudson BP, Ikegawa Y, Kengaku Y, Lawson CL, Liang Y, Mak L, Mukhopadhyay A, Narayanan B, Nishiyama K, Patwardhan A, Sahni G, Sanz-García E, Sato J, Sekharan MR, Shao C, Smart OS, Tan L, van Ginkel G, Yang H, Zhuravleva MA, Markley JL, Nakamura H, Kurisu G, Kleywegt GJ, Velankar S, Berman HM, Burley SK.

Database (Oxford). 2018 Jan 1;2018. doi: 10.1093/database/bay002.

15.

In silico modeling of oxygen-enhanced MRI of specific ventilation.

Kang W, Tawhai MH, Clark AR, Sá RC, Geier ET, Prisk GK, Burrowes KS.

Physiol Rep. 2018 Apr;6(7):e13659. doi: 10.14814/phy2.13659.

16.

In Vitro Liquid Extraction Surface Analysis Mass Spectrometry (ivLESA-MS) for Direct Metabolic Analysis of Adherent Cells in Culture.

Basu SS, Randall EC, Regan MS, Lopez BGC, Clark AR, Schmitt ND, Agar JN, Dillon DA, Agar NYR.

Anal Chem. 2018 Apr 17;90(8):4987-4991. doi: 10.1021/acs.analchem.8b00530. Epub 2018 Apr 2.

17.

Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis.

Falconer J, Murphy AN, Young SP, Clark AR, Tiziani S, Guma M, Buckley CD.

Arthritis Rheumatol. 2018 Jul;70(7):984-999. doi: 10.1002/art.40504. Epub 2018 Jun 4. Review.

18.

Metrics of lung tissue heterogeneity depend on BMI but not age.

Subramaniam K, Clark AR, Hoffman EA, Tawhai MH.

J Appl Physiol (1985). 2018 Aug 1;125(2):328-339. doi: 10.1152/japplphysiol.00510.2016. Epub 2018 Feb 22.

19.

Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities.

Christov M, Clark AR, Corbin B, Hakroush S, Rhee EP, Saito H, Brooks D, Hesse E, Bouxsein M, Galjart N, Jung JY, Mundel P, Jüppner H, Weins A, Greka A.

JCI Insight. 2018 Feb 22;3(4). pii: 95091. doi: 10.1172/jci.insight.95091. eCollection 2018 Feb 22.

20.

The role of microRNAs in glucocorticoid action.

Clayton SA, Jones SW, Kurowska-Stolarska M, Clark AR.

J Biol Chem. 2018 Feb 9;293(6):1865-1874. doi: 10.1074/jbc.R117.000366. Epub 2018 Jan 4. Review.

21.

Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment.

Bulbrook D, Brazier H, Mahajan P, Kliszczak M, Fedorov O, Marchese FP, Aubareda A, Chalk R, Picaud S, Strain-Damerell C, Filippakopoulos P, Gileadi O, Clark AR, Yue WW, Burgess-Brown NA, Dean JLE.

J Mol Biol. 2018 Mar 2;430(5):722-736. doi: 10.1016/j.jmb.2017.12.018. Epub 2017 Dec 29.

PMID:
29291391
22.

A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.

Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A.

Science. 2017 Dec 8;358(6368):1332-1336. doi: 10.1126/science.aal4178.

23.

MAPK p38 regulates inflammatory gene expression via tristetraprolin: Doing good by stealth.

O'Neil JD, Ammit AJ, Clark AR.

Int J Biochem Cell Biol. 2018 Jan;94:6-9. doi: 10.1016/j.biocel.2017.11.003. Epub 2017 Nov 8. Review.

24.

PDBe: towards reusable data delivery infrastructure at protein data bank in Europe.

Mir S, Alhroub Y, Anyango S, Armstrong DR, Berrisford JM, Clark AR, Conroy MJ, Dana JM, Deshpande M, Gupta D, Gutmanas A, Haslam P, Mak L, Mukhopadhyay A, Nadzirin N, Paysan-Lafosse T, Sehnal D, Sen S, Smart OS, Varadi M, Kleywegt GJ, Velankar S.

Nucleic Acids Res. 2018 Jan 4;46(D1):D486-D492. doi: 10.1093/nar/gkx1070.

25.

Gravity outweighs the contribution of structure to passive ventilation-perfusion matching in the supine adult human lung.

Kang W, Clark AR, Tawhai MH.

J Appl Physiol (1985). 2018 Jan 1;124(1):23-33. doi: 10.1152/japplphysiol.00791.2016. Epub 2017 Oct 19.

26.

Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin.

Tang T, Scambler TE, Smallie T, Cunliffe HE, Ross EA, Rosner DR, O'Neil JD, Clark AR.

Sci Rep. 2017 Jun 28;7(1):4350. doi: 10.1038/s41598-017-04100-1.

27.

Targeting PP2A and proteasome activity ameliorates features of allergic airway disease in mice.

Nair PM, Starkey MR, Haw TJ, Liu G, Horvat JC, Morris JC, Verrills NM, Clark AR, Ammit AJ, Hansbro PM.

Allergy. 2017 Dec;72(12):1891-1903. doi: 10.1111/all.13212. Epub 2017 Jun 21.

PMID:
28543283
28.

Capturing complexity in pulmonary system modelling.

Clark AR, Kumar H, Burrowes K.

Proc Inst Mech Eng H. 2017 May;231(5):355-368. doi: 10.1177/0954411916683221. Review.

PMID:
28427314
29.

Feeding Your Baby In Utero: How the Uteroplacental Circulation Impacts Pregnancy.

James JL, Chamley LW, Clark AR.

Physiology (Bethesda). 2017 May;32(3):234-245. doi: 10.1152/physiol.00033.2016. Review.

30.

The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome.

Haneklaus M, O'Neil JD, Clark AR, Masters SL, O'Neill LAJ.

J Biol Chem. 2017 Apr 28;292(17):6869-6881. doi: 10.1074/jbc.M116.772947. Epub 2017 Mar 16.

31.

Association of Placental Jets and Mega-Jets With Reduced Villous Density.

Saghian R, James JL, Tawhai MH, Collins SL, Clark AR.

J Biomech Eng. 2017 May 1;139(5). doi: 10.1115/1.4036145.

PMID:
28267189
32.

Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo.

O'Neil JD, Ross EA, Ridley ML, Ding Q, Tang T, Rosner DR, Crowley T, Malhi D, Dean JL, Smallie T, Buckley CD, Clark AR.

Mol Cell Biol. 2017 May 16;37(11). pii: e00536-16. doi: 10.1128/MCB.00536-16. Print 2017 Jun 1.

33.

Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts.

Crowley T, O'Neil JD, Adams H, Thomas AM, Filer A, Buckley CD, Clark AR.

Arthritis Res Ther. 2017 Feb 10;19(1):35. doi: 10.1186/s13075-017-1248-6.

34.

TNF superfamily members promote hepatitis C virus entry via an NF-κB and myosin light chain kinase dependent pathway.

Fletcher NF, Clark AR, Balfe P, McKeating JA.

J Gen Virol. 2017 Mar;98(3):405-412. doi: 10.1099/jgv.0.000689. Epub 2017 Apr 1.

35.
36.

The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells.

Rahman MM, Prünte L, Lebender LF, Patel BS, Gelissen I, Hansbro PM, Morris JC, Clark AR, Verrills NM, Ammit AJ.

Sci Rep. 2016 Nov 16;6:37297. doi: 10.1038/srep37297.

37.

Strain dependent differences in glucocorticoid-induced bone loss between C57BL/6J and CD-1 mice.

Ersek A, Santo AI, Vattakuzhi Y, George S, Clark AR, Horwood NJ.

Sci Rep. 2016 Nov 4;6:36513. doi: 10.1038/srep36513.

38.

Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways.

McGuire VA, Rosner D, Ananieva O, Ross EA, Elcombe SE, Naqvi S, van den Bosch MMW, Monk CE, Ruiz-Zorrilla Diez T, Clark AR, Arthur JSC.

Mol Cell Biol. 2016 Dec 19;37(1). pii: e00454-16. doi: 10.1128/MCB.00454-16. Print 2017 Jan 1.

39.

Mathematical modeling of the female reproductive system: from oocyte to delivery.

Clark AR, Kruger JA.

Wiley Interdiscip Rev Syst Biol Med. 2017 Jan;9(1). doi: 10.1002/wsbm.1353. Epub 2016 Sep 9. Review.

PMID:
27612162
40.

Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.

Ross EA, Naylor AJ, O'Neil JD, Crowley T, Ridley ML, Crowe J, Smallie T, Tang TJ, Turner JD, Norling LV, Dominguez S, Perlman H, Verrills NM, Kollias G, Vitek MP, Filer A, Buckley CD, Dean JL, Clark AR.

Ann Rheum Dis. 2017 Mar;76(3):612-619. doi: 10.1136/annrheumdis-2016-209424. Epub 2016 Sep 5.

41.

A multiscale model of placental oxygen exchange: The effect of villous tree structure on exchange efficiency.

Lin M, Mauroy B, James JL, Tawhai MH, Clark AR.

J Theor Biol. 2016 Nov 7;408:1-12. doi: 10.1016/j.jtbi.2016.06.037. Epub 2016 Jul 1.

PMID:
27378004
42.

The Development of White-Asian Categorization: Contributions from Skin Color and Other Physiognomic Cues.

Dunham Y, Dotsch R, Clark AR, Stepanova EV.

PLoS One. 2016 Jun 29;11(6):e0158211. doi: 10.1371/journal.pone.0158211. eCollection 2016.

43.

In Vivo Neural Tissue Engineering: Cylindrical Biocompatible Hydrogels That Create New Neural Tracts in the Adult Mammalian Brain.

Clark AR, Carter AB, Hager LE, Price EM.

Stem Cells Dev. 2016 Aug 1;25(15):1109-18. doi: 10.1089/scd.2016.0069. Epub 2016 Jul 11.

PMID:
27295980
44.

Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells.

Rahman MM, Rumzhum NN, Hansbro PM, Morris JC, Clark AR, Verrills NM, Ammit AJ.

Cell Signal. 2016 Apr;28(4):325-34. doi: 10.1016/j.cellsig.2016.01.009. Epub 2016 Jan 26.

PMID:
26820662
45.

PDBe: improved accessibility of macromolecular structure data from PDB and EMDB.

Velankar S, van Ginkel G, Alhroub Y, Battle GM, Berrisford JM, Conroy MJ, Dana JM, Gore SP, Gutmanas A, Haslam P, Hendrickx PM, Lagerstedt I, Mir S, Fernandez Montecelo MA, Mukhopadhyay A, Oldfield TJ, Patwardhan A, Sanz-García E, Sen S, Slowley RA, Wainwright ME, Deshpande MS, Iudin A, Sahni G, Salavert Torres J, Hirshberg M, Mak L, Nadzirin N, Armstrong DR, Clark AR, Smart OS, Korir PK, Kleywegt GJ.

Nucleic Acids Res. 2016 Jan 4;44(D1):D385-95. doi: 10.1093/nar/gkv1047. Epub 2015 Oct 17.

46.

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.

Kugel S, Feldman JL, Klein MA, Silberman DM, Sebastián C, Mermel C, Dobersch S, Clark AR, Getz G, Denu JM, Mostoslavsky R.

Cell Rep. 2015 Oct 20;13(3):479-488. doi: 10.1016/j.celrep.2015.09.022. Epub 2015 Oct 8.

47.
48.

Translating Atopic Dermatitis Management Guidelines Into Practice for Primary Care Providers.

Eichenfield LF, Boguniewicz M, Simpson EL, Russell JJ, Block JK, Feldman SR, Clark AR, Tofte S, Dunn JD, Paller AS.

Pediatrics. 2015 Sep;136(3):554-65. doi: 10.1542/peds.2014-3678. Epub 2015 Aug 3. Review.

49.

Differences in solution dynamics between lens β-crystallin homodimers and heterodimers probed by hydrogen-deuterium exchange and deamidation.

Lampi KJ, Murray MR, Peterson MP, Eng BS, Yue E, Clark AR, Barbar E, David LL.

Biochim Biophys Acta. 2016 Jan;1860(1 Pt B):304-14. doi: 10.1016/j.bbagen.2015.06.014. Epub 2015 Jul 3.

50.

Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide.

Smallie T, Ross EA, Ammit AJ, Cunliffe HE, Tang T, Rosner DR, Ridley ML, Buckley CD, Saklatvala J, Dean JL, Clark AR.

J Immunol. 2015 Jul 1;195(1):277-88. doi: 10.4049/jimmunol.1402830. Epub 2015 May 27.

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