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Items: 1 to 50 of 381

1.

Pyonitrins A-D: Chimeric Natural Products Produced by Pseudomonas protegens.

Mevers E, Saurí J, Helfrich EJN, Henke M, Barns KJ, Bugni TS, Andes D, Currie CR, Clardy J.

J Am Chem Soc. 2019 Oct 16. doi: 10.1021/jacs.9b09739. [Epub ahead of print]

PMID:
31600443
2.

Microbial community modulates growth of symbiotic fungus required for stingless bee metamorphosis.

Paludo CR, Pishchany G, Andrade-Dominguez A, Silva-Junior EA, Menezes C, Nascimento FS, Currie CR, Kolter R, Clardy J, Pupo MT.

PLoS One. 2019 Jul 25;14(7):e0219696. doi: 10.1371/journal.pone.0219696. eCollection 2019.

3.

An elusive electron shuttle from a facultative anaerobe.

Mevers E, Su L, Pishchany G, Baruch M, Cornejo J, Hobert E, Dimise E, Ajo-Franklin CM, Clardy J.

Elife. 2019 Jun 24;8. pii: e48054. doi: 10.7554/eLife.48054.

4.

Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide.

Henke MT, Kenny DJ, Cassilly CD, Vlamakis H, Xavier RJ, Clardy J.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12672-12677. doi: 10.1073/pnas.1904099116. Epub 2019 Jun 10.

5.

Metabolites Involved in Immune Evasion by Batrachochytrium dendrobatidis Include the Polyamine Spermidine.

Rollins-Smith LA, Ruzzini AC, Fites JS, Reinert LK, Hall EM, Joosse BA, Ravikumar VI, Huebner MI, Aka A, Kehs MH, Gillard BM, Doe E, Tasca JA, Umile TP, Clardy J, Minbiole KPC.

Infect Immun. 2019 Apr 23;87(5). pii: e00035-19. doi: 10.1128/IAI.00035-19. Print 2019 Mar.

PMID:
30833338
6.

A One-Year Institutional View of Resident Physician Burnout.

Thrush CR, Guise JB, Gathright MM, Messias E, Flynn V, Belknap T, Thapa PB, Williams DK, Nada EM, Clardy JA.

Acad Psychiatry. 2019 Aug;43(4):361-368. doi: 10.1007/s40596-019-01043-9. Epub 2019 Feb 28.

PMID:
30820845
7.

Differences in burnout prevalence between clinical professionals and biomedical scientists in an academic medical centre: a cross-sectional survey.

Messias E, Gathright MM, Freeman ES, Flynn V, Atkinson T, Thrush CR, Clardy JA, Thapa P.

BMJ Open. 2019 Feb 19;9(2):e023506. doi: 10.1136/bmjopen-2018-023506.

8.

One-Year Changes in Intern Physicians' Quality Improvement and Patient Safety Knowledge, Awareness, Engagement, and Interest.

Filip AB, Thrush CR, Atkinson T, Podrazik P, Eastin T, Jaffar M, Clardy JA.

Am J Med Qual. 2019 Sep/Oct;34(5):517-518. doi: 10.1177/1062860619830506. Epub 2019 Feb 13. No abstract available.

PMID:
30758219
9.

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM.

ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5.

10.

A high-throughput, whole cell assay to identify compounds active against carbapenem-resistant Klebsiella pneumoniae.

Liao J, Xu G, Mevers EE, Clardy J, Watnick PI.

PLoS One. 2018 Dec 21;13(12):e0209389. doi: 10.1371/journal.pone.0209389. eCollection 2018.

11.

Tiny crystals have big potential for determining structures of small molecules.

Brown A, Clardy J.

Nature. 2018 Dec;564(7736):348-349. doi: 10.1038/d41586-018-07756-5. No abstract available.

PMID:
30559356
12.

GABA-modulating bacteria of the human gut microbiota.

Strandwitz P, Kim KH, Terekhova D, Liu JK, Sharma A, Levering J, McDonald D, Dietrich D, Ramadhar TR, Lekbua A, Mroue N, Liston C, Stewart EJ, Dubin MJ, Zengler K, Knight R, Gilbert JA, Clardy J, Lewis K.

Nat Microbiol. 2019 Mar;4(3):396-403. doi: 10.1038/s41564-018-0307-3. Epub 2018 Dec 10.

13.

Convergent evolution of complex structures for ant-bacterial defensive symbiosis in fungus-farming ants.

Li H, Sosa-Calvo J, Horn HA, Pupo MT, Clardy J, Rabeling C, Schultz TR, Currie CR.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10720-10725. doi: 10.1073/pnas.1809332115. Epub 2018 Oct 3.

14.

Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen.

Pishchany G, Mevers E, Ndousse-Fetter S, Horvath DJ Jr, Paludo CR, Silva-Junior EA, Koren S, Skaar EP, Clardy J, Kolter R.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10124-10129. doi: 10.1073/pnas.1807613115. Epub 2018 Sep 18.

15.

A plant-responsive bacterial-signaling system senses an ethanolamine derivative.

Coutinho BG, Mevers E, Schaefer AL, Pelletier DA, Harwood CS, Clardy J, Greenberg EP.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9785-9790. doi: 10.1073/pnas.1809611115. Epub 2018 Sep 6.

16.

Mammalian Cells Engineered To Produce New Steroids.

Spady ES, Wyche TP, Rollins NJ, Clardy J, Way JC, Silver PA.

Chembiochem. 2018 Sep 4;19(17):1827-1833. doi: 10.1002/cbic.201800214. Epub 2018 Jul 26.

17.

Oridonin inhibits aberrant AKT activation in breast cancer.

Sun B, Wang G, Liu H, Liu P, Twal WO, Cheung H, Carroll SL, Ethier SP, Mevers EE, Clardy J, Roberts T, Chen C, Li Q, Wang L, Yang M, Zhao JJ, Wang Q.

Oncotarget. 2018 Feb 1;9(35):23878-23889. doi: 10.18632/oncotarget.24378. eCollection 2018 May 8.

18.

Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes.

Ganley JG, Carr G, Ioerger TR, Sacchettini JC, Clardy J, Derbyshire ER.

Chembiochem. 2018 Aug 6;19(15):1590-1594. doi: 10.1002/cbic.201800124. Epub 2018 Jun 10.

PMID:
29700993
19.

A Repeating Sulfated Galactan Motif Resuscitates Dormant Micrococcus luteus Bacteria.

Böttcher T, Szamosvári D, Clardy J.

Appl Environ Microbiol. 2018 Jun 18;84(13). pii: e00745-18. doi: 10.1128/AEM.00745-18. Print 2018 Jul 1.

20.

Absolute Configurations of Griseorhodins A and C.

Ortega HE, Batista JM Jr, Melo WGP, Clardy J, Pupo MT.

Tetrahedron Lett. 2017 Dec 13;58(50):4721-4723. doi: 10.1016/j.tetlet.2017.11.008. Epub 2017 Nov 7.

21.

Pyrazines from bacteria and ants: convergent chemistry within an ecological niche.

Silva-Junior EA, Ruzzini AC, Paludo CR, Nascimento FS, Currie CR, Clardy J, Pupo MT.

Sci Rep. 2018 Feb 7;8(1):2595. doi: 10.1038/s41598-018-20953-6.

22.

Tundrenone: An Atypical Secondary Metabolite from Bacteria with Highly Restricted Primary Metabolism.

Puri AW, Mevers E, Ramadhar TR, Petras D, Liu D, Piel J, Dorrestein PC, Greenberg EP, Lidstrom ME, Clardy J.

J Am Chem Soc. 2018 Feb 14;140(6):2002-2006. doi: 10.1021/jacs.7b12240. Epub 2018 Jan 30.

23.

Stingless Bee Larvae Require Fungal Steroid to Pupate.

Paludo CR, Menezes C, Silva-Junior EA, Vollet-Neto A, Andrade-Dominguez A, Pishchany G, Khadempour L, do Nascimento FS, Currie CR, Kolter R, Clardy J, Pupo MT.

Sci Rep. 2018 Jan 18;8(1):1122. doi: 10.1038/s41598-018-19583-9.

24.

Quinones are growth factors for the human gut microbiota.

Fenn K, Strandwitz P, Stewart EJ, Dimise E, Rubin S, Gurubacharya S, Clardy J, Lewis K.

Microbiome. 2017 Dec 20;5(1):161. doi: 10.1186/s40168-017-0380-5.

25.

The Crystalline Sponge Method: A Solvent-Based Strategy to Facilitate Noncovalent Ordered Trapping of Solid and Liquid Organic Compounds.

Ramadhar TR, Zheng SL, Chen YS, Clardy J.

CrystEngComm. 2017 Aug 21;19(31):4528-4534. doi: 10.1039/C7CE00885F. Epub 2017 Jul 14.

26.

Chemical Interaction among Termite-Associated Microbes.

Mevers E, Chouvenc T, Su NY, Clardy J.

J Chem Ecol. 2017 Dec;43(11-12):1078-1085. doi: 10.1007/s10886-017-0900-6. Epub 2017 Nov 13.

27.

Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum.

Brancucci NMB, Gerdt JP, Wang C, De Niz M, Philip N, Adapa SR, Zhang M, Hitz E, Niederwieser I, Boltryk SD, Laffitte MC, Clark MA, Grüring C, Ravel D, Blancke Soares A, Demas A, Bopp S, Rubio-Ruiz B, Conejo-Garcia A, Wirth DF, Gendaszewska-Darmach E, Duraisingh MT, Adams JH, Voss TS, Waters AP, Jiang RHY, Clardy J, Marti M.

Cell. 2017 Dec 14;171(7):1532-1544.e15. doi: 10.1016/j.cell.2017.10.020. Epub 2017 Nov 9.

28.

Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata.

Guo H, Rischer M, Sperfeld M, Weigel C, Menzel KD, Clardy J, Beemelmanns C.

Bioorg Med Chem. 2017 Nov 15;25(22):6088-6097. doi: 10.1016/j.bmc.2017.06.053. Epub 2017 Jul 1.

29.

Mating in the Closest Living Relatives of Animals Is Induced by a Bacterial Chondroitinase.

Woznica A, Gerdt JP, Hulett RE, Clardy J, King N.

Cell. 2017 Sep 7;170(6):1175-1183.e11. doi: 10.1016/j.cell.2017.08.005. Epub 2017 Aug 31.

30.

Tryptorubin A: A Polycyclic Peptide from a Fungus-Derived Streptomycete.

Wyche TP, Ruzzini AC, Schwab L, Currie CR, Clardy J.

J Am Chem Soc. 2017 Sep 20;139(37):12899-12902. doi: 10.1021/jacs.7b06176. Epub 2017 Sep 6.

31.

The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK.

Boccitto M, Lee N, Sakamoto S, Spruce LA, Handa H, Clardy J, Seeholzer SH, Kalb RG.

Mar Drugs. 2017 Aug 7;15(8). pii: E246. doi: 10.3390/md15080246.

32.

Defense contracts: molecular protection in insect-microbe symbioses.

Van Arnam EB, Currie CR, Clardy J.

Chem Soc Rev. 2018 Mar 5;47(5):1638-1651. doi: 10.1039/c7cs00340d. Review.

PMID:
28745342
33.

Unequivocal determination of complex molecular structures using anisotropic NMR measurements.

Liu Y, Saurí J, Mevers E, Peczuh MW, Hiemstra H, Clardy J, Martin GE, Williamson RT.

Science. 2017 Apr 7;356(6333). pii: eaam5349. doi: 10.1126/science.aam5349.

34.

Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides.

Wyche TP, Ruzzini AC, Beemelmanns C, Kim KH, Klassen JL, Cao S, Poulsen M, Bugni TS, Currie CR, Clardy J.

Org Lett. 2017 Apr 7;19(7):1772-1775. doi: 10.1021/acs.orglett.7b00545. Epub 2017 Mar 22.

35.

Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39.

Beemelmanns C, Ramadhar TR, Kim KH, Klassen JL, Cao S, Wyche TP, Hou Y, Poulsen M, Bugni TS, Currie CR, Clardy J.

Org Lett. 2017 Mar 3;19(5):1000-1003. doi: 10.1021/acs.orglett.6b03831. Epub 2017 Feb 16.

36.

Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases.

Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA.

Cell. 2017 Jan 26;168(3):517-526.e18. doi: 10.1016/j.cell.2016.12.021. Epub 2017 Jan 19.

37.

A common bacterial metabolite elicits prion-based bypass of glucose repression.

Garcia DM, Dietrich D, Clardy J, Jarosz DF.

Elife. 2016 Nov 29;5. pii: e17978. doi: 10.7554/eLife.17978.

38.

Dynamic metabolic exchange governs a marine algal-bacterial interaction.

Segev E, Wyche TP, Kim KH, Petersen J, Ellebrandt C, Vlamakis H, Barteneva N, Paulson JN, Chai L, Clardy J, Kolter R.

Elife. 2016 Nov 18;5. pii: e17473. doi: 10.7554/eLife.17473.

39.

Selvamicin, an atypical antifungal polyene from two alternative genomic contexts.

Van Arnam EB, Ruzzini AC, Sit CS, Horn H, Pinto-Tomás AA, Currie CR, Clardy J.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):12940-12945. Epub 2016 Nov 1.

40.

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail JA, Mitasev B, Moss EL, Sayes M, Van Gessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusovsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler EA, Wirth DF, Scherer CA, Schreiber SL.

Nature. 2016 Oct 20;538(7625):344-349. doi: 10.1038/nature19804. Epub 2016 Sep 7.

41.

Compounds that select against the tetracycline-resistance efflux pump.

Stone LK, Baym M, Lieberman TD, Chait R, Clardy J, Kishony R.

Nat Chem Biol. 2016 Nov;12(11):902-904. doi: 10.1038/nchembio.2176. Epub 2016 Sep 19.

42.

Gene Flow and Molecular Innovation in Bacteria.

Ruzzini AC, Clardy J.

Curr Biol. 2016 Sep 26;26(18):R859-R864. doi: 10.1016/j.cub.2016.08.004. Review.

43.

Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors.

Vafai SB, Mevers E, Higgins KW, Fomina Y, Zhang J, Mandinova A, Newman D, Shaw SY, Clardy J, Mootha VK.

PLoS One. 2016 Sep 13;11(9):e0162686. doi: 10.1371/journal.pone.0162686. eCollection 2016.

44.

Homodimericin A: A Complex Hexacyclic Fungal Metabolite.

Mevers E, Saurí J, Liu Y, Moser A, Ramadhar TR, Varlan M, Williamson RT, Martin GE, Clardy J.

J Am Chem Soc. 2016 Sep 28;138(38):12324-7. doi: 10.1021/jacs.6b07588. Epub 2016 Sep 16.

45.

Genome Sequence of Streptomyces sp. Strain RTd22, an Endophyte of the Mexican Sunflower.

Chagas FO, Ruzzini AC, Bacha LV, Samborskyy M, Conti R, Pessotti RC, de Oliveira LG, Clardy J, Pupo MT.

Genome Announc. 2016 Jul 21;4(4). pii: e00693-16. doi: 10.1128/genomeA.00693-16.

46.

A New Diketopiperazine, Cyclo(D-trans-Hyp-L-Leu) from a Kenyan Bacterium Bacillus licheniformis LB 8CT.

Lee SR, Beemelmanns C, Tsuma LM, Clardy J, Cao S, Kim KH.

Nat Prod Commun. 2016 Apr;11(4):461-3.

PMID:
27396193
47.

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.

Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG Jr.

Cell. 2016 Jun 30;166(1):126-39. doi: 10.1016/j.cell.2016.05.042.

48.

Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates.

Woznica A, Cantley AM, Beemelmanns C, Freinkman E, Clardy J, King N.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7894-9. doi: 10.1073/pnas.1605015113. Epub 2016 Jun 27.

49.

Total chemical synthesis of lassomycin and lassomycin-amide.

Lear S, Munshi T, Hudson AS, Hatton C, Clardy J, Mosely JA, Bull TJ, Sit CS, Cobb SL.

Org Biomol Chem. 2016 May 11;14(19):4534-41. doi: 10.1039/c6ob00631k.

PMID:
27101411
50.

Diketopiperazines from Costa Rican endolichenic fungus Colpoma sp. CR1465A.

Lee S, Tamayo-Castillo G, Pang C, Clardy J, Cao S, Kim KH.

Bioorg Med Chem Lett. 2016 May 15;26(10):2438-2441. doi: 10.1016/j.bmcl.2016.03.115. Epub 2016 Apr 2.

PMID:
27080179

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