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Making Medicines Baby Size: The Challenges in Bridging the Formulation Gap in Neonatal Medicine.

O'Brien F, Clapham D, Krysiak K, Batchelor H, Field P, Caivano G, Pertile M, Nunn A, Tuleu C.

Int J Mol Sci. 2019 May 31;20(11). pii: E2688. doi: 10.3390/ijms20112688. Review.


Automation and Scale Up of Somatic Embryogenesis for Commercial Plant Production, With Emphasis on Conifers.

Egertsdotter U, Ahmad I, Clapham D.

Front Plant Sci. 2019 Feb 18;10:109. doi: 10.3389/fpls.2019.00109. eCollection 2019. Review.


Structure of the mammalian TRPM7, a magnesium channel required during embryonic development.

Duan J, Li Z, Li J, Hulse RE, Santa-Cruz A, Valinsky WC, Abiria SA, Krapivinsky G, Zhang J, Clapham DE.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8201-E8210. doi: 10.1073/pnas.1810719115. Epub 2018 Aug 14.


Structure of the mouse TRPC4 ion channel.

Duan J, Li J, Zeng B, Chen GL, Peng X, Zhang Y, Wang J, Clapham DE, Li Z, Zhang J.

Nat Commun. 2018 Aug 6;9(1):3102. doi: 10.1038/s41467-018-05247-9.


Cryo-EM structure of the polycystin 2-l1 ion channel.

Hulse RE, Li Z, Huang RK, Zhang J, Clapham DE.

Elife. 2018 Jul 13;7. pii: e36931. doi: 10.7554/eLife.36931.


Influences: Short circuits.

Clapham DE.

J Gen Physiol. 2018 Apr 2;150(4):513-515. doi: 10.1085/jgp.201812034. Epub 2018 Mar 20. No abstract available.


Structure of full-length human TRPM4.

Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J, Clapham DE.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2377-2382. doi: 10.1073/pnas.1722038115. Epub 2018 Feb 20.


Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium.

Liu X, Vien T, Duan J, Sheu SH, DeCaen PG, Clapham DE.

Elife. 2018 Feb 14;7. pii: e33183. doi: 10.7554/eLife.33183.


Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression.

Krapivinsky G, Krapivinsky L, Renthal NE, Santa-Cruz A, Manasian Y, Clapham DE.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7092-E7100. doi: 10.1073/pnas.1708427114. Epub 2017 Aug 7.


TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles.

Abiria SA, Krapivinsky G, Sah R, Santa-Cruz AG, Chaudhuri D, Zhang J, Adstamongkonkul P, DeCaen PG, Clapham DE.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6079-E6088. doi: 10.1073/pnas.1707380114. Epub 2017 Jul 10.


Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Walker AL, Ancellin N, Beaufils B, Bergeal M, Binnie M, Bouillot A, Clapham D, Denis A, Haslam CP, Holmes DS, Hutchinson JP, Liddle J, McBride A, Mirguet O, Mowat CG, Rowland P, Tiberghien N, Trottet L, Uings I, Webster SP, Zheng X, Mole DJ.

J Med Chem. 2017 Apr 27;60(8):3383-3404. doi: 10.1021/acs.jmedchem.7b00055. Epub 2017 Apr 11.


CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility.

Chung JJ, Miki K, Kim D, Shim SH, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, Clapham DE.

Elife. 2017 Feb 23;6. pii: e23082. doi: 10.7554/eLife.23082.


Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function.

Platt CD, Chou J, Houlihan P, Badran YR, Kumar L, Bainter W, Poliani PL, Perez CJ, Dent SYR, Clapham DE, Benavides F, Geha RS.

J Allergy Clin Immunol. 2017 Dec;140(6):1651-1659.e1. doi: 10.1016/j.jaci.2016.12.974. Epub 2017 Feb 10.


Progress in ciliary ion channel physiology.

Pablo JL, DeCaen PG, Clapham DE.

J Gen Physiol. 2017 Jan;149(1):37-47. doi: 10.1085/jgp.201611696. Epub 2016 Dec 20. Review.


The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.

Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E.

Cell. 2016 Oct 20;167(3):763-773.e11. doi: 10.1016/j.cell.2016.09.048.


Effect of formulation variables on oral grittiness and preferences of multiparticulate formulations in adult volunteers.

Lopez FL, Bowles A, Gul MO, Clapham D, Ernest TB, Tuleu C.

Eur J Pharm Sci. 2016 Sep 20;92:156-62. doi: 10.1016/j.ejps.2016.07.006. Epub 2016 Jul 9.


Atypical calcium regulation of the PKD2-L1 polycystin ion channel.

DeCaen PG, Liu X, Abiria S, Clapham DE.

Elife. 2016 Jun 27;5. pii: e13413. doi: 10.7554/eLife.13413.


Implications of In-Use Photostability: Proposed Guidance for Photostability Testing and Labeling to Support the Administration of Photosensitive Pharmaceutical Products, Part 3. Oral Drug Products.

Allain L, Baertschi SW, Clapham D, Foti C, Lantaff WM, Reed RA, Templeton AC, Tønnesen HH.

J Pharm Sci. 2016 May;105(5):1586-1594. doi: 10.1016/j.xphs.2016.02.035. Epub 2016 Apr 5. Review.


Primary cilia are not calcium-responsive mechanosensors.

Delling M, Indzhykulian AA, Liu X, Li Y, Xie T, Corey DP, Clapham DE.

Nature. 2016 Mar 31;531(7596):656-60. doi: 10.1038/nature17426. Epub 2016 Mar 23.


Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition.

Chaudhuri D, Artiga DJ, Abiria SA, Clapham DE.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1872-80. doi: 10.1073/pnas.1602264113. Epub 2016 Mar 14.


Molecular basis of ion permeability in a voltage-gated sodium channel.

Naylor CE, Bagnéris C, DeCaen PG, Sula A, Scaglione A, Clapham DE, Wallace BA.

EMBO J. 2016 Apr 15;35(8):820-30. doi: 10.15252/embj.201593285. Epub 2016 Feb 12.


Naturally Produced Defensive Alkenal Compounds Activate TRPA1.

Blair NT, Philipson BI, Richards PM, Doerner JF, Segura A, Silver WL, Clapham DE.

Chem Senses. 2016 May;41(4):281-92. doi: 10.1093/chemse/bjv071. Epub 2016 Feb 3.


Bitter tastant responses in the amoeba Dictyostelium correlate with rat and human taste assays.

Cocorocchio M, Ives R, Clapham D, Andrews PL, Williams RS.

ALTEX. 2016;33(3):225-36. doi: 10.14573/altex.1509011. Epub 2015 Dec 22.


The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex.

Syeda SS, Carlson EJ, Miller MR, Francis R, Clapham DE, Lishko PV, Hawkinson JE, Hook D, Georg GI.

ACS Chem Biol. 2016 Feb 19;11(2):452-9. doi: 10.1021/acschembio.5b00748. Epub 2015 Dec 16.


Ion channels and calcium signaling in motile cilia.

Doerner JF, Delling M, Clapham DE.

Elife. 2015 Dec 9;4. pii: e11066. doi: 10.7554/eLife.11066.


Structural biology: Pain-sensing TRPA1 channel resolved.

Clapham DE.

Nature. 2015 Apr 23;520(7548):439-41. doi: 10.1038/nature14383. Epub 2015 Apr 8. No abstract available.


Implications of In-Use Photostability: Proposed Guidance for Photostability Testing and Labeling to Support the Administration of Photosensitive Pharmaceutical Products, Part 2: Topical Drug Product.

Baertschi SW, Clapham D, Foti C, Kleinman MH, Kristensen S, Reed RA, Templeton AC, Tønnesen HH.

J Pharm Sci. 2015 Sep;104(9):2688-701. doi: 10.1002/jps.24396. Epub 2015 Feb 24. Review.


Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view.

Cai X, Wang X, Patel S, Clapham DE.

Cell Calcium. 2015 Mar;57(3):166-73. doi: 10.1016/j.ceca.2014.11.007. Epub 2014 Dec 2. Review.


Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus.

DeCaen PG, Takahashi Y, Krulwich TA, Ito M, Clapham DE.

Elife. 2014 Nov 11;3. doi: 10.7554/eLife.04387.


Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex.

Cai X, Wang X, Clapham DE.

Mol Biol Evol. 2014 Oct;31(10):2735-40. doi: 10.1093/molbev/msu218. Epub 2014 Jul 24.


The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase.

Krapivinsky G, Krapivinsky L, Manasian Y, Clapham DE.

Cell. 2014 May 22;157(5):1061-72. doi: 10.1016/j.cell.2014.03.046.


Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.

Bagnéris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8428-33. doi: 10.1073/pnas.1406855111. Epub 2014 May 21.


Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility.

Chung JJ, Shim SH, Everley RA, Gygi SP, Zhuang X, Clapham DE.

Cell. 2014 May 8;157(4):808-22. doi: 10.1016/j.cell.2014.02.056.


Outstanding questions regarding the permeation, selectivity, and regulation of the mitochondrial calcium uniporter.

Chaudhuri D, Clapham DE.

Biochem Biophys Res Commun. 2014 Jul 11;449(4):367-9. doi: 10.1016/j.bbrc.2014.04.141. Epub 2014 Apr 30.


Caspase-11 controls interleukin-1β release through degradation of TRPC1.

Py BF, Jin M, Desai BN, Penumaka A, Zhu H, Kober M, Dietrich A, Lipinski MM, Henry T, Clapham DE, Yuan J.

Cell Rep. 2014 Mar 27;6(6):1122-1128. doi: 10.1016/j.celrep.2014.02.015. Epub 2014 Mar 13.


Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels.

Riccio A, Li Y, Tsvetkov E, Gapon S, Yao GL, Smith KS, Engin E, Rudolph U, Bolshakov VY, Clapham DE.

J Neurosci. 2014 Mar 5;34(10):3653-67. doi: 10.1523/JNEUROSCI.2274-13.2014.


The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.


Performance of a redesigned HIV Selectest enzyme-linked immunosorbent assay optimized to minimize vaccine-induced seropositivity in HIV vaccine trial participants.

Penezina O, Krueger NX, Rodriguez-Chavez IR, Busch MP, Hural J, Kim JH, O'Connell RJ, Hunter E, Aboud S, Higgins K, Kovalenko V, Clapham D, Crane D, Levin AE; HIV Selectest Study Group.

Clin Vaccine Immunol. 2014 Mar;21(3):391-8. doi: 10.1128/CVI.00748-13. Epub 2014 Jan 8.


No time for spruce: rapid dampening of circadian rhythms in Picea abies (L. Karst).

Gyllenstrand N, Karlgren A, Clapham D, Holm K, Hall A, Gould PD, Källman T, Lagercrantz U.

Plant Cell Physiol. 2014 Mar;55(3):535-50. doi: 10.1093/pcp/pct199. Epub 2013 Dec 19.


Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1.

Tsai MF, Jiang D, Zhao L, Clapham D, Miller C.

J Gen Physiol. 2014 Jan;143(1):67-73. doi: 10.1085/jgp.201311096. Epub 2013 Dec 16.


Autophagy and metacaspase determine the mode of cell death in plants.

Minina EA, Filonova LH, Fukada K, Savenkov EI, Gogvadze V, Clapham D, Sanchez-Vera V, Suarez MF, Zhivotovsky B, Daniel G, Smertenko A, Bozhkov PV.

J Cell Biol. 2013 Dec 23;203(6):917-27.


Direct recording and molecular identification of the calcium channel of primary cilia.

DeCaen PG, Delling M, Vien TN, Clapham DE.

Nature. 2013 Dec 12;504(7479):315-8. doi: 10.1038/nature12832. Erratum in: Nature. 2014 Sep 11;513(7517):266.


Primary cilia are specialized calcium signalling organelles.

Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE.

Nature. 2013 Dec 12;504(7479):311-4. doi: 10.1038/nature12833.


TRPV3 channels mediate strontium-induced mouse-egg activation.

Carvacho I, Lee HC, Fissore RA, Clapham DE.

Cell Rep. 2013 Dec 12;5(5):1375-86. doi: 10.1016/j.celrep.2013.11.007. Epub 2013 Dec 5.


The mother of all endocytosis.

Clapham DE.

Elife. 2013 Nov 26;2:e01738. doi: 10.7554/eLife.01738.


EMRE is an essential component of the mitochondrial calcium uniporter complex.

Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK.

Science. 2013 Dec 13;342(6164):1379-82. doi: 10.1126/science.1242993. Epub 2013 Nov 14.


Sperm BerserKers.

Clapham DE.

Elife. 2013 Oct 8;2:e01469. doi: 10.7554/eLife.01469.


Role of the C-terminal domain in the structure and function of tetrameric sodium channels.

Bagnéris C, Decaen PG, Hall BA, Naylor CE, Clapham DE, Kay CW, Wallace BA.

Nat Commun. 2013;4:2465. doi: 10.1038/ncomms3465.


Implications of in-use photostability: proposed guidance for photostability testing and labeling to support the administration of photosensitive pharmaceutical products, part 1: drug products administered by injection.

Baertschi SW, Clapham D, Foti C, Jansen PJ, Kristensen S, Reed RA, Templeton AC, Tønnesen HH.

J Pharm Sci. 2013 Nov;102(11):3888-99. doi: 10.1002/jps.23717. Epub 2013 Sep 5.


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