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Items: 50

1.

The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.

Pervolaraki E, Tyson AL, Pibiri F, Poulter SL, Reichelt AC, Rodgers RJ, Clapcote SJ, Lever C, Andreae LC, Dachtler J.

Mol Autism. 2019 Feb 28;10:8. doi: 10.1186/s13229-019-0261-9. eCollection 2019.

2.

Downregulation of the Central Noradrenergic System by Toxoplasma gondii Infection.

Alsaady I, Tedford E, Alsaad M, Bristow G, Kohli S, Murray M, Reeves M, Vijayabaskar MS, Clapcote SJ, Wastling J, McConkey GA.

Infect Immun. 2019 Jan 24;87(2). pii: e00789-18. doi: 10.1128/IAI.00789-18. Print 2019 Feb.

3.

LHFPL5 mutation: A rare cause of non-syndromic autosomal recessive hearing loss.

Al-Amri AH, Al Saegh A, Al-Mamari W, El-Asrag ME, Al-Kindi MN, Al Khabouri M, Al Wardy N, Al Lamki K, Gabr A, Idris A, Inglehearn CF, Clapcote SJ, Ali M.

Eur J Med Genet. 2018 Nov 23. pii: S1769-7212(18)30102-2. doi: 10.1016/j.ejmg.2018.11.026. [Epub ahead of print]

PMID:
30476627
4.

TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.

Cheung SY, Henrot M, Al-Saad M, Baumann M, Muller H, Unger A, Rubaiy HN, Mathar I, Dinkel K, Nussbaumer P, Klebl B, Freichel M, Rode B, Trainor S, Clapcote SJ, Christmann M, Waldmann H, Abbas SK, Beech DJ, Vasudev NS.

Oncotarget. 2018 Jul 3;9(51):29634-29643. doi: 10.18632/oncotarget.25659. eCollection 2018 Jul 3.

5.

Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-Related Metabolic Diseases.

Clapcote SJ.

Adv Neurobiol. 2017;17:103-131. doi: 10.1007/978-3-319-58811-7_5. Review.

PMID:
28956331
6.

Circadian Disruptions in the Myshkin Mouse Model of Mania Are Independent of Deficits in Suprachiasmatic Molecular Clock Function.

Timothy JWS, Klas N, Sanghani HR, Al-Mansouri T, Hughes ATL, Kirshenbaum GS, Brienza V, Belle MDC, Ralph MR, Clapcote SJ, Piggins HD.

Biol Psychiatry. 2018 Dec 1;84(11):827-837. doi: 10.1016/j.biopsych.2017.04.018. Epub 2017 May 20.

7.

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.

McGirr A, Lipina TV, Mun HS, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JG, Liu F, Baillie GS, Clapcote SJ, Roder JC.

Neuropsychopharmacology. 2017 Apr;42(5):1178. doi: 10.1038/npp.2016.263. No abstract available.

8.

Deficits in social behavioral tests in a mouse model of alternating hemiplegia of childhood.

Kirshenbaum GS, Idris NF, Dachtler J, Roder JC, Clapcote SJ.

J Neurogenet. 2016 Mar;30(1):42-9. doi: 10.1080/01677063.2016.1182525.

9.

Homozygous single base deletion in TUSC3 causes intellectual disability with developmental delay in an Omani family.

Al-Amri A, Saegh AA, Al-Mamari W, El-Asrag ME, Ivorra JL, Cardno AG, Inglehearn CF, Clapcote SJ, Ali M.

Am J Med Genet A. 2016 Jul;170(7):1826-31. doi: 10.1002/ajmg.a.37690. Epub 2016 May 5.

10.

Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice.

Dachtler J, Elliott C, Rodgers RJ, Baillie GS, Clapcote SJ.

Sci Rep. 2016 Jan 5;6:18748. doi: 10.1038/srep18748.

11.

Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.

Dachtler J, Ivorra JL, Rowland TE, Lever C, Rodgers RJ, Clapcote SJ.

Behav Neurosci. 2015 Dec;129(6):765-76. doi: 10.1037/bne0000108.

12.

Characterization of cognitive deficits in mice with an alternating hemiplegia-linked mutation.

Kirshenbaum GS, Dachtler J, Roder JC, Clapcote SJ.

Behav Neurosci. 2015 Dec;129(6):822-31. doi: 10.1037/bne0000097. Epub 2015 Oct 26.

13.

Transgenic rescue of phenotypic deficits in a mouse model of alternating hemiplegia of childhood.

Kirshenbaum GS, Dachtler J, Roder JC, Clapcote SJ.

Neurogenetics. 2016 Jan;17(1):57-63. doi: 10.1007/s10048-015-0461-1. Epub 2015 Oct 13.

14.

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.

McGirr A, Lipina TV, Mun HS, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JG, Liu F, Baillie GS, Clapcote SJ, Roder JC.

Neuropsychopharmacology. 2016 Mar;41(4):1080-92. doi: 10.1038/npp.2015.240. Epub 2015 Aug 14. Erratum in: Neuropsychopharmacology. 2017 Apr;42(5):1178.

15.

Deletion of α-neurexin II results in autism-related behaviors in mice.

Dachtler J, Glasper J, Cohen RN, Ivorra JL, Swiffen DJ, Jackson AJ, Harte MK, Rodgers RJ, Clapcote SJ.

Transl Psychiatry. 2014 Nov 25;4:e484. doi: 10.1038/tp.2014.123.

16.

Disc1 variation leads to specific alterations in adult neurogenesis.

Chandran JS, Kazanis I, Clapcote SJ, Ogawa F, Millar JK, Porteous DJ, Ffrench-Constant C.

PLoS One. 2014 Oct 1;9(10):e108088. doi: 10.1371/journal.pone.0108088. eCollection 2014.

17.

Distinct neurological disorders with ATP1A3 mutations.

Heinzen EL, Arzimanoglou A, Brashear A, Clapcote SJ, Gurrieri F, Goldstein DB, Jóhannesson SH, Mikati MA, Neville B, Nicole S, Ozelius LJ, Poulsen H, Schyns T, Sweadner KJ, van den Maagdenberg A, Vilsen B; ATP1A3 Working Group.

Lancet Neurol. 2014 May;13(5):503-14. doi: 10.1016/S1474-4422(14)70011-0. Review.

18.

DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan.

Porteous DJ, Thomson PA, Millar JK, Evans KL, Hennah W, Soares DC, McCarthy S, McCombie WR, Clapcote SJ, Korth C, Brandon NJ, Sawa A, Kamiya A, Roder JC, Lawrie SM, McIntosh AM, St Clair D, Blackwood DH.

Mol Psychiatry. 2014 Feb;19(2):141-3. doi: 10.1038/mp.2013.160. No abstract available.

19.

Na+/K+ ATPase α1 and α3 isoforms are differentially expressed in α- and γ-motoneurons.

Edwards IJ, Bruce G, Lawrenson C, Howe L, Clapcote SJ, Deuchars SA, Deuchars J.

J Neurosci. 2013 Jun 12;33(24):9913-9. doi: 10.1523/JNEUROSCI.5584-12.2013.

20.
21.

Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPase α3 missense mutant mice.

Kirshenbaum GS, Dawson N, Mullins JG, Johnston TH, Drinkhill MJ, Edwards IJ, Fox SH, Pratt JA, Brotchie JM, Roder JC, Clapcote SJ.

PLoS One. 2013;8(3):e60141. doi: 10.1371/journal.pone.0060141. Epub 2013 Mar 20.

22.

Genetic suppression of agrin reduces mania-like behavior in Na+ , K+ -ATPase α3 mutant mice.

Kirshenbaum GS, Clapcote SJ, Petersen J, Vilsen B, Ralph MR, Roder JC.

Genes Brain Behav. 2012 Jun;11(4):436-43. doi: 10.1111/j.1601-183X.2012.00800.x. Epub 2012 May 11.

23.

Mice Lacking Ras-GRF1 Show Contextual Fear Conditioning but not Spatial Memory Impairments: Convergent Evidence from Two Independently Generated Mouse Mutant Lines.

d'Isa R, Clapcote SJ, Voikar V, Wolfer DP, Giese KP, Brambilla R, Fasano S.

Front Behav Neurosci. 2011 Dec 6;5:78. doi: 10.3389/fnbeh.2011.00078. eCollection 2011.

24.

Genetic analysis of Down syndrome facilitated by mouse chromosome engineering.

Zhang L, Fu D, Belichenko PV, Liu C, Kleschevnikov AM, Pao A, Liang P, Clapcote SJ, Mobley WC, Yu YE.

Bioeng Bugs. 2012 Jan 1;3(1):8-12. doi: 10.4161/bbug.3.1.17696. Epub 2012 Jan 1.

25.

Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump.

Kirshenbaum GS, Clapcote SJ, Duffy S, Burgess CR, Petersen J, Jarowek KJ, Yücel YH, Cortez MA, Snead OC 3rd, Vilsen B, Peever JH, Ralph MR, Roder JC.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18144-9. doi: 10.1073/pnas.1108416108. Epub 2011 Oct 24. Erratum in: Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2174.

26.

Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3.

Sha L, MacIntyre L, Machell JA, Kelly MP, Porteous DJ, Brandon NJ, Muir WJ, Blackwood DH, Watson DG, Clapcote SJ, Pickard BS.

Mol Psychiatry. 2012 Mar;17(3):267-79. doi: 10.1038/mp.2011.73. Epub 2011 Jun 28.

PMID:
21709683
27.

Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice.

Lazar NL, Singh S, Paton T, Clapcote SJ, Gondo Y, Fukumura R, Roder JC, Cain DP.

Behav Brain Res. 2011 Oct 10;224(1):73-9. doi: 10.1016/j.bbr.2011.05.020. Epub 2011 May 27.

PMID:
21645550
28.

Disc1 point mutations in mice affect development of the cerebral cortex.

Lee FH, Fadel MP, Preston-Maher K, Cordes SP, Clapcote SJ, Price DJ, Roder JC, Wong AH.

J Neurosci. 2011 Mar 2;31(9):3197-206. doi: 10.1523/JNEUROSCI.4219-10.2011.

29.

Synaptic modulators Nrxn1 and Nrxn3 are disregulated in a Disc1 mouse model of schizophrenia.

Brown SM, Clapcote SJ, Millar JK, Torrance HS, Anderson SM, Walker R, Rampino A, Roder JC, Thomson PA, Porteous DJ, Evans KL.

Mol Psychiatry. 2011 Jun;16(6):585-7. doi: 10.1038/mp.2010.134. Epub 2011 Feb 15. No abstract available. Erratum in: Mol Psychiatry. 2012 Apr;17(4):469.

PMID:
21321563
30.

The role of neurexins in schizophrenia and autistic spectrum disorder.

Reichelt AC, Rodgers RJ, Clapcote SJ.

Neuropharmacology. 2012 Mar;62(3):1519-26. doi: 10.1016/j.neuropharm.2011.01.024. Epub 2011 Jan 22. Review.

PMID:
21262241
31.

Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.

Yu T, Liu C, Belichenko P, Clapcote SJ, Li S, Pao A, Kleschevnikov A, Bechard AR, Asrar S, Chen R, Fan N, Zhou Z, Jia Z, Chen C, Roder JC, Liu B, Baldini A, Mobley WC, Yu YE.

Brain Res. 2010 Dec 17;1366:162-71. doi: 10.1016/j.brainres.2010.09.107. Epub 2010 Oct 26.

32.

A new Kv1.2 channelopathy underlying cerebellar ataxia.

Xie G, Harrison J, Clapcote SJ, Huang Y, Zhang JY, Wang LY, Roder JC.

J Biol Chem. 2010 Oct 15;285(42):32160-73. doi: 10.1074/jbc.M110.153676. Epub 2010 Aug 9.

33.

Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.

Lipina TV, Kaidanovich-Beilin O, Patel S, Wang M, Clapcote SJ, Liu F, Woodgett JR, Roder JC.

Synapse. 2011 Mar;65(3):234-48. doi: 10.1002/syn.20839.

34.

Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice.

Yu T, Clapcote SJ, Li Z, Liu C, Pao A, Bechard AR, Carattini-Rivera S, Matsui S, Roder JC, Baldini A, Mobley WC, Bradley A, Yu YE.

Mamm Genome. 2010 Jun;21(5-6):258-67. doi: 10.1007/s00335-010-9262-x. Epub 2010 May 29.

35.

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions.

Yu T, Li Z, Jia Z, Clapcote SJ, Liu C, Li S, Asrar S, Pao A, Chen R, Fan N, Carattini-Rivera S, Bechard AR, Spring S, Henkelman RM, Stoica G, Matsui S, Nowak NJ, Roder JC, Chen C, Bradley A, Yu YE.

Hum Mol Genet. 2010 Jul 15;19(14):2780-91. doi: 10.1093/hmg/ddq179. Epub 2010 May 4.

36.

Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS.

Clapcote SJ, Duffy S, Xie G, Kirshenbaum G, Bechard AR, Rodacker Schack V, Petersen J, Sinai L, Saab BJ, Lerch JP, Minassian BA, Ackerley CA, Sled JG, Cortez MA, Henderson JT, Vilsen B, Roder JC.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14085-90. doi: 10.1073/pnas.0904817106. Epub 2009 Aug 3.

37.

Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.

Ng D, Pitcher GM, Szilard RK, Sertié A, Kanisek M, Clapcote SJ, Lipina T, Kalia LV, Joo D, McKerlie C, Cortez M, Roder JC, Salter MW, McInnes RR.

PLoS Biol. 2009 Feb 24;7(2):e41. doi: 10.1371/journal.pbio.1000041.

38.

Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors.

Labrie V, Clapcote SJ, Roder JC.

Pharmacol Biochem Behav. 2009 Feb;91(4):610-20. doi: 10.1016/j.pbb.2008.09.016. Epub 2008 Oct 7.

PMID:
18940194
39.

Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice.

Ishizuka K, Chen J, Taya S, Li W, Millar JK, Xu Y, Clapcote SJ, Hookway C, Morita M, Kamiya A, Tomoda T, Lipska BK, Roder JC, Pletnikov M, Porteous D, Silva AJ, Cannon TD, Kaibuchi K, Brandon NJ, Weinberger DR, Sawa A.

Mol Psychiatry. 2007 Oct;12(10):897-9. No abstract available.

PMID:
17895924
40.

Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness.

Millar JK, Mackie S, Clapcote SJ, Murdoch H, Pickard BS, Christie S, Muir WJ, Blackwood DH, Roder JC, Houslay MD, Porteous DJ.

J Physiol. 2007 Oct 15;584(Pt 2):401-5. Epub 2007 Sep 6. Review.

41.

Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1-targeted mice.

Young EJ, Lipina T, Tam E, Mandel A, Clapcote SJ, Bechard AR, Chambers J, Mount HT, Fletcher PJ, Roder JC, Osborne LR.

Genes Brain Behav. 2008 Mar;7(2):224-34. Epub 2007 Aug 3.

42.

Behavioral phenotypes of Disc1 missense mutations in mice.

Clapcote SJ, Lipina TV, Millar JK, Mackie S, Christie S, Ogawa F, Lerch JP, Trimble K, Uchiyama M, Sakuraba Y, Kaneda H, Shiroishi T, Houslay MD, Henkelman RM, Sled JG, Gondo Y, Porteous DJ, Roder JC.

Neuron. 2007 May 3;54(3):387-402.

43.

Forward genetic screen of mouse reveals dominant missense mutation in the P/Q-type voltage-dependent calcium channel, CACNA1A.

Xie G, Clapcote SJ, Nieman BJ, Tallerico T, Huang Y, Vukobradovic I, Cordes SP, Osborne LR, Rossant J, Sled JG, Henderson JT, Roder JC.

Genes Brain Behav. 2007 Nov;6(8):717-27. Epub 2007 Mar 21.

44.

Methods to rapidly and accurately screen a large number of ENU mutagenized mice for abnormal motor phenotypes.

Abramow-Newerly W, Lipina T, Abramow-Newerly M, Kim D, Bechard AR, Xie G, Clapcote SJ, Roder JC.

Amyotroph Lateral Scler. 2006 Jun;7(2):112-8.

PMID:
16753976
45.
46.

Novel strategies for the development of animal models of refractory epilepsy.

Snead OC 3rd, Clapcote SJ, Roder JC, Boulianne GL.

Adv Neurol. 2006;97:155-71. Review. No abstract available.

PMID:
16383125
47.

Effects of the rd1 mutation and host strain on hippocampal learning in mice.

Clapcote SJ, Lazar NL, Bechard AR, Roder JC.

Behav Genet. 2005 Sep;35(5):591-601.

PMID:
16184487
48.

NIH Swiss and Black Swiss mice have retinal degeneration and performance deficits in cognitive tests.

Clapcote SJ, Lazar NL, Bechard AR, Wood GA, Roder JC.

Comp Med. 2005 Aug;55(4):310-6.

PMID:
16158906
49.

Simplex PCR assay for sex determination in mice.

Clapcote SJ, Roder JC.

Biotechniques. 2005 May;38(5):702, 704, 706. No abstract available.

50.

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