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Advance of Seriniquinone Analogues as Melanoma Agents.

Hammons JC, Trzoss L, Jimenez PC, Hirata AS, Costa-Lotufo LV, La Clair JJ, Fenical W.

ACS Med Chem Lett. 2019 Feb 6;10(2):186-190. doi: 10.1021/acsmedchemlett.8b00391. eCollection 2019 Feb 14.


Daedal Facets of Splice Modulator Optimization.

Chan WC, León B, Krug KA, Patel A, La Clair JJ, Burkart MD.

ACS Med Chem Lett. 2018 Oct 29;9(11):1070-1072. doi: 10.1021/acsmedchemlett.8b00456. eCollection 2018 Nov 8.


Isolated Posterior Cruciate Reconstruction Results in Improved Functional Outcome but Low Rates of Return to Preinjury Level of Sport: A Systematic Review and Meta-analysis.

Devitt BM, Dissanayake R, Clair J, Napier RJ, Porter TJ, Feller JA, Webster KE.

Orthop J Sports Med. 2018 Oct 26;6(10):2325967118804478. doi: 10.1177/2325967118804478. eCollection 2018 Oct. Review.


Trapping the Complex Molecular Machinery of Polyketide and Fatty Acid Synthases with Tunable Silylcyanohydrin Crosslinkers.

Konno S, La Clair JJ, Burkart MD.

Angew Chem Int Ed Engl. 2018 Dec 21;57(52):17009-17013. doi: 10.1002/anie.201806865. Epub 2018 Nov 27.


Metabolic and Biosynthetic Diversity in Marine Myxobacteria.

Gemperlein K, Zaburannyi N, Garcia R, La Clair JJ, Müller R.

Mar Drugs. 2018 Sep 5;16(9). pii: E314. doi: 10.3390/md16090314. Review.


Future Directions of Marine Myxobacterial Natural Product Discovery Inferred from Metagenomics.

Garcia R, La Clair JJ, Müller R.

Mar Drugs. 2018 Aug 29;16(9). pii: E303. doi: 10.3390/md16090303. Review.


AHNS Series: Do you know your guidelines? Principles for treatment of cancer of the paranasal sinuses: A review of the National Comprehensive Cancer Network guidelines.

Byrd JK, Clair JM, El-Sayed I.

Head Neck. 2018 Sep;40(9):1889-1896. doi: 10.1002/hed.25143. Epub 2018 Jun 27.


Quantitative survival impact of composite treatment delays in head and neck cancer.

Ho AS, Kim S, Tighiouart M, Mita A, Scher KS, Epstein JB, Laury A, Prasad R, Ali N, Patio C, Clair JM, Zumsteg ZS.

Cancer. 2018 Aug 1;124(15):3154-3162. doi: 10.1002/cncr.31533. Epub 2018 May 9.


Development of a novel salivary gland cancer lymph node staging system.

Aro K, Ho AS, Luu M, Kim S, Tighiouart M, Clair JM, Yoshida EJ, Shiao SL, Leivo I, Zumsteg ZS.

Cancer. 2018 Aug 1;124(15):3171-3180. doi: 10.1002/cncr.31535. Epub 2018 May 9.


Correction: Encoding matter with regiospecific 12C/13C isotopic labels.

La Clair JJ.

Chem Commun (Camb). 2018 Apr 3;54(28):3543. doi: 10.1039/c8cc90124d.


Encoding matter with regiospecific 12C/13C isotopic labels.

La Clair JJ.

Chem Commun (Camb). 2018 Mar 8;54(21):2611-2614. doi: 10.1039/c8cc00080h. Erratum in: Chem Commun (Camb). 2018 Mar 26;:.


The survival impact of surgical therapy in squamous cell carcinoma of the hard palate.

Alonso JE, Han AY, Kuan EC, Strohl M, Clair JM, St John MA, Ryan WR, Heaton CM.

Laryngoscope. 2018 Sep;128(9):2050-2055. doi: 10.1002/lary.27080. Epub 2018 Feb 5.


Mammalian γ2 AMPK regulates intrinsic heart rate.

Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H.

Nat Commun. 2017 Nov 2;8(1):1258. doi: 10.1038/s41467-017-01342-5.


Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation.

Kornienko A, La Clair JJ.

Nat Prod Rep. 2017 Aug 30;34(9):1051-1060. doi: 10.1039/c7np00024c. Review.


Irreversible Protein Labeling by Paal-Knorr Conjugation.

Dasari R, La Clair JJ, Kornienko A.

Chembiochem. 2017 Sep 19;18(18):1792-1796. doi: 10.1002/cbic.201700210. Epub 2017 Aug 10.


Risk of genetic maladaptation due to climate change in three major European tree species.

Frank A, Howe GT, Sperisen C, Brang P, Clair JBS, Schmatz DR, Heiri C.

Glob Chang Biol. 2017 Dec;23(12):5358-5371. doi: 10.1111/gcb.13802. Epub 2017 Aug 10.


Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.

Barajas JF, Shakya G, Moreno G, Rivera H Jr, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4142-E4148. doi: 10.1073/pnas.1609001114. Epub 2017 May 8.


A Challenging Pie to Splice: Drugging the Spliceosome.

León B, Kashyap MK, Chan WC, Krug KA, Castro JE, La Clair JJ, Burkart MD.

Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12052-12063. doi: 10.1002/anie.201701065. Epub 2017 Aug 15. Review.


Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ.

Wu CC, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel JP, Evans RM.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2563-E2570. doi: 10.1073/pnas.1621513114. Epub 2017 Mar 20.


Ritterostatin GN 1N , a Cephalostatin-Ritterazine Bis-steroidal Pyrazine Hybrid, Selectively Targets GRP78.

Ambrose AJ, Santos EA, Jimenez PC, Rocha DD, Wilke DV, Beuzer P, Axelrod J, Kumar Kanduluru A, Fuchs PL, Cang H, Costa-Lotufo LV, Chapman E, La Clair JJ.

Chembiochem. 2017 Mar 16;18(6):506-510. doi: 10.1002/cbic.201600669. Epub 2017 Feb 2.


Brusatol overcomes chemoresistance through inhibition of protein translation.

Harder B, Tian W, La Clair JJ, Tan AC, Ooi A, Chapman E, Zhang DD.

Mol Carcinog. 2017 May;56(5):1493-1500. doi: 10.1002/mc.22609. Epub 2017 Feb 8.


Physician Communication in Pediatric End-of-Life Care: A Simulation Study.

Bateman LB, Tofil NM, White ML, Dure LS, Clair JM, Needham BL.

Am J Hosp Palliat Care. 2016 Dec;33(10):935-941. Epub 2015 Jul 12.


Selectivity in Small Molecule Splicing Modulation.

Kumar D, Kashyap MK, La Clair JJ, Villa R, Spaanderman I, Chien S, Rassenti LZ, Kipps TJ, Burkart MD, Castro JE.

ACS Chem Biol. 2016 Oct 21;11(10):2716-2723. Epub 2016 Aug 8.


More than just tissue diagnosis in a patient with maxillofacial bony lesions and hypercalcemia.

Vahabzadeh-Hagh AM, Zipser BD, Tan HT, Hong AY, Clair JM, Armin BB.

Laryngoscope. 2017 Jun;127(6):1318-1321. doi: 10.1002/lary.26300. Epub 2016 Sep 19.


RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML.

Crews LA, Balaian L, Delos Santos NP, Leu HS, Court AC, Lazzari E, Sadarangani A, Zipeto MA, La Clair JJ, Villa R, Kulidjian A, Storb R, Morris SR, Ball ED, Burkart MD, Jamieson CHM.

Cell Stem Cell. 2016 Nov 3;19(5):599-612. doi: 10.1016/j.stem.2016.08.003. Epub 2016 Aug 25.


Single dish gradient screening of small molecule localization.

Beuzer P, Axelrod J, Trzoss L, Fenical W, Dasari R, Evidente A, Kornienko A, Cang H, La Clair JJ.

Org Biomol Chem. 2016 Sep 21;14(35):8241-5. doi: 10.1039/c6ob01418f. Epub 2016 Aug 17.


A Qualitative Examination of Physician Gender and Parental Status in Pediatric End-of-Life Communication.

Bateman LB, White ML, Tofil NM, Clair JM, Needham BL.

Health Commun. 2017 Jul;32(7):903-909. doi: 10.1080/10410236.2016.1196412. Epub 2016 Jul 19.


An unusual intramolecular trans-amidation.

Rivera H Jr, Dhar S, La Clair JJ, Tsai SC, Burkart MD.

Tetrahedron. 2016 Jun 23;72(25):3605-3608.


Fluorescent Mechanism-Based Probe for Aerobic Flavin-Dependent Enzyme Activity.

McCulloch IP, La Clair JJ, Jaremko MJ, Burkart MD.

Chembiochem. 2016 Sep 2;17(17):1598-601. doi: 10.1002/cbic.201600275. Epub 2016 Aug 5.


De Novo Asymmetric Synthesis and Biological Analysis of the Daumone Pheromones in Caenorhabditis elegans and in the Soybean Cyst Nematode Heterodera glycines.

Guo H, La Clair JJ, Masler EP, O'Doherty G, Xing Y.

Tetrahedron. 2016 May 5;72(18):2280-2286. doi: 10.1016/j.tet.2016.03.033. Epub 2016 Mar 16.


A Carbohydrate-Derived Splice Modulator.

Dhar S, La Clair JJ, León B, Hammons JC, Yu Z, Kashyap MK, Castro JE, Burkart MD.

J Am Chem Soc. 2016 Apr 20;138(15):5063-8. doi: 10.1021/jacs.5b13427. Epub 2016 Apr 8.


Color-Coded Super-Resolution Small-Molecule Imaging.

Beuzer P, La Clair JJ, Cang H.

Chembiochem. 2016 Jun 2;17(11):999-1003. doi: 10.1002/cbic.201600013. Epub 2016 Apr 26.


Trapping of the Enoyl-Acyl Carrier Protein Reductase-Acyl Carrier Protein Interaction.

Tallorin L, Finzel K, Nguyen QG, Beld J, La Clair JJ, Burkart MD.

J Am Chem Soc. 2016 Mar 30;138(12):3962-5. doi: 10.1021/jacs.5b13456. Epub 2016 Mar 15.


Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products.

Vickery CR, La Clair JJ, Burkart MD, Noel JP.

Curr Opin Chem Biol. 2016 Apr;31:66-73. doi: 10.1016/j.cbpa.2016.01.008. Epub 2016 Feb 4. Review.


Physician Religion and End-of-Life Pediatric Care: A Qualitative Examination of Physicians' Perspectives.

Bateman LB, Clair JM.

Narrat Inq Bioeth. 2015 Winter;5(3):251-69. doi: 10.1353/nib.2015.0065.


The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway.

Álvarez-Micó X, Rocha DD, Guimarães LA, Ambrose A, Chapman E, Costa-Lotufo LV, La Clair JJ, Fenical W.

Chembiochem. 2015 Sep 21;16(14):2002-6. doi: 10.1002/cbic.201500229. Epub 2015 Aug 12.


Formation of Low Volatility Organic Compounds and Secondary Organic Aerosol from Isoprene Hydroxyhydroperoxide Low-NO Oxidation.

Krechmer JE, Coggon MM, Massoli P, Nguyen TB, Crounse JD, Hu W, Day DA, Tyndall GS, Henze DK, Rivera-Rios JC, Nowak JB, Kimmel JR, Mauldin RL 3rd, Stark H, Jayne JT, Sipilä M, Junninen H, Clair JM, Zhang X, Feiner PA, Zhang L, Miller DO, Brune WH, Keutsch FN, Wennberg PO, Seinfeld JH, Worsnop DR, Jimenez JL, Canagaratna MR.

Environ Sci Technol. 2015 Sep 1;49(17):10330-9. doi: 10.1021/acs.est.5b02031. Epub 2015 Aug 14.


Fluorescent kapakahines serve as non-toxic probes for live cell Golgi imaging.

Rocha DD, Espejo VR, Rainier JD, La Clair JJ, Costa-Lotufo LV.

Life Sci. 2015 Sep 1;136:163-7. doi: 10.1016/j.lfs.2015.06.014. Epub 2015 Jul 2.


Withaferin A Analogs That Target the AAA+ Chaperone p97.

Tao S, Tillotson J, Wijeratne EMK, Xu YM, Kang M, Wu T, Lau EC, Mesa C, Mason DJ, Brown RV, Clair JJ, Gunatilaka AAL, Zhang DD, Chapman E.

ACS Chem Biol. 2015 Aug 21;10(8):1916-1924. doi: 10.1021/acschembio.5b00367. Epub 2015 Jun 3.


Characterisation of clinical meticillin-resistant Staphylococcus epidermidis demonstrating high levels of linezolid resistance (>256 μg/ml) resulting from transmissible and mutational mechanisms.

Gabriel EM, Fitzgibbon S, Clair J, Coffey A, O'Mahony JM.

J Infect Chemother. 2015 Jul;21(7):547-9. doi: 10.1016/j.jiac.2015.03.012. Epub 2015 Mar 30.


Cytotoxic Plakortides from the Brazilian Marine Sponge Plakortis angulospiculatus.

Santos EA, Quintela AL, Ferreira EG, Sousa TS, Pinto Fd, Hajdu E, Carvalho MS, Salani S, Rocha DD, Wilke DV, Torres Mda C, Jimenez PC, Silveira ER, La Clair JJ, Pessoa OD, Costa-Lotufo LV.

J Nat Prod. 2015 May 22;78(5):996-1004. doi: 10.1021/np5008944. Epub 2015 Apr 16.


Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B.

Kashyap MK, Kumar D, Villa R, La Clair JJ, Benner C, Sasik R, Jones H, Ghia EM, Rassenti LZ, Kipps TJ, Burkart MD, Castro JE.

Haematologica. 2015 Jul;100(7):945-54. doi: 10.3324/haematol.2014.122069. Epub 2015 Apr 10.


Correction: Chapman, E.; et al. Inhibitors of the AAA+ chaperone p97. Molecules 2015, 20, 3027-3049.

Chapman E, Maksim N, de la Cruz F, La Clair JJ.

Molecules. 2015 Mar 9;20(3):4357-8. doi: 10.3390/molecules20034357. No abstract available.


Inhibitors of the AAA+ chaperone p97.

Chapman E, Maksim N, de la Cruz F, La Clair JJ.

Molecules. 2015 Feb 12;20(2):3027-49. doi: 10.3390/molecules20023027. Review. Erratum in: Molecules. 2015;20(3):4357-8.


Functional chromatographic technique for natural product isolation.

Lau EC, Mason DJ, Eichhorst N, Engelder P, Mesa C, Kithsiri Wijeratne EM, Gunaherath GM, Gunatilaka AA, La Clair JJ, Chapman E.

Org Biomol Chem. 2015 Feb 28;13(8):2255-9. doi: 10.1039/c4ob02292k.


Modeling linear and cyclic PKS intermediates through atom replacement.

Shakya G, Rivera H Jr, Lee DJ, Jaremko MJ, La Clair JJ, Fox DT, Haushalter RW, Schaub AJ, Bruegger J, Barajas JF, White AR, Kaur P, Gwozdziowski ER, Wong F, Tsai SC, Burkart MD.

J Am Chem Soc. 2014 Dec 3;136(48):16792-9. doi: 10.1021/ja5064857. Epub 2014 Nov 19.


Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin.

Trzoss L, Fukuda T, Costa-Lotufo LV, Jimenez P, La Clair JJ, Fenical W.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14687-92. doi: 10.1073/pnas.1410932111. Epub 2014 Sep 30.


Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action.

Kang MJ, Wu T, Wijeratne EM, Lau EC, Mason DJ, Mesa C, Tillotson J, Zhang DD, Gunatilaka AA, La Clair JJ, Chapman E.

Chembiochem. 2014 Sep 22;15(14):2125-31. doi: 10.1002/cbic.201402258. Epub 2014 Aug 14.


In situ natural product discovery via an artificial marine sponge.

La Clair JJ, Loveridge ST, Tenney K, O'Neil-Johnson M, Chapman E, Crews P.

PLoS One. 2014 Jul 8;9(7):e100474. doi: 10.1371/journal.pone.0100474. eCollection 2014.


Adapt or perish--a relentless fight for survival: designing superbugs out of the intensive care unit.

Colatrella S, Clair JD.

Crit Care Nurs Q. 2014 Jul-Sep;37(3):251-67. doi: 10.1097/CNQ.0000000000000029.


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