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Items: 1 to 50 of 101

1.

The impact of pH on catalytically critical protein conformational changes: the case of the urease, a nickel enzyme.

Mazzei L, Cianci M, Benini S, Ciurli S.

Chemistry. 2019 Jul 4. doi: 10.1002/chem.201902320. [Epub ahead of print]

PMID:
31271481
2.

Inhibition Mechanism of Urease by Au(III) Compounds Unveiled by X-ray Diffraction Analysis.

Mazzei L, Wenzel MN, Cianci M, Palombo M, Casini A, Ciurli S.

ACS Med Chem Lett. 2019 Jan 4;10(4):564-570. doi: 10.1021/acsmedchemlett.8b00585. eCollection 2019 Apr 11.

PMID:
30996797
3.

The Structure of the Elusive Urease-Urea Complex Unveils the Mechanism of a Paradigmatic Nickel-Dependent Enzyme.

Mazzei L, Cianci M, Benini S, Ciurli S.

Angew Chem Int Ed Engl. 2019 May 27;58(22):7415-7419. doi: 10.1002/anie.201903565. Epub 2019 Apr 30.

PMID:
30969470
4.

The carbon monoxide dehydrogenase accessory protein CooJ is a histidine-rich multidomain dimer containing an unexpected Ni(II)-binding site.

Alfano M, Pérard J, Carpentier P, Basset C, Zambelli B, Timm J, Crouzy S, Ciurli S, Cavazza C.

J Biol Chem. 2019 May 10;294(19):7601-7614. doi: 10.1074/jbc.RA119.008011. Epub 2019 Mar 11.

PMID:
30858174
5.

Insights into Urease Inhibition by N-( n-Butyl) Phosphoric Triamide through an Integrated Structural and Kinetic Approach.

Mazzei L, Cianci M, Contaldo U, Ciurli S.

J Agric Food Chem. 2019 Feb 27;67(8):2127-2138. doi: 10.1021/acs.jafc.8b04791. Epub 2019 Feb 18.

PMID:
30735374
6.

Structure and dynamics of Helicobacter pylori nickel-chaperone HypA: an integrated approach using NMR spectroscopy, functional assays and computational tools.

Spronk CAEM, Żerko S, Górka M, Koźmiński W, Bardiaux B, Zambelli B, Musiani F, Piccioli M, Basak P, Blum FC, Johnson RC, Hu H, Merrell DS, Maroney M, Ciurli S.

J Biol Inorg Chem. 2018 Dec;23(8):1309-1330. doi: 10.1007/s00775-018-1616-y. Epub 2018 Sep 27.

PMID:
30264175
7.

Targeting Helicobacter pylori urease activity and maturation: In-cell high-throughput approach for drug discovery.

Tarsia C, Danielli A, Florini F, Cinelli P, Ciurli S, Zambelli B.

Biochim Biophys Acta Gen Subj. 2018 Oct;1862(10):2245-2253. doi: 10.1016/j.bbagen.2018.07.020. Epub 2018 Jul 24.

PMID:
30048738
8.

Smart urea ionic co-crystals with enhanced urease inhibition activity for improved nitrogen cycle management.

Casali L, Mazzei L, Shemchuk O, Honer K, Grepioni F, Ciurli S, Braga D, Baltrusaitis J.

Chem Commun (Camb). 2018 Jul 5;54(55):7637-7640. doi: 10.1039/c8cc03777a.

PMID:
29931002
9.

The structure of urease inactivated by Ag(i): a new paradigm for enzyme inhibition by heavy metals.

Mazzei L, Cianci M, Gonzalez Vara A, Ciurli S.

Dalton Trans. 2018 Jun 25;47(25):8240-8247. doi: 10.1039/c8dt01190g.

PMID:
29845996
10.

Structural analysis of the interaction between Jaburetox, an intrinsically disordered protein, and membrane models.

Broll V, Martinelli AHS, Lopes FC, Fruttero LL, Zambelli B, Salladini E, Dobrovolska O, Ciurli S, Carlini CR.

Colloids Surf B Biointerfaces. 2017 Nov 1;159:849-860. doi: 10.1016/j.colsurfb.2017.08.053. Epub 2017 Aug 30.

PMID:
28892869
11.

Urease Inhibition in the Presence of N-(n-Butyl)thiophosphoric Triamide, a Suicide Substrate: Structure and Kinetics.

Mazzei L, Cianci M, Contaldo U, Musiani F, Ciurli S.

Biochemistry. 2017 Oct 10;56(40):5391-5404. doi: 10.1021/acs.biochem.7b00750. Epub 2017 Sep 15.

PMID:
28857549
12.

The relationship between folding and activity in UreG, an intrinsically disordered enzyme.

Palombo M, Bonucci A, Etienne E, Ciurli S, Uversky VN, Guigliarelli B, Belle V, Mileo E, Zambelli B.

Sci Rep. 2017 Jul 20;7(1):5977. doi: 10.1038/s41598-017-06330-9.

13.

Development of a multisite model for Ni(II) ion in solution from thermodynamic and kinetic data.

Masetti M, Musiani F, Bernetti M, Falchi F, Cavalli A, Ciurli S, Recanatini M.

J Comput Chem. 2017 Jun 5;38(21):1834-1843. doi: 10.1002/jcc.24827. Epub 2017 May 30.

PMID:
28558120
14.

Glutamate Ligation in the Ni(II)- and Co(II)-Responsive Escherichia coli Transcriptional Regulator, RcnR.

Carr CE, Musiani F, Huang HT, Chivers PT, Ciurli S, Maroney MJ.

Inorg Chem. 2017 Jun 5;56(11):6459-6476. doi: 10.1021/acs.inorgchem.7b00527. Epub 2017 May 18.

15.

The CO dehydrogenase accessory protein CooT is a novel nickel-binding protein.

Timm J, Brochier-Armanet C, Perard J, Zambelli B, Ollagnier-de-Choudens S, Ciurli S, Cavazza C.

Metallomics. 2017 May 24;9(5):575-583. doi: 10.1039/c7mt00063d.

PMID:
28447092
16.

Protein Tunnels: The Case of Urease Accessory Proteins.

Musiani F, Gioia D, Masetti M, Falchi F, Cavalli A, Recanatini M, Ciurli S.

J Chem Theory Comput. 2017 May 9;13(5):2322-2331. doi: 10.1021/acs.jctc.7b00042. Epub 2017 Apr 12.

PMID:
28379694
17.

Inactivation of urease by catechol: Kinetics and structure.

Mazzei L, Cianci M, Musiani F, Lente G, Palombo M, Ciurli S.

J Inorg Biochem. 2017 Jan;166:182-189. doi: 10.1016/j.jinorgbio.2016.11.016. Epub 2016 Nov 9.

PMID:
27888701
18.

On the role of a specific insert in acetate permeases (ActP) for tellurite uptake in bacteria: Functional and structural studies.

Borghese R, Canducci L, Musiani F, Cappelletti M, Ciurli S, Turner RJ, Zannoni D.

J Inorg Biochem. 2016 Oct;163:103-109. doi: 10.1016/j.jinorgbio.2016.06.029. Epub 2016 Jun 25.

PMID:
27421695
19.

Surface plasmon resonance and isothermal titration calorimetry to monitor the Ni(II)-dependent binding of Helicobacter pylori NikR to DNA.

Fabini E, Zambelli B, Mazzei L, Ciurli S, Bertucci C.

Anal Bioanal Chem. 2016 Nov;408(28):7971-7980. Epub 2016 Aug 31.

PMID:
27580605
20.

Nickel impact on human health: An intrinsic disorder perspective.

Zambelli B, Uversky VN, Ciurli S.

Biochim Biophys Acta. 2016 Dec;1864(12):1714-1731. doi: 10.1016/j.bbapap.2016.09.008. Epub 2016 Sep 17. Review.

PMID:
27645710
21.

Inactivation of urease by 1,4-benzoquinone: chemistry at the protein surface.

Mazzei L, Cianci M, Musiani F, Ciurli S.

Dalton Trans. 2016 Apr 7;45(13):5455-9. doi: 10.1039/c6dt00652c. Epub 2016 Mar 10.

PMID:
26961812
22.

Isothermal Titration Calorimetry to Characterize Enzymatic Reactions.

Mazzei L, Ciurli S, Zambelli B.

Methods Enzymol. 2016;567:215-36. doi: 10.1016/bs.mie.2015.07.022. Epub 2015 Sep 1.

PMID:
26794356
23.

Kinetic and structural studies reveal a unique binding mode of sulfite to the nickel center in urease.

Mazzei L, Cianci M, Benini S, Bertini L, Musiani F, Ciurli S.

J Inorg Biochem. 2016 Jan;154:42-9. doi: 10.1016/j.jinorgbio.2015.11.003. Epub 2015 Nov 5.

PMID:
26580226
24.

Evolution of Macromolecular Docking Techniques: The Case Study of Nickel and Iron Metabolism in Pathogenic Bacteria.

Musiani F, Ciurli S.

Molecules. 2015 Aug 5;20(8):14265-92. doi: 10.3390/molecules200814265. Review.

25.

On the interaction of Helicobacter pylori NikR, a Ni(II)-responsive transcription factor, with the urease operator: in solution and in silico studies.

Mazzei L, Dobrovolska O, Musiani F, Zambelli B, Ciurli S.

J Biol Inorg Chem. 2015 Sep;20(6):1021-37. doi: 10.1007/s00775-015-1284-0. Epub 2015 Jul 24.

PMID:
26204982
26.

Nickel-responsive transcriptional regulators.

Musiani F, Zambelli B, Bazzani M, Mazzei L, Ciurli S.

Metallomics. 2015 Sep;7(9):1305-18. doi: 10.1039/c5mt00072f. Review.

PMID:
26099858
27.

Intrinsic disorder and metal binding in UreG proteins from Archae hyperthermophiles: GTPase enzymes involved in the activation of Ni(II) dependent urease.

Miraula M, Ciurli S, Zambelli B.

J Biol Inorg Chem. 2015 Jun;20(4):739-55. doi: 10.1007/s00775-015-1261-7. Epub 2015 Apr 7.

PMID:
25846143
28.

Pliable natural biocide: Jaburetox is an intrinsically disordered insecticidal and fungicidal polypeptide derived from jack bean urease.

Lopes FC, Dobrovolska O, Real-Guerra R, Broll V, Zambelli B, Musiani F, Uversky VN, Carlini CR, Ciurli S.

FEBS J. 2015 Mar;282(6):1043-64. doi: 10.1111/febs.13201. Epub 2015 Feb 11.

29.

The conformational response to Zn(II) and Ni(II) binding of Sporosarcina pasteurii UreG, an intrinsically disordered GTPase.

D'Urzo A, Santambrogio C, Grandori R, Ciurli S, Zambelli B.

J Biol Inorg Chem. 2014 Dec;19(8):1341-54. doi: 10.1007/s00775-014-1191-9. Epub 2014 Sep 9.

PMID:
25200810
30.

Promiscuous nickel import in human pathogens: structure, thermodynamics, and evolution of extracytoplasmic nickel-binding proteins.

Lebrette H, Brochier-Armanet C, Zambelli B, de Reuse H, Borezée-Durant E, Ciurli S, Cavazza C.

Structure. 2014 Oct 7;22(10):1421-32. doi: 10.1016/j.str.2014.07.012. Epub 2014 Sep 4.

31.

Fluoride inhibition of Sporosarcina pasteurii urease: structure and thermodynamics.

Benini S, Cianci M, Mazzei L, Ciurli S.

J Biol Inorg Chem. 2014 Dec;19(8):1243-61. doi: 10.1007/s00775-014-1182-x. Epub 2014 Aug 12.

PMID:
25113581
32.

Molecular landscape of the interaction between the urease accessory proteins UreE and UreG.

Merloni A, Dobrovolska O, Zambelli B, Agostini F, Bazzani M, Musiani F, Ciurli S.

Biochim Biophys Acta. 2014 Sep;1844(9):1662-74. doi: 10.1016/j.bbapap.2014.06.016. Epub 2014 Jun 27.

PMID:
24982029
33.

Hot biological catalysis: isothermal titration calorimetry to characterize enzymatic reactions.

Mazzei L, Ciurli S, Zambelli B.

J Vis Exp. 2014 Apr 4;(86). doi: 10.3791/51487.

34.

Nickel and human health.

Zambelli B, Ciurli S.

Met Ions Life Sci. 2013;13:321-57. doi: 10.1007/978-94-007-7500-8_10. Review.

PMID:
24470096
35.

Nonredox nickel enzymes.

Maroney MJ, Ciurli S.

Chem Rev. 2014 Apr 23;114(8):4206-28. doi: 10.1021/cr4004488. Epub 2013 Dec 26. Review. No abstract available.

36.

FeON-FeOFF: the Helicobacter pylori Fur regulator commutates iron-responsive transcription by discriminative readout of opposed DNA grooves.

Agriesti F, Roncarati D, Musiani F, Del Campo C, Iurlaro M, Sparla F, Ciurli S, Danielli A, Scarlato V.

Nucleic Acids Res. 2014 Mar;42(5):3138-51. doi: 10.1093/nar/gkt1258. Epub 2013 Dec 9.

37.

Nickel binding properties of Helicobacter pylori UreF, an accessory protein in the nickel-based activation of urease.

Zambelli B, Berardi A, Martin-Diaconescu V, Mazzei L, Musiani F, Maroney MJ, Ciurli S.

J Biol Inorg Chem. 2014 Mar;19(3):319-34. doi: 10.1007/s00775-013-1068-3. Epub 2013 Nov 30.

38.

Selectivity of Ni(II) and Zn(II) binding to Sporosarcina pasteurii UreE, a metallochaperone in the urease assembly: a calorimetric and crystallographic study.

Zambelli B, Banaszak K, Merloni A, Kiliszek A, Rypniewski W, Ciurli S.

J Biol Inorg Chem. 2013 Dec;18(8):1005-17. doi: 10.1007/s00775-013-1049-6. Epub 2013 Oct 15.

PMID:
24126709
39.

Structure of the UreD-UreF-UreG-UreE complex in Helicobacter pylori: a model study.

Biagi F, Musiani F, Ciurli S.

J Biol Inorg Chem. 2013 Jun;18(5):571-7. doi: 10.1007/s00775-013-1002-8. Epub 2013 May 10.

PMID:
23661161
40.

Conformational fluctuations of UreG, an intrinsically disordered enzyme.

Musiani F, Ippoliti E, Micheletti C, Carloni P, Ciurli S.

Biochemistry. 2013 Apr 30;52(17):2949-54. doi: 10.1021/bi4001744. Epub 2013 Apr 18.

PMID:
23560717
41.

The crystal structure of Sporosarcina pasteurii urease in a complex with citrate provides new hints for inhibitor design.

Benini S, Kosikowska P, Cianci M, Mazzei L, Vara AG, Berlicki Ł, Ciurli S.

J Biol Inorg Chem. 2013 Mar;18(3):391-9. doi: 10.1007/s00775-013-0983-7. Epub 2013 Feb 15. Erratum in: J Biol Inorg Chem. 2013 Apr;18(4):483.

PMID:
23412551
42.

Denaturant-induced conformational transitions in intrinsically disordered proteins.

Neyroz P, Ciurli S, Uversky VN.

Methods Mol Biol. 2012;896:197-213. doi: 10.1007/978-1-4614-3704-8_12.

PMID:
22821525
43.

Engineered biosealant strains producing inorganic and organic biopolymers.

Bergdale TE, Pinkelman RJ, Hughes SR, Zambelli B, Ciurli S, Bang SS.

J Biotechnol. 2012 Oct 31;161(3):181-9. doi: 10.1016/j.jbiotec.2012.07.001. Epub 2012 Jul 10.

PMID:
22789480
44.

Intrinsic fluorescence of intrinsically disordered proteins.

Neyroz P, Ciurli S.

Methods Mol Biol. 2012;895:435-40. doi: 10.1007/978-1-61779-927-3_25.

PMID:
22760332
45.

Biochemical and structural studies on native and recombinant Glycine max UreG: a detailed characterization of a plant urease accessory protein.

Real-Guerra R, Staniscuaski F, Zambelli B, Musiani F, Ciurli S, Carlini CR.

Plant Mol Biol. 2012 Mar;78(4-5):461-75. doi: 10.1007/s11103-012-9878-1. Epub 2012 Jan 22.

PMID:
22271305
46.

Metal ion-mediated DNA-protein interactions.

Zambelli B, Musiani F, Ciurli S.

Met Ions Life Sci. 2012;10:135-70. doi: 10.1007/978-94-007-2172-2_5. Review.

PMID:
22210338
47.

Unraveling the Helicobacter pylori UreG zinc binding site using X-ray absorption spectroscopy (XAS) and structural modeling.

Martin-Diaconescu V, Bellucci M, Musiani F, Ciurli S, Maroney MJ.

J Biol Inorg Chem. 2012 Mar;17(3):353-61. doi: 10.1007/s00775-011-0857-9. Epub 2011 Nov 9.

48.

Crystallographic and X-ray absorption spectroscopic characterization of Helicobacter pylori UreE bound to Ni²⁺ and Zn²⁺ reveals a role for the disordered C-terminal arm in metal trafficking.

Banaszak K, Martin-Diaconescu V, Bellucci M, Zambelli B, Rypniewski W, Maroney MJ, Ciurli S.

Biochem J. 2012 Feb 1;441(3):1017-26. doi: 10.1042/BJ20111659.

49.

Insights in the (un)structural organization of Bacillus pasteurii UreG, an intrinsically disordered GTPase enzyme.

Zambelli B, Cremades N, Neyroz P, Turano P, Uversky VN, Ciurli S.

Mol Biosyst. 2012 Jan;8(1):220-8. doi: 10.1039/c1mb05227f. Epub 2011 Sep 16.

PMID:
21922108
50.

Holo-Ni2+ Helicobacter pylori NikR contains four square-planar nickel-binding sites at physiological pH.

Benini S, Cianci M, Ciurli S.

Dalton Trans. 2011 Aug 21;40(31):7831-3. doi: 10.1039/c1dt11107h. Epub 2011 Jul 4.

PMID:
21725560

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