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Items: 11


Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators.

Clapper JR, Henry CL, Niphakis MJ, Knize AM, Coppola AR, Simon GM, Ngo N, Herbst RA, Herbst DM, Reed AW, Cisar JS, Weber OD, Viader A, Alexander JP, Cunningham ML, Jones TK, Fraser IP, Grice CA, Ezekowitz RAB, O'Neill GP, Blankman JL.

J Pharmacol Exp Ther. 2018 Dec;367(3):494-508. doi: 10.1124/jpet.118.252296. Epub 2018 Oct 10.


Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders.

Cisar JS, Weber OD, Clapper JR, Blankman JL, Henry CL, Simon GM, Alexander JP, Jones TK, Ezekowitz RAB, O'Neill GP, Grice CA.

J Med Chem. 2018 Oct 25;61(20):9062-9084. doi: 10.1021/acs.jmedchem.8b00951. Epub 2018 Aug 23.


Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.

Lun S, Guo H, Adamson J, Cisar JS, Davis TD, Chavadi SS, Warren JD, Quadri LE, Tan DS, Bishai WR.

Antimicrob Agents Chemother. 2013 Oct;57(10):5138-40. doi: 10.1128/AAC.00918-13. Epub 2013 Jul 15.


Simultaneous structure-activity studies and arming of natural products by C-H amination reveal cellular targets of eupalmerin acetate.

Li J, Cisar JS, Zhou CY, Vera B, Williams H, Rodríguez AD, Cravatt BF, Romo D.

Nat Chem. 2013 Jun;5(6):510-7. doi: 10.1038/nchem.1653. Epub 2013 May 19. Erratum in: Nat Chem. 2013 Jul;5(7):634.


Activity-based labeling of matrix metalloproteinases in living vertebrate embryos.

Keow JY, Pond ED, Cisar JS, Cravatt BF, Crawford BD.

PLoS One. 2012;7(8):e43434. doi: 10.1371/journal.pone.0043434. Epub 2012 Aug 28.


Fully functionalized small-molecule probes for integrated phenotypic screening and target identification.

Cisar JS, Cravatt BF.

J Am Chem Soc. 2012 Jun 27;134(25):10385-8. doi: 10.1021/ja304213w. Epub 2012 Jun 13.


Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids.

Long JZ, Cisar JS, Milliken D, Niessen S, Wang C, Trauger SA, Siuzdak G, Cravatt BF.

Nat Chem Biol. 2011 Sep 18;7(11):763-5. doi: 10.1038/nchembio.659.


Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.

Lu X, Olsen SK, Capili AD, Cisar JS, Lima CD, Tan DS.

J Am Chem Soc. 2010 Feb 17;132(6):1748-9. doi: 10.1021/ja9088549.


Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy.

Cisar JS, Tan DS.

Chem Soc Rev. 2008 Jul;37(7):1320-9. doi: 10.1039/b702780j. Epub 2008 May 21. Review.


Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules.

Cisar JS, Ferreras JA, Soni RK, Quadri LE, Tan DS.

J Am Chem Soc. 2007 Jun 27;129(25):7752-3. Epub 2007 Jun 2. No abstract available.


Functional self-assembling bolaamphiphilic polydiacetylenes as colorimetric sensor scaffolds.

Song J, Cisar JS, Bertozzi CR.

J Am Chem Soc. 2004 Jul 14;126(27):8459-65.


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