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Items: 17

1.

Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response.

Sinnige T, Ciryam P, Casford S, Dobson CM, de Bono M, Vendruscolo M.

PLoS One. 2019 May 31;14(5):e0217746. doi: 10.1371/journal.pone.0217746. eCollection 2019.

2.

A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data.

Sharma AK, Sormanni P, Ahmed N, Ciryam P, Friedrich UA, Kramer G, O'Brien EP.

PLoS Comput Biol. 2019 May 23;15(5):e1007070. doi: 10.1371/journal.pcbi.1007070. eCollection 2019 May.

3.

Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming.

Ahmed N, Sormanni P, Ciryam P, Vendruscolo M, Dobson CM, O'Brien EP.

Sci Rep. 2019 Apr 18;9(1):6256. doi: 10.1038/s41598-019-42348-x.

4.

Clinical Utilization of the FilmArray Meningitis/Encephalitis (ME) Multiplex Polymerase Chain Reaction (PCR) Assay.

Radmard S, Reid S, Ciryam P, Boubour A, Ho N, Zucker J, Sayre D, Greendyke WG, Miko BA, Pereira MR, Whittier S, Green DA, Thakur KT.

Front Neurol. 2019 Mar 26;10:281. doi: 10.3389/fneur.2019.00281. eCollection 2019.

5.

The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS.

Yerbury JJ, Ooi L, Blair IP, Ciryam P, Dobson CM, Vendruscolo M.

Neurosci Lett. 2019 Apr 3;704:89-94. doi: 10.1016/j.neulet.2019.04.001. [Epub ahead of print]

PMID:
30953736
6.

SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS.

Farrawell NE, Lambert-Smith I, Mitchell K, McKenna J, McAlary L, Ciryam P, Vine KL, Saunders DN, Yerbury JJ.

J Cell Sci. 2018 Jun 12;131(11). pii: jcs209122. doi: 10.1242/jcs.209122.

7.

Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.

Kundra R, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5703-E5711. doi: 10.1073/pnas.1618417114. Epub 2017 Jun 26.

8.

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.

Ciryam P, Lambert-Smith IA, Bean DM, Freer R, Cid F, Tartaglia GG, Saunders DN, Wilson MR, Oliver SG, Morimoto RI, Dobson CM, Vendruscolo M, Favrin G, Yerbury JJ.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):E3935-E3943. doi: 10.1073/pnas.1613854114. Epub 2017 Apr 10.

9.

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU.

Cell. 2017 Feb 23;168(5):944. doi: 10.1016/j.cell.2016.12.041. No abstract available.

10.

A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease.

Freer R, Sormanni P, Vecchi G, Ciryam P, Dobson CM, Vendruscolo M.

Sci Adv. 2016 Aug 10;2(8):e1600947. doi: 10.1126/sciadv.1600947. eCollection 2016 Aug.

11.

A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation.

Ciryam P, Kundra R, Freer R, Morimoto RI, Dobson CM, Vendruscolo M.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4753-8. doi: 10.1073/pnas.1516604113. Epub 2016 Apr 11.

12.

Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU.

Cell. 2015 May 7;161(4):919-32. doi: 10.1016/j.cell.2015.03.032. Erratum in: Cell. 2017 Feb 23;168(5):944.

13.

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases.

Ciryam P, Kundra R, Morimoto RI, Dobson CM, Vendruscolo M.

Trends Pharmacol Sci. 2015 Feb;36(2):72-7. doi: 10.1016/j.tips.2014.12.004. Epub 2015 Jan 27. Review.

14.

Understanding the influence of codon translation rates on cotranslational protein folding.

O'Brien EP, Ciryam P, Vendruscolo M, Dobson CM.

Acc Chem Res. 2014 May 20;47(5):1536-44. doi: 10.1021/ar5000117. Epub 2014 May 1. Review.

PMID:
24784899
15.

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins.

Ciryam P, Tartaglia GG, Morimoto RI, Dobson CM, Vendruscolo M.

Cell Rep. 2013 Nov 14;5(3):781-90. doi: 10.1016/j.celrep.2013.09.043. Epub 2013 Oct 31.

16.

In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome.

Ciryam P, Morimoto RI, Vendruscolo M, Dobson CM, O'Brien EP.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):E132-40. doi: 10.1073/pnas.1213624110. Epub 2012 Dec 19.

17.

A market for compassion: single-payer health insurance.

Ciryam P.

Medscape J Med. 2008;10(9):208. Epub 2008 Sep 5. No abstract available.

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