Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 193

1.

Phosphoproteomic Alterations of Ionotropic Glutamate Receptors in the Hippocampus of the Ts65Dn Mouse Model of Down Syndrome.

Gómez de Salazar M, Grau C, Ciruela F, Altafaj X.

Front Mol Neurosci. 2018 Jul 25;11:226. doi: 10.3389/fnmol.2018.00226. eCollection 2018.

2.

Functional coupling of GABAA/B receptors and the channel TRPV4 mediates rapid progesterone signaling in the oviduct.

Jung C, Fernández-Dueñas V, Plata C, Garcia-Elias A, Ciruela F, Fernández-Fernández JM, Valverde MA.

Sci Signal. 2018 Aug 14;11(543). pii: eaam6558. doi: 10.1126/scisignal.aam6558.

PMID:
30108184
3.

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation.

Morató X, Luján R, Gonçalves N, Watanabe M, Altafaj X, Carvalho AL, Fernández-Dueñas V, Cunha RA, Ciruela F.

Hum Mol Genet. 2018 Jul 16. doi: 10.1093/hmg/ddy264. [Epub ahead of print]

PMID:
30010864
4.

Effects of the Dopamine Stabilizer, Pridopidine, on Basal and Phencyclidine-Induced Locomotion: Role of Dopamine D2 and Sigma-1 Receptors.

Sahlholm K, Valle-Leon M, Taura J, Fernandez-Duenas V, Ciruela F.

CNS Neurol Disord Drug Targets. 2018;17(7):522-527. doi: 10.2174/1871527317666180627103337.

PMID:
29952269
5.

Remote control of movement disorders using a photoactive adenosine A2A receptor antagonist.

Taura J, Nolen EG, Cabré G, Hernando J, Squarcialupi L, López-Cano M, Jacobson KA, Fernández-Dueñas V, Ciruela F.

J Control Release. 2018 Aug 10;283:135-142. doi: 10.1016/j.jconrel.2018.05.033. Epub 2018 May 31.

PMID:
29859955
6.

Pridopidine Reverses Phencyclidine-Induced Memory Impairment.

Sahlholm K, Valle-León M, Fernández-Dueñas V, Ciruela F.

Front Pharmacol. 2018 Apr 10;9:338. doi: 10.3389/fphar.2018.00338. eCollection 2018.

7.

Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase.

Ferré S, Bonaventura J, Zhu W, Hatcher-Solis C, Taura J, Quiroz C, Cai NS, Moreno E, Casadó-Anguera V, Kravitz AV, Thompson KR, Tomasi DG, Navarro G, Cordomí A, Pardo L, Lluís C, Dessauer CW, Volkow ND, Casadó V, Ciruela F, Logothetis DE, Zwilling D.

Front Pharmacol. 2018 Apr 9;9:243. doi: 10.3389/fphar.2018.00243. eCollection 2018.

8.

Adenosine A2A-dopamine D2 receptor heteromers operate striatal function: impact on Parkinson's disease pharmacotherapeutics.

Fernandez-Duenas V, Ferré S, Ciruela F.

Neural Regen Res. 2018 Feb;13(2):241-243. doi: 10.4103/1673-5374.226388. No abstract available.

9.

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.

Font J, López-Cano M, Notartomaso S, Scarselli P, Di Prieto P, Bresolí-Obach R, Battaglia G, Malhaire F, Rovira X, Catena J, Giraldo J, Pin JP, Fernández-Dueñas V, Goudet C, Nonell S, Nicoletti F, Llebaria A, Ciruela F.

Elife. 2018 Jan 8;7. pii: e34752. doi: 10.7554/eLife.34752. No abstract available.

10.

Bitopic fluorescent antagonists of the A2A adenosine receptor based on pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine functionalized congeners.

Duroux R, Ciancetta A, Mannes P, Yu J, Boyapati S, Gizewski E, Yous S, Ciruela F, Auchampach JA, Gao ZG, Jacobson KA.

Medchemcomm. 2017 Aug 1;8(8):1659-1667. doi: 10.1039/C7MD00247E. Epub 2017 Jun 22.

11.

Adenosine A1-A2A Receptor Heteromer as a Possible Target for Early-Onset Parkinson's Disease.

Fernández-Dueñas V, Pérez-Arévalo A, Altafaj X, Ferré S, Ciruela F.

Front Neurosci. 2017 Nov 22;11:652. doi: 10.3389/fnins.2017.00652. eCollection 2017. No abstract available.

12.

Differential association of GABAB receptors with their effector ion channels in Purkinje cells.

Luján R, Aguado C, Ciruela F, Cózar J, Kleindienst D, de la Ossa L, Bettler B, Wickman K, Watanabe M, Shigemoto R, Fukazawa Y.

Brain Struct Funct. 2018 Apr;223(3):1565-1587. doi: 10.1007/s00429-017-1568-y. Epub 2017 Nov 25.

13.

Behavioral control by striatal adenosine A2A -dopamine D2 receptor heteromers.

Taura J, Valle-León M, Sahlholm K, Watanabe M, Van Craenenbroeck K, Fernández-Dueñas V, Ferré S, Ciruela F.

Genes Brain Behav. 2018 Apr;17(4):e12432. doi: 10.1111/gbb.12432. Epub 2017 Nov 17.

PMID:
29053217
14.

Antiparkinsonian Efficacy of Guanosine in Rodent Models of Movement Disorder.

Massari CM, López-Cano M, Núñez F, Fernández-Dueñas V, Tasca CI, Ciruela F.

Front Pharmacol. 2017 Oct 4;8:700. doi: 10.3389/fphar.2017.00700. eCollection 2017.

15.

Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses.

Manils J, Fischer H, Climent J, Casas E, García-Martínez C, Bas J, Sukseree S, Vavouri T, Ciruela F, de Anta JM, Tschachler E, Eckhart L, Soler C.

Sci Rep. 2017 Sep 19;7(1):11902. doi: 10.1038/s41598-017-12308-4.

16.

Cognitive impairments associated with alterations in synaptic proteins induced by the genetic loss of adenosine A2A receptors in mice.

Moscoso-Castro M, López-Cano M, Gracia-Rubio I, Ciruela F, Valverde O.

Neuropharmacology. 2017 Nov;126:48-57. doi: 10.1016/j.neuropharm.2017.08.027. Epub 2017 Aug 26.

PMID:
28844595
17.

The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo.

Morató X, Luján R, López-Cano M, Gandía J, Stagljar I, Watanabe M, Cunha RA, Fernández-Dueñas V, Ciruela F.

Sci Rep. 2017 Aug 25;7(1):9452. doi: 10.1038/s41598-017-10147-x.

18.

Antipsychotic-Like Efficacy of Dopamine D2 Receptor-Biased Ligands is Dependent on Adenosine A2A Receptor Expression.

Sahlholm K, Gómez-Soler M, Valle-León M, López-Cano M, Taura JJ, Ciruela F, Fernández-Dueñas V.

Mol Neurobiol. 2018 Jun;55(6):4952-4958. doi: 10.1007/s12035-017-0696-y. Epub 2017 Aug 5.

PMID:
28779351
19.

Rett-like Severe Encephalopathy Caused by a De Novo GRIN2B Mutation Is Attenuated by D-serine Dietary Supplement.

Soto D, Olivella M, Grau C, Armstrong J, Alcon C, Gasull X, Gómez de Salazar M, Gratacòs-Batlle E, Ramos-Vicente D, Fernández-Dueñas V, Ciruela F, Bayés À, Sindreu C, López-Sala A, García-Cazorla À, Altafaj X.

Biol Psychiatry. 2018 Jan 15;83(2):160-172. doi: 10.1016/j.biopsych.2017.05.028. Epub 2017 Jun 16. Retraction in: Biol Psychiatry. 2018 Apr 15;83(8):715.

PMID:
28734458
20.

Special Issue: Adenosine Receptors.

Ciruela F, Sotelo E.

Molecules. 2017 Jul 20;22(7). pii: E1220. doi: 10.3390/molecules22071220.

21.

Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization.

Morató X, López-Cano M, Canas PM, Cunha RA, Ciruela F.

J Vis Exp. 2017 May 12;(123). doi: 10.3791/55661.

PMID:
28570537
22.

Angiotensin II type 1/adenosine A 2A receptor oligomers: a novel target for tardive dyskinesia.

Oliveira PA, Dalton JAR, López-Cano M, Ricarte A, Morató X, Matheus FC, Cunha AS, Müller CE, Takahashi RN, Fernández-Dueñas V, Giraldo J, Prediger RD, Ciruela F.

Sci Rep. 2017 May 12;7(1):1857. doi: 10.1038/s41598-017-02037-z.

23.

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.

Font J, López-Cano M, Notartomaso S, Scarselli P, Di Pietro P, Bresolí-Obach R, Battaglia G, Malhaire F, Rovira X, Catena J, Giraldo J, Pin JP, Fernández-Dueñas V, Goudet C, Nonell S, Nicoletti F, Llebaria A, Ciruela F.

Elife. 2017 Apr 11;6. pii: e23545. doi: 10.7554/eLife.23545. Erratum in: Elife. 2018 Jan 08;7:.

24.

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gandía J, Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, Malty RH, Deineko V, Aoki H, Amin S, Yao Z, Morató X, Otasek D, Kobayashi H, Menendez J, Auerbach D, Angers S, Pržulj N, Bouvier M, Babu M, Ciruela F, Jockers R, Jurisica I, Stagljar I.

Mol Syst Biol. 2017 Mar 15;13(3):918. doi: 10.15252/msb.20167430.

25.

Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid.

Fernández-Dueñas V, Azuaje J, Morató X, Cordobilla B, Domingo JC, Sotelo E, Ciruela F.

Molecules. 2017 Feb 27;22(3). pii: E366. doi: 10.3390/molecules22030366.

26.

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals.

Gómez-Santacana X, Pittolo S, Rovira X, Lopez M, Zussy C, Dalton JA, Faucherre A, Jopling C, Pin JP, Ciruela F, Goudet C, Giraldo J, Gorostiza P, Llebaria A.

ACS Cent Sci. 2017 Jan 25;3(1):81-91. doi: 10.1021/acscentsci.6b00353. Epub 2016 Dec 19.

27.

Exploring Drug-Receptor Interaction Kinetics: Lessons from a Sigma-1 Receptor Transmembrane Biosensor.

Fernández-Dueñas V, Burgueño J, Ciruela F.

Front Pharmacol. 2017 Jan 17;8:4. doi: 10.3389/fphar.2017.00004. eCollection 2017. No abstract available.

28.

Calcium modulates calmodulin/α-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor.

Piirainen H, Taura J, Kursula P, Ciruela F, Jaakola VP.

Biochim Biophys Acta. 2017 Apr;1864(4):674-686. doi: 10.1016/j.bbamcr.2017.01.013. Epub 2017 Jan 24.

29.

Locus coeruleus at asymptomatic early and middle Braak stages of neurofibrillary tangle pathology.

Andrés-Benito P, Fernández-Dueñas V, Carmona M, Escobar LA, Torrejón-Escribano B, Aso E, Ciruela F, Ferrer I.

Neuropathol Appl Neurobiol. 2017 Aug;43(5):373-392. doi: 10.1111/nan.12386. Epub 2017 Apr 19.

PMID:
28117912
30.

Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum.

Moreno E, Chiarlone A, Medrano M, Puigdellívol M, Bibic L, Howell LA, Resel E, Puente N, Casarejos MJ, Perucho J, Botta J, Suelves N, Ciruela F, Ginés S, Galve-Roperh I, Casadó V, Grandes P, Lutz B, Monory K, Canela EI, Lluís C, McCormick PJ, Guzmán M.

Neuropsychopharmacology. 2018 Apr;43(5):964-977. doi: 10.1038/npp.2017.12. Epub 2017 Jan 19.

31.

Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.

Rial D, Morató X, Real JI, Gonçalves FQ, Stagljar I, Pereira FC, Fernández-Dueñas V, Cunha RA, Ciruela F.

Neurosci Lett. 2017 Jan 18;638:162-166. doi: 10.1016/j.neulet.2016.12.040. Epub 2016 Dec 19.

PMID:
28007645
32.

Investigation of LRRC8-Mediated Volume-Regulated Anion Currents in Xenopus Oocytes.

Gaitán-Peñas H, Gradogna A, Laparra-Cuervo L, Solsona C, Fernández-Dueñas V, Barrallo-Gimeno A, Ciruela F, Lakadamyali M, Pusch M, Estévez R.

Biophys J. 2016 Oct 4;111(7):1429-1443. doi: 10.1016/j.bpj.2016.08.030.

33.

The Guanine-Based Purinergic System: The Tale of An Orphan Neuromodulation.

Di Liberto V, Mudò G, Garozzo R, Frinchi M, Fernandez-Dueñas V, Di Iorio P, Ciccarelli R, Caciagli F, Condorelli DF, Ciruela F, Belluardo N.

Front Pharmacol. 2016 Jun 17;7:158. doi: 10.3389/fphar.2016.00158. eCollection 2016. Review.

34.

The Exonuclease Trex2 Shapes Psoriatic Phenotype.

Manils J, Casas E, Viña-Vilaseca A, López-Cano M, Díez-Villanueva A, Gómez D, Marruecos L, Ferran M, Benito C, Perrino FW, Vavouri T, de Anta JM, Ciruela F, Soler C.

J Invest Dermatol. 2016 Dec;136(12):2345-2355. doi: 10.1016/j.jid.2016.05.122. Epub 2016 Jun 27.

35.

Genetic blockade of adenosine A2A receptors induces cognitive impairments and anatomical changes related to psychotic symptoms in mice.

Moscoso-Castro M, Gracia-Rubio I, Ciruela F, Valverde O.

Eur Neuropsychopharmacol. 2016 Jul;26(7):1227-40. doi: 10.1016/j.euroneuro.2016.04.003. Epub 2016 Apr 28.

PMID:
27133030
36.

Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.

Rodrigues RJ, Almeida T, Díaz-Hernández M, Marques JM, Franco R, Solsona C, Miras-Portugal MT, Ciruela F, Cunha RA.

Neuropharmacology. 2016 Jun;105:241-257. doi: 10.1016/j.neuropharm.2016.01.022. Epub 2016 Jan 19.

PMID:
26801076
37.

Membrane omega-3 fatty acids modulate the oligomerisation kinetics of adenosine A2A and dopamine D2 receptors.

Guixà-González R, Javanainen M, Gómez-Soler M, Cordobilla B, Domingo JC, Sanz F, Pastor M, Ciruela F, Martinez-Seara H, Selent J.

Sci Rep. 2016 Jan 22;6:19839. doi: 10.1038/srep19839.

38.

Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells.

Soto-Cerrato V, Manuel-Manresa P, Hernando E, Calabuig-Fariñas S, Martínez-Romero A, Fernández-Dueñas V, Sahlholm K, Knöpfel T, García-Valverde M, Rodilla AM, Jantus-Lewintre E, Farràs R, Ciruela F, Pérez-Tomás R, Quesada R.

J Am Chem Soc. 2015 Dec 23;137(50):15892-8. doi: 10.1021/jacs.5b09970. Epub 2015 Dec 17.

PMID:
26632983
39.

Visualizing G Protein-Coupled Receptor-Receptor Interactions in Brain Using Proximity Ligation In Situ Assay.

Taura J, Fernández-Dueñas V, Ciruela F.

Curr Protoc Cell Biol. 2015 Jun 1;67:17.17.1-16. doi: 10.1002/0471143030.cb1717s67.

PMID:
26061241
40.

Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression.

Borroto-Escuela DO, Pérez-Alea M, Narvaez M, Tarakanov AO, Mudó G, Jiménez-Beristain A, Agnati LF, Ciruela F, Belluardo N, Fuxe K.

Biochem Biophys Res Commun. 2015 Jul 31;463(3):180-6. doi: 10.1016/j.bbrc.2015.04.133. Epub 2015 May 6.

PMID:
25957476
41.

Lighting up G protein-coupled purinergic receptors with engineered fluorescent ligands.

Ciruela F, Fernández-Dueñas V, Jacobson KA.

Neuropharmacology. 2015 Nov;98:58-67. doi: 10.1016/j.neuropharm.2015.04.001. Epub 2015 Apr 16. Review.

42.

Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent.

Gandía J, Morató X, Stagljar I, Fernández-Dueñas V, Ciruela F.

Behav Brain Res. 2015 Jul 15;288:103-6. doi: 10.1016/j.bbr.2015.04.001. Epub 2015 Apr 9.

PMID:
25862943
43.

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system.

Lopes JP, Morató X, Souza C, Pinhal C, Machado NJ, Canas PM, Silva HB, Stagljar I, Gandía J, Fernández-Dueñas V, Luján R, Cunha RA, Ciruela F.

J Neurochem. 2015 Jul;134(1):135-46. doi: 10.1111/jnc.13109. Epub 2015 Apr 21.

44.

GPCR oligomerization analysis by means of BRET and dFRAP.

Ciruela F, Fernández-Dueñas V.

Methods Mol Biol. 2015;1272:133-41. doi: 10.1007/978-1-4939-2336-6_10.

PMID:
25563182
45.

Adenosine A1 receptor activation modulates N-methyl-d-aspartate (NMDA) preconditioning phenotype in the brain.

Constantino LC, Pamplona FA, Matheus FC, Ludka FK, Gomez-Soler M, Ciruela F, Boeck CR, Prediger RD, Tasca CI.

Behav Brain Res. 2015 Apr 1;282:103-10. doi: 10.1016/j.bbr.2014.12.056. Epub 2014 Dec 31.

PMID:
25557798
46.

Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system.

Borroto-Escuela DO, Narvaez M, Pérez-Alea M, Tarakanov AO, Jiménez-Beristain A, Mudó G, Agnati LF, Ciruela F, Belluardo N, Fuxe K.

Biochem Biophys Res Commun. 2015 Jan 2;456(1):489-93. doi: 10.1016/j.bbrc.2014.11.112. Epub 2014 Dec 6.

PMID:
25485703
47.

Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats.

Fernández-Dueñas V, Taura JJ, Cottet M, Gómez-Soler M, López-Cano M, Ledent C, Watanabe M, Trinquet E, Pin JP, Luján R, Durroux T, Ciruela F.

Dis Model Mech. 2015 Jan;8(1):57-63. doi: 10.1242/dmm.018143. Epub 2014 Nov 14.

48.

Coassembly and coupling of SK2 channels and mGlu5 receptors.

García-Negredo G, Soto D, Llorente J, Morató X, Galenkamp KM, Gómez-Soler M, Fernández-Dueñas V, Watanabe M, Adelman JP, Shigemoto R, Fukazawa Y, Luján R, Ciruela F.

J Neurosci. 2014 Oct 29;34(44):14793-802. doi: 10.1523/JNEUROSCI.2038-14.2014.

49.

Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism.

Fernández-Dueñas V, Gómez-Soler M, López-Cano M, Taura JJ, Ledent C, Watanabe M, Jacobson KA, Vilardaga JP, Ciruela F.

ACS Chem Biol. 2014 Nov 21;9(11):2496-501. doi: 10.1021/cb5005383. Epub 2014 Oct 2.

50.

Photomodulation of G protein-coupled adenosine receptors by a novel light-switchable ligand.

Bahamonde MI, Taura J, Paoletta S, Gakh AA, Chakraborty S, Hernando J, Fernández-Dueñas V, Jacobson KA, Gorostiza P, Ciruela F.

Bioconjug Chem. 2014 Oct 15;25(10):1847-54. doi: 10.1021/bc5003373. Epub 2014 Oct 2.

Supplemental Content

Loading ...
Support Center