Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 208

1.

Functional and Neuroprotective Role of Striatal Adenosine A2A Receptor Heterotetramers.

Ferré S, Ciruela F.

J Caffeine Adenosine Res. 2019 Sep 1;9(3):89-97. doi: 10.1089/caff.2019.0008. Epub 2019 Sep 17. Review.

2.

Proximity Ligation Assay Image Analysis Protocol: Addressing Receptor-Receptor Interactions.

López-Cano M, Fernández-Dueñas V, Ciruela F.

Methods Mol Biol. 2019;2040:41-50. doi: 10.1007/978-1-4939-9686-5_3.

PMID:
31432474
3.

Revealing Adenosine A2A-Dopamine D2 Receptor Heteromers in Parkinson's Disease Post-Mortem Brain through a New AlphaScreen-Based Assay.

Fernández-Dueñas V, Gómez-Soler M, Valle-León M, Watanabe M, Ferrer I, Ciruela F.

Int J Mol Sci. 2019 Jul 23;20(14). pii: E3600. doi: 10.3390/ijms20143600.

4.

G protein-coupled receptor 37 (GPR37) emerges as an important modulator of adenosinergic transmission in the striatum.

Morato X, Cunha RA, Ciruela F.

Neural Regen Res. 2019 Nov;14(11):1912-1914. doi: 10.4103/1673-5374.259610. No abstract available.

5.

l-Serine dietary supplementation is associated with clinical improvement of loss-of-function GRIN2B-related pediatric encephalopathy.

Soto D, Olivella M, Grau C, Armstrong J, Alcon C, Gasull X, Santos-Gómez A, Locubiche S, Gómez de Salazar M, García-Díaz R, Gratacòs-Batlle E, Ramos-Vicente D, Chu-Van E, Colsch B, Fernández-Dueñas V, Ciruela F, Bayés À, Sindreu C, López-Sala A, García-Cazorla À, Altafaj X.

Sci Signal. 2019 Jun 18;12(586). pii: eaaw0936. doi: 10.1126/scisignal.aaw0936.

PMID:
31213567
6.

Optical Modulation of Metabotropic Glutamate Receptor Type 5 In Vivo Using a Photoactive Drug.

López-Cano M, Font J, Llebaria A, Fernández-Dueñas V, Ciruela F.

Methods Mol Biol. 2019;1947:351-359. doi: 10.1007/978-1-4939-9121-1_20.

PMID:
30969427
7.

Editorial: Purinergic Pharmacology.

Ciruela F, Jacobson KA.

Front Pharmacol. 2019 Jan 23;10:21. doi: 10.3389/fphar.2019.00021. eCollection 2019. No abstract available.

8.

New ionic targets of 3,3',5'-triiodothyronine at the plasma membrane of rat Sertoli cells.

Zanatta AP, Gonçalves R, Zanatta L, de Oliveria GT, Ludwig Moraes AL, Zamoner A, Fernández-Dueñas V, Lanznaster D, Ciruela F, Tasca CI, Delalande C, Menegaz D, Mena Barreto Silva FR.

Biochim Biophys Acta Biomembr. 2019 Apr 1;1861(4):748-759. doi: 10.1016/j.bbamem.2019.01.002. Epub 2019 Jan 9.

PMID:
30639285
9.

Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Hippocampus: Cannabidiol Blunts Δ9-Tetrahydrocannabinol-Induced Cognitive Impairment.

Aso E, Fernández-Dueñas V, López-Cano M, Taura J, Watanabe M, Ferrer I, Luján R, Ciruela F.

Mol Neurobiol. 2019 Aug;56(8):5382-5391. doi: 10.1007/s12035-018-1456-3. Epub 2019 Jan 4.

PMID:
30610611
10.

Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice.

Morató X, Gonçalves FQ, Lopes JP, Jauregui O, Soler C, Fernández-Dueñas V, Cunha RA, Ciruela F.

J Neurochem. 2019 Mar;148(6):796-809. doi: 10.1111/jnc.14653. Epub 2019 Jan 28.

PMID:
30578680
11.

Dopamine receptor heteromers: biasing antipsychotics.

Sahlholm K, Valle-León M, Fernández-Dueñas V, Ciruela F.

Future Med Chem. 2018 Dec 6. doi: 10.4155/fmc-2018-0335. [Epub ahead of print] No abstract available.

12.

Neuromodulatory Effects of Guanine-Based Purines in Health and Disease.

Tasca CI, Lanznaster D, Oliveira KA, Fernández-Dueñas V, Ciruela F.

Front Cell Neurosci. 2018 Oct 23;12:376. doi: 10.3389/fncel.2018.00376. eCollection 2018. Review.

13.

PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders.

Núñez F, Taura J, Camacho J, López-Cano M, Fernández-Dueñas V, Castro N, Castro J, Ciruela F.

Front Pharmacol. 2018 Oct 19;9:1200. doi: 10.3389/fphar.2018.01200. eCollection 2018.

14.

SK2 Channels Associate With mGlu Receptors and CaV2.1 Channels in Purkinje Cells.

Luján R, Aguado C, Ciruela F, Arus XM, Martín-Belmonte A, Alfaro-Ruiz R, Martínez-Gómez J, de la Ossa L, Watanabe M, Adelman JP, Shigemoto R, Fukazawa Y.

Front Cell Neurosci. 2018 Sep 19;12:311. doi: 10.3389/fncel.2018.00311. eCollection 2018.

15.

Triglyceride Form of Docosahexaenoic Acid Mediates Neuroprotection in Experimental Parkinsonism.

Gómez-Soler M, Cordobilla B, Morató X, Fernández-Dueñas V, Domingo JC, Ciruela F.

Front Neurosci. 2018 Aug 28;12:604. doi: 10.3389/fnins.2018.00604. eCollection 2018.

16.

Phosphoproteomic Alterations of Ionotropic Glutamate Receptors in the Hippocampus of the Ts65Dn Mouse Model of Down Syndrome.

Gómez de Salazar M, Grau C, Ciruela F, Altafaj X.

Front Mol Neurosci. 2018 Jul 25;11:226. doi: 10.3389/fnmol.2018.00226. eCollection 2018.

17.

Functional coupling of GABAA/B receptors and the channel TRPV4 mediates rapid progesterone signaling in the oviduct.

Jung C, Fernández-Dueñas V, Plata C, Garcia-Elias A, Ciruela F, Fernández-Fernández JM, Valverde MA.

Sci Signal. 2018 Aug 14;11(543). pii: eaam6558. doi: 10.1126/scisignal.aam6558.

PMID:
30108184
18.

Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation.

Morató X, Luján R, Gonçalves N, Watanabe M, Altafaj X, Carvalho AL, Fernández-Dueñas V, Cunha RA, Ciruela F.

Hum Mol Genet. 2018 Oct 15;27(20):3528-3541. doi: 10.1093/hmg/ddy264.

PMID:
30010864
19.

Effects of the Dopamine Stabilizer, Pridopidine, on Basal and Phencyclidine-Induced Locomotion: Role of Dopamine D2 and Sigma-1 Receptors.

Sahlholm K, Valle-Leon M, Taura J, Fernandez-Duenas V, Ciruela F.

CNS Neurol Disord Drug Targets. 2018;17(7):522-527. doi: 10.2174/1871527317666180627103337.

PMID:
29952269
20.

Remote control of movement disorders using a photoactive adenosine A2A receptor antagonist.

Taura J, Nolen EG, Cabré G, Hernando J, Squarcialupi L, López-Cano M, Jacobson KA, Fernández-Dueñas V, Ciruela F.

J Control Release. 2018 Aug 10;283:135-142. doi: 10.1016/j.jconrel.2018.05.033. Epub 2018 May 31.

21.

Pridopidine Reverses Phencyclidine-Induced Memory Impairment.

Sahlholm K, Valle-León M, Fernández-Dueñas V, Ciruela F.

Front Pharmacol. 2018 Apr 10;9:338. doi: 10.3389/fphar.2018.00338. eCollection 2018.

22.

Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase.

Ferré S, Bonaventura J, Zhu W, Hatcher-Solis C, Taura J, Quiroz C, Cai NS, Moreno E, Casadó-Anguera V, Kravitz AV, Thompson KR, Tomasi DG, Navarro G, Cordomí A, Pardo L, Lluís C, Dessauer CW, Volkow ND, Casadó V, Ciruela F, Logothetis DE, Zwilling D.

Front Pharmacol. 2018 Apr 9;9:243. doi: 10.3389/fphar.2018.00243. eCollection 2018.

23.

Adenosine A2A-dopamine D2 receptor heteromers operate striatal function: impact on Parkinson's disease pharmacotherapeutics.

Fernandez-Duenas V, Ferré S, Ciruela F.

Neural Regen Res. 2018 Feb;13(2):241-243. doi: 10.4103/1673-5374.226388. No abstract available.

24.

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.

Font J, López-Cano M, Notartomaso S, Scarselli P, Di Prieto P, Bresolí-Obach R, Battaglia G, Malhaire F, Rovira X, Catena J, Giraldo J, Pin JP, Fernández-Dueñas V, Goudet C, Nonell S, Nicoletti F, Llebaria A, Ciruela F.

Elife. 2018 Jan 8;7. pii: e34752. doi: 10.7554/eLife.34752. No abstract available.

25.

Bitopic fluorescent antagonists of the A2A adenosine receptor based on pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine functionalized congeners.

Duroux R, Ciancetta A, Mannes P, Yu J, Boyapati S, Gizewski E, Yous S, Ciruela F, Auchampach JA, Gao ZG, Jacobson KA.

Medchemcomm. 2017 Aug 1;8(8):1659-1667. doi: 10.1039/C7MD00247E. Epub 2017 Jun 22.

26.

Adenosine A1-A2A Receptor Heteromer as a Possible Target for Early-Onset Parkinson's Disease.

Fernández-Dueñas V, Pérez-Arévalo A, Altafaj X, Ferré S, Ciruela F.

Front Neurosci. 2017 Nov 22;11:652. doi: 10.3389/fnins.2017.00652. eCollection 2017. No abstract available.

27.

Differential association of GABAB receptors with their effector ion channels in Purkinje cells.

Luján R, Aguado C, Ciruela F, Cózar J, Kleindienst D, de la Ossa L, Bettler B, Wickman K, Watanabe M, Shigemoto R, Fukazawa Y.

Brain Struct Funct. 2018 Apr;223(3):1565-1587. doi: 10.1007/s00429-017-1568-y. Epub 2017 Nov 25.

28.

Behavioral control by striatal adenosine A2A -dopamine D2 receptor heteromers.

Taura J, Valle-León M, Sahlholm K, Watanabe M, Van Craenenbroeck K, Fernández-Dueñas V, Ferré S, Ciruela F.

Genes Brain Behav. 2018 Apr;17(4):e12432. doi: 10.1111/gbb.12432. Epub 2017 Nov 17.

PMID:
29053217
29.

Antiparkinsonian Efficacy of Guanosine in Rodent Models of Movement Disorder.

Massari CM, López-Cano M, Núñez F, Fernández-Dueñas V, Tasca CI, Ciruela F.

Front Pharmacol. 2017 Oct 4;8:700. doi: 10.3389/fphar.2017.00700. eCollection 2017.

30.

Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses.

Manils J, Fischer H, Climent J, Casas E, García-Martínez C, Bas J, Sukseree S, Vavouri T, Ciruela F, de Anta JM, Tschachler E, Eckhart L, Soler C.

Sci Rep. 2017 Sep 19;7(1):11902. doi: 10.1038/s41598-017-12308-4.

31.

Cognitive impairments associated with alterations in synaptic proteins induced by the genetic loss of adenosine A2A receptors in mice.

Moscoso-Castro M, López-Cano M, Gracia-Rubio I, Ciruela F, Valverde O.

Neuropharmacology. 2017 Nov;126:48-57. doi: 10.1016/j.neuropharm.2017.08.027. Epub 2017 Aug 26.

PMID:
28844595
32.

The Parkinson's disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo.

Morató X, Luján R, López-Cano M, Gandía J, Stagljar I, Watanabe M, Cunha RA, Fernández-Dueñas V, Ciruela F.

Sci Rep. 2017 Aug 25;7(1):9452. doi: 10.1038/s41598-017-10147-x.

33.

Antipsychotic-Like Efficacy of Dopamine D2 Receptor-Biased Ligands is Dependent on Adenosine A2A Receptor Expression.

Sahlholm K, Gómez-Soler M, Valle-León M, López-Cano M, Taura JJ, Ciruela F, Fernández-Dueñas V.

Mol Neurobiol. 2018 Jun;55(6):4952-4958. doi: 10.1007/s12035-017-0696-y. Epub 2017 Aug 5.

PMID:
28779351
34.

Rett-like Severe Encephalopathy Caused by a De Novo GRIN2B Mutation Is Attenuated by D-serine Dietary Supplement.

Soto D, Olivella M, Grau C, Armstrong J, Alcon C, Gasull X, Gómez de Salazar M, Gratacòs-Batlle E, Ramos-Vicente D, Fernández-Dueñas V, Ciruela F, Bayés À, Sindreu C, López-Sala A, García-Cazorla À, Altafaj X.

Biol Psychiatry. 2018 Jan 15;83(2):160-172. doi: 10.1016/j.biopsych.2017.05.028. Epub 2017 Jun 16. Retraction in: Biol Psychiatry. 2018 Apr 15;83(8):715.

PMID:
28734458
35.

Special Issue: Adenosine Receptors.

Ciruela F, Sotelo E.

Molecules. 2017 Jul 20;22(7). pii: E1220. doi: 10.3390/molecules22071220.

36.

Brain Membrane Fractionation: An Ex Vivo Approach to Assess Subsynaptic Protein Localization.

Morató X, López-Cano M, Canas PM, Cunha RA, Ciruela F.

J Vis Exp. 2017 May 12;(123). doi: 10.3791/55661.

37.

Angiotensin II type 1/adenosine A 2A receptor oligomers: a novel target for tardive dyskinesia.

Oliveira PA, Dalton JAR, López-Cano M, Ricarte A, Morató X, Matheus FC, Cunha AS, Müller CE, Takahashi RN, Fernández-Dueñas V, Giraldo J, Prediger RD, Ciruela F.

Sci Rep. 2017 May 12;7(1):1857. doi: 10.1038/s41598-017-02037-z.

38.

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.

Font J, López-Cano M, Notartomaso S, Scarselli P, Di Pietro P, Bresolí-Obach R, Battaglia G, Malhaire F, Rovira X, Catena J, Giraldo J, Pin JP, Fernández-Dueñas V, Goudet C, Nonell S, Nicoletti F, Llebaria A, Ciruela F.

Elife. 2017 Apr 11;6. pii: e23545. doi: 10.7554/eLife.23545. Erratum in: Elife. 2018 Jan 08;7:.

39.

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gandía J, Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, Malty RH, Deineko V, Aoki H, Amin S, Yao Z, Morató X, Otasek D, Kobayashi H, Menendez J, Auerbach D, Angers S, Pržulj N, Bouvier M, Babu M, Ciruela F, Jockers R, Jurisica I, Stagljar I.

Mol Syst Biol. 2017 Mar 15;13(3):918. doi: 10.15252/msb.20167430.

40.

Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid.

Fernández-Dueñas V, Azuaje J, Morató X, Cordobilla B, Domingo JC, Sotelo E, Ciruela F.

Molecules. 2017 Feb 27;22(3). pii: E366. doi: 10.3390/molecules22030366.

41.

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals.

Gómez-Santacana X, Pittolo S, Rovira X, Lopez M, Zussy C, Dalton JA, Faucherre A, Jopling C, Pin JP, Ciruela F, Goudet C, Giraldo J, Gorostiza P, Llebaria A.

ACS Cent Sci. 2017 Jan 25;3(1):81-91. doi: 10.1021/acscentsci.6b00353. Epub 2016 Dec 19.

42.

Exploring Drug-Receptor Interaction Kinetics: Lessons from a Sigma-1 Receptor Transmembrane Biosensor.

Fernández-Dueñas V, Burgueño J, Ciruela F.

Front Pharmacol. 2017 Jan 17;8:4. doi: 10.3389/fphar.2017.00004. eCollection 2017. No abstract available.

43.

Calcium modulates calmodulin/α-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor.

Piirainen H, Taura J, Kursula P, Ciruela F, Jaakola VP.

Biochim Biophys Acta Mol Cell Res. 2017 Apr;1864(4):674-686. doi: 10.1016/j.bbamcr.2017.01.013. Epub 2017 Jan 24.

44.

Locus coeruleus at asymptomatic early and middle Braak stages of neurofibrillary tangle pathology.

Andrés-Benito P, Fernández-Dueñas V, Carmona M, Escobar LA, Torrejón-Escribano B, Aso E, Ciruela F, Ferrer I.

Neuropathol Appl Neurobiol. 2017 Aug;43(5):373-392. doi: 10.1111/nan.12386. Epub 2017 Apr 19.

45.

Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum.

Moreno E, Chiarlone A, Medrano M, Puigdellívol M, Bibic L, Howell LA, Resel E, Puente N, Casarejos MJ, Perucho J, Botta J, Suelves N, Ciruela F, Ginés S, Galve-Roperh I, Casadó V, Grandes P, Lutz B, Monory K, Canela EI, Lluís C, McCormick PJ, Guzmán M.

Neuropsychopharmacology. 2018 Apr;43(5):964-977. doi: 10.1038/npp.2017.12. Epub 2017 Jan 19.

46.

Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.

Rial D, Morató X, Real JI, Gonçalves FQ, Stagljar I, Pereira FC, Fernández-Dueñas V, Cunha RA, Ciruela F.

Neurosci Lett. 2017 Jan 18;638:162-166. doi: 10.1016/j.neulet.2016.12.040. Epub 2016 Dec 19.

PMID:
28007645
47.

Investigation of LRRC8-Mediated Volume-Regulated Anion Currents in Xenopus Oocytes.

Gaitán-Peñas H, Gradogna A, Laparra-Cuervo L, Solsona C, Fernández-Dueñas V, Barrallo-Gimeno A, Ciruela F, Lakadamyali M, Pusch M, Estévez R.

Biophys J. 2016 Oct 4;111(7):1429-1443. doi: 10.1016/j.bpj.2016.08.030.

48.

The Guanine-Based Purinergic System: The Tale of An Orphan Neuromodulation.

Di Liberto V, Mudò G, Garozzo R, Frinchi M, Fernandez-Dueñas V, Di Iorio P, Ciccarelli R, Caciagli F, Condorelli DF, Ciruela F, Belluardo N.

Front Pharmacol. 2016 Jun 17;7:158. doi: 10.3389/fphar.2016.00158. eCollection 2016. Review.

49.

The Exonuclease Trex2 Shapes Psoriatic Phenotype.

Manils J, Casas E, Viña-Vilaseca A, López-Cano M, Díez-Villanueva A, Gómez D, Marruecos L, Ferran M, Benito C, Perrino FW, Vavouri T, de Anta JM, Ciruela F, Soler C.

J Invest Dermatol. 2016 Dec;136(12):2345-2355. doi: 10.1016/j.jid.2016.05.122. Epub 2016 Jun 27.

50.

Genetic blockade of adenosine A2A receptors induces cognitive impairments and anatomical changes related to psychotic symptoms in mice.

Moscoso-Castro M, Gracia-Rubio I, Ciruela F, Valverde O.

Eur Neuropsychopharmacol. 2016 Jul;26(7):1227-40. doi: 10.1016/j.euroneuro.2016.04.003. Epub 2016 Apr 28.

PMID:
27133030

Supplemental Content

Loading ...
Support Center