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Items: 27


A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.

Willoughby D, Halls ML, Everett KL, Ciruela A, Skroblin P, Klussmann E, Cooper DM.

J Cell Sci. 2012 Dec 1;125(Pt 23):5850-9. doi: 10.1242/jcs.111427. Epub 2012 Sep 12.


AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems.

Willoughby D, Masada N, Wachten S, Pagano M, Halls ML, Everett KL, Ciruela A, Cooper DM.

J Biol Chem. 2010 Jun 25;285(26):20328-42. doi: 10.1074/jbc.M110.120725. Epub 2010 Apr 21.


Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells.

Wachten S, Masada N, Ayling LJ, Ciruela A, Nikolaev VO, Lohse MJ, Cooper DM.

J Cell Sci. 2010 Jan 1;123(Pt 1):95-106. doi: 10.1242/jcs.058594.


Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibition.

Macdougall DA, Wachten S, Ciruela A, Sinz A, Cooper DM.

J Biol Chem. 2009 Jun 5;284(23):15573-88. doi: 10.1074/jbc.M809585200. Epub 2009 Mar 21.


Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8.

Martin AC, Willoughby D, Ciruela A, Ayling LJ, Pagano M, Wachten S, Tengholm A, Cooper DM.

Mol Pharmacol. 2009 Apr;75(4):830-42. doi: 10.1124/mol.108.051748. Epub 2009 Jan 26. Erratum in: Mol Pharmacol. 2009 May;75(5):1248.


Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry.

Pagano M, Clynes MA, Masada N, Ciruela A, Ayling LJ, Wachten S, Cooper DM.

Am J Physiol Cell Physiol. 2009 Mar;296(3):C607-19. doi: 10.1152/ajpcell.00488.2008. Epub 2009 Jan 21.


Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles.

Masada N, Ciruela A, Macdougall DA, Cooper DM.

J Biol Chem. 2009 Feb 13;284(7):4451-63. doi: 10.1074/jbc.M807359200. Epub 2008 Nov 24. Erratum in: J Biol Chem. 2010 Jun 4;285(23):18122.


Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.

Goraya TA, Masada N, Ciruela A, Willoughby D, Clynes MA, Cooper DM.

Cell Signal. 2008 Feb;20(2):359-74.


Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during beta2-adrenoceptor and prostanoid receptor cAMP signaling.

Willoughby D, Baillie GS, Lynch MJ, Ciruela A, Houslay MD, Cooper DM.

J Biol Chem. 2007 Nov 23;282(47):34235-49. Epub 2007 Sep 13.


The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8.

Simpson RE, Ciruela A, Cooper DM.

J Biol Chem. 2006 Jun 23;281(25):17379-89. Epub 2006 Apr 13.


A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.

Crossthwaite AJ, Ciruela A, Rayner TF, Cooper DM.

Mol Pharmacol. 2006 Feb;69(2):608-17. Epub 2005 Oct 28.


Localized Na+/H+ exchanger 1 expression protects Ca2+-regulated adenylyl cyclases from changes in intracellular pH.

Willoughby D, Masada N, Crossthwaite AJ, Ciruela A, Cooper DM.

J Biol Chem. 2005 Sep 2;280(35):30864-72. Epub 2005 Jul 7.


The cytosolic domains of Ca2+-sensitive adenylyl cyclases dictate their targeting to plasma membrane lipid rafts.

Crossthwaite AJ, Seebacher T, Masada N, Ciruela A, Dufraux K, Schultz JE, Cooper DM.

J Biol Chem. 2005 Feb 25;280(8):6380-91. Epub 2004 Dec 1.


Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A.

Goraya TA, Masada N, Ciruela A, Cooper DM.

J Biol Chem. 2004 Sep 24;279(39):40494-504. Epub 2004 Jul 22.


Identification of MEK1 as a novel target for the treatment of neuropathic pain.

Ciruela A, Dixon AK, Bramwell S, Gonzalez MI, Pinnock RD, Lee K.

Br J Pharmacol. 2003 Mar;138(5):751-6.


The type II PIPkins (PtdIns5P 4-kinases): enzymes in search of a function?

Hinchliffe KA, Ciruela A, Morris JA, Divecha N, Irvine RF.

Biochem Soc Trans. 1999 Aug;27(4):657-61. Review. No abstract available.


Thrombin stimulation of platelets causes an increase in phosphatidylinositol 5-phosphate revealed by mass assay.

Morris JB, Hinchliffe KA, Ciruela A, Letcher AJ, Irvine RF.

FEBS Lett. 2000 Jun 9;475(1):57-60.


Regulation of type IIalpha phosphatidylinositol phosphate kinase localisation by the protein kinase CK2.

Hinchliffe KA, Ciruela A, Letcher AJ, Divecha N, Irvine RF.

Curr Biol. 1999 Sep 9;9(17):983-6. Erratum in: Curr Biol. 2003 Jan 21;13(2):178..


A family IIb xylan-binding domain has a similar secondary structure to a homologous family IIa cellulose-binding domain but different ligand specificity.

Simpson PJ, Bolam DN, Cooper A, Ciruela A, Hazlewood GP, Gilbert HJ, Williamson MP.

Structure. 1999 Jul 15;7(7):853-64.


PIPkins1, their substrates and their products: new functions for old enzymes.

Hinchliffe KA, Ciruela A, Irvine RF.

Biochim Biophys Acta. 1998 Dec 8;1436(1-2):87-104. Review.


Pseudomonas cellulose-binding domains mediate their effects by increasing enzyme substrate proximity.

Bolam DN, Ciruela A, McQueen-Mason S, Simpson P, Williamson MP, Rixon JE, Boraston A, Hazlewood GP, Gilbert HJ.

Biochem J. 1998 May 1;331 ( Pt 3):775-81.


Family-10 and family-11 xylanases differ in their capacity to enhance the bleachability of hardwood and softwood paper pulps.

Clarke JH, Rixon JE, Ciruela A, Gilbert HJ, Hazlewood GP.

Appl Microbiol Biotechnol. 1997 Aug;48(2):177-83.


Sequence and transcriptional analysis of groES and groEL genes from the thermophilic bacterium Clostridium thermocellum.

Ciruela A, Cross S, Freedman RB, Hazlewood GP.

Gene. 1997 Feb 20;186(1):143-7.


Thermostable chaperonin from Clostridium thermocellum.

Cross SJ, Ciruela A, Poomputsa K, Romaniec MP, Freedman RB.

Biochem J. 1996 Jun 1;316 ( Pt 2):615-22.


Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule.

Powis SJ, Deverson EV, Coadwell WJ, Ciruela A, Huskisson NS, Smith H, Butcher GW, Howard JC.

Nature. 1992 May 21;357(6375):211-5.


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