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MicroRNA-143-3p inhibits growth and invasiveness of melanoma cells by targeting cyclooxygenase-2 and inversely correlates with malignant melanoma progression.

Panza E, Ercolano G, De Cicco P, Armogida C, Scognamiglio G, Botti G, Cirino G, Ianaro A.

Biochem Pharmacol. 2018 Aug 8. pii: S0006-2952(18)30328-9. doi: 10.1016/j.bcp.2018.08.008. [Epub ahead of print]


Launch of mini-reviews in hot topics.

Ahluwalia A, Cirino G.

Br J Pharmacol. 2018 Jul;175(13):2537. doi: 10.1111/bph.14342. No abstract available.


Hydrogen Sulfide Reduces Myeloid-Derived Suppressor Cell-Mediated Inflammatory Response in a Model of Helicobacter hepaticus-Induced Colitis.

De Cicco P, Sanders T, Cirino G, Maloy KJ, Ianaro A.

Front Immunol. 2018 Mar 27;9:499. doi: 10.3389/fimmu.2018.00499. eCollection 2018.


Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers.

Curtis MJ, Alexander S, Cirino G, Docherty JR, George CH, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Stanford SC, Teixeira MM, Wonnacott S, Ahluwalia A.

Br J Pharmacol. 2018 Apr;175(7):987-993. doi: 10.1111/bph.14153.


Mercaptopyruvate acts as endogenous vasodilator independently of 3-mercaptopyruvate sulfurtransferase activity.

Mitidieri E, Tramontano T, Gurgone D, Citi V, Calderone V, Brancaleone V, Katsouda A, Nagahara N, Papapetropoulos A, Cirino G, d'Emmanuele di Villa Bianca R, Sorrentino R.

Nitric Oxide. 2018 May 1;75:53-59. doi: 10.1016/j.niox.2018.02.003. Epub 2018 Feb 13.


Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology.

Alexander SPH, Roberts RE, Broughton BRS, Sobey CG, George CH, Stanford SC, Cirino G, Docherty JR, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Mangum J, Wonnacott S, Ahluwalia A.

Br J Pharmacol. 2018 Feb;175(3):407-411. doi: 10.1111/bph.14112. No abstract available.


1,2,4-Thiadiazolidin-3,5-diones as novel hydrogen sulfide donors.

Severino B, Corvino A, Fiorino F, Luciano P, Frecentese F, Magli E, Saccone I, Di Vaio P, Citi V, Calderone V, Servillo L, Casale R, Cirino G, Vellecco V, Bucci M, Perissutti E, Santagada V, Caliendo G.

Eur J Med Chem. 2018 Jan 1;143:1677-1686. doi: 10.1016/j.ejmech.2017.10.068. Epub 2017 Nov 11.


Development of 1,2,3-Triazole-Based Sphingosine Kinase Inhibitors and Their Evaluation as Antiproliferative Agents.

Corvino A, Rosa R, Incisivo GM, Fiorino F, Frecentese F, Magli E, Perissutti E, Saccone I, Santagada V, Cirino G, Riemma MA, Temussi PA, Ciciola P, Bianco R, Caliendo G, Roviezzo F, Severino B.

Int J Mol Sci. 2017 Nov 5;18(11). pii: E2332. doi: 10.3390/ijms18112332.


Toll-Like Receptor 4 Is Essential for the Expression of Sphingosine-1-Phosphate-Dependent Asthma-Like Disease in Mice.

Roviezzo F, Sorrentino R, Terlizzi M, Riemma MA, Iacono VM, Rossi A, Spaziano G, Pinto A, D'Agostino B, Cirino G.

Front Immunol. 2017 Oct 18;8:1336. doi: 10.3389/fimmu.2017.01336. eCollection 2017.


Targeting inflammation to reduce cardiovascular disease risk.

Maffia P, Cirino G.

Br J Pharmacol. 2017 Nov;174(22):3895-3897. doi: 10.1111/bph.14039.


Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts.

George CH, Stanford SC, Alexander S, Cirino G, Docherty JR, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Wonnacott S, Ahluwalia A.

Br J Pharmacol. 2017 Sep;174(17):2801-2804. doi: 10.1111/bph.13925. No abstract available.


β3 adrenergic receptor activation relaxes human corpus cavernosum and penile artery through a hydrogen sulfide/cGMP-dependent mechanism.

Mitidieri E, Tramontano T, Gurgone D, Imbimbo C, Mirone V, Fusco F, Cirino G, d'Emmanuele di Villa Bianca R, Sorrentino R.

Pharmacol Res. 2017 Oct;124:100-104. doi: 10.1016/j.phrs.2017.07.025. Epub 2017 Jul 29.


Nitric oxide and hydrogen sulfide: the gasotransmitter paradigm of the vascular system.

Cirino G, Vellecco V, Bucci M.

Br J Pharmacol. 2017 Nov;174(22):4021-4031. doi: 10.1111/bph.13815. Epub 2017 May 16. Review.


The Role of the Hydrogen Sulfide Pathway in Male and Female Urogenital System in Health and Disease.

d'Emmanuele di Villa Bianca R, Fusco F, Mirone V, Cirino G, Sorrentino R.

Antioxid Redox Signal. 2017 Oct 1;27(10):654-668. doi: 10.1089/ars.2017.7079. Epub 2017 May 19. Review.


The Hydrogen Sulfide Releasing Molecule Acetyl Deacylasadisulfide Inhibits Metastatic Melanoma.

De Cicco P, Panza E, Armogida C, Ercolano G, Taglialatela-Scafati O, Shokoohinia Y, Camerlingo R, Pirozzi G, Calderone V, Cirino G, Ianaro A.

Front Pharmacol. 2017 Feb 27;8:65. doi: 10.3389/fphar.2017.00065. eCollection 2017.


COX-2 expression positively correlates with PD-L1 expression in human melanoma cells.

Botti G, Fratangelo F, Cerrone M, Liguori G, Cantile M, Anniciello AM, Scala S, D'Alterio C, Trimarco C, Ianaro A, Cirino G, Caracò C, Colombino M, Palmieri G, Pepe S, Ascierto PA, Sabbatino F, Scognamiglio G.

J Transl Med. 2017 Feb 23;15(1):46. doi: 10.1186/s12967-017-1150-7.


ATB-346, a novel hydrogen sulfide-releasing anti-inflammatory drug, induces apoptosis of human melanoma cells and inhibits melanoma development in vivo.

De Cicco P, Panza E, Ercolano G, Armogida C, Sessa G, Pirozzi G, Cirino G, Wallace JL, Ianaro A.

Pharmacol Res. 2016 Dec;114:67-73. doi: 10.1016/j.phrs.2016.10.019. Epub 2016 Oct 21.


Decoding the vasoregulatory activities of bile acid-activated receptors in systemic and portal circulation: role of gaseous mediators.

Fiorucci S, Zampella A, Cirino G, Bucci M, Distrutti E.

Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H21-H32. doi: 10.1152/ajpheart.00577.2016. Epub 2016 Oct 7. Review.


Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate.

Roviezzo F, Sorrentino R, Iacono VM, Brancaleone V, Terlizzi M, Riemma MA, Bertolino A, Rossi A, Matteis M, Spaziano G, Pinto A, D'Agostino B, Cirino G.

Pharmacol Res. 2016 Nov;113(Pt A):626-635. doi: 10.1016/j.phrs.2016.09.014. Epub 2016 Oct 3.


The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress.

Testai L, Marino A, Piano I, Brancaleone V, Tomita K, Di Cesare Mannelli L, Martelli A, Citi V, Breschi MC, Levi R, Gargini C, Bucci M, Cirino G, Ghelardini C, Calderone V.

Pharmacol Res. 2016 Nov;113(Pt A):290-299. doi: 10.1016/j.phrs.2016.09.006. Epub 2016 Sep 9.


Rupturing of Biological Spores As a Source of Secondary Particles in Amazonia.

China S, Wang B, Weis J, Rizzo L, Brito J, Cirino GG, Kovarik L, Artaxo P, Gilles MK, Laskin A.

Environ Sci Technol. 2016 Nov 15;50(22):12179-12186. Epub 2016 Oct 27.


Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production.

Corvino A, Severino B, Fiorino F, Frecentese F, Magli E, Perissutti E, Santagada V, Bucci M, Cirino G, Kelly G, Servillo L, Popowicz G, Pastore A, Caliendo G.

Sci Rep. 2016 Oct 6;6:34398. doi: 10.1038/srep34398.


Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents.

Zotti AI, Di Gennaro E, Corvino A, Frecentese F, Magli E, Perissutti E, Cirino G, Roviezzo F, Terranova-Barberio M, Iannelli F, Caliendo G, Santagada V, Fiorino F, Budillon A, Severino B.

Anticancer Agents Med Chem. 2017;17(7):973-981. doi: 10.2174/1871520616666160926120904.


Proteinase activated receptor-2 counterbalances the vascular effects of endothelin-1 in fibrotic tight-skin mice.

Roviezzo F, Brancaleone V, Mattera Iacono V, Bertolino A, De Cunto G, Vellecco V, Lungarella G, Lucattelli M, Cirino G.

Br J Pharmacol. 2017 Nov;174(22):4032-4042. doi: 10.1111/bph.13618. Epub 2016 Oct 5.


Urothelium muscarinic activation phosphorylates CBS(Ser227) via cGMP/PKG pathway causing human bladder relaxation through H2S production.

d'Emmanuele di Villa Bianca R, Mitidieri E, Fusco F, Russo A, Pagliara V, Tramontano T, Donnarumma E, Mirone V, Cirino G, Russo G, Sorrentino R.

Sci Rep. 2016 Aug 11;6:31491. doi: 10.1038/srep31491.


Differential expression of cyclooxygenase-2 in metastatic melanoma affects progression free survival.

Panza E, De Cicco P, Ercolano G, Armogida C, Scognamiglio G, Anniciello AM, Botti G, Cirino G, Ianaro A.

Oncotarget. 2016 Aug 30;7(35):57077-57085. doi: 10.18632/oncotarget.10976.


Hydrogen sulfide-releasing anti-inflammatory drugs for chemoprevention and treatment of cancer.

Ianaro A, Cirino G, Wallace JL.

Pharmacol Res. 2016 Sep;111:652-658. doi: 10.1016/j.phrs.2016.07.041. Epub 2016 Jul 27. Review.


Vascular effects of linagliptin in non-obese diabetic mice are glucose-independent and involve positive modulation of the endothelial nitric oxide synthase (eNOS)/caveolin-1 (CAV-1) pathway.

Vellecco V, Mitidieri E, Gargiulo A, Brancaleone V, Matassa D, Klein T, Esposito F, Cirino G, Bucci M.

Diabetes Obes Metab. 2016 Dec;18(12):1236-1243. doi: 10.1111/dom.12750. Epub 2016 Aug 30.


Zofenopril Protects Against Myocardial Ischemia-Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability.

Donnarumma E, Ali MJ, Rushing AM, Scarborough AL, Bradley JM, Organ CL, Islam KN, Polhemus DJ, Evangelista S, Cirino G, Jenkins JS, Patel RA, Lefer DJ, Goodchild TT.

J Am Heart Assoc. 2016 Jul 5;5(7). pii: e003531. doi: 10.1161/JAHA.116.003531.


Regulation of soluble guanylyl cyclase redox state by hydrogen sulfide.

Zhou Z, Martin E, Sharina I, Esposito I, Szabo C, Bucci M, Cirino G, Papapetropoulos A.

Pharmacol Res. 2016 Sep;111:556-562. doi: 10.1016/j.phrs.2016.06.029. Epub 2016 Jul 1.


l-Cys/CSE/H2S pathway modulates mouse uterus motility and sildenafil effect.

Mitidieri E, Tramontano T, Donnarumma E, Brancaleone V, Cirino G, D Emmanuele di Villa Bianca R, Sorrentino R.

Pharmacol Res. 2016 Sep;111:283-289. doi: 10.1016/j.phrs.2016.06.017. Epub 2016 Jun 17.


D-Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine-γ-lyase.

Brancaleone V, Esposito I, Gargiulo A, Vellecco V, Asimakopoulou A, Citi V, Calderone V, Gobbetti T, Perretti M, Papapetropoulos A, Bucci M, Cirino G.

Br J Pharmacol. 2016 May;173(9):1556-65. doi: 10.1111/bph.13459. Epub 2016 Mar 23.


Correction: Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.

d'Emmanuele di Villa Bianca R, Mitidieri E, Esposito D, Donnarumma E, Russo A, Fusco F, Ianaro A, Mirone V, Cirino G, Russo G, Sorrentino R.

PLoS One. 2015 Oct 15;10(10):e0141027. doi: 10.1371/journal.pone.0141027. eCollection 2015. No abstract available.


Cystathionine β-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia.

Vellecco V, Mancini A, Ianaro A, Calderone V, Attanasio C, Cantalupo A, Andria B, Savoia G, Panza E, Di Martino A, Cirino G, Bucci M.

Clin Sci (Lond). 2016 Jan;130(1):35-44. doi: 10.1042/CS20150521. Epub 2015 Oct 12.


Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.

d'Emmanuele di Villa Bianca R, Mitidieri E, Esposito D, Donnarumma E, Russo A, Fusco F, Ianaro A, Mirone V, Cirino G, Russo G, Sorrentino R.

PLoS One. 2015 Sep 14;10(9):e0136859. doi: 10.1371/journal.pone.0136859. eCollection 2015. Erratum in: PLoS One. 2015;10(10):e0141027. Donnarumm, Erminia [corrected to Donnarumma, Erminia].


Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative.

Scuotto M, Rivieccio E, Varone A, Corda D, Bucci M, Vellecco V, Cirino G, Virgilio A, Esposito V, Galeone A, Borbone N, Varra M, Mayol L.

Nucleic Acids Res. 2015 Sep 18;43(16):7702-16. doi: 10.1093/nar/gkv789. Epub 2015 Aug 6.


Hydrogen sulfide inhalation ameliorates allergen induced airway hypereactivity by modulating mast cell activation.

Roviezzo F, Bertolino A, Sorrentino R, Terlizzi M, Matteis M, Calderone V, Mattera V, Martelli A, Spaziano G, Pinto A, D'Agostino B, Cirino G.

Pharmacol Res. 2015 Oct;100:85-92. doi: 10.1016/j.phrs.2015.07.032. Epub 2015 Aug 1.


Phosphinodithioate and Phosphoramidodithioate Hydrogen Sulfide Donors.

Whiteman M, Perry A, Zhou Z, Bucci M, Papapetropoulos A, Cirino G, Wood ME.

Handb Exp Pharmacol. 2015;230:337-63. doi: 10.1007/978-3-319-18144-8_17. Review.


Hydrogen Sulfide and Urogenital Tract.

di Villa Bianca Rd, Cirino G, Sorrentino R.

Handb Exp Pharmacol. 2015;230:111-36. doi: 10.1007/978-3-319-18144-8_5. Review.


Gaseous mediators in resolution of inflammation.

Wallace JL, Ianaro A, Flannigan KL, Cirino G.

Semin Immunol. 2015 May;27(3):227-33. doi: 10.1016/j.smim.2015.05.004. Epub 2015 Jun 18. Review.


Methylation reactions, the redox balance and atherothrombosis: the search for a link with hydrogen sulfide.

Lupoli R, Di Minno A, Spadarella G, Franchini M, Sorrentino R, Cirino G, Di Minno G.

Semin Thromb Hemost. 2015 Jun;41(4):423-32. doi: 10.1055/s-0035-1549848. Epub 2015 May 14. Review.


Characterization of zofenoprilat as an inducer of functional angiogenesis through increased H2 S availability.

Terzuoli E, Monti M, Vellecco V, Bucci M, Cirino G, Ziche M, Morbidelli L.

Br J Pharmacol. 2015 Jun;172(12):2961-73. doi: 10.1111/bph.13101. Epub 2015 Mar 27.


Hydrogen sulfide is involved in dexamethasone-induced hypertension in rat.

d'Emmanuele di Villa Bianca R, Mitidieri E, Donnarumma E, Tramontano T, Brancaleone V, Cirino G, Bucci M, Sorrentino R.

Nitric Oxide. 2015 Apr 30;46:80-6. doi: 10.1016/j.niox.2014.11.013. Epub 2014 Nov 25.


S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms.

Roviezzo F, Sorrentino R, Bertolino A, De Gruttola L, Terlizzi M, Pinto A, Napolitano M, Castello G, D'Agostino B, Ianaro A, Sorrentino R, Cirino G.

Br J Pharmacol. 2015 Apr;172(7):1882-93. doi: 10.1111/bph.13033. Epub 2015 Jan 23.


B cell depletion increases sphingosine-1-phosphate-dependent airway inflammation in mice.

Sorrentino R, Bertolino A, Terlizzi M, Iacono VM, Maiolino P, Cirino G, Roviezzo F, Pinto A.

Am J Respir Cell Mol Biol. 2015 May;52(5):571-83. doi: 10.1165/rcmb.2014-0207OC.


Role of the cystathionine γ lyase/hydrogen sulfide pathway in human melanoma progression.

Panza E, De Cicco P, Armogida C, Scognamiglio G, Gigantino V, Botti G, Germano D, Napolitano M, Papapetropoulos A, Bucci M, Cirino G, Ianaro A.

Pigment Cell Melanoma Res. 2015 Jan;28(1):61-72. doi: 10.1111/pcmr.12312. Epub 2014 Oct 6.


A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands.

di Villa Bianca Rd, Mitidieri E, Donnarumma E, Fusco F, Longo N, Rosa GD, Novellino E, Grieco P, Mirone V, Cirino G, Sorrentino R.

Asian J Androl. 2015 Jan-Feb;17(1):81-5. doi: 10.4103/1008-682X.133322.


Annexin A1 mediates hydrogen sulfide properties in the control of inflammation.

Brancaleone V, Mitidieri E, Flower RJ, Cirino G, Perretti M.

J Pharmacol Exp Ther. 2014 Oct;351(1):96-104. doi: 10.1124/jpet.114.217034. Epub 2014 Jul 30.


Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue.

Scuotto M, Persico M, Bucci M, Vellecco V, Borbone N, Morelli E, Oliviero G, Novellino E, Piccialli G, Cirino G, Varra M, Fattorusso C, Mayol L.

Org Biomol Chem. 2014 Jul 28;12(28):5235-42. doi: 10.1039/c4ob00149d.


Pharmacological tools for hydrogen sulphide research: a brief, introductory guide for beginners.

Papapetropoulos A, Whiteman M, Cirino G.

Br J Pharmacol. 2015 Mar;172(6):1633-7. doi: 10.1111/bph.12806. Epub 2014 Sep 5. Review.

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