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Items: 33

1.

New pre-clinical evidence of anti-inflammatory effect and safety of a substituted fluorophenyl imidazole.

Dos Santos Nascimento MVP, Mattar Munhoz AC, De Campos Facchin BM, Fratoni E, Rossa TA, Mandolesi Sá M, Campa CC, Ciraolo E, Hirsch E, Dalmarco EM.

Biomed Pharmacother. 2019 Mar;111:1399-1407. doi: 10.1016/j.biopha.2019.01.052. Epub 2019 Jan 19.

2.

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.

Campa CC, Silva RL, Margaria JP, Pirali T, Mattos MS, Kraemer LR, Reis DC, Grosa G, Copperi F, Dalmarco EM, Lima-Júnior RCP, Aprile S, Sala V, Dal Bello F, Prado DS, Alves-Filho JC, Medana C, Cassali GD, Tron GC, Teixeira MM, Ciraolo E, Russo RC, Hirsch E.

Nat Commun. 2018 Dec 12;9(1):5232. doi: 10.1038/s41467-018-07698-6.

3.

Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics.

Zamboni V, Armentano M, Berto G, Ciraolo E, Ghigo A, Garzotto D, Umbach A, DiCunto F, Parmigiani E, Boido M, Vercelli A, El-Assawy N, Mauro A, Priano L, Ponzoni L, Murru L, Passafaro M, Hirsch E, Merlo GR.

Sci Rep. 2018 May 8;8(1):7254. doi: 10.1038/s41598-018-25354-3.

4.

Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits.

Duarte LJ, Chaves VC, Nascimento MVPDS, Calvete E, Li M, Ciraolo E, Ghigo A, Hirsch E, Simões CMO, Reginatto FH, Dalmarco EM.

Food Chem. 2018 May 1;247:56-65. doi: 10.1016/j.foodchem.2017.12.015. Epub 2017 Dec 7.

PMID:
29277228
5.

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function.

Gulluni F, Martini M, De Santis MC, Campa CC, Ghigo A, Margaria JP, Ciraolo E, Franco I, Ala U, Annaratone L, Disalvatore D, Bertalot G, Viale G, Noatynska A, Compagno M, Sigismund S, Montemurro F, Thelen M, Fan F, Meraldi P, Marchiò C, Pece S, Sapino A, Chiarle R, Di Fiore PP, Hirsch E.

Cancer Cell. 2017 Oct 9;32(4):444-459.e7. doi: 10.1016/j.ccell.2017.09.002.

6.

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

Pirali T, Ciraolo E, Aprile S, Massarotti A, Berndt A, Griglio A, Serafini M, Mercalli V, Landoni C, Campa CC, Margaria JP, Silva RL, Grosa G, Sorba G, Williams R, Hirsch E, Tron GC.

ChemMedChem. 2017 Sep 21;12(18):1542-1554. doi: 10.1002/cmdc.201700340. Epub 2017 Aug 31.

7.

Rac signal adaptation controls neutrophil mobilization from the bone marrow.

Campa CC, Germena G, Ciraolo E, Copperi F, Sapienza A, Franco I, Ghigo A, Camporeale A, Di Savino A, Martini M, Perino A, Megens RT, Kurz AR, Scheiermann C, Sperandio M, Gamba A, Hirsch E.

Sci Signal. 2016 Dec 20;9(459):ra124. doi: 10.1126/scisignal.aah5882.

PMID:
27999173
8.

Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits.

Zamboni V, Armentano M, Sarò G, Ciraolo E, Ghigo A, Germena G, Umbach A, Valnegri P, Passafaro M, Carabelli V, Gavello D, Bianchi V, D'Adamo P, de Curtis I, El-Assawi N, Mauro A, Priano L, Ferri N, Hirsch E, Merlo GR.

Sci Rep. 2016 Oct 7;6:34877. doi: 10.1038/srep34877.

9.

The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors.

Galli U, Ciraolo E, Massarotti A, Margaria JP, Sorba G, Hirsch E, Tron GC.

Molecules. 2015 Sep 18;20(9):17275-87. doi: 10.3390/molecules200917275.

10.

Genetic Deletion and Pharmacological Inhibition of PI3K γ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease.

Galluzzo M, Ciraolo E, Lucattelli M, Hoxha E, Ulrich M, Campa CC, Lungarella G, Doring G, Zhou-Suckow Z, Mall M, Hirsch E, De Rose V.

Mediators Inflamm. 2015;2015:545417. doi: 10.1155/2015/545417. Epub 2015 Jun 21.

11.

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.

Braccini L, Ciraolo E, Campa CC, Perino A, Longo DL, Tibolla G, Pregnolato M, Cao Y, Tassone B, Damilano F, Laffargue M, Calautti E, Falasca M, Norata GD, Backer JM, Hirsch E.

Nat Commun. 2015 Jun 23;6:7400. doi: 10.1038/ncomms8400.

12.

Crossroads of PI3K and Rac pathways.

Campa CC, Ciraolo E, Ghigo A, Germena G, Hirsch E.

Small GTPases. 2015;6(2):71-80. doi: 10.4161/21541248.2014.989789. Epub 2015 May 5. Review.

13.

Methods to measure the enzymatic activity of PI3Ks.

Ciraolo E, Gulluni F, Hirsch E.

Methods Enzymol. 2014;543:115-40. doi: 10.1016/B978-0-12-801329-8.00006-4.

PMID:
24924130
14.

PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.

Franco I, Gulluni F, Campa CC, Costa C, Margaria JP, Ciraolo E, Martini M, Monteyne D, De Luca E, Germena G, Posor Y, Maffucci T, Marengo S, Haucke V, Falasca M, Perez-Morga D, Boletta A, Merlo GR, Hirsch E.

Dev Cell. 2014 Mar 31;28(6):647-58. doi: 10.1016/j.devcel.2014.01.022.

15.

PI3K in cancer-stroma interactions: bad in seed and ugly in soil.

Hirsch E, Ciraolo E, Franco I, Ghigo A, Martini M.

Oncogene. 2014 Jun 12;33(24):3083-90. doi: 10.1038/onc.2013.265. Epub 2013 Jul 29. Review.

PMID:
23893246
16.

Targeting PI3K in Cancer: Any Good News?

Martini M, Ciraolo E, Gulluni F, Hirsch E.

Front Oncol. 2013 May 8;3:108. doi: 10.3389/fonc.2013.00108. eCollection 2013.

17.

The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.

Cipolla L, Consonni A, Guidetti G, Canobbio I, Okigaki M, Falasca M, Ciraolo E, Hirsch E, Balduini C, Torti M.

J Thromb Haemost. 2013 Feb;11(2):345-56. doi: 10.1111/jth.12099.

18.

PI3K keeps the balance between metabolism and cancer.

Braccini L, Ciraolo E, Martini M, Pirali T, Germena G, Rolfo K, Hirsch E.

Adv Biol Regul. 2012 Sep;52(3):389-405. doi: 10.1016/j.jbior.2012.04.002. Epub 2012 Apr 24. Review.

PMID:
22884032
19.

Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling.

Consonni A, Cipolla L, Guidetti G, Canobbio I, Ciraolo E, Hirsch E, Falasca M, Okigaki M, Balduini C, Torti M.

Blood. 2012 Jan 19;119(3):847-56. doi: 10.1182/blood-2011-07-364992. Epub 2011 Nov 21.

20.

PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism.

Carnevale D, Vecchione C, Mascio G, Esposito G, Cifelli G, Martinello K, Landolfi A, Selvetella G, Grieco P, Damato A, Franco E, Haase H, Maffei A, Ciraolo E, Fucile S, Frati G, Mazzoni O, Hirsch E, Lembo G.

Cardiovasc Res. 2012 Jan 1;93(1):200-9. doi: 10.1093/cvr/cvr288. Epub 2011 Oct 27.

PMID:
22038741
21.

Measuring PI3K lipid kinase activity.

Ciraolo E, Perino A, Hirsch E.

Methods Mol Biol. 2012;795:55-67. doi: 10.1007/978-1-61779-337-0_4.

PMID:
21960215
22.

Present and future of PI3K pathway inhibition in cancer: perspectives and limitations.

Ciraolo E, Morello F, Hirsch E.

Curr Med Chem. 2011;18(18):2674-85. Review.

PMID:
21649577
23.

Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors.

Guasconi M, Lu X, Massarotti A, Caldarelli A, Ciraolo E, Tron GC, Hirsch E, Sorba G, Pirali T.

Org Biomol Chem. 2011 Jun 7;9(11):4144-9. doi: 10.1039/c1ob05336a. Epub 2011 Apr 14.

PMID:
21494711
24.

Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines.

Lu XY, Ciraolo E, Stefenia R, Chen GQ, Zhang Y, Hirsch E.

Appl Microbiol Biotechnol. 2011 Mar;89(5):1423-33. doi: 10.1007/s00253-011-3101-1. Epub 2011 Feb 1.

PMID:
21286711
25.

The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice.

van Dop WA, Marengo S, te Velde AA, Ciraolo E, Franco I, ten Kate FJ, Boeckxstaens GE, Hardwick JC, Hommes DW, Hirsch E, van den Brink GR.

Immunol Lett. 2010 Jun 15;131(1):33-9. doi: 10.1016/j.imlet.2010.03.008. Epub 2010 Mar 27.

PMID:
20347874
26.

Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.

Ciraolo E, Morello F, Hobbs RM, Wolf F, Marone R, Iezzi M, Lu X, Mengozzi G, Altruda F, Sorba G, Guan K, Pandolfi PP, Wymann MP, Hirsch E.

Mol Biol Cell. 2010 Mar 1;21(5):704-11. doi: 10.1091/mbc.E09-08-0744. Epub 2010 Jan 6.

27.

PI3K signaling: a crossroads of metabolic regulation.

Braccini L, Ciraolo E, Morello F, Lu X, Hirsch E.

Expert Rev Endocrinol Metab. 2009 Jul;4(4):349-357. doi: 10.1586/eem.09.19.

PMID:
30781275
28.

Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets.

Canobbio I, Stefanini L, Cipolla L, Ciraolo E, Gruppi C, Balduini C, Hirsch E, Torti M.

Blood. 2009 Sep 3;114(10):2193-6. doi: 10.1182/blood-2009-03-208074. Epub 2009 Jun 10.

29.

Twice upon a time: PI3K's secret double life exposed.

Hirsch E, Braccini L, Ciraolo E, Morello F, Perino A.

Trends Biochem Sci. 2009 May;34(5):244-8. doi: 10.1016/j.tibs.2009.02.003. Epub 2009 Apr 17. Review.

PMID:
19376709
30.

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.

Ciraolo E, Iezzi M, Marone R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H, Dastrù W, Martin EL, Silengo L, Altruda F, Turco E, Lanzetti L, Musiani P, Rückle T, Rommel C, Backer JM, Forni G, Wymann MP, Hirsch E.

Sci Signal. 2008 Sep 9;1(36):ra3. doi: 10.1126/scisignal.1161577.

31.

Taming the PI3K team to hold inflammation and cancer at bay.

Hirsch E, Ciraolo E, Ghigo A, Costa C.

Pharmacol Ther. 2008 May;118(2):192-205. doi: 10.1016/j.pharmthera.2008.02.004. Epub 2008 Mar 5. Review.

PMID:
18420279
32.

Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma.

Costa C, Barberis L, Ambrogio C, Manazza AD, Patrucco E, Azzolino O, Neilsen PO, Ciraolo E, Altruda F, Prestwich GD, Chiarle R, Wymann M, Ridley A, Hirsch E.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14354-9. Epub 2007 Aug 24.

33.

Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.

Hirsch E, Costa C, Ciraolo E.

J Endocrinol. 2007 Aug;194(2):243-56. Review.

PMID:
17641274

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