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Items: 27


A dual mechanism of activation of the Sonic Hedgehog pathway in anaplastic thyroid cancer: crosstalk with RAS-BRAF-MEK pathway and ligand secretion by tumor stroma.

Parascandolo A, Laukkanen MO, De Rosa N, Ugolini C, Cantisani MC, Cirafici AM, Basolo F, Santoro M, Castellone MD.

Oncotarget. 2017 Dec 17;9(4):4496-4510. doi: 10.18632/oncotarget.23388. eCollection 2018 Jan 12.


NCOA4 transcriptional coactivator inhibits activation of DNA replication origins.

Bellelli R, Castellone MD, Guida T, Limongello R, Dathan NA, Merolla F, Cirafici AM, Affuso A, Masai H, Costanzo V, Grieco D, Fusco A, Santoro M, Carlomagno F.

Mol Cell. 2014 Jul 3;55(1):123-37. doi: 10.1016/j.molcel.2014.04.031. Epub 2014 Jun 5.


A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.

Salvatore G, Nappi TC, Salerno P, Jiang Y, Garbi C, Ugolini C, Miccoli P, Basolo F, Castellone MD, Cirafici AM, Melillo RM, Fusco A, Bittner ML, Santoro M.

Cancer Res. 2007 Nov 1;67(21):10148-58.


RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase.

De Falco V, Castellone MD, De Vita G, Cirafici AM, Hershman JM, Guerrero C, Fusco A, Melillo RM, Santoro M.

Cancer Res. 2007 Jan 1;67(1):381-90.


Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness.

Guarino V, Faviana P, Salvatore G, Castellone MD, Cirafici AM, De Falco V, Celetti A, Giannini R, Basolo F, Melillo RM, Santoro M.

J Clin Endocrinol Metab. 2005 Sep;90(9):5270-8. Epub 2005 Jul 5.


RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors.

De Falco V, Guarino V, Malorni L, Cirafici AM, Troglio F, Erreni M, Pelicci G, Santoro M, Melillo RM.

Oncogene. 2005 Sep 15;24(41):6303-13.


The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells.

Melillo RM, Castellone MD, Guarino V, De Falco V, Cirafici AM, Salvatore G, Caiazzo F, Basolo F, Giannini R, Kruhoffer M, Orntoft T, Fusco A, Santoro M.

J Clin Invest. 2005 Apr;115(4):1068-81. Epub 2005 Mar 10. Retraction in: J Clin Invest. 2016 Apr 1;126(4):1603.


The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma.

Melillo RM, Cirafici AM, De Falco V, Bellantoni M, Chiappetta G, Fusco A, Carlomagno F, Picascia A, Tramontano D, Tallini G, Santoro M.

Am J Pathol. 2004 Aug;165(2):511-21.


Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells.

Castellone MD, Celetti A, Guarino V, Cirafici AM, Basolo F, Giannini R, Medico E, Kruhoffer M, Orntoft TF, Curcio F, Fusco A, Melillo RM, Santoro M.

Oncogene. 2004 Mar 18;23(12):2188-96.


Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes.

Castellone MD, Cirafici AM, De Vita G, De Falco V, Malorni L, Tallini G, Fagin JA, Fusco A, Melillo RM, Santoro M.

Oncogene. 2003 Jan 16;22(2):246-55.


Assessment of RET/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursors of papillary cancer.

Fusco A, Chiappetta G, Hui P, Garcia-Rostan G, Golden L, Kinder BK, Dillon DA, Giuliano A, Cirafici AM, Santoro M, Rosai J, Tallini G.

Am J Pathol. 2002 Jun;160(6):2157-67.


Ret-mediated mitogenesis requires Src kinase activity.

Melillo RM, Barone MV, Lupoli G, Cirafici AM, Carlomagno F, Visconti R, Matoskova B, Di Fiore PP, Vecchio G, Fusco A, Santoro M.

Cancer Res. 1999 Mar 1;59(5):1120-6.


Expression of the RET/PTC1 oncogene impairs the activity of TTF-1 and Pax-8 thyroid transcription factors.

De Vita G, Zannini M, Cirafici AM, Melillo RM, Di Lauro R, Fusco A, Santoro M.

Cell Growth Differ. 1998 Jan;9(1):97-103.


Only the substitution of methionine 918 with a threonine and not with other residues activates RET transforming potential.

Cirafici AM, Salvatore G, De Vita G, Carlomagno F, Dathan NA, Visconti R, Melillo RM, Fusco A, Santoro M.

Endocrinology. 1997 Apr;138(4):1450-5.


The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype.

Carlomagno F, Salvatore G, Cirafici AM, De Vita G, Melillo RM, de Franciscis V, Billaud M, Fusco A, Santoro M.

Cancer Res. 1997 Feb 1;57(3):391-5.


Loss of thyrotropin regulation and transforming growth factor beta-induced growth arrest in erbB-2 overexpressing rat thyroid cells.

Mincione G, Cirafici AM, Lazzareschi D, Pepe S, Ciardiello F, Colletta G.

Cancer Res. 1993 Nov 15;53(22):5548-53.


Thyroid-stimulating hormone-regulated growth and cell cycle distribution of thyroid cells involve type I isozyme of cyclic AMP-dependent protein kinase.

Tortora G, Pepe S, Cirafici AM, Ciardiello F, Porcellini A, Clair T, Colletta G, Cho-Chung YS, Bianco AR.

Cell Growth Differ. 1993 May;4(5):359-65.


TGF beta inhibits rat thyroid cell proliferation without alterations in the expression of TSH-induced cell cycle-related genes.

Cirafici AM, Pepe S, Mincione G, Esposito D, Colletta G.

Biochem Biophys Res Commun. 1992 Aug 31;187(1):225-33.


TSH is able to induce cell cycle-related gene expression in rat thyroid cell.

Colletta G, Cirafici AM.

Biochem Biophys Res Commun. 1992 Feb 28;183(1):265-72.


Constitutive expression of transforming growth factor alpha does not transform rat thyroid epithelial cells.

Colletta G, Cirafici AM, Di Carlo A, Ciardiello F, Salomon DS, Vecchio G.

Oncogene. 1991 Apr;6(4):583-7.


Transforming growth factor-beta induces cytoskeleton and extracellular matrix modifications in FRTL-5 thyroid epithelial cells.

Garbi C, Colletta G, Cirafici AM, Marchisio PC, Nitsch L.

Eur J Cell Biol. 1990 Dec;53(2):281-9.


Thyrotropin receptor gene expression in oncogene-transfected rat thyroid cells: correlation between transformation, loss of thyrotropin-dependent growth, and loss of thyrotropin receptor gene expression.

Berlingieri MT, Akamizu T, Fusco A, Grieco M, Colletta G, Cirafici AM, Ikuyama S, Kohn LD, Vecchio G.

Biochem Biophys Res Commun. 1990 Nov 30;173(1):172-8.


Adenylate cyclase activity of v-ras-k transformed rat epithelial thyroid cells.

Colletta G, Corda D, Schettini G, Cirafici AM, Kohn LD, Consiglio E.

FEBS Lett. 1988 Feb 8;228(1):37-41.


Inhibitory action of transforming growth factor beta on thyroid cells.

Colletta G, Cirafici AM, Imbriaco M, Vecchio G.

Ann N Y Acad Sci. 1988;551:372-3. No abstract available.


Induction of the c-fos oncogene by thyrotropic hormone in rat thyroid cells in culture.

Colletta G, Cirafici AM, Vecchio G.

Science. 1986 Jul 25;233(4762):458-60.


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