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Items: 38

1.

Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis.

Ma Z, King K, Alqahtani M, Worden M, Muthuraman P, Cioffi CL, Bakshi CS, Malik M.

PLoS One. 2019 Oct 24;14(10):e0224094. doi: 10.1371/journal.pone.0224094. eCollection 2019.

2.

Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.

Cioffi CL, Racz B, Varadi A, Freeman EE, Conlon MP, Chen P, Zhu L, Kitchen DB, Barnes KD, Martin WH, Pearson PG, Johnson G, Blaner WS, Petrukhin K.

J Med Chem. 2019 Jun 13;62(11):5470-5500. doi: 10.1021/acs.jmedchem.9b00352. Epub 2019 May 28.

3.

A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle.

Racz B, Varadi A, Kong J, Allikmets R, Pearson PG, Johnson G, Cioffi CL, Petrukhin K.

J Biol Chem. 2018 Jul 20;293(29):11574-11588. doi: 10.1074/jbc.RA118.002062. Epub 2018 Jun 5.

4.

A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration.

Shin Y, Moiseyev G, Petrukhin K, Cioffi CL, Muthuraman P, Takahashi Y, Ma JX.

Biochim Biophys Acta Mol Basis Dis. 2018 Jul;1864(7):2420-2429. doi: 10.1016/j.bbadis.2018.04.014. Epub 2018 Apr 21.

5.

Glycine transporter-1 inhibitors: a patent review (2011-2016).

Cioffi CL.

Expert Opin Ther Pat. 2018 Mar;28(3):197-210. doi: 10.1080/13543776.2018.1429408. Epub 2018 Jan 24. Review. Erratum in: Expert Opin Ther Pat. 2018 Mar;28(3):5.

PMID:
29338548
6.

Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain.

Cioffi CL.

J Med Chem. 2018 Apr 12;61(7):2652-2679. doi: 10.1021/acs.jmedchem.7b00956. Epub 2017 Sep 22. Review.

PMID:
28876062
7.

Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1.

Cioffi CL, Liu S, Wolf MA, Guzzo PR, Sadalapure K, Parthasarathy V, Loong DT, Maeng JH, Carulli E, Fang X, Karunakaran K, Matta L, Choo SH, Panduga S, Buckle RN, Davis RN, Sakwa SA, Gupta P, Sargent BJ, Moore NA, Luche MM, Carr GJ, Khmelnitsky YL, Ismail J, Chung M, Bai M, Leong WY, Sachdev N, Swaminathan S, Mhyre AJ.

J Med Chem. 2016 Sep 22;59(18):8473-94. doi: 10.1021/acs.jmedchem.6b00914. Epub 2016 Sep 9.

8.

Inhibitors of Glycine Transporter-1: Potential Therapeutics for the Treatment of CNS Disorders.

Cioffi CL, Guzzo PR.

Curr Top Med Chem. 2016;16(29):3404-3437. Review.

PMID:
27048272
9.

Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease.

Cioffi CL, Racz B, Freeman EE, Conlon MP, Chen P, Stafford DG, Schwarz DM, Zhu L, Kitchen DB, Barnes KD, Dobri N, Michelotti E, Cywin CL, Martin WH, Pearson PG, Johnson G, Petrukhin K.

J Med Chem. 2015 Aug 13;58(15):5863-88. doi: 10.1021/acs.jmedchem.5b00423. Epub 2015 Aug 4.

10.

Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease.

Cioffi CL, Dobri N, Freeman EE, Conlon MP, Chen P, Stafford DG, Schwarz DM, Golden KC, Zhu L, Kitchen DB, Barnes KD, Racz B, Qin Q, Michelotti E, Cywin CL, Martin WH, Pearson PG, Johnson G, Petrukhin K.

J Med Chem. 2014 Sep 25;57(18):7731-57. doi: 10.1021/jm5010013. Epub 2014 Sep 11.

11.

Modulation of NMDA receptor function as a treatment for schizophrenia.

Cioffi CL.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5034-44. doi: 10.1016/j.bmcl.2013.07.019. Epub 2013 Jul 19. Review.

PMID:
23916256
12.

Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1.

Cioffi CL, Wolf MA, Guzzo PR, Sadalapure K, Parthasarathy V, Dethe D, Maeng JH, Carulli E, Loong DT, Fang X, Hu M, Gupta P, Chung M, Bai M, Moore N, Luche M, Khmelnitsky Y, Love PL, Watson MA, Mhyre AJ, Liu S.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1257-61. doi: 10.1016/j.bmcl.2013.01.006. Epub 2013 Jan 11.

PMID:
23380375
13.

Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome.

Manning DD, Cioffi CL, Usyatinsky A, Fitzpatrick K, Masih L, Guo C, Zhang Z, Choo SH, Sikkander MI, Ryan KN, Naginskaya J, Hassler C, Dobritsa S, Wierschke JD, Earley WG, Butler AS, Brady CA, Barnes NM, Cohen ML, Guzzo PR.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):58-61. doi: 10.1016/j.bmcl.2010.11.080. Epub 2010 Nov 21.

PMID:
21146988
14.

Synthesis of 2-aminobenzoxazoles using tetramethyl orthocarbonate or 1,1-dichlorodiphenoxymethane.

Cioffi CL, Lansing JJ, YĆ¼ksel H.

J Org Chem. 2010 Nov 19;75(22):7942-5. doi: 10.1021/jo1017052. Epub 2010 Oct 25.

PMID:
20973518
15.

The meanings of quality of life: interpretative analysis based on experiences of people in burns rehabilitation.

Costa MC, Rossi LA, Lopes LM, Cioffi CL.

Rev Lat Am Enfermagem. 2008 Mar-Apr;16(2):252-9.

16.

Generation of 3-pyridyl biaryl systems via palladium-catalyzed Suzuki cross-couplings of aryl halides with 3-pyridylboroxin.

Cioffi CL, Spencer WT, Richards JJ, Herr RJ.

J Org Chem. 2004 Mar 19;69(6):2210-2.

PMID:
15058977
17.

Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells.

Cioffi CL, Liu XQ, Kosinski PA, Garay M, Bowen BR.

Biochem Biophys Res Commun. 2003 Apr 11;303(3):947-53.

PMID:
12670503
18.

Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines.

Wentland MP, Ye Y, Cioffi CL, Lou R, Zhou Q, Xu G, Duan W, Dehnhardt CM, Sun X, Cohen DJ, Bidlack JM.

J Med Chem. 2003 Feb 27;46(5):838-49.

PMID:
12593663
19.

Gene therapy vector-mediated expression of insulin-like growth factors protects cardiomyocytes from apoptosis and enhances neovascularization.

Su EJ, Cioffi CL, Stefansson S, Mittereder N, Garay M, Hreniuk D, Liau G.

Am J Physiol Heart Circ Physiol. 2003 Apr;284(4):H1429-40. Epub 2002 Dec 27.

20.
21.

Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors.

Buchdunger E, Cioffi CL, Law N, Stover D, Ohno-Jones S, Druker BJ, Lydon NB.

J Pharmacol Exp Ther. 2000 Oct;295(1):139-45.

PMID:
10991971
22.

Inhibition of hypoxia/reoxygenation-induced apoptosis by an antisense oligonucleotide targeted to JNK1 in human kidney cells.

Garay M, Gaarde W, Monia BP, Nero P, Cioffi CL.

Biochem Pharmacol. 2000 May 1;59(9):1033-43.

PMID:
10704932
23.

8-Aminocyclazocine analogues: synthesis and structure-activity relationships.

Wentland MP, Xu G, Cioffi CL, Ye Y, Duan W, Cohen DJ, Colasurdo AM, Bidlack JM.

Bioorg Med Chem Lett. 2000 Jan 17;10(2):183-7.

PMID:
10673107
24.

Evaluation of biological role of c-Jun N-terminal kinase using an antisense approach.

Cioffi CL, Monia BP.

Methods Enzymol. 2000;314:363-78. No abstract available.

PMID:
10565025
25.

Exposure of human vascular smooth muscle cells to Raf-1 antisense oligodeoxynucleotides: cellular responses and pharmacodynamic implications.

Schumacher C, Cioffi CL, Sharif H, Haston W, Monia BP, Wennogle L.

Mol Pharmacol. 1998 Jan;53(1):97-104.

PMID:
9443936
26.
27.

In vitro and in vivo evaluation of an endothelin inhibitor reveals novel K+ channel opening activity.

Webb RL, Hu S, Sills MA, Bazil MK, Cioffi CL, Shetty SS, Lappe RW, Rigel DF.

Biochem Biophys Res Commun. 1996 Oct 3;227(1):176-81.

PMID:
8858121
28.

The unusual binding properties of the endothelin receptor antagonist CGS 27830 distinguishes receptor/agonist interactions.

Chin MH, Cioffi CL, Garay M, Neale RF, Shetty SS, DelGrande D, Mugrage B, Sills MA, Lipson KE.

J Pharmacol Exp Ther. 1996 Jan;276(1):74-83.

PMID:
8558459
29.
30.

Characterization of rat lung endothelin receptor subtypes which are coupled to phosphoinositide hydrolysis.

Cioffi CL, Neale RF Jr, Jackson RH, Sills MA.

J Pharmacol Exp Ther. 1992 Aug;262(2):611-8.

PMID:
1323655
32.

Molecular mechanisms of regulation of neuronal muscarinic receptor sensitivity.

el-Fakahany EE, Cioffi CL.

Membr Biochem. 1990 Jan-Mar;9(1):9-27. Review.

PMID:
2077364
34.

Pseudo-noncompetitive antagonism of muscarinic receptor-mediated cyclic GMP formation and phosphoinositide hydrolysis by pirenzepine.

el-Fakahany EE, Surichamorn W, Amrhein CL, Stenstrom S, Cioffi CL, Richelson E, McKinney M.

J Pharmacol Exp Ther. 1988 Dec;247(3):934-40.

PMID:
2849677
35.
36.
37.

Competitive interaction of pirenzepine with rat brain muscarinic acetylcholine receptors.

el-Fakahany EE, Cioffi CL, Abdellatif MM, Miller MM.

Eur J Pharmacol. 1986 Nov 19;131(2-3):237-47.

PMID:
3816954

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