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Items: 15


NF-Y controls fidelity of transcription initiation at gene promoters through maintenance of the nucleosome-depleted region.

Oldfield AJ, Henriques T, Kumar D, Burkholder AB, Cinghu S, Paulet D, Bennett BD, Yang P, Scruggs BS, Lavender CA, Rivals E, Adelman K, Jothi R.

Nat Commun. 2019 Jul 11;10(1):3072. doi: 10.1038/s41467-019-10905-7.


Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency.

Yang P, Humphrey SJ, Cinghu S, Pathania R, Oldfield AJ, Kumar D, Perera D, Yang JYH, James DE, Mann M, Jothi R.

Cell Syst. 2019 May 22;8(5):427-445.e10. doi: 10.1016/j.cels.2019.03.012. Epub 2019 May 8.


Intragenic Enhancers Attenuate Host Gene Expression.

Cinghu S, Yang P, Kosak JP, Conway AE, Kumar D, Oldfield AJ, Adelman K, Jothi R.

Mol Cell. 2017 Oct 5;68(1):104-117.e6. doi: 10.1016/j.molcel.2017.09.010.


DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.

Pathania R, Ramachandran S, Elangovan S, Padia R, Yang P, Cinghu S, Veeranan-Karmegam R, Arjunan P, Gnana-Prakasam JP, Sadanand F, Pei L, Chang CS, Choi JH, Shi H, Manicassamy S, Prasad PD, Sharma S, Ganapathy V, Jothi R, Thangaraju M.

Nat Commun. 2015 Apr 24;6:6910. doi: 10.1038/ncomms7910.


Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors.

Oldfield AJ, Yang P, Conway AE, Cinghu S, Freudenberg JM, Yellaboina S, Jothi R.

Mol Cell. 2014 Sep 4;55(5):708-22. doi: 10.1016/j.molcel.2014.07.005. Epub 2014 Aug 14.


Integrative framework for identification of key cell identity genes uncovers determinants of ES cell identity and homeostasis.

Cinghu S, Yellaboina S, Freudenberg JM, Ghosh S, Zheng X, Oldfield AJ, Lackford BL, Zaykin DV, Hu G, Jothi R.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):E1581-90. doi: 10.1073/pnas.1318598111. Epub 2014 Apr 7.


MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma.

van der Deen M, Taipaleenmäki H, Zhang Y, Teplyuk NM, Gupta A, Cinghu S, Shogren K, Maran A, Yaszemski MJ, Ling L, Cool SM, Leong DT, Dierkes C, Zustin J, Salto-Tellez M, Ito Y, Bae SC, Zielenska M, Squire JA, Lian JB, Stein JL, Zambetti GP, Jones SN, Galindo M, Hesse E, Stein GS, van Wijnen AJ.

J Biol Chem. 2013 Jul 19;288(29):21307-19. doi: 10.1074/jbc.M112.445890. Epub 2013 May 29.


Phosphorylation of the gastric tumor suppressor RUNX3 following H. pylori infection results in its localization to the cytoplasm.

Cinghu S, Goh YM, Oh BC, Lee YS, Lee OJ, Devaraj H, Bae SC.

J Cell Physiol. 2012 Mar;227(3):1071-80. doi: 10.1002/jcp.22820.


Fused Toes Homolog modulates radiation cytotoxicity in uterine cervical cancer cells.

Anandharaj A, Cinghu S, Kim WD, Yu JR, Park WY.

Mol Biol Rep. 2011 Nov;38(8):5361-70. doi: 10.1007/s11033-011-0688-3. Epub 2011 Mar 20.


Rapamycin-mediated mTOR inhibition attenuates survivin and sensitizes glioblastoma cells to radiation therapy.

Anandharaj A, Cinghu S, Park WY.

Acta Biochim Biophys Sin (Shanghai). 2011 Apr;43(4):292-300. doi: 10.1093/abbs/gmr012. Epub 2011 Mar 1.


FTS (fused toes homolog) a novel oncoprotein involved in uterine cervical carcinogenesis and a potential diagnostic marker for cervical cancer.

Cinghu S, Anandharaj A, Lee HC, Yu JR, Park WY.

J Cell Physiol. 2011 Jun;226(6):1564-72. doi: 10.1002/jcp.22486.


Helicase-like transcription factor confers radiation resistance in cervical cancer through enhancing the DNA damage repair capacity.

Cho S, Cinghu S, Yu JR, Park WY.

J Cancer Res Clin Oncol. 2011 Apr;137(4):629-37. doi: 10.1007/s00432-010-0925-5. Epub 2010 Jun 10.


Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.

Lee KS, Lee YS, Lee JM, Ito K, Cinghu S, Kim JH, Jang JW, Li YH, Goh YM, Chi XZ, Wee H, Lee HW, Hosoya A, Chung JH, Jang JJ, Kundu JK, Surh YJ, Kim WJ, Ito Y, Jung HS, Bae SC.

Oncogene. 2010 Jun 10;29(23):3349-61. doi: 10.1038/onc.2010.79. Epub 2010 Mar 15.


Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.

Goh YM, Cinghu S, Hong ET, Lee YS, Kim JH, Jang JW, Li YH, Chi XZ, Lee KS, Wee H, Ito Y, Oh BC, Bae SC.

J Biol Chem. 2010 Mar 26;285(13):10122-9. doi: 10.1074/jbc.M109.071381. Epub 2010 Jan 25.


Jab1/CSN5 induces the cytoplasmic localization and degradation of RUNX3.

Kim JH, Choi JK, Cinghu S, Jang JW, Lee YS, Li YH, Goh YM, Chi XZ, Lee KS, Wee H, Bae SC.

J Cell Biochem. 2009 Jun 1;107(3):557-65. doi: 10.1002/jcb.22157.


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