Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 20

1.

Correction to Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.

Cinelli MA, Li H, Chreifi G, Poulos TL, Silverman RB.

J Med Chem. 2019 Jan 11. doi: 10.1021/acs.jmedchem.8b02033. [Epub ahead of print] No abstract available.

PMID:
30633512
2.

Topoisomerase 1B poisons: Over a half-century of drug leads, clinical candidates, and serendipitous discoveries.

Cinelli MA.

Med Res Rev. 2018 Nov 19. doi: 10.1002/med.21546. [Epub ahead of print] Review.

PMID:
30456874
3.

Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acids.

Cinelli MA, Yang J, Scharmen A, Woodman J, Karchalla LM, Lee KSS.

J Lipid Res. 2018 Nov;59(11):2237-2252. doi: 10.1194/jlr.D089136. Epub 2018 Sep 12.

PMID:
30209076
4.

Activity of Aromathecins against African Trypanosomes.

Nenortas NP, Cinelli MA, Morrell AE, Cushman M, Shapiro TA.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e00786-18. doi: 10.1128/AAC.00786-18. Print 2018 Nov.

PMID:
30104277
5.

Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.

Pensa AV, Cinelli MA, Li H, Chreifi G, Mukherjee P, Roman LJ, Martásek P, Poulos TL, Silverman RB.

J Med Chem. 2017 Aug 24;60(16):7146-7165. doi: 10.1021/acs.jmedchem.7b00835. Epub 2017 Aug 4.

6.

Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.

Cinelli MA, Li H, Chreifi G, Poulos TL, Silverman RB.

J Med Chem. 2017 May 11;60(9):3958-3978. doi: 10.1021/acs.jmedchem.7b00259. Epub 2017 Apr 19.

7.

Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors.

Holden JK, Lewis MC, Cinelli MA, Abdullatif Z, Pensa AV, Silverman RB, Poulos TL.

Biochemistry. 2016 Oct 4;55(39):5587-5594. Epub 2016 Sep 21.

8.

Correction to Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.

Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB.

J Med Chem. 2016 Feb 11;59(3):1246. doi: 10.1021/acs.jmedchem.6b00036. Epub 2016 Jan 25. No abstract available.

9.

Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.

Cinelli MA, Li H, Pensa AV, Kang S, Roman LJ, Martásek P, Poulos TL, Silverman RB.

J Med Chem. 2015 Nov 12;58(21):8694-712. doi: 10.1021/acs.jmedchem.5b01330. Epub 2015 Oct 27. Erratum in: J Med Chem. 2016 Feb 11;59(3):1246.

10.

Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus.

Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL.

Chem Biol. 2015 Jun 18;22(6):785-92. doi: 10.1016/j.chembiol.2015.05.013.

11.

Structures of human constitutive nitric oxide synthases.

Li H, Jamal J, Plaza C, Pineda SH, Chreifi G, Jing Q, Cinelli MA, Silverman RB, Poulos TL.

Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2667-74. doi: 10.1107/S1399004714017064. Epub 2014 Sep 27.

12.

Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.

Mukherjee P, Cinelli MA, Kang S, Silverman RB.

Chem Soc Rev. 2014 Oct 7;43(19):6814-38. doi: 10.1039/c3cs60467e. Review.

13.

Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.

Cinelli MA, Li H, Chreifi G, Martásek P, Roman LJ, Poulos TL, Silverman RB.

J Med Chem. 2014 Feb 27;57(4):1513-30. doi: 10.1021/jm401838x. Epub 2014 Feb 10.

14.

Visible light mediated activation and O-glycosylation of thioglycosides.

Wever WJ, Cinelli MA, Bowers AA.

Org Lett. 2013 Jan 4;15(1):30-3. doi: 10.1021/ol302941q. Epub 2012 Dec 20.

PMID:
23256636
15.
16.

Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity.

Peterson KE, Cinelli MA, Morrell AE, Mehta A, Dexheimer TS, Agama K, Antony S, Pommier Y, Cushman M.

J Med Chem. 2011 Jul 28;54(14):4937-53. doi: 10.1021/jm101338z. Epub 2011 Jun 28.

17.

Cancer chemopreventive potential of aromathecins and phenazines, novel natural product derivatives.

Marler L, Conda-Sheridan M, Cinelli MA, Morrell AE, Cushman M, Chen L, Huang K, Van Breemen R, Pezzuto JM.

Anticancer Res. 2010 Dec;30(12):4873-82.

PMID:
21187465
18.

The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.

Cinelli MA, Morrell AE, Dexheimer TS, Agama K, Agrawal S, Pommier Y, Cushman M.

Bioorg Med Chem. 2010 Aug 1;18(15):5535-52. doi: 10.1016/j.bmc.2010.06.040. Epub 2010 Jun 20.

19.

Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.

Cinelli MA, Cordero B, Dexheimer TS, Pommier Y, Cushman M.

Bioorg Med Chem. 2009 Oct 15;17(20):7145-55. doi: 10.1016/j.bmc.2009.08.066. Epub 2009 Sep 6.

20.

Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.

Cinelli MA, Morrell A, Dexheimer TS, Scher ES, Pommier Y, Cushman M.

J Med Chem. 2008 Aug 14;51(15):4609-19. doi: 10.1021/jm800259e. Epub 2008 Jul 17.

Supplemental Content

Loading ...
Support Center