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Items: 48

1.

Plinabulin, an inhibitor of tubulin polymerization, targets KRAS signaling through disruption of endosomal recycling.

Cimino PJ, Huang L, Du L, Wu Y, Bishop J, Dalsing-Hernandez J, Kotlarczyk K, Gonzales P, Carew J, Nawrocki S, Jordan MA, Wilson L, Lloyd GK, Wirsching HG.

Biomed Rep. 2019 Apr;10(4):218-224. doi: 10.3892/br.2019.1196. Epub 2019 Mar 5.

2.

The molecular landscape of adult diffuse gliomas and relevance to clinical trials.

Cimino PJ, Holland EC.

Oncotarget. 2019 Mar 5;10(19):1758-1759. doi: 10.18632/oncotarget.26750. eCollection 2019 Mar 5. No abstract available.

3.

IgG4-positive Cell Quantification Distinguishes Between Inflammatory and Noninflammatory Diseases of the Orbit.

Sweeney AR, Keene CD, Cimino PJ, Chang SH.

Appl Immunohistochem Mol Morphol. 2019 Apr 3. doi: 10.1097/PAI.0000000000000767. [Epub ahead of print]

PMID:
30950839
4.

Targeted copy number analysis outperforms histologic grading in predicting patient survival for WHO grades II/III IDH-mutant astrocytomas.

Cimino PJ, Holland EC.

Neuro Oncol. 2019 Jun 10;21(6):819-821. doi: 10.1093/neuonc/noz052. No abstract available.

PMID:
30918961
5.

Copy number profiling across glioblastoma populations has implications for clinical trial design.

Cimino PJ, McFerrin L, Wirsching HG, Arora S, Bolouri H, Rabadan R, Weller M, Holland EC.

Neuro Oncol. 2018 Sep 3;20(10):1368-1373. doi: 10.1093/neuonc/noy108.

PMID:
29982740
6.

Giant Pediatric Rhabdoid Meningioma Associated with a Germline BAP1 Pathogenic Variation: A Rare Clinical Case.

Ravanpay AC, Barkley A, White-Dzuro GA, Cimino PJ, Gonzalez-Cuyar LF, Lockwood C, Halasz LM, Hisama FM, Ferreira M.

World Neurosurg. 2018 Nov;119:402-415. doi: 10.1016/j.wneu.2018.06.227. Epub 2018 Jul 6.

PMID:
29981911
7.

An anatomic transcriptional atlas of human glioblastoma.

Puchalski RB, Shah N, Miller J, Dalley R, Nomura SR, Yoon JG, Smith KA, Lankerovich M, Bertagnolli D, Bickley K, Boe AF, Brouner K, Butler S, Caldejon S, Chapin M, Datta S, Dee N, Desta T, Dolbeare T, Dotson N, Ebbert A, Feng D, Feng X, Fisher M, Gee G, Goldy J, Gourley L, Gregor BW, Gu G, Hejazinia N, Hohmann J, Hothi P, Howard R, Joines K, Kriedberg A, Kuan L, Lau C, Lee F, Lee H, Lemon T, Long F, Mastan N, Mott E, Murthy C, Ngo K, Olson E, Reding M, Riley Z, Rosen D, Sandman D, Shapovalova N, Slaughterbeck CR, Sodt A, Stockdale G, Szafer A, Wakeman W, Wohnoutka PE, White SJ, Marsh D, Rostomily RC, Ng L, Dang C, Jones A, Keogh B, Gittleman HR, Barnholtz-Sloan JS, Cimino PJ, Uppin MS, Keene CD, Farrokhi FR, Lathia JD, Berens ME, Iavarone A, Bernard A, Lein E, Phillips JW, Rostad SW, Cobbs C, Hawrylycz MJ, Foltz GD.

Science. 2018 May 11;360(6389):660-663. doi: 10.1126/science.aaf2666.

8.

Genomic profiling of anaplastic meningioma identifies recurrent genetic alterations with relevance to lower-grade meningioma.

Cimino PJ, Yoda RA, Wirsching HG, Warrick JI, Dorschner MO, Ferreira M.

Neuropathol Appl Neurobiol. 2019 Feb;45(2):179-182. doi: 10.1111/nan.12487. Epub 2018 May 8. No abstract available.

PMID:
29675951
9.

Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma.

Cimino PJ, Kim Y, Wu HJ, Alexander J, Wirsching HG, Szulzewsky F, Pitter K, Ozawa T, Wang J, Vazquez J, Arora S, Rabadan R, Levine R, Michor F, Holland EC.

Genes Dev. 2018 Apr 1;32(7-8):512-523. doi: 10.1101/gad.312157.118. Epub 2018 Apr 9.

10.

Neurofibromatosis type 1.

Cimino PJ, Gutmann DH.

Handb Clin Neurol. 2018;148:799-811. doi: 10.1016/B978-0-444-64076-5.00051-X. Review.

PMID:
29478615
11.

Neuropathological Comparison of Adult Onset and Juvenile Huntington's Disease with Cerebellar Atrophy: A Report of a Father and Son.

Latimer CS, Flanagan ME, Cimino PJ, Jayadev S, Davis M, Hoffer ZS, Montine TJ, Gonzalez-Cuyar LF, Bird TD, Keene CD.

J Huntingtons Dis. 2017;6(4):337-348. doi: 10.3233/JHD-170261.

12.

Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment.

Szulzewsky F, Schwendinger N, Güneykaya D, Cimino PJ, Hambardzumyan D, Synowitz M, Holland EC, Kettenmann H.

Neuro Oncol. 2018 Feb 19;20(3):355-366. doi: 10.1093/neuonc/nox165.

13.

Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas.

Herting CJ, Chen Z, Pitter KL, Szulzewsky F, Kaffes I, Kaluzova M, Park JC, Cimino PJ, Brennan C, Wang B, Hambardzumyan D.

Glia. 2017 Dec;65(12):1914-1926. doi: 10.1002/glia.23203. Epub 2017 Aug 24.

14.

Application of the condensed protocol for the NIA-AA guidelines for the neuropathological assessment of Alzheimer's disease in an academic clinical practice.

Bharadwaj R, Cimino PJ, Flanagan ME, Latimer CS, Gonzalez-Cuyar LF, Juric-Sekhar G, Montine TJ, Marshall DA, Keene CD.

Histopathology. 2018 Feb;72(3):433-440. doi: 10.1111/his.13345. Epub 2017 Nov 22.

15.

Multidimensional scaling of diffuse gliomas: application to the 2016 World Health Organization classification system with prognostically relevant molecular subtype discovery.

Cimino PJ, Zager M, McFerrin L, Wirsching HG, Bolouri H, Hentschel B, von Deimling A, Jones D, Reifenberger G, Weller M, Holland EC.

Acta Neuropathol Commun. 2017 May 22;5(1):39. doi: 10.1186/s40478-017-0443-7.

16.

The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation.

Solga AC, Toonen JA, Pan Y, Cimino PJ, Ma Y, Castillon GA, Gianino SM, Ellisman MH, Lee DY, Gutmann DH.

Oncotarget. 2017 Jul 18;8(29):47206-47215. doi: 10.18632/oncotarget.17589.

17.

Clival paragangliomas: a report of two cases involving the midline skull base and review of the literature.

Ruzevick J, Koh EK, Gonzalez-Cuyar LF, Cimino PJ, Moe K, Wright LA, Failor R, Ferreira M.

J Neurooncol. 2017 May;132(3):473-478. doi: 10.1007/s11060-017-2396-x. Epub 2017 Mar 16. Review.

PMID:
28299533
18.

Clinicopathologic characteristics of metastatic esophageal carcinoma isolated to the pineal region: A case report and review of the literature.

Flanagan ME, Williams JR, Emerson SN, Chiarelli PA, Ellenbogen RG, Cimino PJ.

Exp Mol Pathol. 2017 Apr;102(2):247-250. doi: 10.1016/j.yexmp.2017.02.011. Epub 2017 Feb 16. Review.

PMID:
28215583
19.

Immunohistochemical profiling including beta-catenin in conjunctival melanocytic lesions.

Reddy HS, Keene CD, Chang SH, Jian-Amadi A, Cimino PJ.

Exp Mol Pathol. 2017 Apr;102(2):198-202. doi: 10.1016/j.yexmp.2017.01.016. Epub 2017 Feb 1.

PMID:
28161440
20.

Targeted Next-Generation Sequencing in Molecular Subtyping of Lower-Grade Diffuse Gliomas: Application of the World Health Organization's 2016 Revised Criteria for Central Nervous System Tumors.

Carter JH, McNulty SN, Cimino PJ, Cottrell CE, Heusel JW, Vigh-Conrad KA, Duncavage EJ.

J Mol Diagn. 2017 Mar;19(2):328-337. doi: 10.1016/j.jmoldx.2016.10.010. Epub 2016 Dec 30.

PMID:
28042970
21.

Primary Gliosarcoma of the Optic Nerve: A Unique Adult Optic Pathway Glioma.

Cimino PJ, Sychev YV, Gonzalez-Cuyar LF, Mudumbai RC, Keene CD.

Ophthalmic Plast Reconstr Surg. 2017 Jul/Aug;33(4):e88-e92. doi: 10.1097/IOP.0000000000000798.

PMID:
27792048
22.

A 71-Year-Old Man Presenting with Headache, Blurry Vision and Alexia without Agraphia.

Cimino PJ, Perrin RJ.

Brain Pathol. 2016 Nov;26(6):799-800. doi: 10.1111/bpa.12448. No abstract available.

PMID:
27647576
23.

Orbital peripheral nerve sheath tumors.

Sweeney AR, Gupta D, Keene CD, Cimino PJ, Chambers CB, Chang SH, Hanna E.

Surv Ophthalmol. 2017 Jan - Feb;62(1):43-57. doi: 10.1016/j.survophthal.2016.08.002. Epub 2016 Aug 26. Review.

PMID:
27570221
24.

Mutational status of IDH1 in uveal melanoma.

Cimino PJ, Kung Y, Warrick JI, Chang SH, Keene CD.

Exp Mol Pathol. 2016 Jun;100(3):476-81. doi: 10.1016/j.yexmp.2016.05.002. Epub 2016 May 4.

PMID:
27155448
25.

ABCG1 maintains high-grade glioma survival in vitro and in vivo.

Chen YH, Cimino PJ, Luo J, Dahiya S, Gutmann DH.

Oncotarget. 2016 Apr 26;7(17):23416-24. doi: 10.18632/oncotarget.8030.

26.

Neurologic manifestations of intravascular large B-cell lymphoma.

Tahsili-Fahadan P, Rashidi A, Cimino PJ, Bucelli RC, Keyrouz SG.

Neurol Clin Pract. 2016 Feb;6(1):55-60. Review.

27.

RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth.

Solga AC, Pong WW, Kim KY, Cimino PJ, Toonen JA, Walker J, Wylie T, Magrini V, Griffith M, Griffith OL, Ly A, Ellisman MH, Mardis ER, Gutmann DH.

Neoplasia. 2015 Oct;17(10):776-88. doi: 10.1016/j.neo.2015.10.002.

28.

Malignant progression to anaplastic meningioma: Neuropathology, molecular pathology, and experimental models.

Cimino PJ.

Exp Mol Pathol. 2015 Oct;99(2):354-9. doi: 10.1016/j.yexmp.2015.08.007. Epub 2015 Aug 22. Review.

PMID:
26302177
29.

Peripheral nervous system hyperexcitability in VV2 sporadic Creutzfeldt-Jakob disease.

Ong CJ, Al-Lozi M, Cimino PJ, Bucelli R.

Neurol Clin Pract. 2015 Aug;5(4):326-332. doi: 10.1212/CPJ.0000000000000160.

30.

Lack of BRAF-V600E Mutation in Papillary Tumor of the Pineal Region.

Cimino PJ, Gonzalez-Cuyar LF, Perry A, Dahiya S.

Neurosurgery. 2015 Oct;77(4):621-8. doi: 10.1227/NEU.0000000000000877.

PMID:
26125673
31.

A wide spectrum of EGFR mutations in glioblastoma is detected by a single clinical oncology targeted next-generation sequencing panel.

Cimino PJ, Bredemeyer A, Abel HJ, Duncavage EJ.

Exp Mol Pathol. 2015 Jun;98(3):568-73. doi: 10.1016/j.yexmp.2015.04.006. Epub 2015 Apr 22.

32.

Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties.

Chen YH, McGowan LD, Cimino PJ, Dahiya S, Leonard JR, Lee DY, Gutmann DH.

Cell Rep. 2015 Mar 24;10(11):1899-912. doi: 10.1016/j.celrep.2015.02.041. Epub 2015 Mar 12.

33.

Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.

Kaul A, Toonen JA, Cimino PJ, Gianino SM, Gutmann DH.

Neuro Oncol. 2015 Jun;17(6):843-53. doi: 10.1093/neuonc/nou329. Epub 2014 Dec 21.

34.

Myxopapillary ependymoma in children: a study of 11 cases and a comparison with the adult experience.

Cimino PJ, Agarwal A, Dehner LP.

Pediatr Blood Cancer. 2014 Nov;61(11):1969-71. doi: 10.1002/pbc.25125. Epub 2014 Jul 25.

PMID:
25066546
35.

Detection of viral pathogens in high grade gliomas from unmapped next-generation sequencing data.

Cimino PJ, Zhao G, Wang D, Sehn JK, Lewis JS Jr, Duncavage EJ.

Exp Mol Pathol. 2014 Jun;96(3):310-5. doi: 10.1016/j.yexmp.2014.03.010. Epub 2014 Apr 1.

PMID:
24704430
36.

Retinoblastoma gene mutations detected by whole exome sequencing of Merkel cell carcinoma.

Cimino PJ, Robirds DH, Tripp SR, Pfeifer JD, Abel HJ, Duncavage EJ.

Mod Pathol. 2014 Aug;27(8):1073-87. doi: 10.1038/modpathol.2013.235. Epub 2014 Jan 10.

37.

Mammaglobin-A immunohistochemistry in primary central nervous system neoplasms and intracranial metastatic breast carcinoma.

Cimino PJ Jr, Perrin RJ.

Appl Immunohistochem Mol Morphol. 2014 Jul;22(6):442-8. doi: 10.1097/PAI.0b013e318294ca46.

38.

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.

Linette GP, Stadtmauer EA, Maus MV, Rapoport AP, Levine BL, Emery L, Litzky L, Bagg A, Carreno BM, Cimino PJ, Binder-Scholl GK, Smethurst DP, Gerry AB, Pumphrey NJ, Bennett AD, Brewer JE, Dukes J, Harper J, Tayton-Martin HK, Jakobsen BK, Hassan NJ, Kalos M, June CH.

Blood. 2013 Aug 8;122(6):863-71. doi: 10.1182/blood-2013-03-490565. Epub 2013 Jun 14.

39.

Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease.

Cimino PJ, Yang Y, Li X, Hemingway JF, Cherne MK, Khademi SB, Fukui Y, Montine KS, Montine TJ, Keene CD.

Exp Mol Pathol. 2013 Apr;94(2):366-71. doi: 10.1016/j.yexmp.2013.01.002. Epub 2013 Jan 11.

40.

Detection of Merkel cell polyomavirus in chronic lymphocytic leukemia T-cells.

Cimino PJ Jr, Bahler DW, Duncavage EJ.

Exp Mol Pathol. 2013 Feb;94(1):40-4. doi: 10.1016/j.yexmp.2012.09.019. Epub 2012 Sep 28.

PMID:
23026399
41.

Case series of completed suicides by burning over a 13-year period.

Cimino PJ, Williams TL, Fusaro A, Harruff R.

J Forensic Sci. 2011 Jan;56 Suppl 1:S109-11. doi: 10.1111/j.1556-4029.2010.01597.x. Epub 2010 Oct 15.

PMID:
20950319
42.

DOCK2 is a microglial specific regulator of central nervous system innate immunity found in normal and Alzheimer's disease brain.

Cimino PJ, Sokal I, Leverenz J, Fukui Y, Montine TJ.

Am J Pathol. 2009 Oct;175(4):1622-30. doi: 10.2353/ajpath.2009.090443. Epub 2009 Sep 3.

43.

Therapeutic targets in prostaglandin E2 signaling for neurologic disease.

Cimino PJ, Keene CD, Breyer RM, Montine KS, Montine TJ.

Curr Med Chem. 2008;15(19):1863-9. Review.

44.

Selectively increased oxidative modifications mapped to detergent-insoluble forms of Abeta and beta-III tubulin in Alzheimer's disease.

Boutte AM, Woltjer RL, Zimmerman LJ, Stamer SL, Montine KS, Manno MV, Cimino PJ, Liebler DC, Montine TJ.

FASEB J. 2006 Jul;20(9):1473-83.

PMID:
16816122
45.

Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease.

Woltjer RL, Cimino PJ, Boutté AM, Schantz AM, Montine KS, Larson EB, Bird T, Quinn JF, Zhang J, Montine TJ.

FASEB J. 2005 Nov;19(13):1923-5. Epub 2005 Aug 29.

PMID:
16129700
46.

The clinical and genetic spectrum of spinocerebellar ataxia 14.

Chen DH, Cimino PJ, Ranum LP, Zoghbi HY, Yabe I, Schut L, Margolis RL, Lipe HP, Feleke A, Matsushita M, Wolff J, Morgan C, Lau D, Fernandez M, Sasaki H, Raskind WH, Bird TD.

Neurology. 2005 Apr 12;64(7):1258-60.

PMID:
15824357
47.

Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein.

Wang Q, Woltjer RL, Cimino PJ, Pan C, Montine KS, Zhang J, Montine TJ.

FASEB J. 2005 May;19(7):869-71. Epub 2005 Mar 3.

PMID:
15746184
48.

Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia.

Chen DH, Brkanac Z, Verlinde CL, Tan XJ, Bylenok L, Nochlin D, Matsushita M, Lipe H, Wolff J, Fernandez M, Cimino PJ, Bird TD, Raskind WH.

Am J Hum Genet. 2003 Apr;72(4):839-49. Epub 2003 Mar 17.

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