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Kir7.1 inwardly rectifying K+ channel is expressed in ciliary body non pigment epithelial cells and might contribute to intraocular pressure regulation.

Burgos J, Villanueva S, Ojeda M, Cornejo I, Cid LP, Sepúlveda FV.

Exp Eye Res. 2019 Sep;186:107723. doi: 10.1016/j.exer.2019.107723. Epub 2019 Jul 15.


A novel Kir7.1 splice variant expressed in various mouse tissues shares organisational and functional properties with human Leber amaurosis-causing mutations of this K+ channel.

Vera E, Cornejo I, Burgos J, Niemeyer MI, Sepúlveda FV, Cid LP.

Biochem Biophys Res Commun. 2019 Jun 30;514(3):574-579. doi: 10.1016/j.bbrc.2019.04.169. Epub 2019 May 3.


Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse.

Philp AR, Riquelme TT, Millar-Büchner P, González R, Sepúlveda FV, Cid LP, Flores CA.

Sci Rep. 2018 Jun 18;8(1):9320. doi: 10.1038/s41598-018-27465-3.


Tissue Distribution of Kir7.1 Inwardly Rectifying K+ Channel Probed in a Knock-in Mouse Expressing a Haemagglutinin-Tagged Protein.

Cornejo I, Villanueva S, Burgos J, López-Cayuqueo KI, Chambrey R, Julio-Kalajzić F, Buelvas N, Niemeyer MI, Figueiras-Fierro D, Brown PD, Sepúlveda FV, Cid LP.

Front Physiol. 2018 Apr 23;9:428. doi: 10.3389/fphys.2018.00428. eCollection 2018.


Reply from L. P. Cid, T. J. Jentsch and F. V. Sepúlveda: intestinal electrolyte and fluid secretion - a model in trouble?

Cid LP, Jentsch TJ, Sepúlveda FV.

J Physiol. 2018 Jun;596(12):2465-2466. doi: 10.1113/JP276139. Epub 2018 Apr 16. No abstract available.


K2P TASK-2 and KCNQ1-KCNE3 K+ channels are major players contributing to intestinal anion and fluid secretion.

Julio-Kalajzić F, Villanueva S, Burgos J, Ojeda M, Cid LP, Jentsch TJ, Sepúlveda FV.

J Physiol. 2018 Feb 1;596(3):393-407. doi: 10.1113/JP275178. Epub 2017 Dec 18.


Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K2P background K+ channel TASK-2.

Niemeyer MI, Cid LP, Paulais M, Teulon J, Sepúlveda FV.

Sci Rep. 2017 Mar 30;7:45407. doi: 10.1038/srep45407.


Gating, Regulation, and Structure in K2P K+ Channels: In Varietate Concordia?

Niemeyer MI, Cid LP, González W, Sepúlveda FV.

Mol Pharmacol. 2016 Sep;90(3):309-17. doi: 10.1124/mol.116.103895. Epub 2016 Jun 6. Review.


Cleft Palate, Moderate Lung Developmental Retardation and Early Postnatal Lethality in Mice Deficient in the Kir7.1 Inwardly Rectifying K+ Channel.

Villanueva S, Burgos J, López-Cayuqueo KI, Lai KM, Valenzuela DM, Cid LP, Sepúlveda FV.

PLoS One. 2015 Sep 24;10(9):e0139284. doi: 10.1371/journal.pone.0139284. eCollection 2015.


TASK-2 K₂p K⁺ channel: thoughts about gating and its fitness to physiological function.

López-Cayuqueo KI, Peña-Münzenmayer G, Niemeyer MI, Sepúlveda FV, Cid LP.

Pflugers Arch. 2015 May;467(5):1043-53. doi: 10.1007/s00424-014-1627-7. Epub 2014 Oct 15. Review.


Identification and functional expression of a glutamate- and avermectin-gated chloride channel from Caligus rogercresseyi, a southern Hemisphere sea louse affecting farmed fish.

Cornejo I, Andrini O, Niemeyer MI, Marabolí V, González-Nilo FD, Teulon J, Sepúlveda FV, Cid LP.

PLoS Pathog. 2014 Sep 25;10(9):e1004402. doi: 10.1371/journal.ppat.1004402. eCollection 2014 Sep.


Zebrafish and mouse TASK-2 K(+) channels are inhibited by increased CO2 and intracellular acidification.

Peña-Münzenmayer G, Niemeyer MI, Sepúlveda FV, Cid LP.

Pflugers Arch. 2014 Jul;466(7):1317-27. doi: 10.1007/s00424-013-1365-2. Epub 2013 Oct 1.


TASK-2: a K2P K(+) channel with complex regulation and diverse physiological functions.

Cid LP, Roa-Rojas HA, Niemeyer MI, González W, Araki M, Araki K, Sepúlveda FV.

Front Physiol. 2013 Jul 29;4:198. doi: 10.3389/fphys.2013.00198. eCollection 2013.


G protein modulation of K2P potassium channel TASK-2 : a role of basic residues in the C terminus domain.

Añazco C, Peña-Münzenmayer G, Araya C, Cid LP, Sepúlveda FV, Niemeyer MI.

Pflugers Arch. 2013 Dec;465(12):1715-26. doi: 10.1007/s00424-013-1314-0. Epub 2013 Jun 28.


Novel CLCNKB mutations causing Bartter syndrome affect channel surface expression.

Keck M, Andrini O, Lahuna O, Burgos J, Cid LP, Sepúlveda FV, L'hoste S, Blanchard A, Vargas-Poussou R, Lourdel S, Teulon J.

Hum Mutat. 2013 Sep;34(9):1269-78. doi: 10.1002/humu.22361. Epub 2013 Jun 12.


An extracellular ion pathway plays a central role in the cooperative gating of a K(2P) K+ channel by extracellular pH.

González W, Zúñiga L, Cid LP, Arévalo B, Niemeyer MI, Sepúlveda FV.

J Biol Chem. 2013 Feb 22;288(8):5984-91. doi: 10.1074/jbc.M112.445528. Epub 2013 Jan 14.


Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K⁺ channels.

Alzamora R, O'Mahony F, Bustos V, Rapetti-Mauss R, Urbach V, Cid LP, Sepúlveda FV, Harvey BJ.

J Physiol. 2011 Nov 1;589(Pt 21):5091-107. doi: 10.1113/jphysiol.2011.215772. Epub 2011 Sep 12.


Extracellular pH in restricted domains as a gating signal for ion channels involved in transepithelial transport.

Sandoval M, Burgos J, Sepúlveda FV, Cid LP.

Biol Pharm Bull. 2011;34(6):803-9. Review.


B lymphocytes taken to task: a role for a background conductance K2P K+ channel in B cells. Focus on "Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells".

Flores CA, Cid LP, Niemeyer MI, Sepúlveda FV.

Am J Physiol Cell Physiol. 2011 May;300(5):C976-8. doi: 10.1152/ajpcell.00050.2011. Epub 2011 Mar 9. No abstract available.


Gating of a pH-sensitive K(2P) potassium channel by an electrostatic effect of basic sensor residues on the selectivity filter.

Zúñiga L, Márquez V, González-Nilo FD, Chipot C, Cid LP, Sepúlveda FV, Niemeyer MI.

PLoS One. 2011 Jan 25;6(1):e16141. doi: 10.1371/journal.pone.0016141.


A tale from the Crypt: splice variants of BK channels in colonic potassium secretion.

Flores CA, Cid LP, Sepúlveda FV.

J Physiol. 2010 Jun 1;588(Pt 11):1807-8. doi: 10.1113/jphysiol.2010.191783. No abstract available.


Separate gating mechanisms mediate the regulation of K2P potassium channel TASK-2 by intra- and extracellular pH.

Niemeyer MI, Cid LP, Peña-Münzenmayer G, Sepúlveda FV.

J Biol Chem. 2010 May 28;285(22):16467-75. doi: 10.1074/jbc.M110.107060. Epub 2010 Mar 29.


Strain-dependent differences in electrogenic secretion of electrolytes across mouse colon epithelium.

Flores CA, Cid LP, Sepúlveda FV.

Exp Physiol. 2010 Jun;95(6):686-98. doi: 10.1113/expphysiol.2009.051102. Epub 2010 Feb 12.


No evidence for a role of CLCN2 variants in idiopathic generalized epilepsy.

Niemeyer MI, Cid LP, Sepúlveda FV, Blanz J, Auberson M, Jentsch TJ.

Nat Genet. 2010 Jan;42(1):3. doi: 10.1038/ng0110-3. No abstract available.


TMEM16 proteins: the long awaited calcium-activated chloride channels?

Flores CA, Cid LP, Sepúlveda FV, Niemeyer MI.

Braz J Med Biol Res. 2009 Nov;42(11):993-1001. Epub 2009 Sep 25. Review.


Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval.

Cornejo I, Niemeyer MI, Zúñiga L, Yusef YR, Sepúlveda FV, Cid LP.

J Cell Physiol. 2009 Dec;221(3):650-7. doi: 10.1002/jcp.21900.


Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons.

Niemeyer MI, Cid LP, Yusef YR, Briones R, Sepúlveda FV.

J Physiol. 2009 Apr 1;587(Pt 7):1387-400. doi: 10.1113/jphysiol.2008.167353. Epub 2009 Jan 19.


A genetically encoded ratiometric sensor to measure extracellular pH in microdomains bounded by basolateral membranes of epithelial cells.

Urra J, Sandoval M, Cornejo I, Barros LF, Sepúlveda FV, Cid LP.

Pflugers Arch. 2008 Oct;457(1):233-42. doi: 10.1007/s00424-008-0497-2. Epub 2008 Apr 22.


Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel.

Niemeyer MI, González-Nilo FD, Zúñiga L, González W, Cid LP, Sepúlveda FV.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):666-71. Epub 2006 Dec 29.


Gating of two-pore domain K+ channels by extracellular pH.

Niemeyer MI, González-Nilo FD, Zúñiga L, González W, Cid LP, Sepúlveda FV.

Biochem Soc Trans. 2006 Nov;34(Pt 5):899-902.


Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase.

Ramirez A, Heimbach A, Gründemann J, Stiller B, Hampshire D, Cid LP, Goebel I, Mubaidin AF, Wriekat AL, Roeper J, Al-Din A, Hillmer AM, Karsak M, Liss B, Woods CG, Behrens MI, Kubisch C.

Nat Genet. 2006 Oct;38(10):1184-91. Epub 2006 Sep 10.


Two splice variants derived from a Drosophila melanogaster candidate ClC gene generate ClC-2-type Cl- channels.

Flores CA, Niemeyer MI, Sepúlveda FV, Cid LP.

Mol Membr Biol. 2006 Mar-Apr;23(2):149-56.


Putative ClC-2 chloride channel mediates inward rectification in Drosophila retinal photoreceptors.

Ugarte G, Delgado R, O'Day PM, Farjah F, Cid LP, Vergara C, Bacigalupo J.

J Membr Biol. 2005 Oct;207(3):151-60.


Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain.

Yusef YR, Zúñiga L, Catalán M, Niemeyer MI, Cid LP, Sepúlveda FV.

J Physiol. 2006 Apr 1;572(Pt 1):173-81. Epub 2006 Feb 9.


ClC-2 channels get new partners. Focus on "association between Hsp90 and the ClC-2 chloride channel upregulates channel function".

Cid LP, Niemeyer MI, Sepúlveda FV.

Am J Physiol Cell Physiol. 2006 Jan;290(1):C42-4. Review. No abstract available.


Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif.

Peña-Münzenmayer G, Catalán M, Cornejo I, Figueroa CD, Melvin JE, Niemeyer MI, Cid LP, Sepúlveda FV.

J Cell Sci. 2005 Sep 15;118(Pt 18):4243-52.


Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies.

Niemeyer MI, Yusef YR, Cornejo I, Flores CA, Sepúlveda FV, Cid LP.

Physiol Genomics. 2004 Sep 16;19(1):74-83. Epub 2004 Jul 13.


Basolateral ClC-2 chloride channels in surface colon epithelium: regulation by a direct effect of intracellular chloride.

Catalán M, Niemeyer MI, Cid LP, Sepúlveda FV.

Gastroenterology. 2004 Apr;126(4):1104-14.


The voltage-dependent ClC-2 chloride channel has a dual gating mechanism.

Zúñiga L, Niemeyer MI, Varela D, Catalán M, Cid LP, Sepúlveda FV.

J Physiol. 2004 Mar 16;555(Pt 3):671-82. Epub 2004 Jan 14.


A conserved pore-lining glutamate as a voltage- and chloride-dependent gate in the ClC-2 chloride channel.

Niemeyer MI, Cid LP, Zúñiga L, Catalán M, Sepúlveda FV.

J Physiol. 2003 Dec 15;553(Pt 3):873-9. Epub 2003 Nov 14.


Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K+ channel without having an essential effect upon activity.

Niemeyer MI, Cid LP, Valenzuela X, Paeile V, Sepúlveda FV.

Mol Membr Biol. 2003 Apr-Jun;20(2):185-91.


Effect of an N-terminus deletion on voltage-dependent gating of the ClC-2 chloride channel.

Varela D, Niemeyer MI, Cid LP, Sepúlveda FV.

J Physiol. 2002 Oct 15;544(2):363-72.


ClC-2 in guinea pig colon: mRNA, immunolabeling, and functional evidence for surface epithelium localization.

Catalán M, Cornejo I, Figueroa CD, Niemeyer MI, Sepúlveda FV, Cid LP.

Am J Physiol Gastrointest Liver Physiol. 2002 Oct;283(4):G1004-13.


K+ conductance activated during regulatory volume decrease. The channels in Ehrlich cells and their possible molecular counterpart.

Niemeyer MI, Cid LP, Sepúlveda FV.

Comp Biochem Physiol A Mol Integr Physiol. 2001 Oct;130(3):565-75. Review.


Modulation of the two-pore domain acid-sensitive K+ channel TASK-2 (KCNK5) by changes in cell volume.

Niemeyer MI, Cid LP, Barros LF, Sepúlveda FV.

J Biol Chem. 2001 Nov 16;276(46):43166-74. Epub 2001 Sep 17.


Aquaporin-2, a regulated water channel, is expressed in apical membranes of rat distal colon epithelium.

Gallardo P, Cid LP, Vio CP, Sepúlveda FV.

Am J Physiol Gastrointest Liver Physiol. 2001 Sep;281(3):G856-63.


Cloning, cellular distribution and functional expression of small intestinal epithelium guinea pig ClC-5 chloride channel.

Cornejo I, Niemeyer MI, Sepúlveda FV, Cid LP.

Biochim Biophys Acta. 2001 Jun 6;1512(2):367-74.


Splice variants of a ClC-2 chloride channel with differing functional characteristics.

Cid LP, Niemeyer MI, Ramírez A, Sepúlveda FV.

Am J Physiol Cell Physiol. 2000 Oct;279(4):C1198-210.


Separate taurine and chloride efflux pathways activated during regulatory volume decrease.

Stutzin A, Torres R, Oporto M, Pacheco P, Eguiguren AL, Cid LP, Sepúlveda FV.

Am J Physiol. 1999 Sep;277(3):C392-402. doi: 10.1152/ajpcell.1999.277.3.C392.


Modulation by extracellular Cl- of volume-activated organic osmolyte and halide permeabilities in HeLa cells.

Stutzin A, Eguiguren AL, Cid LP, Sepúlveda FV.

Am J Physiol. 1997 Sep;273(3 Pt 1):C999-1007.


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