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Items: 21


Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene.

Luo YS, Cichocki JA, Hsieh NH, Lewis L, Wright FA, Threadgill DW, Chiu WA, Rusyn I.

Environ Health Perspect. 2019 Jun;127(6):67011. doi: 10.1289/EHP5105. Epub 2019 Jun 27.


Histopathological and Molecular Signatures of a Mouse Model of Acute-on-Chronic Alcoholic Liver Injury Demonstrate Concordance With Human Alcoholic Hepatitis.

Furuya S, Cichocki JA, Konganti K, Dreval K, Uehara T, Katou Y, Fukushima H, Kono H, Pogribny IP, Argemi J, Bataller R, Rusyn I.

Toxicol Sci. 2019 Aug 1;170(2):427-437. doi: 10.1093/toxsci/kfy292.


Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice.

Cichocki JA, Luo YS, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2019 Jan 1;167(1):126-137. doi: 10.1093/toxsci/kfy223.


Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice.

Dalaijamts C, Cichocki JA, Luo YS, Rusyn I, Chiu WA.

Toxicol Appl Pharmacol. 2018 Aug 1;352:142-152. doi: 10.1016/j.taap.2018.05.033. Epub 2018 May 29.


Effects of pirfenidone in acute and sub-chronic liver fibrosis, and an initiation-promotion cancer model in the mouse.

Seniutkin O, Furuya S, Luo YS, Cichocki JA, Fukushima H, Kato Y, Sugimoto H, Matsumoto T, Uehara T, Rusyn I.

Toxicol Appl Pharmacol. 2018 Jan 15;339:1-9. doi: 10.1016/j.taap.2017.11.024. Epub 2017 Dec 6.


Editor's Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse.

Zhou YH, Cichocki JA, Soldatow VY, Scholl EH, Gallins PJ, Jima D, Yoo HS, Chiu WA, Wright FA, Rusyn I.

Toxicol Sci. 2017 Nov 1;160(1):95-110. doi: 10.1093/toxsci/kfx165.


Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

Cichocki JA, Furuya S, Luo YS, Iwata Y, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2017 Oct 1;159(2):481. doi: 10.1093/toxsci/kfx158. No abstract available.


Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

Cichocki JA, Furuya S, Luo YS, Iwata Y, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2017 Sep 1;159(1):102-113. doi: 10.1093/toxsci/kfx120. Erratum in: Toxicol Sci. 2017 Oct 1;159(2):481.


Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population.

Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap AH, Wade T, Sweet S, Chiu WA, Threadgill DW, Rusyn I.

Environ Health Perspect. 2017 May 30;125(5):057006. doi: 10.1289/EHP788.


Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice.

Cichocki JA, Furuya S, Konganti K, Luo YS, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

J Pharmacol Exp Ther. 2017 Apr;361(1):17-28. doi: 10.1124/jpet.116.238790. Epub 2017 Feb 1.


Inhalation dosimetry modeling provides insights into regional respiratory tract toxicity of inhaled diacetyl.

Cichocki JA, Morris JB.

Toxicology. 2017 Aug 1;388:30-39. doi: 10.1016/j.tox.2016.11.007. Epub 2016 Nov 13.


Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps.

Cichocki JA, Guyton KZ, Guha N, Chiu WA, Rusyn I, Lash LH.

J Pharmacol Exp Ther. 2016 Oct;359(1):110-23. doi: 10.1124/jpet.116.232629. Epub 2016 Aug 10. Review.


Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice.

Smith GJ, Cichocki JA, Doughty BJ, Manautou JE, Jordt SE, Morris JB.

Environ Health Perspect. 2016 May;124(5):642-50. doi: 10.1289/ehp.1509851. Epub 2015 Oct 9.


The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.

Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar W, Sweet S, Knap A, Wade T, Campbell J, Clewell HJ, Melnyk SB, Chiu WA, Rusyn I.

Toxicol Sci. 2015 Oct;147(2):339-49. doi: 10.1093/toxsci/kfv134. Epub 2015 Jul 1.


Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice.

Ha MA, Smith GJ, Cichocki JA, Fan L, Liu YS, Caceres AI, Jordt SE, Morris JB.

PLoS One. 2015 Feb 13;10(2):e0117128. doi: 10.1371/journal.pone.0117128. eCollection 2015.


Tissue sensitivity of the rat upper and lower extrapulmonary airways to the inhaled electrophilic air pollutants diacetyl and acrolein.

Cichocki JA, Smith GJ, Morris JB.

Toxicol Sci. 2014 Nov;142(1):126-36. doi: 10.1093/toxsci/kfu165. Epub 2014 Aug 21.


Sex differences in the acute nasal antioxidant/antielectrophilic response of the rat to inhaled naphthalene.

Cichocki JA, Smith GJ, Mendoza R, Buckpitt AR, Van Winkle LS, Morris JB.

Toxicol Sci. 2014 May;139(1):234-44. doi: 10.1093/toxsci/kfu031. Epub 2014 Feb 22.


In situ measurement of vapor uptake in the rodent upper respiratory tract.

Morris JB, Cichocki JA, Smith GJ.

Curr Protoc Toxicol. 2013 Feb;Chapter 24:Unit 24.1. doi: 10.1002/0471140856.tx2401s55.


Detection of post-translational modifications on native intact nucleosomes by ELISA.

Dai B, Dahmani F, Cichocki JA, Swanson LC, Rasmussen TP.

J Vis Exp. 2011 Apr 26;(50). pii: 2593. doi: 10.3791/2593.

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