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Items: 20

1.

Determination of Real Time in Vivo Drug Receptor Occupancy for a Covalent Binding Drug as a Clinical Pharmacodynamic Biomarker by Immunocapture-LC-MS/MS.

Zheng N, Catlett IM, Taylor K, Gu H, Pattoli MA, Neely RJ, Li W, Allentoff A, Yuan X, Ciccimaro E, Yao M, Warrack BM, Burke JR, Zhang YJ, Pillutla R, Zeng J.

Anal Chem. 2019 Jul 2;91(13):8443-8452. doi: 10.1021/acs.analchem.9b01462. Epub 2019 Jun 19.

PMID:
31247719
2.

2017 White Paper: rise of hybrid LBA/LCMS immunogenicity assays (Part 2: hybrid LBA/LCMS biotherapeutics, biomarkers & immunogenicity assays and regulatory agencies' inputs).

Neubert H, Song A, Lee A, Wei C, Duggan J, Xu K, Woolf E, Evans C, Palandra J, Laterza O, Amur S, Berger I, Bustard M, Cancilla M, Chen SC, Cho SJ, Ciccimaro E, Cludts I, Cocea L, D'Arienzo C, Danan-Leon L, Donato LD, Garofolo F, Haidar S, Ishii-Watabe A, Jiang H, Kadavil J, Kassim S, Kurki P, Blaye OL, Liu K, Mathews R, Lima Santos GM, Niwa M, Pedras-Vasconcelos J, Qian M, Rago B, Saad O, Saito Y, Savoie N, Su D, Szapacs M, Tampal N, Vinter S, Wang J, Welink J, Whale E, Wilson A, Xue YJ.

Bioanalysis. 2017 Dec;9(23):1895-1912. doi: 10.4155/bio-2017-4973. Epub 2017 Dec 5.

3.

Analytical considerations for quantitative LC-MS strategies for measuring antibody drug-target engagement in tissues.

Shipkova P, Ciccimaro E, Olah TV.

Bioanalysis. 2017 Dec;9(23):1845-1847. doi: 10.4155/bio-2017-0215. Epub 2017 Nov 24. No abstract available.

PMID:
29171760
4.

Immunoaffinity LC-MS/MS for quantitative determination of a free and total protein target as a target engagement biomarker.

Zhang H, Gu H, Shipkova P, Ciccimaro E, Sun H, Zhao Q, Olah TV.

Bioanalysis. 2017 Oct;9(20):1573-1588. doi: 10.4155/bio-2017-0152. Epub 2017 Oct 26.

5.

Antibody Drug-Target Engagement Measurement in Tissue Using Quantitative Affinity Extraction Liquid Chromatography-Mass Spectrometry: Method Development and Qualification.

Ciccimaro E, Zhu Y, Ostanin D, Suchard S, MacGuire J, Xiao Q, Dongre A, Chimalakonda A, Olah T, Shipkova P.

Anal Chem. 2017 May 2;89(9):5115-5123. doi: 10.1021/acs.analchem.7b00688. Epub 2017 Apr 21.

PMID:
28383906
7.

2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV) (Part 1 - small molecules, peptides and small molecule biomarkers by LCMS).

Yang E, Welink J, Cape S, Woolf E, Sydor J, James C, Goykhman D, Arnold M, Addock N, Bauer R, Buonarati M, Ciccimaro E, Dodda R, Evans C, Garofolo F, Hughes N, Islam R, Nehls C, Wilson A, Briscoe C, Bustard M, Coppola L, Croft S, Drexler D, Ferrari L, Fraier D, Jenkins R, Kadavil J, King L, Li W, Lima Santos GM, Musuku A, Ramanathan R, Saito Y, Savoie N, Summerfield S, Sun R, Tampal N, Vinter S, Wakelin-Smith J, Yue Q.

Bioanalysis. 2016 Nov;8(22):2363-2378. doi: 10.4155/bio-2016-4992. Epub 2016 Oct 7.

8.

Quantification of in vivo site-specific Asp isomerization and Asn deamidation of mAbs in animal serum using IP-LC-MS.

Mehl JT, Sleczka BG, Ciccimaro EF, Kozhich AT, Gilbertson DG, Vuppugalla R, Huang CS, Stevens B, Mo J, Deyanova EG, Wang Y, Huang RY, Chen G, Olah TV.

Bioanalysis. 2016 Aug;8(15):1611-1622. Epub 2016 Jul 11.

PMID:
27397670
9.

Exploitation of the Ornithine Effect Enhances Characterization of Stapled and Cyclic Peptides.

Crittenden CM, Parker WR, Jenner ZB, Bruns KA, Akin LD, McGee WM, Ciccimaro E, Brodbelt JS.

J Am Soc Mass Spectrom. 2016 May;27(5):856-63. doi: 10.1007/s13361-016-1355-7. Epub 2016 Feb 10.

PMID:
26864791
10.

Strategy to improve the quantitative LC-MS analysis of molecular ions resistant to gas-phase collision induced dissociation: application to disulfide-rich cyclic peptides.

Ciccimaro E, Ranasinghe A, D'Arienzo C, Xu C, Onorato J, Drexler DM, Josephs JL, Poss M, Olah T.

Anal Chem. 2014 Dec 2;86(23):11523-7. doi: 10.1021/ac502678y. Epub 2014 Nov 18.

PMID:
25371986
11.

Accurate Quantitation of Dystrophin Protein in Human Skeletal Muscle Using Mass Spectrometry.

Brown KJ, Marathi R, Fiorillo AA, Ciccimaro EF, Sharma S, Rowlands DS, Rayavarapu S, Nagaraju K, Hoffman EP, Hathout Y.

J Bioanal Biomed. 2012 Dec 18;Suppl 7. pii: 001.

12.

Biochemical fractionation and stable isotope dilution liquid chromatography-mass spectrometry for targeted and microdomain-specific protein quantification in human postmortem brain tissue.

MacDonald ML, Ciccimaro E, Prakash A, Banerjee A, Seeholzer SH, Blair IA, Hahn CG.

Mol Cell Proteomics. 2012 Dec;11(12):1670-81. doi: 10.1074/mcp.M112.021766. Epub 2012 Aug 31.

13.

Bioanalysis young investigator: Eugene Ciccimaro.

Ciccimaro E, Blair IA.

Bioanalysis. 2012 May;4(8):875-7. doi: 10.4155/bio.12.63. No abstract available.

14.

Liquid chromatography/mass spectrometry of pre-ionized Girard P derivatives for quantifying estrone and its metabolites in serum from postmenopausal women.

Rangiah K, Shah SJ, Vachani A, Ciccimaro E, Blair IA.

Rapid Commun Mass Spectrom. 2011 May 15;25(9):1297-307. doi: 10.1002/rcm.4982.

15.

Stable-isotope dilution LC–MS for quantitative biomarker analysis.

Ciccimaro E, Blair IA.

Bioanalysis. 2010 Feb;2(2):311-41. doi: 10.4155/bio.09.185. Review.

16.

The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses.

Hahn CG, Banerjee A, Macdonald ML, Cho DS, Kamins J, Nie Z, Borgmann-Winter KE, Grosser T, Pizarro A, Ciccimaro E, Arnold SE, Wang HY, Blair IA.

PLoS One. 2009;4(4):e5251. doi: 10.1371/journal.pone.0005251. Epub 2009 Apr 16.

17.
18.

Quantification of focal adhesion kinase activation loop phosphorylation as a biomarker of Src activity.

Ciccimaro E, Hanks SK, Blair IA.

Mol Pharmacol. 2009 Mar;75(3):658-66. doi: 10.1124/mol.108.052464. Epub 2008 Dec 19.

19.
20.

The balance between pro-apoptotic and anti-apoptotic pathways in the failing myocardium.

McGowan BS, Ciccimaro EF, Chan TO, Feldman AM.

Cardiovasc Toxicol. 2003;3(3):191-206. Review.

PMID:
14555786

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