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Items: 1 to 50 of 112

1.

Design and construction of a new human naïve single-chain fragment variable antibody library, IORISS1.

Pasello M, Zamboni S, Mallano A, Flego M, Picci P, Cianfriglia M, Scotlandi K.

J Biotechnol. 2016 Apr 20;224:1-11. doi: 10.1016/j.jbiotec.2016.02.034. Epub 2016 Mar 2.

PMID:
26945728
2.

Process development of a human recombinant diabody expressed in E. coli: engagement of CD99-induced apoptosis for target therapy in Ewing's sarcoma.

Moricoli D, Carbonella DC, Dominici S, Fiori V, Balducci MC, Guerzoni C, Manara MC, Pasello M, Laguardia ME, Cianfriglia M, Scotlandi K, Magnani M.

Appl Microbiol Biotechnol. 2016 May;100(9):3949-63. doi: 10.1007/s00253-015-7226-5. Epub 2015 Dec 21.

PMID:
26685854
3.

The human antibody fragment DIATHIS1 specific for CEACAM1 enhances natural killer cell cytotoxicity against melanoma cell lines in vitro.

Dupuis ML, Fiori V, Soriani A, Ricci B, Dominici S, Moricoli D, Ascione A, Santoni A, Magnani M, Cianfriglia M.

J Immunother. 2015 Nov-Dec;38(9):357-70. doi: 10.1097/CJI.0000000000000100.

4.

CD99 triggering in Ewing sarcoma delivers a lethal signal through p53 pathway reactivation and cooperates with doxorubicin.

Guerzoni C, Fiori V, Terracciano M, Manara MC, Moricoli D, Pasello M, Sciandra M, Nicoletti G, Gellini M, Dominici S, Chiodoni C, Fornasari PM, Lollini PL, Colombo MP, Picci P, Cianfriglia M, Magnani M, Scotlandi K.

Clin Cancer Res. 2015 Jan 1;21(1):146-56. doi: 10.1158/1078-0432.CCR-14-0492. Epub 2014 Dec 11.

5.

Blocking monocyte transmigration in in vitro system by a human antibody scFv anti-CD99. Efficient large scale purification from periplasmic inclusion bodies in E. coli expression system.

Moricoli D, Muller WA, Carbonella DC, Balducci MC, Dominici S, Watson R, Fiori V, Weber E, Cianfriglia M, Scotlandi K, Magnani M.

J Immunol Methods. 2014 Jun;408:35-45. doi: 10.1016/j.jim.2014.04.012. Epub 2014 May 4.

6.

Isolation of a new human scFv antibody recognizing a cell surface binding site to CEACAM1. Large yield production, purification and characterization in E. coli expression system.

Moricoli D, Laguardia ME, Carbonella DC, Balducci MC, Dominici S, Fiori V, Serafini G, Flego M, Cianfriglia M, Magnani M.

Protein Expr Purif. 2014 Jan;93:38-45. doi: 10.1016/j.pep.2013.10.009. Epub 2013 Oct 30.

PMID:
24184403
7.

Raltegravir does not revert efflux activity of MDR1-P-glycoprotein in human MDR cells.

Dupuis ML, Ascione A, Palmisano L, Vella S, Cianfriglia M.

BMC Pharmacol Toxicol. 2013 Sep 20;14:47. doi: 10.1186/2050-6511-14-47.

8.

Targeting MDR1-P-glycoprotein (MDR1-Pgp) in immunochemotherapy of acute myeloid leukemia (AML).

Cianfriglia M.

Ann Ist Super Sanita. 2013;49(2):190-208. doi: 10.4415/ANN_13_02_11. Review.

9.
10.

Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases.

Flego M, Ascione A, Cianfriglia M, Vella S.

BMC Med. 2013 Jan 4;11:4. doi: 10.1186/1741-7015-11-4. Review.

11.

The expression and modulation of CEACAM1 and tumor cell transformation.

Fiori V, Magnani M, Cianfriglia M.

Ann Ist Super Sanita. 2012;48(2):161-71. doi: 10.4415/ANN_12_02_09. Review.

12.

Generation of human single-chain antibody to the CD99 cell surface determinant specifically recognizing Ewing's sarcoma tumor cells.

Gellini M, Ascione A, Flego M, Mallano A, Dupuis ML, Zamboni S, Terrinoni M, D'Alessio V, Manara MC, Scotlandi K, Picci P, Cianfriglia M.

Curr Pharm Biotechnol. 2013;14(4):449-63.

PMID:
22335486
13.

P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma.

Brambilla D, Zamboni S, Federici C, Lugini L, Lozupone F, De Milito A, Cecchetti S, Cianfriglia M, Fais S.

Int J Cancer. 2012 Jun 15;130(12):2824-34. doi: 10.1002/ijc.26285. Epub 2011 Oct 20.

14.

The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor.

Riccioni R, Dupuis ML, Bernabei M, Petrucci E, Pasquini L, Mariani G, Cianfriglia M, Testa U.

Blood Cells Mol Dis. 2010 Jun 15;45(1):86-92. doi: 10.1016/j.bcmd.2010.03.008. Epub 2010 May 4.

PMID:
20444629
16.

Human monoclonal antibodies in single chain fragment variable format with potent neutralization activity against influenza virus H5N1.

Ascione A, Capecchi B, Campitelli L, Imperiale V, Flego M, Zamboni S, Gellini M, Alberini I, Pittiglio E, Donatelli I, Temperton NJ, Cianfriglia M.

Antiviral Res. 2009 Sep;83(3):238-44. doi: 10.1016/j.antiviral.2009.05.005. Epub 2009 May 27.

PMID:
19481117
17.

The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells.

Ascione A, Cianfriglia M, Dupuis ML, Mallano A, Sau A, Pellizzari Tregno F, Pezzola S, Caccuri AM.

Cancer Chemother Pharmacol. 2009 Jul;64(2):419-24. doi: 10.1007/s00280-009-0960-6. Epub 2009 Mar 15.

PMID:
19288261
18.

Inhibition of MDR1 activity in vitro by a novel class of diltiazem analogues: toward new candidates.

Viale M, Cordazzo C, Cosimelli B, de Totero D, Castagnola P, Aiello C, Severi E, Petrillo G, Cianfriglia M, Spinelli D.

J Med Chem. 2009 Jan 22;52(2):259-66. doi: 10.1021/jm801195k.

PMID:
19093883
19.

Generation and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from yeast.

Mallano A, Zamboni S, Carpinelli G, Santoro F, Flego M, Ascione A, Gellini M, Tombesi M, Podo F, Cianfriglia M.

BMC Biotechnol. 2008 Sep 10;8:68. doi: 10.1186/1472-6750-8-68.

20.

Genetic construction, expression, and characterization of a single chain anti-CEA antibody fused to cytosine deaminase from yeast.

Zamboni S, Mallano A, Flego M, Ascione A, Dupuis ML, Gellini M, Barca S, Cianfriglia M.

Int J Oncol. 2008 Jun;32(6):1245-51.

PMID:
18497986
21.

6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer.

Filomeni G, Turella P, Dupuis ML, Forini O, Ciriolo MR, Cianfriglia M, Pezzola S, Federici G, Caccuri AM.

Mol Cancer Ther. 2008 Feb;7(2):371-9. doi: 10.1158/1535-7163.MCT-07-0487.

22.

The multidrug transporter P-glycoprotein: a mediator of melanoma invasion?

Colone M, Calcabrini A, Toccacieli L, Bozzuto G, Stringaro A, Gentile M, Cianfriglia M, Ciervo A, Caraglia M, Budillon A, Meo G, Arancia G, Molinari A.

J Invest Dermatol. 2008 Apr;128(4):957-71. Epub 2007 Oct 18.

23.

Generation of human scFvs antibodies recognizing a prion protein epitope expressed on the surface of human lymphoblastoid cells.

Flego M, Ascione A, Zamboni S, Dupuis ML, Imperiale V, Cianfriglia M.

BMC Biotechnol. 2007 Jul 2;7:38.

24.

Human brain tumors: multidrug-resistance P-glycoprotein expression in tumor cells and intratumoral capillary endothelial cells.

Fattori S, Becherini F, Cianfriglia M, Parenti G, Romanini A, Castagna M.

Virchows Arch. 2007 Jul;451(1):81-7. Epub 2007 Jun 26.

PMID:
17593388
25.

HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein.

Cianfriglia M, Dupuis ML, Molinari A, Verdoliva A, Costi R, Galluzzo CM, Andreotti M, Cara A, Di Santo R, Palmisano L.

Retrovirology. 2007 Mar 7;4:17.

26.

New display vector reduces biological bias for expression of antibodies in E. coli.

Pavoni E, Monteriù G, Cianfriglia M, Minenkova O.

Gene. 2007 Apr 15;391(1-2):120-9. Epub 2006 Dec 22.

PMID:
17267141
27.

A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells.

Turella P, Filomeni G, Dupuis ML, Ciriolo MR, Molinari A, De Maria F, Tombesi M, Cianfriglia M, Federici G, Ricci G, Caccuri AM.

J Biol Chem. 2006 Aug 18;281(33):23725-32. Epub 2006 Jun 12.

28.

Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein.

Pavoni E, Flego M, Dupuis ML, Barca S, Petronzelli F, Anastasi AM, D'Alessio V, Pelliccia A, Vaccaro P, Monteriù G, Ascione A, De Santis R, Felici F, Cianfriglia M, Minenkova O.

BMC Cancer. 2006 Feb 24;6:41.

29.

Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells.

Meschini S, Marra M, Condello M, Calcabrini A, Federici E, Dupuis ML, Cianfriglia M, Arancia G.

Int J Oncol. 2005 Dec;27(6):1597-603.

PMID:
16273216
30.

Generation of human antibody fragments recognizing distinct epitopes of the nucleocapsid (N) SARS-CoV protein using a phage display approach.

Flego M, Di Bonito P, Ascione A, Zamboni S, Carattoli A, Grasso F, Cassone A, Cianfriglia M.

BMC Infect Dis. 2005 Sep 19;5:73.

31.
32.

Proapoptotic activity of new glutathione S-transferase inhibitors.

Turella P, Cerella C, Filomeni G, Bullo A, De Maria F, Ghibelli L, Ciriolo MR, Cianfriglia M, Mattei M, Federici G, Ricci G, Caccuri AM.

Cancer Res. 2005 May 1;65(9):3751-61.

33.

Isolation and characterization of the human monoclonal antibodies C10 in single-chain fragment variable (scFv) format to glucose oxidase from Aspergillus niger.

Ascione A, Flego M, Zamboni S, De Cinti E, Dupuis ML, Cianfriglia M.

Hybrid Hybridomics. 2004 Dec;23(6):380-4.

PMID:
15684666
34.

P-glycoprotein expression affects the intracellular concentration and antiviral activity of the protease inhibitor saquinavir in a T cell line.

Maffeo A, Bellomi F, Solimeo I, Bambacioni F, Scagnolari C, De Pisa F, Dupuis ML, Cianfriglia M, Antonelli G, Turriziani O.

New Microbiol. 2004 Apr;27(2 Suppl 1):119-26.

PMID:
15646074
35.

Identification of a panel of tumor-associated antigens from breast carcinoma cell lines, solid tumors and testis cDNA libraries displayed on lambda phage.

Pavoni E, Vaccaro P, Pucci A, Monteriù G, Beghetto E, Barca S, Dupuis ML, De Pasquale Ceratti A, Lugini A, Cianfriglia M, Cortesi E, Felici F, Minenkova O.

BMC Cancer. 2004 Nov 12;4:78.

36.

Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.

Nagy H, Goda K, Fenyvesi F, Bacsó Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabó G Jr.

Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9.

PMID:
14985103
37.
38.

Identification of tumor-associated antigens by screening phage-displayed human cDNA libraries with sera from tumor patients.

Minenkova O, Pucci A, Pavoni E, De Tomassi A, Fortugno P, Gargano N, Cianfriglia M, Barca S, De Placido S, Martignetti A, Felici F, Cortese R, Monaci P.

Int J Cancer. 2003 Sep 10;106(4):534-44.

39.

[Use of phage libraries for the in vitro production of recombinant monoclonal antibodies of predetermined specificity].

Flego M, Ascione A, Pini A, Mennella V, Dupuis ML, Benagiano G, Cianfriglia M.

Ann Ist Super Sanita. 2002;38(4):401-10. Italian.

PMID:
12760337
40.
41.
42.

Identification by phage display of the linear continuous MRPr1 epitope in the multidrug resistance-associated protein (MRP1).

Flego M, Mennella V, Moretti F, Poloni F, Dupuis ML, Ascione A, Barca S, Felici F, Cianfriglia M.

Biol Chem. 2003 Jan;384(1):139-42.

PMID:
12674507
43.

Subcellular detection and localization of the drug transporter P-glycoprotein in cultured tumor cells.

Molinari A, Calcabrini A, Meschini S, Stringaro A, Crateri P, Toccacieli L, Marra M, Colone M, Cianfriglia M, Arancia G.

Curr Protein Pept Sci. 2002 Dec;3(6):653-70. Review.

PMID:
12470219
44.

Monoclonal antibodies as a tool for structure-function studies of the MDR1-P-glycoprotein.

Cianfriglia M, Cenciarelli C, Barca S, Tombesi M, Flego M, Dupuis ML.

Curr Protein Pept Sci. 2002 Oct;3(5):513-30. Review.

PMID:
12369999
45.

Detection of human P-glycoprotein-like molecule in azole-resistant Candida albicans from HIV+ patients.

Stringaro A, Molinari A, Calcabrini A, Arancia G, Ceddia PG, Cianfriglia M, Poloni F, Mondello F, Angiolella L, De Bernardis F, Cassone A.

Microb Drug Resist. 2002 Fall;8(3):235-44.

PMID:
12363014
46.

Effects of ATP depletion and phosphate analogues on P-glycoprotein conformation in live cells.

Goda K, Nagy H, Mechetner E, Cianfriglia M, Szabó G Jr.

Eur J Biochem. 2002 Jun;269(11):2672-7.

47.

What is the relationship between P-glycoprotein and adhesion molecule expression in melanoma cells?

Molinari A, Calcabrini A, Meschini S, Marra M, Stringaro A, Toccacieli L, Cianfriglia M, Arancia G.

Melanoma Res. 2002 Apr;12(2):109-14.

PMID:
11930106
48.

Nephroblastoma: multidrug-resistance P-glycoprotein expression in tumor cells and intratumoral capillary endothelial cells.

Camassei FD, Arancia G, Cianfriglia M, Bosman C, Francalanci P, Ravà L, Jenkner A, Donfrancesco A, Boldrini R.

Am J Clin Pathol. 2002 Mar;117(3):484-90.

PMID:
11888090
49.

P-glycoprotein-actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin.

Luciani F, Molinari A, Lozupone F, Calcabrini A, Lugini L, Stringaro A, Puddu P, Arancia G, Cianfriglia M, Fais S.

Blood. 2002 Jan 15;99(2):641-8.

PMID:
11781249
50.

Intracellular P-glycoprotein in multidrug resistant tumor cells.

Arancia G, Molinari A, Calcabrini A, Meschini S, Cianfriglia M.

Ital J Anat Embryol. 2001;106(2 Suppl 1):59-68.

PMID:
11729998

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