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Items: 45

1.

NMR for screening and a biochemical assay: Identification of new FPPS inhibitors exerting anticancer activity.

Grimaldi M, Randino R, Ciaglia E, Scrima M, Buonocore M, Stillitano I, Abate M, Covelli V, Tosco A, Gazzerro P, Bifulco M, Rodriquez M, D'Ursi AM.

Bioorg Chem. 2019 Nov 21:103449. doi: 10.1016/j.bioorg.2019.103449. [Epub ahead of print]

PMID:
32057422
2.

Corrigendum to "A bioavailability study on microbeads and nanoliposomes fabricated by dense carbon dioxide technologies using human-primary monocytes and flow cytometry assay" [Int. J. Pharm. 570 (2019) 118686].

Ciaglia E, Montella F, Trucillo P, Ciardulli MC, Di Pietro P, Amodio G, Remondelli P, Vecchione C, Reverchon E, Maffulli N, Puca AA, Della Porta G.

Int J Pharm. 2020 Mar 15;577:119107. doi: 10.1016/j.ijpharm.2020.119107. Epub 2020 Feb 6. No abstract available.

PMID:
32037078
3.

Genetic Signatures of Centenarians: Implications for Achieving Successful Aging.

Caruso C, Aiello A, Accardi G, Ciaglia E, Cattaneo M, Puca A.

Curr Pharm Des. 2019;25(39):4133-4138. doi: 10.2174/1381612825666191112094544.

PMID:
31721694
4.

Correction for: LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.

Malavolta M, Dato S, Villa F, De Rango F, Iannone F, Ferrario A, Maciag A, Ciaglia E, D'amato A, Carrizzo A, Basso A, Orlando F, Provinciali M, Madeddu P, Passarino G, Vecchione C, Rose G, Puca AA.

Aging (Albany NY). 2019 Oct 25;11(20):9220. doi: 10.18632/aging.102398. Epub 2019 Oct 25. No abstract available.

5.

A bioavailability study on microbeads and nanoliposomes fabricated by dense carbon dioxide technologies using human-primary monocytes and flow cytometry assay.

Ciaglia E, Montella F, Trucillo P, Ciardulli MC, Di Pietro P, Amodio G, Remondelli P, Vecchione C, Reverchon E, Maffulli N, Puca AA, Della Porta G.

Int J Pharm. 2019 Oct 30;570:118686. doi: 10.1016/j.ijpharm.2019.118686. Epub 2019 Sep 9. Erratum in: Int J Pharm. 2020 Mar 15;577:119107.

PMID:
31513874
6.

LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.

Malavolta M, Dato S, Villa F, Rango F, Iannone F, Ferrario A, Maciag A, Ciaglia E, D'amato A, Carrizzo A, Basso A, Orlando F, Provinciali M, Madeddu P, Passarino G, Vecchione C, Rose G, Puca AA.

Aging (Albany NY). 2019 Aug 28;11(16):6555-6568. doi: 10.18632/aging.102209. Epub 2019 Aug 28. Erratum in: Aging (Albany NY). 2019 Oct 25;11(20):9220.

7.

Single systemic transfer of a human gene associated with exceptional longevity halts the progression of atherosclerosis and inflammation in ApoE knockout mice through a CXCR4-mediated mechanism.

Puca AA, Carrizzo A, Spinelli C, Damato A, Ambrosio M, Villa F, Ferrario A, Maciag A, Fornai F, Lenzi P, Valenti V, di Nonno F, Accarino G, Madonna M, Forte M, Calì G, Baragetti A, Norata GD, Catapano AL, Cattaneo M, Izzo R, Trimarco V, Montella F, Versaci F, Auricchio A, Frati G, Sciarretta S, Madeddu P, Ciaglia E, Vecchione C.

Eur Heart J. 2019 Jul 10. pii: ehz459. doi: 10.1093/eurheartj/ehz459. [Epub ahead of print]

8.

Longevity-Associated Variant of BPIFB4 Mitigates Monocyte-Mediated Acquired Immune Response.

Ciaglia E, Montella F, Maciag A, Scala P, Ferrario A, Banco C, Carrizzo A, Spinelli CC, Cattaneo M, De Candia P, Vecchione C, Villa F, Puca AA.

J Gerontol A Biol Sci Med Sci. 2019 Nov 13;74(Supplement_1):S38-S44. doi: 10.1093/gerona/glz036.

PMID:
31074771
9.

A Model of Evolutionary Selection: The Cardiovascular Protective Function of the Longevity Associated Variant of BPIFB4.

Villa F, Carrizzo A, Ferrario A, Maciag A, Cattaneo M, Spinelli CC, Montella F, Damato A, Ciaglia E, Puca AA.

Int J Mol Sci. 2018 Oct 19;19(10). pii: E3229. doi: 10.3390/ijms19103229. Review.

10.

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system.

Chicca A, Arena C, Bertini S, Gado F, Ciaglia E, Abate M, Digiacomo M, Lapillo M, Poli G, Bifulco M, Macchia M, Tuccinardi T, Gertsch J, Manera C.

Eur J Med Chem. 2018 Jun 25;154:155-171. doi: 10.1016/j.ejmech.2018.05.019. Epub 2018 May 14.

PMID:
29793210
11.

Innate immunity and cellular senescence: The good and the bad in the developmental and aged brain.

Santoro A, Spinelli CC, Martucciello S, Nori SL, Capunzo M, Puca AA, Ciaglia E.

J Leukoc Biol. 2018 Mar;103(3):509-524. doi: 10.1002/JLB.3MR0118-003R. Epub 2018 Feb 1. Review.

PMID:
29389023
12.

The isoprenoid end product N6-isopentenyladenosine reduces inflammatory response through the inhibition of the NFκB and STAT3 pathways in cystic fibrosis cells.

Santoro A, Ciaglia E, Nicolin V, Pescatore A, Prota L, Capunzo M, Ursini MV, Nori SL, Bifulco M.

Inflamm Res. 2018 Apr;67(4):315-326. doi: 10.1007/s00011-017-1123-6. Epub 2017 Dec 11.

13.

Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma.

Abate M, Laezza C, Pisanti S, Torelli G, Seneca V, Catapano G, Montella F, Ranieri R, Notarnicola M, Gazzerro P, Bifulco M, Ciaglia E.

Sci Rep. 2017 Oct 26;7(1):14123. doi: 10.1038/s41598-017-14495-6.

14.

N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux.

Ranieri R, Ciaglia E, Amodio G, Picardi P, Proto MC, Gazzerro P, Laezza C, Remondelli P, Bifulco M, Pisanti S.

Cell Death Differ. 2018 Feb;25(2):353-367. doi: 10.1038/cdd.2017.165. Epub 2017 Oct 13.

15.

Recognition by natural killer cells of N6-isopentenyladenosine-treated human glioma cell lines.

Ciaglia E, Laezza C, Abate M, Pisanti S, Ranieri R, D'alessandro A, Picardi P, Gazzerro P, Bifulco M.

Int J Cancer. 2018 Jan 1;142(1):176-190. doi: 10.1002/ijc.31036. Epub 2017 Sep 21.

16.

Immuno-Modulatory and Anti-Inflammatory Effects of Dihydrogracilin A, a Terpene Derived from the Marine Sponge Dendrilla membranosa.

Ciaglia E, Malfitano AM, Laezza C, Fontana A, Nuzzo G, Cutignano A, Abate M, Pelin M, Sosa S, Bifulco M, Gazzerro P.

Int J Mol Sci. 2017 Jul 28;18(8). pii: E1643. doi: 10.3390/ijms18081643.

17.

The isoprenoid derivative N6 -benzyladenosine CM223 exerts antitumor effects in glioma patient-derived primary cells through the mevalonate pathway.

Ciaglia E, Grimaldi M, Abate M, Scrima M, Rodriquez M, Laezza C, Ranieri R, Pisanti S, Ciuffreda P, Manera C, Gazzerro P, D'Ursi AM, Bifulco M.

Br J Pharmacol. 2017 Jul;174(14):2287-2301. doi: 10.1111/bph.13824. Epub 2017 Jun 11.

18.

Cannabidiol: State of the art and new challenges for therapeutic applications.

Pisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, Abate M, Faggiana G, Proto MC, Fiore D, Laezza C, Bifulco M.

Pharmacol Ther. 2017 Jul;175:133-150. doi: 10.1016/j.pharmthera.2017.02.041. Epub 2017 Feb 22. Review.

PMID:
28232276
19.

The complex interplay among hepatocytes and immune cells at the crossroad between inflammation and cholesterol metabolism in hyperglycemia.

Bifulco M, Pisanti S, Ciaglia E.

Endocrine. 2017 Oct;58(1):21-23. doi: 10.1007/s12020-017-1254-0. Epub 2017 Feb 8. Review.

PMID:
28181143
20.

Updates on "adiponcosis": More new incoming evidence strengthening the obesity-cancer link.

Bifulco M, Ciaglia E.

Eur J Intern Med. 2017 Jun;41:e19-e20. doi: 10.1016/j.ejim.2016.12.016. Epub 2016 Dec 27. No abstract available.

PMID:
28038825
21.

Statins for inflammatory bowel disease: Can off-label drug help it?

Bifulco M, Ciaglia E.

Eur J Intern Med. 2017 Mar;38:e23. doi: 10.1016/j.ejim.2016.11.008. Epub 2016 Nov 14. No abstract available.

PMID:
27856092
22.

Brain cancer risk: the weight of obesity.

Bifulco M, Ranieri R, Ciaglia E.

J Neurooncol. 2017 Jan;131(2):421-422. doi: 10.1007/s11060-016-2315-6. Epub 2016 Nov 9. No abstract available.

PMID:
27830478
23.

Antiglioma effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, through the downregulation of epidermal growth factor receptor.

Ciaglia E, Abate M, Laezza C, Pisanti S, Vitale M, Seneca V, Torelli G, Franceschelli S, Catapano G, Gazzerro P, Bifulco M.

Int J Cancer. 2017 Feb 15;140(4):959-972. doi: 10.1002/ijc.30505. Epub 2016 Nov 16.

24.

p53 regulates the mevalonate pathway in human glioblastoma multiforme.

Laezza C, D'Alessandro A, Di Croce L, Picardi P, Ciaglia E, Pisanti S, Malfitano AM, Comegna M, Faraonio R, Gazzerro P, Bifulco M.

Cell Death Dis. 2015 Oct 15;6:e1909. doi: 10.1038/cddis.2015.279.

25.

Statin reduces orbitopathy risk in patients with Graves' disease by modulating apoptosis and autophagy activities.

Bifulco M, Ciaglia E.

Endocrine. 2016 Sep;53(3):649-50. doi: 10.1007/s12020-015-0762-z. Epub 2015 Oct 5.

PMID:
26438397
26.

Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients' cells.

Ciaglia E, Torelli G, Pisanti S, Picardi P, D'Alessandro A, Laezza C, Malfitano AM, Fiore D, Pagano Zottola AC, Proto MC, Catapano G, Gazzerro P, Bifulco M.

Oncotarget. 2015 Jun 20;6(17):15464-81.

27.

New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity.

Manera C, Malfitano AM, Parkkari T, Lucchesi V, Carpi S, Fogli S, Bertini S, Laezza C, Ligresti A, Saccomanni G, Savinainen JR, Ciaglia E, Pisanti S, Gazzerro P, Di Marzo V, Nieri P, Macchia M, Bifulco M.

Eur J Med Chem. 2015 Jun 5;97:10-8. doi: 10.1016/j.ejmech.2015.04.034. Epub 2015 Apr 24.

PMID:
25935384
28.

Cannabinoid receptor 1 antagonism in hepatocellular carcinoma: killing two birds with one stone.

Bifulco M, Ciaglia E.

Eur J Gastroenterol Hepatol. 2015 Jun;27(6):747-8. doi: 10.1097/MEG.0000000000000337. No abstract available.

PMID:
25831132
29.

Enrichment of CD56(dim)KIR + CD57 + highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients.

Ali TH, Pisanti S, Ciaglia E, Mortarini R, Anichini A, Garofalo C, Tallerico R, Santinami M, Gulletta E, Ietto C, Galgani M, Matarese G, Bifulco M, Ferrone S, Colucci F, Moretta A, Kärre K, Carbone E.

Nat Commun. 2014 Dec 4;5:5639. doi: 10.1038/ncomms6639.

30.

Anandamide inhibits breast tumor-induced angiogenesis.

Picardi P, Ciaglia E, Proto M, Pisanti S.

Transl Med UniSa. 2014 Apr 8;10:8-12. eCollection 2014 Sep.

31.

N6-isopentenyladenosine affects cytotoxic activity and cytokines production by IL-2 activated NK cells and exerts topical anti-inflammatory activity in mice.

Ciaglia E, Pisanti S, Picardi P, Laezza C, Sosa S, Tubaro A, Vitale M, Gazzerro P, Malfitano AM, Bifulco M.

Pharmacol Res. 2014 Nov;89:1-10. doi: 10.1016/j.phrs.2014.07.003. Epub 2014 Jul 22.

PMID:
25063359
32.

Novel prospects of statins as therapeutic agents in cancer.

Pisanti S, Picardi P, Ciaglia E, D'Alessandro A, Bifulco M.

Pharmacol Res. 2014 Oct;88:84-98. doi: 10.1016/j.phrs.2014.06.013. Epub 2014 Jul 5. Review.

PMID:
25009097
33.

The effect of visible blue light on the differentiation of dendritic cells in vitro.

Monfrecola G, Lembo S, Cantelli M, Ciaglia E, Scarpato L, Fabbrocini G, Balato A.

Biochimie. 2014 Jun;101:252-5. doi: 10.1016/j.biochi.2014.02.001. Epub 2014 Feb 12.

PMID:
24530862
34.

Antiangiogenic effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, mediated by AMPK activation.

Pisanti S, Picardi P, Ciaglia E, Margarucci L, Ronca R, Giacomini A, Malfitano AM, Casapullo A, Laezza C, Gazzerro P, Bifulco M.

FASEB J. 2014 Mar;28(3):1132-44. doi: 10.1096/fj.13-238238. Epub 2013 Nov 21.

PMID:
24265487
35.

Immune-modulation and properties of absorption and blood brain barrier permeability of 1,8-naphthyridine derivatives.

Malfitano AM, Laezza C, Saccomanni G, Tuccinardi T, Manera C, Martinelli A, Ciaglia E, Pisanti S, Vitale M, Gazzerro P, Bifulco M.

J Neuroimmune Pharmacol. 2013 Dec;8(5):1077-86. doi: 10.1007/s11481-013-9494-0. Epub 2013 Oct 1.

PMID:
24081326
36.

N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulation.

Ciaglia E, Pisanti S, Picardi P, Laezza C, Malfitano AM, D'Alessandro A, Gazzerro P, Vitale M, Carbone E, Bifulco M.

J Leukoc Biol. 2013 Dec;94(6):1207-19. doi: 10.1189/jlb.0413190. Epub 2013 Jul 11.

PMID:
23847096
37.

A focus on Trotula dé Ruggiero: a pioneer in women's and children's health in history of medicine.

Bifulco M, Ciaglia E, Marasco M, Gangemi G.

J Matern Fetal Neonatal Med. 2014 Jan;27(2):204-5. doi: 10.3109/14767058.2013.804056. Epub 2013 Jun 5.

PMID:
23662591
38.

Statins and cancer-related mortality: an open question.

Gazzerro P, Ciaglia E, Bifulco M.

Basic Clin Pharmacol Toxicol. 2013 Aug;113(2):73-4. doi: 10.1111/bcpt.12080. Epub 2013 May 25. No abstract available.

39.

Anandamide inhibits the Wnt/β-catenin signalling pathway in human breast cancer MDA MB 231 cells.

Laezza C, D'Alessandro A, Paladino S, Maria Malfitano A, Chiara Proto M, Gazzerro P, Pisanti S, Santoro A, Ciaglia E, Bifulco M; Endocannabinoid Research Group.

Eur J Cancer. 2012 Nov;48(16):3112-22. doi: 10.1016/j.ejca.2012.02.062. Epub 2012 Mar 14.

PMID:
22425263
40.

Pharmacological actions of statins: a critical appraisal in the management of cancer.

Gazzerro P, Proto MC, Gangemi G, Malfitano AM, Ciaglia E, Pisanti S, Santoro A, Laezza C, Bifulco M.

Pharmacol Rev. 2012 Jan;64(1):102-46. doi: 10.1124/pr.111.004994. Epub 2011 Nov 21. Review.

PMID:
22106090
41.

Update on the endocannabinoid system as an anticancer target.

Malfitano AM, Ciaglia E, Gangemi G, Gazzerro P, Laezza C, Bifulco M.

Expert Opin Ther Targets. 2011 Mar;15(3):297-308. doi: 10.1517/14728222.2011.553606. Epub 2011 Jan 19. Review.

PMID:
21244344
42.

Dendritic cells/natural killer cross-talk: a novel target for human immunodeficiency virus type-1 protease inhibitors.

Giardino Torchia ML, Ciaglia E, Masci AM, Vitiello L, Fogli M, la Sala A, Mavilio D, Racioppi L.

PLoS One. 2010 Jun 10;5(6):e11052. doi: 10.1371/journal.pone.0011052.

43.

Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells.

Illario M, Giardino-Torchia ML, Sankar U, Ribar TJ, Galgani M, Vitiello L, Masci AM, Bertani FR, Ciaglia E, Astone D, Maulucci G, Cavallo A, Vitale M, Cimini V, Pastore L, Means AR, Rossi G, Racioppi L.

Blood. 2008 Jan 15;111(2):723-31. Epub 2007 Oct 1.

44.

[Vitamin E in the treatment of pregnancy complicated by uterine myoma].

Fruscella L, Ciaglia EM, Danti M, Fiumara D.

Minerva Ginecol. 1997 Apr;49(4):175-9. Italian.

PMID:
9206770
45.

[A case of uterine leiomyosarcoma in a young patient].

Fruscella L, Toti R, Satta MT, Ciaglia EM, Stella P.

Minerva Ginecol. 1991 Sep;43(9):413-4. Italian.

PMID:
1945031

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