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Items: 31


Dexamethasone Predisposes Human Erythroblasts Toward Impaired Lipid Metabolism and Renders Their ex vivo Expansion Highly Dependent on Plasma Lipoproteins.

Zingariello M, Bardelli C, Sancillo L, Ciaffoni F, Genova ML, Girelli G, Migliaccio AR.

Front Physiol. 2019 Apr 4;10:281. doi: 10.3389/fphys.2019.00281. eCollection 2019.


Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells.

Castiello L, Sestili P, Schiavoni G, Dattilo R, Monque DM, Ciaffoni F, Iezzi M, Lamolinara A, Sistigu A, Moschella F, Pacca AM, Macchia D, Ferrantini M, Zeuner A, Biffoni M, Proietti E, Belardelli F, Aricò E.

Cancer Immunol Res. 2018 Jun;6(6):658-670. doi: 10.1158/2326-6066.CIR-17-0675. Epub 2018 Apr 5.


The thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature.

Zingariello M, Sancillo L, Martelli F, Ciaffoni F, Marra M, Varricchio L, Rana RA, Zhao C, Crispino JD, Migliaccio AR.

Blood Cancer J. 2017 Jun 16;7(6):e572. doi: 10.1038/bcj.2017.51.


2p15-p16.1 microdeletions encompassing and proximal to BCL11A are associated with elevated HbF in addition to neurologic impairment.

Funnell AP, Prontera P, Ottaviani V, Piccione M, Giambona A, Maggio A, Ciaffoni F, Stehling-Sun S, Marra M, Masiello F, Varricchio L, Stamatoyannopoulos JA, Migliaccio AR, Papayannopoulou T.

Blood. 2015 Jul 2;126(1):89-93. doi: 10.1182/blood-2015-04-638528. Epub 2015 May 27.


Activation of non-canonical TGF-β1 signaling indicates an autoimmune mechanism for bone marrow fibrosis in primary myelofibrosis.

Ciaffoni F, Cassella E, Varricchio L, Massa M, Barosi G, Migliaccio AR.

Blood Cells Mol Dis. 2015 Mar;54(3):234-41. doi: 10.1016/j.bcmd.2014.12.005. Epub 2015 Jan 15.


Transcriptomic and phospho-proteomic analyzes of erythroblasts expanded in vitro from normal donors and from patients with polycythemia vera.

Hricik T, Federici G, Zeuner A, Alimena G, Tafuri A, Tirelli V, Varricchio L, Masiello F, Ciaffoni F, Vaglio S, Petricoin EF, Girelli G, Levine RL, Migliaccio AR.

Am J Hematol. 2013 Sep;88(9):723-9. doi: 10.1002/ajh.23487. Epub 2013 Jul 3.


Characterization of the TGF-β1 signaling abnormalities in the Gata1low mouse model of myelofibrosis.

Zingariello M, Martelli F, Ciaffoni F, Masiello F, Ghinassi B, D'Amore E, Massa M, Barosi G, Sancillo L, Li X, Goldberg JD, Rana RA, Migliaccio AR.

Blood. 2013 Apr 25;121(17):3345-63. doi: 10.1182/blood-2012-06-439661. Epub 2013 Mar 5.


Evaluation of the spontaneous reversibility of carbon tetrachloride-induced liver cirrhosis in rabbits.

Bravo E, D'Amore E, Ciaffoni F, Mammola CL.

Lab Anim. 2012 Apr;46(2):122-8. doi: 10.1258/la.2012.011035. Epub 2012 Apr 20.


Hepatic VLDL assembly is disturbed in a rat model of nonalcoholic fatty liver disease: is there a role for dietary coenzyme Q?

Cano A, Ciaffoni F, Safwat GM, Aspichueta P, Ochoa B, Bravo E, Botham KM.

J Appl Physiol (1985). 2009 Sep;107(3):707-17. doi: 10.1152/japplphysiol.00297.2009. Epub 2009 Jul 16.


Saposin B binds and transfers phospholipids.

Ciaffoni F, Tatti M, Boe A, Salvioli R, Fluharty A, Sonnino S, Vaccaro AM.

J Lipid Res. 2006 May;47(5):1045-53. Epub 2006 Feb 6.


The N370S (Asn370-->Ser) mutation affects the capacity of glucosylceramidase to interact with anionic phospholipid-containing membranes and saposin C.

Salvioli R, Tatti M, Scarpa S, Moavero SM, Ciaffoni F, Felicetti F, Kaneski CR, Brady RO, Vaccaro AM.

Biochem J. 2005 Aug 15;390(Pt 1):95-103.


Glucosylceramidase mass and subcellular localization are modulated by cholesterol in Niemann-Pick disease type C.

Salvioli R, Scarpa S, Ciaffoni F, Tatti M, Ramoni C, Vanier MT, Vaccaro AM.

J Biol Chem. 2004 Apr 23;279(17):17674-80. Epub 2004 Feb 2.


Interaction of saposin D with membranes: effect of anionic phospholipids and sphingolipids.

Ciaffoni F, Tatti M, Salvioli R, Vaccaro AM.

Biochem J. 2003 Aug 1;373(Pt 3):785-92.


Saposin D solubilizes anionic phospholipid-containing membranes.

Ciaffoni F, Salvioli R, Tatti M, Arancia G, Crateri P, Vaccaro AM.

J Biol Chem. 2001 Aug 24;276(34):31583-9. Epub 2001 Jun 13.


Further studies on the reconstitution of glucosylceramidase activity by Sap C and anionic phospholipids.

Salvioli R, Tatti M, Ciaffoni F, Vaccaro AM.

FEBS Lett. 2000 Apr 21;472(1):17-21.


Structural and membrane-binding properties of saposin D.

Tatti M, Salvioli R, Ciaffoni F, Pucci P, Andolfo A, Amoresano A, Vaccaro AM.

Eur J Biochem. 1999 Jul;263(2):486-94.


Saposins and their interaction with lipids.

Vaccaro AM, Salvioli R, Tatti M, Ciaffoni F.

Neurochem Res. 1999 Feb;24(2):307-14. Review.


Effect of saposins A and C on the enzymatic hydrolysis of liposomal glucosylceramide.

Vaccaro AM, Tatti M, Ciaffoni F, Salvioli R, Barca A, Scerch C.

J Biol Chem. 1997 Jul 4;272(27):16862-7.


pH-dependent conformational properties of saposins and their interactions with phospholipid membranes.

Vaccaro AM, Ciaffoni F, Tatti M, Salvioli R, Barca A, Tognozzi D, Scerch C.

J Biol Chem. 1995 Dec 22;270(51):30576-80.


Structural analysis of saposin C and B. Complete localization of disulfide bridges.

Vaccaro AM, Salvioli R, Barca A, Tatti M, Ciaffoni F, Maras B, Siciliano R, Zappacosta F, Amoresano A, Pucci P.

J Biol Chem. 1995 Apr 28;270(17):9953-60.


Saposin C induces pH-dependent destabilization and fusion of phosphatidylserine-containing vesicles.

Vaccaro AM, Tatti M, Ciaffoni F, Salvioli R, Serafino A, Barca A.

FEBS Lett. 1994 Aug 1;349(2):181-6.


Function of saposin C in the reconstitution of glucosylceramidase by phosphatidylserine liposomes.

Vaccaro AM, Tatti M, Ciaffoni F, Salvioli R, Maras B, Barca A.

FEBS Lett. 1993 Dec 20;336(1):159-62.


Studies on glucosylceramidase binding to phosphatidylserine liposomes: the role of bilayer curvature.

Vaccaro AM, Tatti M, Ciaffoni F, Salvioli R, Barca A, Roncaioli P.

Biochim Biophys Acta. 1993 Jun 18;1149(1):55-62.


Reconstitution of glucosylceramidase on binding to acidic phospholipid-containing vesicles.

Vaccaro AM, Tatti M, Ciaffoni F, Salvioli R, Roncaioli P.

Biochim Biophys Acta. 1992 Mar 12;1119(3):239-46.


Correlation between the activity of glucosylceramidase and its binding to glucosylceramide-containing liposomes. Role of acidic phospholipids and fatty acids.

Vaccaro AM, Tatti M, Salvioli R, Ciaffoni F, Gallozzi E.

Biochim Biophys Acta. 1990 Jan 29;1033(1):73-9.


Factors affecting the binding of glucosylceramidase to its natural substrate dispersion.

Vaccaro AM, Tatti M, Ciaffoni F, Salvioli R.

Enzyme. 1989;42(2):87-97.


Presence of activator proteins for the enzymatic degradation of glucosylceramide in several human tissues.

Vaccaro AM, Ciaffoni F, Mandara I, Suzuki K.

Clin Chim Acta. 1988 Mar 15;172(2-3):323-34.


Polymorphism of galactose-1-phosphate uridyltransferase in the Albanian and Croatian settlements of Molise (Italy).

Vaccaro AM, Mandara I, Ciaffoni F, Biondi G.

Anthropol Anz. 1984 Dec;42(4):307-14.


Polymorphism of erythrocyte galactose-1-phosphate uridyl-transferase in Italy: segregation analysis in 693 families.

Vaccaro AM, Mandara I, Muscillo M, Ciaffoni F, De Pellegrin S, Benincasa A, Novelletto A, Terrenato L.

Hum Hered. 1984;34(4):197-206.


[Efficacy of dietetic treatment in a case of galactosemia diagnosed late].

Sebastio G, Albini F, di Martino L, Magurno T, Baffa E, Ciaffoni F.

Pediatr Med Chir. 1982 Nov-Dec;4(6):685-6. Italian.


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