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Items: 1 to 50 of 75

1.

Early-Life Compartmentalization of Immune Cells in Human Fetal Tissues Revealed by High-Dimensional Mass Cytometry.

Li N, van Unen V, Guo N, Abdelaal T, Somarakis A, Eggermont J, Mahfouz A, Chuva de Sousa Lopes SM, Lelieveldt BPF, Koning F.

Front Immunol. 2019 Aug 14;10:1932. doi: 10.3389/fimmu.2019.01932. eCollection 2019.

2.

Single-cell reconstruction of follicular remodeling in the human adult ovary.

Fan X, Bialecka M, Moustakas I, Lam E, Torrens-Juaneda V, Borggreven NV, Trouw L, Louwe LA, Pilgram GSK, Mei H, van der Westerlaken L, Chuva de Sousa Lopes SM.

Nat Commun. 2019 Jul 18;10(1):3164. doi: 10.1038/s41467-019-11036-9.

3.

Human blastocyst outgrowths recapitulate primordial germ cell specification events.

Popovic M, Bialecka M, Fernandes MG, Taelman J, Van Der Jeught M, De Sutter P, Heindryckx B, Chuva De Sousa Lopes SM.

Mol Hum Reprod. 2019 Jun 18. pii: gaz035. doi: 10.1093/molehr/gaz035. [Epub ahead of print]

PMID:
31211841
4.

Early divergence of mutational processes in human fetal tissues.

Kuijk E, Blokzijl F, Jager M, Besselink N, Boymans S, Chuva de Sousa Lopes SM, van Boxtel R, Cuppen E.

Sci Adv. 2019 May 29;5(5):eaaw1271. doi: 10.1126/sciadv.aaw1271. eCollection 2019 May.

5.

Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5.

Quinn PM, Buck TM, Mulder AA, Ohonin C, Alves CH, Vos RM, Bialecka M, van Herwaarden T, van Dijk EHC, Talib M, Freund C, Mikkers HMM, Hoeben RC, Goumans MJ, Boon CJF, Koster AJ, Chuva de Sousa Lopes SM, Jost CR, Wijnholds J.

Stem Cell Reports. 2019 May 14;12(5):906-919. doi: 10.1016/j.stemcr.2019.03.002. Epub 2019 Apr 4.

6.

Variation in DNA methylation in the KvDMR1 (ICR2) region in first-trimester human pregnancies.

Miranda Furtado CL, Salomão KB, Verruma CG, Paulino Leite SB, Lopes Rios ÁF, Bialecka M, Moustakas I, Mei H, de Paz CCP, Duarte G, Chuva de Sousa Lopes SM, Ramos ES.

Fertil Steril. 2019 Jun;111(6):1186-1193. doi: 10.1016/j.fertnstert.2019.01.036. Epub 2019 Mar 25.

PMID:
30922639
7.

Two decades of embryonic stem cells: a historical overview.

Eguizabal C, Aran B, Chuva de Sousa Lopes SM, Geens M, Heindryckx B, Panula S, Popovic M, Vassena R, Veiga A.

Hum Reprod Open. 2019 Jan 29;2019(1):hoy024. doi: 10.1093/hropen/hoy024. eCollection 2019.

8.

Accelerating maturation of kidney organoids.

Chuva de Sousa Lopes SM.

Nat Mater. 2019 Apr;18(4):303-304. doi: 10.1038/s41563-019-0326-3. No abstract available.

PMID:
30894757
9.

Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy.

Popovic M, Dhaenens L, Taelman J, Dheedene A, Bialecka M, De Sutter P, Chuva de Sousa Lopes SM, Menten B, Heindryckx B.

Hum Reprod. 2019 Apr 1;34(4):758-769. doi: 10.1093/humrep/dez012.

PMID:
30838420
10.

WNT Inhibition and Increased FGF Signaling Promotes Derivation of Less Heterogeneous Primed Human Embryonic Stem Cells, Compatible with Differentiation.

Taelman J, Popovic M, Bialecka M, Tilleman L, Warrier S, Van Der Jeught M, Menten B, Deforce D, De Sutter P, Van Nieuwerburgh F, Abe K, Heindryckx B, Chuva de Sousa Lopes SM.

Stem Cells Dev. 2019 May 1;28(9):579-592. doi: 10.1089/scd.2018.0199. Epub 2019 Apr 2.

PMID:
30827199
11.

Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development.

Hochane M, van den Berg PR, Fan X, Bérenger-Currias N, Adegeest E, Bialecka M, Nieveen M, Menschaart M, Chuva de Sousa Lopes SM, Semrau S.

PLoS Biol. 2019 Feb 21;17(2):e3000152. doi: 10.1371/journal.pbio.3000152. eCollection 2019 Feb.

12.

Memory CD4+ T cells are generated in the human fetal intestine.

Li N, van Unen V, Abdelaal T, Guo N, Kasatskaya SA, Ladell K, McLaren JE, Egorov ES, Izraelson M, Chuva de Sousa Lopes SM, Höllt T, Britanova OV, Eggermont J, de Miranda NFCC, Chudakov DM, Price DA, Lelieveldt BPF, Koning F.

Nat Immunol. 2019 Mar;20(3):301-312. doi: 10.1038/s41590-018-0294-9. Epub 2019 Jan 21.

13.

Skewed X-inactivation is common in the general female population.

Shvetsova E, Sofronova A, Monajemi R, Gagalova K, Draisma HHM, White SJ, Santen GWE, Chuva de Sousa Lopes SM, Heijmans BT, van Meurs J, Jansen R, Franke L, Kiełbasa SM, den Dunnen JT, 't Hoen PAC; BIOS consortium; GoNL consortium.

Eur J Hum Genet. 2019 Mar;27(3):455-465. doi: 10.1038/s41431-018-0291-3. Epub 2018 Dec 14.

14.

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.

Hu H, Gehart H, Artegiani B, LÖpez-Iglesias C, Dekkers F, Basak O, van Es J, Chuva de Sousa Lopes SM, Begthel H, Korving J, van den Born M, Zou C, Quirk C, Chiriboga L, Rice CM, Ma S, Rios A, Peters PJ, de Jong YP, Clevers H.

Cell. 2018 Nov 29;175(6):1591-1606.e19. doi: 10.1016/j.cell.2018.11.013.

PMID:
30500538
15.

3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling.

Zhang Y, Yang Y, Jiang M, Huang SX, Zhang W, Al Alam D, Danopoulos S, Mori M, Chen YW, Balasubramanian R, Chuva de Sousa Lopes SM, Serra C, Bialecka M, Kim E, Lin S, Toste de Carvalho ALR, Riccio PN, Cardoso WV, Zhang X, Snoeck HW, Que J.

Cell Stem Cell. 2018 Oct 4;23(4):516-529.e5. doi: 10.1016/j.stem.2018.08.009. Epub 2018 Sep 20.

PMID:
30244870
16.

Transcriptional landscape changes during human embryonic stem cell derivation.

Warrier S, Taelman J, Tilleman L, Van der Jeught M, Duggal G, Lierman S, Popovic M, Van Soom A, Peelman L, Van Nieuwerburgh F, Deforce D, Chuva de Sousa Lopes SM, De Sutter P, Heindryckx B.

Mol Hum Reprod. 2018 Nov 1;24(11):543-555. doi: 10.1093/molehr/gay039.

PMID:
30239859
17.

Correction: Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling (doi: 10.1242/dev.157222).

Dobreva MP, Escalona VA, Lawson KA, Sanchez MN, Ponomarev LC, Pereira PNG, Stryjewska A, Criem N, Huylebroeck D, Chuva de Sousa Lopes SM, Aerts S, Zwijsen A.

Development. 2018 Aug 2;145(15). pii: dev169722. doi: 10.1242/dev.169722. No abstract available.

18.

Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling.

Dobreva MP, Abon Escalona V, Lawson KA, Sanchez MN, Ponomarev LC, Pereira PNG, Stryjewska A, Criem N, Huylebroeck D, Chuva de Sousa Lopes SM, Aerts S, Zwijsen A.

Development. 2018 Jul 2;145(13). pii: dev157222. doi: 10.1242/dev.157222. Erratum in: Development. 2018 Aug 2;145(15):.

19.

Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells.

Vértesy Á, Arindrarto W, Roost MS, Reinius B, Torrens-Juaneda V, Bialecka M, Moustakas I, Ariyurek Y, Kuijk E, Mei H, Sandberg R, van Oudenaarden A, Chuva de Sousa Lopes SM.

Nat Commun. 2018 May 14;9(1):1873. doi: 10.1038/s41467-018-04215-7.

20.

Characterization of migratory primordial germ cells in the aorta-gonad-mesonephros of a 4.5-week-old human embryo: a toolbox to evaluate in vitro early gametogenesis.

Gomes Fernandes M, Bialecka M, Salvatori DCF, Chuva de Sousa Lopes SM.

Mol Hum Reprod. 2018 May 1;24(5):233-243. doi: 10.1093/molehr/gay011.

21.

Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine.

Li N, van Unen V, Höllt T, Thompson A, van Bergen J, Pezzotti N, Eisemann E, Vilanova A, Chuva de Sousa Lopes SM, Lelieveldt BPF, Koning F.

J Exp Med. 2018 May 7;215(5):1383-1396. doi: 10.1084/jem.20171934. Epub 2018 Mar 6.

22.

Human-specific subcellular compartmentalization of P-element induced wimpy testis-like (PIWIL) granules during germ cell development and spermatogenesis.

Gomes Fernandes M, He N, Wang F, Van Iperen L, Eguizabal C, Matorras R, Roelen BAJ, Chuva De Sousa Lopes SM.

Hum Reprod. 2018 Feb 1;33(2):258-269. doi: 10.1093/humrep/dex365.

23.

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells.

Roost MS, Slieker RC, Bialecka M, van Iperen L, Gomes Fernandes MM, He N, Suchiman HED, Szuhai K, Carlotti F, de Koning EJP, Mummery CL, Heijmans BT, Chuva de Sousa Lopes SM.

Nat Commun. 2017 Oct 13;8(1):908. doi: 10.1038/s41467-017-01077-3.

24.

At Term, XmO and XpO Mouse Placentas Show Differences in Glucose Metabolism in the Trophectoderm-Derived Outer Zone.

He N, Lim SJ, Moreira de Mello JC, Navarro I, Bialecka M, Salvatori DCF, van der Westerlaken LAJ, Pereira LV, Chuva de Sousa Lopes SM.

Front Cell Dev Biol. 2017 Jun 21;5:63. doi: 10.3389/fcell.2017.00063. eCollection 2017.

25.

X chromosome inactivation in human pluripotent stem cells as a model for human development: back to the drawing board?

Geens M, Chuva De Sousa Lopes SM.

Hum Reprod Update. 2017 Sep 1;23(5):520-532. doi: 10.1093/humupd/dmx015. Review.

PMID:
28582519
26.

PDGFRα+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors.

Lo Nigro A, de Jaime-Soguero A, Khoueiry R, Cho DS, Ferlazzo GM, Perini I, Abon Escalona V, Aranguren XL, Chuva de Sousa Lopes SM, Koh KP, Conaldi PG, Hu WS, Zwijsen A, Lluis F, Verfaillie CM.

Stem Cell Reports. 2017 Feb 14;8(2):318-333. doi: 10.1016/j.stemcr.2016.12.010. Epub 2017 Jan 12.

27.

Human Extravillous Trophoblasts Penetrate Decidual Veins and Lymphatics before Remodeling Spiral Arteries during Early Pregnancy.

He N, van Iperen L, de Jong D, Szuhai K, Helmerhorst FM, van der Westerlaken LA, Chuva de Sousa Lopes SM.

PLoS One. 2017 Jan 12;12(1):e0169849. doi: 10.1371/journal.pone.0169849. eCollection 2017.

28.

Germline development in amniotes: A paradigm shift in primordial germ cell specification.

Bertocchini F, Chuva de Sousa Lopes SM.

Bioessays. 2016 Aug;38(8):791-800. doi: 10.1002/bies.201600025. Epub 2016 Jun 6. Review.

29.

Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.

Alves da Silva AF, Machado FB, Pavarino ÉC, Biselli-Périco JM, Zampieri BL, da Silva Francisco Junior R, Mozer Rodrigues PT, Terra Machado D, Santos-Rebouças CB, Gomes Fernandes M, Chuva de Sousa Lopes SM, Lopes Rios ÁF, Medina-Acosta E.

PLoS One. 2016 Apr 21;11(4):e0154108. doi: 10.1371/journal.pone.0154108. eCollection 2016.

30.

BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo.

Crisan M, Solaimani Kartalaei P, Neagu A, Karkanpouna S, Yamada-Inagawa T, Purini C, Vink CS, van der Linden R, van Ijcken W, Chuva de Sousa Lopes SM, Monteiro R, Mummery C, Dzierzak E.

Stem Cell Reports. 2016 Mar 8;6(3):383-95. doi: 10.1016/j.stemcr.2016.01.016. Epub 2016 Feb 25.

31.

On the development of extragonadal and gonadal human germ cells.

Heeren AM, He N, de Souza AF, Goercharn-Ramlal A, van Iperen L, Roost MS, Gomes Fernandes MM, van der Westerlaken LA, Chuva de Sousa Lopes SM.

Biol Open. 2016 Feb 1;5(2):185-94. doi: 10.1242/bio.013847.

32.

DNA Methylation Landscapes of Human Fetal Development.

Slieker RC, Roost MS, van Iperen L, Suchiman HE, Tobi EW, Carlotti F, de Koning EJ, Slagboom PE, Heijmans BT, Chuva de Sousa Lopes SM.

PLoS Genet. 2015 Oct 22;11(10):e1005583. doi: 10.1371/journal.pgen.1005583. eCollection 2015 Oct.

33.

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis.

Takasato M, Er PX, Chiu HS, Maier B, Baillie GJ, Ferguson C, Parton RG, Wolvetang EJ, Roost MS, Chuva de Sousa Lopes SM, Little MH.

Nature. 2015 Oct 22;526(7574):564-8. doi: 10.1038/nature15695. Epub 2015 Oct 7. Erratum in: Nature. 2016 Aug 11;536(7615):238.

PMID:
26444236
34.

Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells.

van den Berg CW, Okawa S, Chuva de Sousa Lopes SM, van Iperen L, Passier R, Braam SR, Tertoolen LG, del Sol A, Davis RP, Mummery CL.

Development. 2015 Sep 15;142(18):3231-8. doi: 10.1242/dev.123810. Epub 2015 Jul 24.

35.

Application Of Small Molecules Favoring Naïve Pluripotency during Human Embryonic Stem Cell Derivation.

Van der Jeught M, Taelman J, Duggal G, Ghimire S, Lierman S, Chuva de Sousa Lopes SM, Deforce D, Deroo T, De Sutter P, Heindryckx B.

Cell Reprogram. 2015 Jun;17(3):170-80. doi: 10.1089/cell.2014.0085.

36.

KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas.

Roost MS, van Iperen L, Ariyurek Y, Buermans HP, Arindrarto W, Devalla HD, Passier R, Mummery CL, Carlotti F, de Koning EJ, van Zwet EW, Goeman JJ, Chuva de Sousa Lopes SM.

Stem Cell Reports. 2015 Jun 9;4(6):1112-24. doi: 10.1016/j.stemcr.2015.05.002. Epub 2015 May 28.

37.

A Bmp Reporter Transgene Mouse Embryonic Stem Cell Model as a Tool to Identify and Characterize Chemical Teratogens.

Kugler J, Tharmann J, Chuva de Sousa Lopes SM, Kemler R, Luch A, Oelgeschläger M.

Toxicol Sci. 2015 Aug;146(2):374-85. doi: 10.1093/toxsci/kfv103. Epub 2015 May 21.

PMID:
26001961
38.

A simple and robust method for establishing homogeneous mouse epiblast stem cell lines by wnt inhibition.

Sugimoto M, Kondo M, Koga Y, Shiura H, Ikeda R, Hirose M, Ogura A, Murakami A, Yoshiki A, Chuva de Sousa Lopes SM, Abe K.

Stem Cell Reports. 2015 Apr 14;4(4):744-57. doi: 10.1016/j.stemcr.2015.02.014. Epub 2015 Mar 26.

39.

Piwi proteins and piRNAs in mammalian oocytes and early embryos.

Roovers EF, Rosenkranz D, Mahdipour M, Han CT, He N, Chuva de Sousa Lopes SM, van der Westerlaken LA, Zischler H, Butter F, Roelen BA, Ketting RF.

Cell Rep. 2015 Mar 31;10(12):2069-82. doi: 10.1016/j.celrep.2015.02.062. Epub 2015 Mar 26.

40.

Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology.

Devalla HD, Schwach V, Ford JW, Milnes JT, El-Haou S, Jackson C, Gkatzis K, Elliott DA, Chuva de Sousa Lopes SM, Mummery CL, Verkerk AO, Passier R.

EMBO Mol Med. 2015 Apr;7(4):394-410. doi: 10.15252/emmm.201404757.

41.

Development of the stria vascularis and potassium regulation in the human fetal cochlea: Insights into hereditary sensorineural hearing loss.

Locher H, de Groot JC, van Iperen L, Huisman MA, Frijns JH, Chuva de Sousa Lopes SM.

Dev Neurobiol. 2015 Nov;75(11):1219-40. doi: 10.1002/dneu.22279. Epub 2015 Feb 28.

42.

Development of the follicular basement membrane during human gametogenesis and early folliculogenesis.

Heeren AM, van Iperen L, Klootwijk DB, de Melo Bernardo A, Roost MS, Gomes Fernandes MM, Louwe LA, Hilders CG, Helmerhorst FM, van der Westerlaken LA, Chuva de Sousa Lopes SM.

BMC Dev Biol. 2015 Jan 21;15:4. doi: 10.1186/s12861-015-0054-0.

43.

A conserved role for non-neural ectoderm cells in early neural development.

Cajal M, Creuzet SE, Papanayotou C, Sabéran-Djoneidi D, Chuva de Sousa Lopes SM, Zwijsen A, Collignon J, Camus A.

Development. 2014 Nov;141(21):4127-38. doi: 10.1242/dev.107425. Epub 2014 Oct 1.

44.

The involvement of the proamnion in the development of the anterior amnion fold in the chicken.

de Melo Bernardo A, Chuva de Sousa Lopes SM.

PLoS One. 2014 Mar 19;9(3):e92672. doi: 10.1371/journal.pone.0092672. eCollection 2014.

45.

Differential expression of the MHM region and of sex-determining-related genes during gonadal development in chicken embryos.

Caetano LC, Gennaro FG, Coelho K, Araújo FM, Vila RA, Araújo A, de Melo Bernardo A, Marcondes CR, Chuva de Sousa Lopes SM, Ramos ES.

Genet Mol Res. 2014 Feb 13;13(1):838-49. doi: 10.4238/2014.February.13.2.

46.

Distribution and development of peripheral glial cells in the human fetal cochlea.

Locher H, de Groot JC, van Iperen L, Huisman MA, Frijns JH, Chuva de Sousa Lopes SM.

PLoS One. 2014 Jan 31;9(1):e88066. doi: 10.1371/journal.pone.0088066. eCollection 2014.

47.

Lymphangiogenesis and angiogenesis during human fetal pancreas development.

Roost MS, van Iperen L, de Melo Bernardo A, Mummery CL, Carlotti F, de Koning EJ, Chuva de Sousa Lopes SM.

Vasc Cell. 2014 Nov 1;6:22. doi: 10.1186/2045-824X-6-22. eCollection 2014.

48.

Treatment of human embryos with the TGFβ inhibitor SB431542 increases epiblast proliferation and permits successful human embryonic stem cell derivation.

Van der Jeught M, Heindryckx B, O'Leary T, Duggal G, Ghimire S, Lierman S, Van Roy N, Chuva de Sousa Lopes SM, Deroo T, Deforce D, De Sutter P.

Hum Reprod. 2014 Jan;29(1):41-8. doi: 10.1093/humrep/det400. Epub 2013 Nov 19.

PMID:
24256991
49.

TUBB3: neuronal marker or melanocyte mimic?

Locher H, Frijns JH, Huisman MA, Chuva de Sousa Lopes SM.

Cell Transplant. 2014;23(11):1471-3. doi: 10.3727/096368913X674099. Epub 2013 Oct 22. No abstract available.

PMID:
24152858
50.

Neurosensory development and cell fate determination in the human cochlea.

Locher H, Frijns JH, van Iperen L, de Groot JC, Huisman MA, Chuva de Sousa Lopes SM.

Neural Dev. 2013 Oct 16;8:20. doi: 10.1186/1749-8104-8-20.

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