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Items: 34

1.

Linking Clinical Parameters and Genotype in Dilated Cardiomyopathy.

Churko JM.

Circ Heart Fail. 2018 Nov;11(11):e005459. doi: 10.1161/CIRCHEARTFAILURE.118.005459. No abstract available.

PMID:
30525987
2.

Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis.

Churko JM, Garg P, Treutlein B, Venkatasubramanian M, Wu H, Lee J, Wessells QN, Chen SY, Chen WY, Chetal K, Mantalas G, Neff N, Jabart E, Sharma A, Nolan GP, Salomonis N, Wu JC.

Nat Commun. 2018 Nov 21;9(1):4906. doi: 10.1038/s41467-018-07333-4.

3.

Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods.

Churko JM, Lee J, Ameen M, Gu M, Venkatasubramanian M, Diecke S, Sallam K, Im H, Wang G, Gold JD, Salomonis N, Snyder MP, Wu JC.

Nat Biomed Eng. 2017 Oct;1(10):826-837. doi: 10.1038/s41551-017-0141-6. Epub 2017 Oct 3.

4.

Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation.

Sharma A, Zhang Y, Buikema JW, Serpooshan V, Chirikian O, Kosaric N, Churko JM, Dzilic E, Shieh A, Burridge PW, Wu JC, Wu SM.

Sci Rep. 2018 Apr 26;8(1):6618. doi: 10.1038/s41598-018-24954-3.

5.

SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation.

Lee J, Shao NY, Paik DT, Wu H, Guo H, Termglinchan V, Churko JM, Kim Y, Kitani T, Zhao MT, Zhang Y, Wilson KD, Karakikes I, Snyder MP, Wu JC.

Cell Stem Cell. 2018 Mar 1;22(3):428-444.e5. doi: 10.1016/j.stem.2018.02.005.

6.

High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells.

Sharma A, Burridge PW, McKeithan WL, Serrano R, Shukla P, Sayed N, Churko JM, Kitani T, Wu H, Holmström A, Matsa E, Zhang Y, Kumar A, Fan AC, Del Álamo JC, Wu SM, Moslehi JJ, Mercola M, Wu JC.

Sci Transl Med. 2017 Feb 15;9(377). pii: eaaf2584. doi: 10.1126/scitranslmed.aaf2584.

7.

Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome.

Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman MM, Bers DM, Wu JC.

J Am Coll Cardiol. 2016 Nov 8;68(19):2086-2096. doi: 10.1016/j.jacc.2016.07.779.

8.

iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy.

Kodo K, Ong SG, Jahanbani F, Termglinchan V, Hirono K, InanlooRahatloo K, Ebert AD, Shukla P, Abilez OJ, Churko JM, Karakikes I, Jung G, Ichida F, Wu SM, Snyder MP, Bernstein D, Wu JC.

Nat Cell Biol. 2016 Oct;18(10):1031-42. doi: 10.1038/ncb3411. Epub 2016 Sep 19.

9.

Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro.

Matsa E, Burridge PW, Yu KH, Ahrens JH, Termglinchan V, Wu H, Liu C, Shukla P, Sayed N, Churko JM, Shao N, Woo NA, Chao AS, Gold JD, Karakikes I, Snyder MP, Wu JC.

Cell Stem Cell. 2016 Sep 1;19(3):311-25. doi: 10.1016/j.stem.2016.07.006. Epub 2016 Aug 18.

10.

Systematic Characterization of Long Noncoding RNAs Reveals the Contrasting Coordination of Cis- and Trans-Molecular Regulation in Human Fetal and Adult Hearts.

He C, Hu H, Wilson KD, Wu H, Feng J, Xia S, Churko J, Qu K, Chang HY, Wu JC.

Circ Cardiovasc Genet. 2016 Apr;9(2):110-8. doi: 10.1161/CIRCGENETICS.115.001264. Epub 2016 Feb 19.

11.

Assessment of the Radiation Effects of Cardiac CT Angiography Using Protein and Genetic Biomarkers.

Nguyen PK, Lee WH, Li YF, Hong WX, Hu S, Chan C, Liang G, Nguyen I, Ong SG, Churko J, Wang J, Altman RB, Fleischmann D, Wu JC.

JACC Cardiovasc Imaging. 2015 Aug;8(8):873-84. doi: 10.1016/j.jcmg.2015.04.016. Epub 2015 Jul 22. Erratum in: JACC Cardiovasc Imaging. 2015 Nov;8(11):1350.

12.

Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.

Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC.

Cell Stem Cell. 2015 Jul 2;17(1):89-100. doi: 10.1016/j.stem.2015.04.020. Epub 2015 Jun 18.

13.

Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency.

Diecke S, Lu J, Lee J, Termglinchan V, Kooreman NG, Burridge PW, Ebert AD, Churko JM, Sharma A, Kay MA, Wu JC.

Sci Rep. 2015 Jan 28;5:8081. doi: 10.1038/srep08081.

14.

Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism.

Gu M, Mordwinkin NM, Kooreman NG, Lee J, Wu H, Hu S, Churko JM, Diecke S, Burridge PW, He C, Barron FE, Ong SG, Gold JD, Wu JC.

Eur Heart J. 2015 Apr 1;36(13):806-16. doi: 10.1093/eurheartj/ehu411. Epub 2014 Nov 2.

15.

VEGF-C and aortic cardiomyocytes guide coronary artery stem development.

Chen HI, Poduri A, Numi H, Kivela R, Saharinen P, McKay AS, Raftrey B, Churko J, Tian X, Zhou B, Wu JC, Alitalo K, Red-Horse K.

J Clin Invest. 2014 Nov;124(11):4899-914. doi: 10.1172/JCI77483. Epub 2014 Oct 1.

16.

Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system.

Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, de Almeida P, Lan F, Diecke S, Burridge PW, Gold JD, Mochly-Rosen D, Wu JC.

Sci Transl Med. 2014 Sep 24;6(255):255ra130. doi: 10.1126/scitranslmed.3009027.

17.

Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform.

Sharma A, Marceau C, Hamaguchi R, Burridge PW, Rajarajan K, Churko JM, Wu H, Sallam KI, Matsa E, Sturzu AC, Che Y, Ebert A, Diecke S, Liang P, Red-Horse K, Carette JE, Wu SM, Wu JC.

Circ Res. 2014 Aug 29;115(6):556-66. doi: 10.1161/CIRCRESAHA.115.303810. Epub 2014 Jul 11.

18.

Chemically defined generation of human cardiomyocytes.

Burridge PW, Matsa E, Shukla P, Lin ZC, Churko JM, Ebert AD, Lan F, Diecke S, Huber B, Mordwinkin NM, Plews JR, Abilez OJ, Cui B, Gold JD, Wu JC.

Nat Methods. 2014 Aug;11(8):855-60. doi: 10.1038/nmeth.2999. Epub 2014 Jun 15.

19.

Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy.

Asimaki A, Kapoor S, Plovie E, Karin Arndt A, Adams E, Liu Z, James CA, Judge DP, Calkins H, Churko J, Wu JC, MacRae CA, Kléber AG, Saffitz JE.

Sci Transl Med. 2014 Jun 11;6(240):240ra74. doi: 10.1126/scitranslmed.3008008. Erratum in: Sci Transl Med. 2014 Nov 5;6(261):261er6.

20.

Panx1 regulates cellular properties of keratinocytes and dermal fibroblasts in skin development and wound healing.

Penuela S, Kelly JJ, Churko JM, Barr KJ, Berger AC, Laird DW.

J Invest Dermatol. 2014 Jul;134(7):2026-2035. doi: 10.1038/jid.2014.86. Epub 2014 Feb 12.

21.
22.

Overview of high throughput sequencing technologies to elucidate molecular pathways in cardiovascular diseases.

Churko JM, Mantalas GL, Snyder MP, Wu JC.

Circ Res. 2013 Jun 7;112(12):1613-23. doi: 10.1161/CIRCRESAHA.113.300939. Review.

23.

Gap junction remodeling in skin repair following wounding and disease.

Churko JM, Laird DW.

Physiology (Bethesda). 2013 May;28(3):190-8. doi: 10.1152/physiol.00058.2012. Review.

24.

The G60S Cx43 mutant enhances keratinocyte proliferation and differentiation.

Churko JM, Kelly JJ, Macdonald A, Lee J, Sampson J, Bai D, Laird DW.

Exp Dermatol. 2012 Aug;21(8):612-8. doi: 10.1111/j.1600-0625.2012.01532.x.

PMID:
22775996
25.

Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype.

Penuela S, Gyenis L, Ablack A, Churko JM, Berger AC, Litchfield DW, Lewis JD, Laird DW.

J Biol Chem. 2012 Aug 17;287(34):29184-93. doi: 10.1074/jbc.M112.377176. Epub 2012 Jun 29.

26.

The G60S connexin43 mutant regulates hair growth and hair fiber morphology in a mouse model of human oculodentodigital dysplasia.

Churko JM, Chan J, Shao Q, Laird DW.

J Invest Dermatol. 2011 Nov;131(11):2197-204. doi: 10.1038/jid.2011.183. Epub 2011 Jun 30.

27.

Human dermal fibroblasts derived from oculodentodigital dysplasia patients suggest that patients may have wound-healing defects.

Churko JM, Shao Q, Gong XQ, Swoboda KJ, Bai D, Sampson J, Laird DW.

Hum Mutat. 2011 Apr;32(4):456-66. doi: 10.1002/humu.21472.

28.

The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants.

Churko JM, Langlois S, Pan X, Shao Q, Laird DW.

Biochem J. 2010 Aug 1;429(3):473-83. doi: 10.1042/BJ20100155.

29.

Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation.

Celetti SJ, Cowan KN, Penuela S, Shao Q, Churko J, Laird DW.

J Cell Sci. 2010 Apr 15;123(Pt 8):1363-72. doi: 10.1242/jcs.056093. Epub 2010 Mar 23.

30.

Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions.

Bhalla-Gehi R, Penuela S, Churko JM, Shao Q, Laird DW.

J Biol Chem. 2010 Mar 19;285(12):9147-60. doi: 10.1074/jbc.M109.082008. Epub 2010 Jan 10.

31.

Sensor evaluation for tracking upper extremity prosthesis movements in a virtual environment.

Churko JM, Mehr A, Linassi A, Dinh A.

Conf Proc IEEE Eng Med Biol Soc. 2009;2009:2392-5. doi: 10.1109/IEMBS.2009.5334961.

PMID:
19965196
32.

Optical and biochemical dissection of connexin and disease-linked connexin mutants in 3D organotypic epidermis.

Langlois S, Churko JM, Laird DW.

Methods Mol Biol. 2010;585:313-34. doi: 10.1007/978-1-60761-380-0_22.

PMID:
19908013
33.

Cx43 has distinct mobility within plasma-membrane domains, indicative of progressive formation of gap-junction plaques.

Simek J, Churko J, Shao Q, Laird DW.

J Cell Sci. 2009 Feb 15;122(Pt 4):554-62. doi: 10.1242/jcs.036970. Epub 2009 Jan 27.

34.

Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant.

Manias JL, Plante I, Gong XQ, Shao Q, Churko J, Bai D, Laird DW.

Cardiovasc Res. 2008 Dec 1;80(3):385-95. doi: 10.1093/cvr/cvn203. Epub 2008 Aug 4.

PMID:
18678643

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