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Items: 1 to 50 of 95

1.

In vivo localization and postmortem stability of benzo[a]pyrene-DNA adducts.

Poirier MC, Beland FA, Divi KV, Damon AL, Ali M, Vanlandingham MM, Churchwell MI, Von Tungeln LS, Dwyer JE, Divi RL, Beauchamp G, Martineau D.

Environ Mol Mutagen. 2019 Sep 30. doi: 10.1002/em.22337. [Epub ahead of print]

PMID:
31569280
2.

A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results.

Camacho L, Lewis SM, Vanlandingham MM, Olson GR, Davis KJ, Patton RE, Twaddle NC, Doerge DR, Churchwell MI, Bryant MS, McLellen FM, Woodling KA, Felton RP, Maisha MP, Juliar BE, Gamboa da Costa G, Delclos KB.

Food Chem Toxicol. 2019 Oct;132:110728. doi: 10.1016/j.fct.2019.110728. Epub 2019 Jul 28.

PMID:
31365888
3.

Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans.

Zhivagui M, Ng AWT, Ardin M, Churchwell MI, Pandey M, Renard C, Villar S, Cahais V, Robitaille A, Bouaoun L, Heguy A, Guyton KZ, Stampfer MR, McKay J, Hollstein M, Olivier M, Rozen SG, Beland FA, Korenjak M, Zavadil J.

Genome Res. 2019 Apr;29(4):521-531. doi: 10.1101/gr.242453.118. Epub 2019 Mar 7.

4.

Genotoxic and Epigenotoxic Alterations in the Lung and Liver of Mice Induced by Acrylamide: A 28 Day Drinking Water Study.

de Conti A, Tryndyak V, VonTungeln LS, Churchwell MI, Beland FA, Antunes AMM, Pogribny IP.

Chem Res Toxicol. 2019 May 20;32(5):869-877. doi: 10.1021/acs.chemrestox.9b00020. Epub 2019 Mar 12.

PMID:
30807115
5.

Comparative estrogenicity of endogenous, environmental and dietary estrogens in pregnant women II: Total estrogenicity calculations accounting for competitive protein and receptor binding and potency.

Pande P, Fleck SC, Twaddle NC, Churchwell MI, Doerge DR, Teeguarden JG.

Food Chem Toxicol. 2019 Mar;125:341-353. doi: 10.1016/j.fct.2018.12.013. Epub 2018 Dec 13.

PMID:
30553876
6.

Acrylamide Production in Autoclaved Rodent Feed.

Kurtz DM, Glascoe R, Caviness G, Locklear J, Whiteside T, Ward T, Adsit F, Lih F, Deterding LJ, Churchwell MI, Doerge DR, Kissling GE.

J Am Assoc Lab Anim Sci. 2018 Oct 25. doi: 10.30802/AALAS-JAALAS-18-000011. [Epub ahead of print]

7.

Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells.

Tryndyak V, Kindrat I, Dreval K, Churchwell MI, Beland FA, Pogribny IP.

Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.

PMID:
30157460
8.

Comparative estrogenicity of endogenous, environmental and dietary estrogens in pregnant women I: Serum levels, variability and the basis for urinary biomonitoring of serum estrogenicity.

Fleck SC, Twaddle NC, Churchwell MI, Doerge DR, Pande P, Teeguarden JG.

Food Chem Toxicol. 2018 May;115:511-522. doi: 10.1016/j.fct.2018.03.017. Epub 2018 Mar 13.

PMID:
29548854
9.

Metabolism and disposition of arsenic species from controlled oral dosing with sodium arsenite in adult female CD-1 mice. I. Pilot study to determine dosing, analytical measurements, and sampling strategies.

Twaddle NC, Vanlandingham M, Churchwell MI, Doerge DR.

Food Chem Toxicol. 2018 Jan;111:482-493. doi: 10.1016/j.fct.2017.12.005. Epub 2017 Dec 5.

PMID:
29217265
10.

Metabolism and pharmacokinetics of zearalenone following oral and intravenous administration in juvenile female pigs.

Fleck SC, Churchwell MI, Doerge DR.

Food Chem Toxicol. 2017 Aug;106(Pt A):193-201. doi: 10.1016/j.fct.2017.05.048. Epub 2017 May 25.

PMID:
28552786
11.

Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women.

Fleck SC, Churchwell MI, Doerge DR, Teeguarden JG.

Food Chem Toxicol. 2016 Sep;95:19-27. doi: 10.1016/j.fct.2016.05.021. Epub 2016 May 30.

PMID:
27255803
12.

Effects of letrozole on breast cancer micro-metastatic tumor growth in bone and lung in mice inoculated with murine 4T1 cells.

Wang W, Belosay A, Yang X, Hartman JA, Song H, Iwaniec UT, Turner RT, Churchwell MI, Doerge DR, Helferich WG.

Clin Exp Metastasis. 2016 Jun;33(5):475-85. doi: 10.1007/s10585-016-9792-z. Epub 2016 May 21.

PMID:
27209469
13.

Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys.

Doerge DR, Woodling KA, Churchwell MI, Fleck SC, Helferich WG.

Food Chem Toxicol. 2016 Jun;92:165-76. doi: 10.1016/j.fct.2016.04.005. Epub 2016 Apr 12.

PMID:
27084109
14.

Urine and serum biomonitoring of exposure to environmental estrogens I: Bisphenol A in pregnant women.

Teeguarden JG, Twaddle NC, Churchwell MI, Doerge DR.

Food Chem Toxicol. 2016 Jun;92:129-42. doi: 10.1016/j.fct.2016.03.023. Epub 2016 Mar 30.

PMID:
27038865
15.

Evaluation of serum and liver toxicokinetics for furan and liver DNA adduct formation in male Fischer 344 rats.

Churchwell MI, Scheri RC, Von Tungeln LS, Gamboa da Costa G, Beland FA, Doerge DR.

Food Chem Toxicol. 2015 Dec;86:1-8. doi: 10.1016/j.fct.2015.08.029. Epub 2015 Sep 11.

PMID:
26364877
16.

Bisphenol A, Bisphenol S, and 4-Hydro​xyphenyl 4-Isopro​oxyphenyl​sulfone (BPSIP) in Urine and Blood of Cashiers.

Thayer KA, Taylor KW, Garantziotis S, Schurman SH, Kissling GE, Hunt D, Herbert B, Church R, Jankowich R, Churchwell MI, Scheri RC, Birnbaum LS, Bucher JR.

Environ Health Perspect. 2016 Apr;124(4):437-44. doi: 10.1289/ehp.1409427. Epub 2015 Aug 25.

17.

NIEHS/FDA CLARITY-BPA research program update.

Heindel JJ, Newbold RR, Bucher JR, Camacho L, Delclos KB, Lewis SM, Vanlandingham M, Churchwell MI, Twaddle NC, McLellen M, Chidambaram M, Bryant M, Woodling K, Gamboa da Costa G, Ferguson SA, Flaws J, Howard PC, Walker NJ, Zoeller RT, Fostel J, Favaro C, Schug TT.

Reprod Toxicol. 2015 Dec;58:33-44. doi: 10.1016/j.reprotox.2015.07.075. Epub 2015 Jul 29. Review.

18.

24-hour human urine and serum profiles of bisphenol A following ingestion in soup: Individual pharmacokinetic data and emographics.

Teeguarden JG, Twaddle NC, Churchwell MI, Yang X, Fisher JW, Seryak LM, Doerge DR.

Data Brief. 2015 Mar 17;4:83-6. doi: 10.1016/j.dib.2015.03.002. eCollection 2015 Sep.

19.

Pharmacokinetics of bisphenol A in humans following a single oral administration.

Thayer KA, Doerge DR, Hunt D, Schurman SH, Twaddle NC, Churchwell MI, Garantziotis S, Kissling GE, Easterling MR, Bucher JR, Birnbaum LS.

Environ Int. 2015 Oct;83:107-15. doi: 10.1016/j.envint.2015.06.008. Epub 2015 Jun 24.

20.

24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup.

Teeguarden JG, Twaddle NC, Churchwell MI, Yang X, Fisher JW, Seryak LM, Doerge DR.

Toxicol Appl Pharmacol. 2015 Oct 15;288(2):131-42. doi: 10.1016/j.taap.2015.01.009. Epub 2015 Jan 22.

PMID:
25620055
21.

Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver.

de Conti A, Tryndyak V, Churchwell MI, Melnyk S, Latendresse JR, Muskhelishvili L, Beland FA, Pogribny IP.

Toxicology. 2014 Nov 5;325:12-20. doi: 10.1016/j.tox.2014.08.004. Epub 2014 Aug 12.

PMID:
25123088
22.

Comparison of life-stage-dependent internal dosimetry for bisphenol A, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats.

Churchwell MI, Camacho L, Vanlandingham MM, Twaddle NC, Sepehr E, Delclos KB, Fisher JW, Doerge DR.

Toxicol Sci. 2014 May;139(1):4-20. doi: 10.1093/toxsci/kfu021. Epub 2014 Feb 4.

23.

Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cells.

Bandarra S, Fernandes AS, Magro I, Guerreiro PS, Pingarilho M, Churchwell MI, Gil OM, Batinic-Haberle I, Gonçalves S, Rueff J, Miranda JP, Marques MM, Beland FA, Castro M, Gaspar JF, Oliveira NG.

Mutagenesis. 2013 Nov;28(6):721-9. doi: 10.1093/mutage/get052. Erratum in: Mutagenesis. 2014 Jan;29(1):97.

PMID:
24150595
24.

Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: quantification using UPLC-ES/MS/MS.

Sepehr E, Lebl-Rinnova M, Mann MK, Pisani SL, Churchwell MI, Korol DL, Katzenellenbogen JA, Doerge DR.

J Pharm Biomed Anal. 2012 Dec;71:119-26. doi: 10.1016/j.jpba.2012.08.022. Epub 2012 Aug 24.

25.

Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days.

John K, Pratt MM, Beland FA, Churchwell MI, McMullen G, Olivero OA, Pogribny IP, Poirier MC.

Carcinogenesis. 2012 Nov;33(11):2236-41. doi: 10.1093/carcin/bgs247. Epub 2012 Jul 24.

26.

Twenty-four hour human urine and serum profiles of bisphenol a during high-dietary exposure.

Teeguarden JG, Calafat AM, Ye X, Doerge DR, Churchwell MI, Gunawan R, Graham MK.

Toxicol Sci. 2011 Sep;123(1):48-57. doi: 10.1093/toxsci/kfr160. Epub 2011 Jun 24.

PMID:
21705716
27.

Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry.

Twaddle NC, Churchwell MI, Vanlandingham M, Doerge DR.

Rapid Commun Mass Spectrom. 2010 Oct 30;24(20):3011-20. doi: 10.1002/rcm.4733.

PMID:
20872634
28.

Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs.

Lucas PW, Schmit JM, Peterson QP, West DC, Hsu DC, Novotny CJ, Dirikolu L, Churchwell MI, Doerge DR, Garrett LD, Hergenrother PJ, Fan TM.

Invest New Drugs. 2011 Oct;29(5):901-11. doi: 10.1007/s10637-010-9445-z. Epub 2010 May 25.

29.

DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide.

Von Tungeln LS, Churchwell MI, Doerge DR, Shaddock JG, McGarrity LJ, Heflich RH, Gamboa da Costa G, Marques MM, Beland FA.

Int J Cancer. 2009 May 1;124(9):2006-15. doi: 10.1002/ijc.24165.

30.

Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene.

Bagnyukova TV, Tryndyak VP, Montgomery B, Churchwell MI, Karpf AR, James SR, Muskhelishvili L, Beland FA, Pogribny IP.

Carcinogenesis. 2008 Mar;29(3):638-46. doi: 10.1093/carcin/bgm303. Epub 2008 Jan 19.

PMID:
18204080
31.

Tumorigenicity and genotoxicity of an environmental pollutant 2,7-dinitrofluorene after systemic administration at a low dose level to female rats.

Malejka-Giganti D, Parkin DR, Decker RW, Niehans GA, Bliss RL, Churchwell MI, Beland FA.

Int J Cancer. 2008 May 1;122(9):1958-65. doi: 10.1002/ijc.23352.

32.

Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells.

Mei N, Hu J, Churchwell MI, Guo L, Moore MM, Doerge DR, Chen T.

Food Chem Toxicol. 2008 Feb;46(2):628-36. Epub 2007 Sep 22.

33.

Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen.

Gamboa da Costa G, Marques MM, Fu X, Churchwell MI, Wang YP, Doerge DR, Beland FA.

Cancer Lett. 2007 Nov 18;257(2):191-8. Epub 2007 Aug 31.

PMID:
17765393
34.

Tamoxifen, soy, and lifestyle factors in Asian American women with breast cancer.

Wu AH, Pike MC, Williams LD, Spicer D, Tseng CC, Churchwell MI, Doerge DR.

J Clin Oncol. 2007 Jul 20;25(21):3024-30. Epub 2007 May 29. Erratum in: J Clin Oncol. 2007 Oct 20;25(30):4862.

PMID:
17536081
35.

DNA adduct formation in the livers of female Sprague-Dawley rats treated with toremifene or alpha-hydroxytoremifene.

Gamboa da Costa G, Pereira PC, Churchwell MI, Beland FA, Marques MM.

Chem Res Toxicol. 2007 Feb;20(2):300-10. Epub 2007 Jan 30.

PMID:
17261033
36.

Cytogenetic damage induced by acrylamide and glycidamide in mammalian cells: correlation with specific glycidamide-DNA adducts.

Martins C, Oliveira NG, Pingarilho M, Gamboa da Costa G, Martins V, Marques MM, Beland FA, Churchwell MI, Doerge DR, Rueff J, Gaspar JF.

Toxicol Sci. 2007 Feb;95(2):383-90. Epub 2006 Nov 6.

PMID:
17088317
37.

Relationships between biomarkers of exposure and toxicokinetics in Fischer 344 rats and B6C3F1 mice administered single doses of acrylamide and glycidamide and multiple doses of acrylamide.

Tareke E, Twaddle NC, McDaniel LP, Churchwell MI, Young JF, Doerge DR.

Toxicol Appl Pharmacol. 2006 Nov 15;217(1):63-75. Epub 2006 Aug 15.

PMID:
17007897
38.

Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.

Putt KS, Chen GW, Pearson JM, Sandhorst JS, Hoagland MS, Kwon JT, Hwang SK, Jin H, Churchwell MI, Cho MH, Doerge DR, Helferich WG, Hergenrother PJ.

Nat Chem Biol. 2006 Oct;2(10):543-50. Epub 2006 Aug 27.

PMID:
16936720
39.

Quantification of O6-methyl and O6-ethyl deoxyguanosine adducts in C57BL/6N/Tk+/- mice using LC/MS/MS.

Churchwell MI, Beland FA, Doerge DR.

J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Nov 21;844(1):60-6. Epub 2006 Aug 22.

PMID:
16931193
40.
41.

Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis.

Tryndyak VP, Muskhelishvili L, Kovalchuk O, Rodriguez-Juarez R, Montgomery B, Churchwell MI, Ross SA, Beland FA, Pogribny IP.

Carcinogenesis. 2006 Aug;27(8):1713-20. Epub 2006 Apr 22.

PMID:
16632870
42.

Lactational transfer of the soy isoflavone, genistein, in Sprague-Dawley rats consuming dietary genistein.

Doerge DR, Twaddle NC, Churchwell MI, Newbold RR, Delclos KB.

Reprod Toxicol. 2006 Apr;21(3):307-12. Epub 2005 Oct 28. Erratum in: Reprod Toxicol. 2010 Nov;30(3):493.

PMID:
16257506
43.

Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized BALB/c mice.

Allred CD, Twaddle NC, Allred KF, Goeppinger TS, Churchwell MI, Ju YH, Helferich WG, Doerge DR.

J Agric Food Chem. 2005 Nov 2;53(22):8542-50.

PMID:
16248551
44.

Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats.

Doerge DR, Young JF, McDaniel LP, Twaddle NC, Churchwell MI.

Toxicol Appl Pharmacol. 2005 Nov 1;208(3):199-209.

PMID:
16239164
45.

Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts.

Ghanayem BI, McDaniel LP, Churchwell MI, Twaddle NC, Snyder R, Fennell TR, Doerge DR.

Toxicol Sci. 2005 Dec;88(2):311-8. Epub 2005 Sep 1.

PMID:
16141435
46.

High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of benzo[a]pyrene-DNA adducts.

Beland FA, Churchwell MI, Von Tungeln LS, Chen S, Fu PP, Culp SJ, Schoket B, Gyorffy E, Minárovits J, Poirier MC, Bowman ED, Weston A, Doerge DR.

Chem Res Toxicol. 2005 Aug;18(8):1306-15.

PMID:
16097804
47.

Metabolism of pigment yellow 74 by rat and human microsomal proteins.

Cui Y, Churchwell MI, Couch LH, Doerge DR, Howard PC.

Drug Metab Dispos. 2005 Oct;33(10):1459-65. Epub 2005 Jul 13.

PMID:
16014769
48.

Improving LC-MS sensitivity through increases in chromatographic performance: comparisons of UPLC-ES/MS/MS to HPLC-ES/MS/MS.

Churchwell MI, Twaddle NC, Meeker LR, Doerge DR.

J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Oct 25;825(2):134-43. Epub 2005 Jul 5.

PMID:
16002352
49.

Hepatic DNA adduct dosimetry in rats fed tamoxifen: a comparison of methods.

Schild LJ, Phillips DH, Osborne MR, Hewer A, Beland FA, Churchwell MI, Brown K, Gaskell M, Wright E, Poirier MC.

Mutagenesis. 2005 Mar;20(2):115-24. Epub 2005 Mar 8.

PMID:
15755801
50.

DNA adducts derived from administration of acrylamide and glycidamide to mice and rats.

Doerge DR, Gamboa da Costa G, McDaniel LP, Churchwell MI, Twaddle NC, Beland FA.

Mutat Res. 2005 Feb 7;580(1-2):131-41.

PMID:
15668115

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