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Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance.

Churchill GC, Strupp M, Galione A, Platt FM.

PLoS One. 2020 Feb 27;15(2):e0229585. doi: 10.1371/journal.pone.0229585. eCollection 2020.


The putative lithium-mimetic ebselen reduces impulsivity in rodent models.

Barkus C, Ferland JN, Adams WK, Churchill GC, Cowen PJ, Bannerman DM, Rogers RD, Winstanley CA, Sharp T.

J Psychopharmacol. 2018 Sep;32(9):1018-1026. doi: 10.1177/0269881118784876. Epub 2018 Jul 10.


Plasma glutathione suggests oxidative stress is equally present in early- and late-onset bipolar disorder.

Singh N, McMahon H, Bilderbeck A, Reed ZE, Tunbridge E, Brett D, Geddes JR, Churchill GC, Goodwin GM.

Bipolar Disord. 2019 Feb;21(1):61-67. doi: 10.1111/bdi.12640. Epub 2018 Mar 30.


Ebselen has lithium-like effects on central 5-HT2A receptor function.

Antoniadou I, Kouskou M, Arsiwala T, Singh N, Vasudevan SR, Fowler T, Cadirci E, Churchill GC, Sharp T.

Br J Pharmacol. 2018 Jul;175(13):2599-2610. doi: 10.1111/bph.14179. Epub 2018 May 22.


Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.

Fernández B, Fdez E, Gómez-Suaga P, Gil F, Molina-Villalba I, Ferrer I, Patel S, Churchill GC, Hilfiker S.

Autophagy. 2016 Sep;12(9):1487-506. doi: 10.1080/15548627.2016.1190072. Epub 2016 Jul 6.


Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.

Masaki C, Sharpley AL, Cooper CM, Godlewska BR, Singh N, Vasudevan SR, Harmer CJ, Churchill GC, Sharp T, Rogers RD, Cowen PJ.

Psychopharmacology (Berl). 2016 Jul;233(14):2655-61. doi: 10.1007/s00213-016-4319-5. Epub 2016 Jun 2.


Effects of the potential lithium-mimetic, ebselen, on brain neurochemistry: a magnetic resonance spectroscopy study at 7 tesla.

Masaki C, Sharpley AL, Godlewska BR, Berrington A, Hashimoto T, Singh N, Vasudevan SR, Emir UE, Churchill GC, Cowen PJ.

Psychopharmacology (Berl). 2016 Mar;233(6):1097-104. doi: 10.1007/s00213-015-4189-2. Epub 2016 Jan 12.


Endoplasmic reticulum and lysosomal Ca²⁺ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts.

Kilpatrick BS, Magalhaes J, Beavan MS, McNeill A, Gegg ME, Cleeter MW, Bloor-Young D, Churchill GC, Duchen MR, Schapira AH, Patel S.

Cell Calcium. 2016 Jan;59(1):12-20. doi: 10.1016/j.ceca.2015.11.002. Epub 2015 Nov 26.


Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans.

Singh N, Sharpley AL, Emir UE, Masaki C, Herzallah MM, Gluck MA, Sharp T, Harmer CJ, Vasudevan SR, Cowen PJ, Churchill GC.

Neuropsychopharmacology. 2016 Jun;41(7):1768-78. doi: 10.1038/npp.2015.343. Epub 2015 Nov 23.


Release of calcium from endolysosomes increases calcium influx through N-type calcium channels: Evidence for acidic store-operated calcium entry in neurons.

Hui L, Geiger NH, Bloor-Young D, Churchill GC, Geiger JD, Chen X.

Cell Calcium. 2015 Dec;58(6):617-27. doi: 10.1016/j.ceca.2015.10.001. Epub 2015 Oct 9.


Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.

Capel RA, Bolton EL, Lin WK, Aston D, Wang Y, Liu W, Wang X, Burton RA, Bloor-Young D, Shade KT, Ruas M, Parrington J, Churchill GC, Lei M, Galione A, Terrar DA.

J Biol Chem. 2015 Dec 11;290(50):30087-98. doi: 10.1074/jbc.M115.684076. Epub 2015 Oct 5.


Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.

J Biol Chem. 2015 Aug 28;290(35):21376-92. doi: 10.1074/jbc.M115.671248. Epub 2015 Jul 7.


Scaffold hopping with virtual screening from IP3 to a drug-like partial agonist of the inositol trisphosphate receptor.

Vasudevan SR, Singh N, Churchill GC.

Chembiochem. 2014 Dec 15;15(18):2774-82. doi: 10.1002/cbic.201402440. Epub 2014 Nov 14.


Synthesis of caged NAADP.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot076943. doi: 10.1101/pdb.prot076943.


Measurement of luminal pH of acidic stores as a readout for NAADP action.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot076935. doi: 10.1101/pdb.prot076935.


Synthesis of NAADP-AM as a membrane-permeant NAADP analog.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot076927. doi: 10.1101/pdb.prot076927.


Synthesis of [³²P]NAADP for the radioreceptor binding assay.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Sep 2;2014(9):993-5. doi: 10.1101/pdb.prot076919.


Preparation and use of sea urchin egg homogenates for studying NAADP-mediated Ca²⁺ release.

Galione A, Chuang KT, Funnell TM, Davis LC, Morgan AJ, Ruas M, Parrington J, Churchill GC.

Cold Spring Harb Protoc. 2014 Sep 2;2014(9):988-92. doi: 10.1101/pdb.prot076901.


Discovery of novel GPVI receptor antagonists by structure-based repurposing.

Taylor L, Vasudevan SR, Jones CI, Gibbins JM, Churchill GC, Campbell RD, Coxon CH.

PLoS One. 2014 Jun 27;9(6):e101209. doi: 10.1371/journal.pone.0101209. eCollection 2014.


Altered plasma glutathione levels in bipolar disorder indicates higher oxidative stress; a possible risk factor for illness onset despite normal brain-derived neurotrophic factor (BDNF) levels.

Rosa AR, Singh N, Whitaker E, de Brito M, Lewis AM, Vieta E, Churchill GC, Geddes JR, Goodwin GM.

Psychol Med. 2014 Aug;44(11):2409-18. doi: 10.1017/S0033291714000014. Epub 2014 Jan 27.


Characterization of NAADP-mediated calcium signaling in human spermatozoa.

Sánchez-Tusie AA, Vasudevan SR, Churchill GC, Nishigaki T, Treviño CL.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):531-6. doi: 10.1016/j.bbrc.2013.12.011. Epub 2013 Dec 8.


The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.

Jagannath A, Butler R, Godinho SIH, Couch Y, Brown LA, Vasudevan SR, Flanagan KC, Anthony D, Churchill GC, Wood MJA, Steiner G, Ebeling M, Hossbach M, Wettstein JG, Duffield GE, Gatti S, Hankins MW, Foster RG, Peirson SN.

Cell. 2013 Aug 29;154(5):1100-1111. doi: 10.1016/j.cell.2013.08.004.


Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles.

Morgan AJ, Davis LC, Wagner SK, Lewis AM, Parrington J, Churchill GC, Galione A.

J Cell Biol. 2013 Mar 18;200(6):789-805. doi: 10.1083/jcb.201204078. Epub 2013 Mar 11.


Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger in muscarinic receptor-induced contraction of guinea pig trachea.

Aley PK, Singh N, Brailoiu GC, Brailoiu E, Churchill GC.

J Biol Chem. 2013 Apr 19;288(16):10986-93. doi: 10.1074/jbc.M113.458620. Epub 2013 Mar 6.


A safe lithium mimetic for bipolar disorder.

Singh N, Halliday AC, Thomas JM, Kuznetsova OV, Baldwin R, Woon EC, Aley PK, Antoniadou I, Sharp T, Vasudevan SR, Churchill GC.

Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320.


NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.

Davis LC, Morgan AJ, Chen JL, Snead CM, Bloor-Young D, Shenderov E, Stanton-Humphreys MN, Conway SJ, Churchill GC, Parrington J, Cerundolo V, Galione A.

Curr Biol. 2012 Dec 18;22(24):2331-7. doi: 10.1016/j.cub.2012.10.035. Epub 2012 Nov 21.


Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens.

Singh N, Halliday AC, Knight M, Lack NA, Lowe E, Churchill GC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1149-52. doi: 10.1107/S1744309112035191. Epub 2012 Sep 22.


β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart.

Lewis AM, Aley PK, Roomi A, Thomas JM, Masgrau R, Garnham C, Shipman K, Paramore C, Bloor-Young D, Sanders LE, Terrar DA, Galione A, Churchill GC.

Biochem Biophys Res Commun. 2012 Oct 19;427(2):326-9. doi: 10.1016/j.bbrc.2012.09.054. Epub 2012 Sep 18.


A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.

Gómez-Suaga P, Churchill GC, Patel S, Hilfiker S.

Biochem Soc Trans. 2012 Oct;40(5):1140-6. Review.


Shape-based reprofiling of FDA-approved drugs for the H₁ histamine receptor.

Vasudevan SR, Moore JB, Schymura Y, Churchill GC.

J Med Chem. 2012 Aug 23;55(16):7054-60. doi: 10.1021/jm300671m. Epub 2012 Aug 6.


Synthesis and use of cell-permeant cyclic ADP-ribose.

Rosen D, Bloor-Young D, Squires J, Parkesh R, Waters G, Vasudevan SR, Lewis AM, Churchill GC.

Biochem Biophys Res Commun. 2012 Feb 10;418(2):353-8. doi: 10.1016/j.bbrc.2012.01.025. Epub 2012 Jan 17.


Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP.

Gómez-Suaga P, Luzón-Toro B, Churamani D, Zhang L, Bloor-Young D, Patel S, Woodman PG, Churchill GC, Hilfiker S.

Hum Mol Genet. 2012 Feb 1;21(3):511-25. doi: 10.1093/hmg/ddr481. Epub 2011 Oct 19.


NAADP regulates human platelet function.

Coxon CH, Lewis AM, Sadler AJ, Vasudevan SR, Thomas A, Dundas KA, Taylor L, Campbell RD, Gibbins JM, Churchill GC, Tucker KL.

Biochem J. 2012 Jan 1;441(1):435-42. doi: 10.1042/BJ20111175.


NAADP influences excitation-contraction coupling by releasing calcium from lysosomes in atrial myocytes.

Collins TP, Bayliss R, Churchill GC, Galione A, Terrar DA.

Cell Calcium. 2011 Nov;50(5):449-58. doi: 10.1016/j.ceca.2011.07.007. Epub 2011 Sep 8.


NAADP mediates ATP-induced Ca2+ signals in astrocytes.

Barceló-Torns M, Lewis AM, Gubern A, Barneda D, Bloor-Young D, Picatoste F, Churchill GC, Claro E, Masgrau R.

FEBS Lett. 2011 Jul 21;585(14):2300-6. doi: 10.1016/j.febslet.2011.05.062. Epub 2011 Jun 6.


NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells.

Esposito B, Gambara G, Lewis AM, Palombi F, D'Alessio A, Taylor LX, Genazzani AA, Ziparo E, Galione A, Churchill GC, Filippini A.

Blood. 2011 May 5;117(18):4968-77. doi: 10.1182/blood-2010-02-266338. Epub 2011 Mar 1.


Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channels.

Aley PK, Mikolajczyk AM, Munz B, Churchill GC, Galione A, Berger F.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19927-32. doi: 10.1073/pnas.1007381107. Epub 2010 Nov 1. Erratum in: Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5139.


Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure.

Brailoiu GC, Gurzu B, Gao X, Parkesh R, Aley PK, Trifa DI, Galione A, Dun NJ, Madesh M, Patel S, Churchill GC, Brailoiu E.

J Biol Chem. 2010 Nov 26;285(48):37133-7. doi: 10.1074/jbc.C110.169763. Epub 2010 Sep 27.


TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+.

Pitt SJ, Funnell TM, Sitsapesan M, Venturi E, Rietdorf K, Ruas M, Ganesan A, Gosain R, Churchill GC, Zhu MX, Parrington J, Galione A, Sitsapesan R.

J Biol Chem. 2010 Nov 5;285(45):35039-46. doi: 10.1074/jbc.M110.156927. Epub 2010 Aug 18.


The calcium-mobilizing messenger nicotinic acid adenine dinucleotide phosphate participates in sperm activation by mediating the acrosome reaction.

Vasudevan SR, Lewis AM, Chan JW, Machin CL, Sinha D, Galione A, Churchill GC.

J Biol Chem. 2010 Jun 11;285(24):18262-9. doi: 10.1074/jbc.M109.087858. Epub 2010 Apr 16.


Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.

Ruas M, Rietdorf K, Arredouani A, Davis LC, Lloyd-Evans E, Koegel H, Funnell TM, Morgan AJ, Ward JA, Watanabe K, Cheng X, Churchill GC, Zhu MX, Platt FM, Wessel GM, Parrington J, Galione A.

Curr Biol. 2010 Apr 27;20(8):703-9. doi: 10.1016/j.cub.2010.02.049. Epub 2010 Mar 25.


A functional role for nicotinic acid adenine dinucleotide phosphate in oxytocin-mediated contraction of uterine smooth muscle from rat.

Aley PK, Noh HJ, Gao X, Tica AA, Brailoiu E, Churchill GC.

J Pharmacol Exp Ther. 2010 Jun;333(3):726-35. doi: 10.1124/jpet.110.165837. Epub 2010 Mar 19.


Deviant nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated Ca2+ signaling upon lysosome proliferation.

Dickinson GD, Churchill GC, Brailoiu E, Patel S.

J Biol Chem. 2010 Apr 30;285(18):13321-5. doi: 10.1074/jbc.C110.112573. Epub 2010 Mar 15.


Fluorescent copper(II) bis(thiosemicarbazonates): synthesis, structures, electron paramagnetic resonance, radiolabeling, in vitro cytotoxicity and confocal fluorescence microscopy studies.

Pascu SI, Waghorn PA, Kennedy BW, Arrowsmith RL, Bayly SR, Dilworth JR, Christlieb M, Tyrrell RM, Zhong J, Kowalczyk RM, Collison D, Aley PK, Churchill GC, Aigbirhio FI.

Chem Asian J. 2010 Mar 1;5(3):506-19. doi: 10.1002/asia.200900446.


Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor.

Rosen D, Lewis AM, Mizote A, Thomas JM, Aley PK, Vasudevan SR, Parkesh R, Galione A, Izumi M, Ganesan A, Churchill GC.

J Biol Chem. 2009 Dec 11;284(50):34930-4. doi: 10.1074/jbc.M109.016519. Epub 2009 Oct 13.


Mining free compound databases to identify candidates selected by virtual screening.

Vasudevan SR, Churchill GC.

Expert Opin Drug Discov. 2009 Sep;4(9):901-6. doi: 10.1517/17460440903190953. Epub 2009 Aug 1.


Recruitment of NAADP-sensitive acidic Ca2+ stores by glutamate.

Pandey V, Chuang CC, Lewis AM, Aley PK, Brailoiu E, Dun NJ, Churchill GC, Patel S.

Biochem J. 2009 Aug 27;422(3):503-12. doi: 10.1042/BJ20090194.


NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles.

Thai TL, Churchill GC, Arendshorst WJ.

Am J Physiol Renal Physiol. 2009 Aug;297(2):F510-6. doi: 10.1152/ajprenal.00116.2009. Epub 2009 May 13.


NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice.

Leiter EH, Reifsnyder PC, Wallace R, Li R, King B, Churchill GC.

Diabetes. 2009 Jul;58(7):1700-3. doi: 10.2337/db09-0120. Epub 2009 Mar 31.


Identification of a chemical probe for NAADP by virtual screening.

Naylor E, Arredouani A, Vasudevan SR, Lewis AM, Parkesh R, Mizote A, Rosen D, Thomas JM, Izumi M, Ganesan A, Galione A, Churchill GC.

Nat Chem Biol. 2009 Apr;5(4):220-6. doi: 10.1038/nchembio.150. Epub 2009 Feb 22.

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