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Items: 1 to 50 of 221

1.

Erratum: "Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity".

French JE, Gatti DM, Morgan DL, Kissling GE, Shockley KR, Knudsen GA, Shepard KG, Price HC, King D, Witt KL, Pedersen LC, Munger SC, Svenson KL, Churchill GA.

Environ Health Perspect. 2018 Jun 27;126(6):069003. doi: 10.1289/EHP3950. eCollection 2018 Jun.

2.

Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.

Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MTG, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525e.

PMID:
29634685
3.

Genetic Drivers of Pancreatic Islet Function.

Keller MP, Gatti DM, Schueler KL, Rabaglia ME, Stapleton DS, Simecek P, Vincent M, Allen S, Broman AT, Bacher R, Kendziorski C, Broman KW, Yandell BS, Churchill GA, Attie AD.

Genetics. 2018 May;209(1):335-356. doi: 10.1534/genetics.118.300864. Epub 2018 Mar 22.

PMID:
29567659
4.

Hierarchical analysis of RNA-seq reads improves the accuracy of allele-specific expression.

Raghupathy N, Choi K, Vincent MJ, Beane GL, Sheppard KS, Munger SC, Korstanje R, Pardo-Manual de Villena F, Churchill GA.

Bioinformatics. 2018 Jul 1;34(13):2177-2184. doi: 10.1093/bioinformatics/bty078.

PMID:
29444201
5.

High-Resolution Maps of Mouse Reference Populations.

Simecek P, Forejt J, Williams RW, Shiroishi T, Takada T, Lu L, Johnson TE, Bennett B, Deschepper CF, Scott-Boyer MP, Pardo-Manuel de Villena F, Churchill GA.

G3 (Bethesda). 2017 Oct 5;7(10):3427-3434. doi: 10.1534/g3.117.300188.

6.

Genetic background influences susceptibility to chemotherapy-induced hematotoxicity.

Gatti DM, Weber SN, Goodwin NC, Lammert F, Churchill GA.

Pharmacogenomics J. 2018 Apr;18(2):319-330. doi: 10.1038/tpj.2017.23. Epub 2017 Jun 13.

7.

Epistatic Networks Jointly Influence Phenotypes Related to Metabolic Disease and Gene Expression in Diversity Outbred Mice.

Tyler AL, Ji B, Gatti DM, Munger SC, Churchill GA, Svenson KL, Carter GW.

Genetics. 2017 Jun;206(2):621-639. doi: 10.1534/genetics.116.198051.

8.

Structural Variation Shapes the Landscape of Recombination in Mouse.

Morgan AP, Gatti DM, Najarian ML, Keane TM, Galante RJ, Pack AI, Mott R, Churchill GA, de Villena FP.

Genetics. 2017 Jun;206(2):603-619. doi: 10.1534/genetics.116.197988.

9.

Genomes of the Mouse Collaborative Cross.

Srivastava A, Morgan AP, Najarian ML, Sarsani VK, Sigmon JS, Shorter JR, Kashfeen A, McMullan RC, Williams LH, Giusti-Rodríguez P, Ferris MT, Sullivan P, Hock P, Miller DR, Bell TA, McMillan L, Churchill GA, de Villena FP.

Genetics. 2017 Jun;206(2):537-556. doi: 10.1534/genetics.116.198838.

10.

How mice are indispensable for understanding obesity and diabetes genetics.

Attie AD, Churchill GA, Nadeau JH.

Curr Opin Endocrinol Diabetes Obes. 2017 Apr;24(2):83-91. doi: 10.1097/MED.0000000000000321. Review.

11.

Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer.

Winter JM, Gildea DE, Andreas JP, Gatti DM, Williams KA, Lee M, Hu Y, Zhang S; NISC Comparative Sequencing Program, Mullikin JC, Wolfsberg TG, McDonnell SK, Fogarty ZC, Larson MC, French AJ, Schaid DJ, Thibodeau SN, Churchill GA, Crawford NP.

Cell Syst. 2017 Jan 25;4(1):31-45.e6. doi: 10.1016/j.cels.2016.10.018. Epub 2016 Dec 1.

12.

Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection.

Chesler EJ, Gatti DM, Morgan AP, Strobel M, Trepanier L, Oberbeck D, McWeeney S, Hitzemann R, Ferris M, McMullan R, Clayshultle A, Bell TA, Manuel de Villena FP, Churchill GA.

G3 (Bethesda). 2016 Dec 7;6(12):3893-3902. doi: 10.1534/g3.116.035527.

13.

Defining the consequences of genetic variation on a proteome-wide scale.

Chick JM, Munger SC, Simecek P, Huttlin EL, Choi K, Gatti DM, Raghupathy N, Svenson KL, Churchill GA, Gygi SP.

Nature. 2016 Jun 23;534(7608):500-5. doi: 10.1038/nature18270. Epub 2016 Jun 15.

14.

Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.

Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S.

Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115. Epub 2016 Jun 6. Erratum in: Nat Med. 2018 Apr 10;24(4):525.

15.

Eric Lander and David Botstein on Mapping Quantitative Traits.

Churchill GA.

Genetics. 2016 May;203(1):1-3. doi: 10.1534/genetics.116.189803. Epub 2016 May 5. No abstract available.

16.

R2d2 Drives Selfish Sweeps in the House Mouse.

Didion JP, Morgan AP, Yadgary L, Bell TA, McMullan RC, Ortiz de Solorzano L, Britton-Davidian J, Bult CJ, Campbell KJ, Castiglia R, Ching YH, Chunco AJ, Crowley JJ, Chesler EJ, Förster DW, French JE, Gabriel SI, Gatti DM, Garland T Jr, Giagia-Athanasopoulou EB, Giménez MD, Grize SA, Gündüz İ, Holmes A, Hauffe HC, Herman JS, Holt JM, Hua K, Jolley WJ, Lindholm AK, López-Fuster MJ, Mitsainas G, da Luz Mathias M, McMillan L, Ramalhinho Mda G, Rehermann B, Rosshart SP, Searle JB, Shiao MS, Solano E, Svenson KL, Thomas-Laemont P, Threadgill DW, Ventura J, Weinstock GM, Pomp D, Churchill GA, Pardo-Manuel de Villena F.

Mol Biol Evol. 2016 Jun;33(6):1381-95. doi: 10.1093/molbev/msw036. Epub 2016 Feb 15.

17.

Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross.

Tyler AL, Donahue LR, Churchill GA, Carter GW.

PLoS Genet. 2016 Feb 1;12(2):e1005805. doi: 10.1371/journal.pgen.1005805. eCollection 2016 Feb.

18.

The Mouse Universal Genotyping Array: From Substrains to Subspecies.

Morgan AP, Fu CP, Kao CY, Welsh CE, Didion JP, Yadgary L, Hyacinth L, Ferris MT, Bell TA, Miller DR, Giusti-Rodriguez P, Nonneman RJ, Cook KD, Whitmire JK, Gralinski LE, Keller M, Attie AD, Churchill GA, Petkov P, Sullivan PF, Brennan JR, McMillan L, Pardo-Manuel de Villena F.

G3 (Bethesda). 2015 Dec 18;6(2):263-79. doi: 10.1534/g3.115.022087.

19.

Genetic Architectures of Quantitative Variation in RNA Editing Pathways.

Gu T, Gatti DM, Srivastava A, Snyder EM, Raghupathy N, Simecek P, Svenson KL, Dotu I, Chuang JH, Keller MP, Attie AD, Braun RE, Churchill GA.

Genetics. 2016 Feb;202(2):787-98. doi: 10.1534/genetics.115.179481. Epub 2015 Nov 27.

20.

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.

Gralinski LE, Ferris MT, Aylor DL, Whitmore AC, Green R, Frieman MB, Deming D, Menachery VD, Miller DR, Buus RJ, Bell TA, Churchill GA, Threadgill DW, Katze MG, McMillan L, Valdar W, Heise MT, Pardo-Manuel de Villena F, Baric RS.

PLoS Genet. 2015 Oct 9;11(10):e1005504. doi: 10.1371/journal.pgen.1005504. eCollection 2015 Oct.

21.

Genetic properties of the MAGIC maize population: a new platform for high definition QTL mapping in Zea mays.

Dell'Acqua M, Gatti DM, Pea G, Cattonaro F, Coppens F, Magris G, Hlaing AL, Aung HH, Nelissen H, Baute J, Frascaroli E, Churchill GA, Inzé D, Morgante M, Pè ME.

Genome Biol. 2015 Sep 11;16:167. doi: 10.1186/s13059-015-0716-z.

22.

Identification of microRNAs associated with allergic airway disease using a genetically diverse mouse population.

Rutledge H, Baran-Gale J, de Villena FP, Chesler EJ, Churchill GA, Sethupathy P, Kelada SN.

BMC Genomics. 2015 Aug 25;16:633. doi: 10.1186/s12864-015-1732-9.

23.

Collaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database.

Bogue MA, Churchill GA, Chesler EJ.

Mamm Genome. 2015 Oct;26(9-10):511-20. doi: 10.1007/s00335-015-9595-6. Epub 2015 Aug 19.

24.

High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping.

Rau CD, Parks B, Wang Y, Eskin E, Simecek P, Churchill GA, Lusis AJ.

G3 (Bethesda). 2015 Jul 28;5(10):2021-6. doi: 10.1534/g3.115.020784.

25.

Aging Research Using Mouse Models.

Ackert-Bicknell CL, Anderson LC, Sheehan S, Hill WG, Chang B, Churchill GA, Chesler EJ, Korstanje R, Peters LL.

Curr Protoc Mouse Biol. 2015 Jun 1;5(2):95-133. doi: 10.1002/9780470942390.mo140195.

26.

Genetic Analysis of Substrain Divergence in Non-Obese Diabetic (NOD) Mice.

Simecek P, Churchill GA, Yang H, Rowe LB, Herberg L, Serreze DV, Leiter EH.

G3 (Bethesda). 2015 Mar 3;5(5):771-5. doi: 10.1534/g3.115.017046.

27.

A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.

Didion JP, Morgan AP, Clayshulte AM, Mcmullan RC, Yadgary L, Petkov PM, Bell TA, Gatti DM, Crowley JJ, Hua K, Aylor DL, Bai L, Calaway M, Chesler EJ, French JE, Geiger TR, Gooch TJ, Garland T Jr, Harrill AH, Hunter K, McMillan L, Holt M, Miller DR, O'Brien DA, Paigen K, Pan W, Rowe LB, Shaw GD, Simecek P, Sullivan PF, Svenson KL, Weinstock GM, Threadgill DW, Pomp D, Churchill GA, Pardo-Manuel de Villena F.

PLoS Genet. 2015 Feb 13;11(2):e1004850. doi: 10.1371/journal.pgen.1004850. eCollection 2015 Feb.

28.

Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span.

Bogue MA, Peters LL, Paigen B, Korstanje R, Yuan R, Ackert-Bicknell C, Grubb SC, Churchill GA, Chesler EJ.

J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):170-7. doi: 10.1093/gerona/glu223. Epub 2014 Dec 22.

29.

Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice.

Church RJ, Gatti DM, Urban TJ, Long N, Yang X, Shi Q, Eaddy JS, Mosedale M, Ballard S, Churchill GA, Navarro V, Watkins PB, Threadgill DW, Harrill AH.

Food Chem Toxicol. 2015 Feb;76:19-26. doi: 10.1016/j.fct.2014.11.008. Epub 2014 Nov 28.

30.

Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity.

French JE, Gatti DM, Morgan DL, Kissling GE, Shockley KR, Knudsen GA, Shepard KG, Price HC, King D, Witt KL, Pedersen LC, Munger SC, Svenson KL, Churchill GA.

Environ Health Perspect. 2015 Mar;123(3):237-45. doi: 10.1289/ehp.1408202. Epub 2014 Nov 6.

31.

When are results too good to be true?

Churchill GA.

Genetics. 2014 Oct;198(2):447-8. doi: 10.1534/genetics.114.169912. No abstract available.

32.

Quantitative trait locus mapping methods for diversity outbred mice.

Gatti DM, Svenson KL, Shabalin A, Wu LY, Valdar W, Simecek P, Goodwin N, Cheng R, Pomp D, Palmer A, Chesler EJ, Broman KW, Churchill GA.

G3 (Bethesda). 2014 Sep 18;4(9):1623-33. doi: 10.1534/g3.114.013748.

33.

RNA-Seq alignment to individualized genomes improves transcript abundance estimates in multiparent populations.

Munger SC, Raghupathy N, Choi K, Simons AK, Gatti DM, Hinerfeld DA, Svenson KL, Keller MP, Attie AD, Hibbs MA, Graber JH, Chesler EJ, Churchill GA.

Genetics. 2014 Sep;198(1):59-73. doi: 10.1534/genetics.114.165886.

34.

Genetic regulation of Zfp30, CXCL1, and neutrophilic inflammation in murine lung.

Rutledge H, Aylor DL, Carpenter DE, Peck BC, Chines P, Ostrowski LE, Chesler EJ, Churchill GA, de Villena FP, Kelada SN.

Genetics. 2014 Oct;198(2):735-45. doi: 10.1534/genetics.114.168138. Epub 2014 Aug 11.

35.

Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1.

Yuan R, Gatti DM, Krier R, Malay E, Schultz D, Peters LL, Churchill GA, Harrison DE, Paigen B.

J Gerontol A Biol Sci Med Sci. 2015 Jul;70(7):817-26. doi: 10.1093/gerona/glu114. Epub 2014 Jul 28.

36.

Spontaneous voiding by mice reveals strain-specific lower urinary tract function to be a quantitative genetic trait.

Yu W, Ackert-Bicknell C, Larigakis JD, MacIver B, Steers WD, Churchill GA, Hill WG, Zeidel ML.

Am J Physiol Renal Physiol. 2014 Jun 1;306(11):F1296-307. doi: 10.1152/ajprenal.00074.2014. Epub 2014 Apr 9.

37.

Precise genetic mapping and integrative bioinformatics in Diversity Outbred mice reveals Hydin as a novel pain gene.

Recla JM, Robledo RF, Gatti DM, Bult CJ, Churchill GA, Chesler EJ.

Mamm Genome. 2014 Jun;25(5-6):211-22. doi: 10.1007/s00335-014-9508-0. Epub 2014 Apr 5.

38.

Integrative genetic analysis of allergic inflammation in the murine lung.

Kelada SN, Carpenter DE, Aylor DL, Chines P, Rutledge H, Chesler EJ, Churchill GA, Pardo-Manuel de Villena F, Schwartz DA, Collins FS.

Am J Respir Cell Mol Biol. 2014 Sep;51(3):436-45. doi: 10.1165/rcmb.2013-0501OC.

39.

High-resolution sex-specific linkage maps of the mouse reveal polarized distribution of crossovers in male germline.

Liu EY, Morgan AP, Chesler EJ, Wang W, Churchill GA, Pardo-Manuel de Villena F.

Genetics. 2014 May;197(1):91-106. doi: 10.1534/genetics.114.161653. Epub 2014 Feb 27.

40.

Misleading results: don't blame the mice.

Churchill GA.

Science. 2014 Jan 24;343(6169):370. doi: 10.1126/science.343.6169.370-a. No abstract available.

PMID:
24458625
41.

Relationship between obesity phenotypes and genetic determinants in a mouse model for juvenile obesity.

Brockmann GA, Schäfer N, Hesse C, Heise S, Neuschl C, Wagener A, Churchill GA, Li R.

Physiol Genomics. 2013 Sep 16;45(18):817-26. doi: 10.1152/physiolgenomics.00058.2013. Epub 2013 Aug 6.

PMID:
23922126
42.

Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.

Ferris MT, Aylor DL, Bottomly D, Whitmore AC, Aicher LD, Bell TA, Bradel-Tretheway B, Bryan JT, Buus RJ, Gralinski LE, Haagmans BL, McMillan L, Miller DR, Rosenzweig E, Valdar W, Wang J, Churchill GA, Threadgill DW, McWeeney SK, Katze MG, Pardo-Manuel de Villena F, Baric RS, Heise MT.

PLoS Pathog. 2013 Feb;9(2):e1003196. doi: 10.1371/journal.ppat.1003196. Epub 2013 Feb 28.

43.

High-precision genetic mapping of behavioral traits in the diversity outbred mouse population.

Logan RW, Robledo RF, Recla JM, Philip VM, Bubier JA, Jay JJ, Harwood C, Wilcox T, Gatti DM, Bult CJ, Churchill GA, Chesler EJ.

Genes Brain Behav. 2013 Jun;12(4):424-37. doi: 10.1111/gbb.12029. Epub 2013 Mar 20.

44.

Pla2g12b and Hpn are genes identified by mouse ENU mutagenesis that affect HDL cholesterol.

Aljakna A, Choi S, Savage H, Hageman Blair R, Gu T, Svenson KL, Churchill GA, Hibbs M, Korstanje R.

PLoS One. 2012;7(8):e43139. doi: 10.1371/journal.pone.0043139. Epub 2012 Aug 17.

45.

The Diversity Outbred mouse population.

Churchill GA, Gatti DM, Munger SC, Svenson KL.

Mamm Genome. 2012 Oct;23(9-10):713-8. doi: 10.1007/s00335-012-9414-2. Epub 2012 Aug 15.

46.

Genetic analysis of albuminuria in collaborative cross and multiple mouse intercross populations.

Thaisz J, Tsaih SW, Feng M, Philip VM, Zhang Y, Yanas L, Sheehan S, Xu L, Miller DR, Paigen B, Chesler EJ, Churchill GA, Dipetrillo K.

Am J Physiol Renal Physiol. 2012 Oct;303(7):F972-81. doi: 10.1152/ajprenal.00690.2011. Epub 2012 Aug 1.

47.

Discovery of blood transcriptomic markers for depression in animal models and pilot validation in subjects with early-onset major depression.

Pajer K, Andrus BM, Gardner W, Lourie A, Strange B, Campo J, Bridge J, Blizinsky K, Dennis K, Vedell P, Churchill GA, Redei EE.

Transl Psychiatry. 2012 Apr 17;2:e101. doi: 10.1038/tp.2012.26.

48.

Using bioinformatics and systems genetics to dissect HDL-cholesterol genetics in an MRL/MpJ x SM/J intercross.

Leduc MS, Blair RH, Verdugo RA, Tsaih SW, Walsh K, Churchill GA, Paigen B.

J Lipid Res. 2012 Jun;53(6):1163-75. doi: 10.1194/jlr.M025833. Epub 2012 Apr 11.

49.

What can causal networks tell us about metabolic pathways?

Blair RH, Kliebenstein DJ, Churchill GA.

PLoS Comput Biol. 2012;8(4):e1002458. doi: 10.1371/journal.pcbi.1002458. Epub 2012 Apr 5.

50.

Adaptive evolution and effective population size in wild house mice.

Phifer-Rixey M, Bonhomme F, Boursot P, Churchill GA, Piálek J, Tucker PK, Nachman MW.

Mol Biol Evol. 2012 Oct;29(10):2949-55. Epub 2012 Apr 3.

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