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Items: 33

1.

Alteration of myocardial GRK2 produces a global metabolic phenotype.

Woodall BP, Gresham KS, Woodall MA, Valenti MC, Cannavo A, Pfleger J, Chuprun JK, Drosatos K, Koch WJ.

JCI Insight. 2019 Apr 4;5. pii: 123848. doi: 10.1172/jci.insight.123848.

2.

Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation.

Sato PY, Chuprun JK, Grisanti LA, Woodall MC, Brown BR, Roy R, Traynham CJ, Ibetti J, Lucchese AM, Yuan A, Drosatos K, Tilley DG, Gao E, Koch WJ.

Sci Signal. 2018 Dec 11;11(560). pii: eaau0144. doi: 10.1126/scisignal.aau0144.

3.

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity.

Eisner V, Cupo RR, Gao E, Csordás G, Slovinsky WS, Paillard M, Cheng L, Ibetti J, Chen SR, Chuprun JK, Hoek JB, Koch WJ, Hajnóczky G.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E859-E868. doi: 10.1073/pnas.1617288114. Epub 2017 Jan 17.

4.

A peptide of the RGS domain of GRK2 binds and inhibits Gα(q) to suppress pathological cardiac hypertrophy and dysfunction.

Schumacher SM, Gao E, Cohen M, Lieu M, Chuprun JK, Koch WJ.

Sci Signal. 2016 Mar 22;9(420):ra30. doi: 10.1126/scisignal.aae0549.

5.

Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy.

Traynham CJ, Cannavo A, Zhou Y, Vouga AG, Woodall BP, Hullmann J, Ibetti J, Gold JI, Chuprun JK, Gao E, Koch WJ.

Circ Res. 2015 Dec 4;117(12):1001-12. doi: 10.1161/CIRCRESAHA.115.306961. Epub 2015 Oct 29.

6.

GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels.

Sato PY, Chuprun JK, Ibetti J, Cannavo A, Drosatos K, Elrod JW, Koch WJ.

J Mol Cell Cardiol. 2015 Dec;89(Pt B):360-4. doi: 10.1016/j.yjmcc.2015.10.002. Epub 2015 Oct 23.

7.

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.

Shanmughapriya S, Rajan S, Hoffman NE, Higgins AM, Tomar D, Nemani N, Hines KJ, Smith DJ, Eguchi A, Vallem S, Shaikh F, Cheung M, Leonard NJ, Stolakis RS, Wolfers MP, Ibetti J, Chuprun JK, Jog NR, Houser SR, Koch WJ, Elrod JW, Madesh M.

Mol Cell. 2015 Oct 1;60(1):47-62. doi: 10.1016/j.molcel.2015.08.009. Epub 2015 Sep 17.

8.

The evolving impact of g protein-coupled receptor kinases in cardiac health and disease.

Sato PY, Chuprun JK, Schwartz M, Koch WJ.

Physiol Rev. 2015 Apr;95(2):377-404. doi: 10.1152/physrev.00015.2014. Review.

9.

Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction.

Schumacher SM, Gao E, Zhu W, Chen X, Chuprun JK, Feldman AM, Tesmer JJ, Koch WJ.

Sci Transl Med. 2015 Mar 4;7(277):277ra31. doi: 10.1126/scitranslmed.aaa0154.

10.

GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity.

Hullmann JE, Grisanti LA, Makarewich CA, Gao E, Gold JI, Chuprun JK, Tilley DG, Houser SR, Koch WJ.

Circ Res. 2014 Dec 5;115(12):976-85. doi: 10.1161/CIRCRESAHA.116.304475. Epub 2014 Oct 20.

11.

GRK2 in the heart: a GPCR kinase and beyond.

Huang ZM, Gao E, Chuprun JK, Koch WJ.

Antioxid Redox Signal. 2014 Nov 10;21(14):2032-43. doi: 10.1089/ars.2014.5876. Epub 2014 May 13. Review.

12.

p38α regulates SERCA2a function.

Kaikkonen L, Magga J, Ronkainen VP, Koivisto E, Perjes Á, Chuprun JK, Vinge LE, Kilpiö T, Aro J, Ulvila J, Alakoski T, Bibb JA, Szokodi I, Koch WJ, Ruskoaho H, Kerkelä R.

J Mol Cell Cardiol. 2014 Feb;67:86-93. doi: 10.1016/j.yjmcc.2013.12.005. Epub 2013 Dec 17.

13.

Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury.

Huang ZM, Gao E, Fonseca FV, Hayashi H, Shang X, Hoffman NE, Chuprun JK, Tian X, Tilley DG, Madesh M, Lefer DJ, Stamler JS, Koch WJ.

Sci Signal. 2013 Oct 29;6(299):ra95. doi: 10.1126/scisignal.2004225.

14.

Inhibition of Fas-associated death domain-containing protein (FADD) protects against myocardial ischemia/reperfusion injury in a heart failure mouse model.

Fan Q, Huang ZM, Boucher M, Shang X, Zuo L, Brinks H, Lau WB, Zhang J, Chuprun JK, Gao E.

PLoS One. 2013 Sep 13;8(9):e73537. doi: 10.1371/journal.pone.0073537. eCollection 2013.

15.

Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process.

Gold JI, Martini JS, Hullmann J, Gao E, Chuprun JK, Lee L, Tilley DG, Rabinowitz JE, Bossuyt J, Bers DM, Koch WJ.

PLoS One. 2013;8(3):e57324. doi: 10.1371/journal.pone.0057324. Epub 2013 Mar 5.

16.

Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting.

Chen M, Sato PY, Chuprun JK, Peroutka RJ, Otis NJ, Ibetti J, Pan S, Sheu SS, Gao E, Koch WJ.

Circ Res. 2013 Apr 12;112(8):1121-34. doi: 10.1161/CIRCRESAHA.112.300754. Epub 2013 Mar 6.

17.

Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.

Thal DM, Homan KT, Chen J, Wu EK, Hinkle PM, Huang ZM, Chuprun JK, Song J, Gao E, Cheung JY, Sklar LA, Koch WJ, Tesmer JJ.

ACS Chem Biol. 2012 Nov 16;7(11):1830-9. doi: 10.1021/cb3003013. Epub 2012 Aug 21.

18.

Gi-biased β2AR signaling links GRK2 upregulation to heart failure.

Zhu W, Petrashevskaya N, Ren S, Zhao A, Chakir K, Gao E, Chuprun JK, Wang Y, Talan M, Dorn GW 2nd, Lakatta EG, Koch WJ, Feldman AM, Xiao RP.

Circ Res. 2012 Jan 20;110(2):265-74. doi: 10.1161/CIRCRESAHA.111.253260. Epub 2011 Dec 15.

19.

G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.

Ciccarelli M, Chuprun JK, Rengo G, Gao E, Wei Z, Peroutka RJ, Gold JI, Gumpert A, Chen M, Otis NJ, Dorn GW 2nd, Trimarco B, Iaccarino G, Koch WJ.

Circulation. 2011 May 10;123(18):1953-62. doi: 10.1161/CIRCULATIONAHA.110.988642. Epub 2011 Apr 25.

20.

A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse.

Gao E, Lei YH, Shang X, Huang ZM, Zuo L, Boucher M, Fan Q, Chuprun JK, Ma XL, Koch WJ.

Circ Res. 2010 Dec 10;107(12):1445-53. doi: 10.1161/CIRCRESAHA.110.223925. Epub 2010 Oct 21.

21.

Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms.

Brinks H, Boucher M, Gao E, Chuprun JK, Pesant S, Raake PW, Huang ZM, Wang X, Qiu G, Gumpert A, Harris DM, Eckhart AD, Most P, Koch WJ.

Circ Res. 2010 Oct 29;107(9):1140-9. doi: 10.1161/CIRCRESAHA.110.221010. Epub 2010 Sep 2.

22.

Dynamic changes in lymphocyte GRK2 levels in cardiac transplant patients: a biomarker for left ventricular function.

Bonita RE, Raake PW, Otis NJ, Chuprun JK, Spivack T, Dasgupta A, Whellan DJ, Mather PJ, Koch WJ.

Clin Transl Sci. 2010 Feb;3(1):14-8. doi: 10.1111/j.1752-8062.2010.00176.x.

23.

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes.

Martini JS, Raake P, Vinge LE, DeGeorge BR Jr, Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, Koch WJ.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12457-62. doi: 10.1073/pnas.0803153105. Epub 2008 Aug 18. Erratum in: Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17206. DeGeorge, Brent Jr [corrected to DeGeorge, Brent R Jr].

24.

Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress.

DeGeorge BR Jr, Gao E, Boucher M, Vinge LE, Martini JS, Raake PW, Chuprun JK, Harris DM, Kim GW, Soltys S, Eckhart AD, Koch WJ.

Circulation. 2008 Mar 18;117(11):1378-87. doi: 10.1161/CIRCULATIONAHA.107.752618. Epub 2008 Mar 3.

PMID:
18316484
25.

Endothelial S100A1 modulates vascular function via nitric oxide.

Pleger ST, Harris DM, Shan C, Vinge LE, Chuprun JK, Berzins B, Pleger W, Druckman C, Völkers M, Heierhorst J, Øie E, Remppis A, Katus HA, Scalia R, Eckhart AD, Koch WJ, Most P.

Circ Res. 2008 Apr 11;102(7):786-94. doi: 10.1161/CIRCRESAHA.108.172031. Epub 2008 Feb 21.

PMID:
18292599
26.

Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue.

Pleger ST, Most P, Boucher M, Soltys S, Chuprun JK, Pleger W, Gao E, Dasgupta A, Rengo G, Remppis A, Katus HA, Eckhart AD, Rabinowitz JE, Koch WJ.

Circulation. 2007 May 15;115(19):2506-15. Epub 2007 Apr 30.

PMID:
17470693
27.

Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart.

Gao E, Boucher M, Chuprun JK, Zhou RH, Eckhart AD, Koch WJ.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H60-8. Epub 2007 Mar 23.

28.

S100A1 gene therapy preserves in vivo cardiac function after myocardial infarction.

Pleger ST, Remppis A, Heidt B, Völkers M, Chuprun JK, Kuhn M, Zhou RH, Gao E, Szabo G, Weichenhan D, Müller OJ, Eckhart AD, Katus HA, Koch WJ, Most P.

Mol Ther. 2005 Dec;12(6):1120-9. Epub 2005 Sep 15.

29.

Protein kinase C regulation of ATP-induced phosphoinositide hydrolysis in bovine aorta endothelial cells.

Chuprun JK, Rapoport RM.

J Recept Signal Transduct Res. 1997 Nov;17(6):787-814.

PMID:
9365931
30.

5-HT1A receptor activates Na+/H+ exchange in CHO-K1 cells through Gialpha2 and Gialpha3.

Garnovskaya MN, Gettys TW, van Biesen T, Prpic V, Chuprun JK, Raymond JR.

J Biol Chem. 1997 Mar 21;272(12):7770-6.

31.
32.

Inhibition of phorbol ester-induced contraction by calmodulin antagonists in rat aorta.

Chuprun JK, Bazan E, Chang KC, Campbell AK, Rapoport RM.

Am J Physiol. 1991 Oct;261(4 Pt 1):C675-84.

PMID:
1928327

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