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Items: 12

1.

pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1.

Varma MV, Rotter CJ, Chupka J, Whalen KM, Duignan DB, Feng B, Litchfield J, Goosen TC, El-Kattan AF.

Mol Pharm. 2011 Aug 1;8(4):1303-13. doi: 10.1021/mp200103h. Epub 2011 Jul 11.

PMID:
21710988
2.

Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus.

Kalgutkar AS, Tugnait M, Zhu T, Kimoto E, Miao Z, Mascitti V, Yang X, Tan B, Walsky RL, Chupka J, Feng B, Robinson RP.

Drug Metab Dispos. 2011 Sep;39(9):1609-19. doi: 10.1124/dmd.111.040675. Epub 2011 Jun 20.

PMID:
21690265
3.

Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.

Pfefferkorn JA, Litchfield J, Hutchings R, Cheng XM, Larsen SD, Auerbach B, Bush MR, Lee C, Erasga N, Bowles DM, Boyles DC, Lu G, Sekerke C, Askew V, Hanselman JC, Dillon L, Lin Z, Robertson A, Olsen K, Boustany C, Atkinson K, Goosen TC, Sahasrabudhe V, Chupka J, Duignan DB, Feng B, Scialis R, Kimoto E, Bi YA, Lai Y, El-Kattan A, Bakker-Arkema R, Barclay P, Kindt E, Le V, Mandema JW, Milad M, Tait BD, Kennedy R, Trivedi BK, Kowala M.

Bioorg Med Chem Lett. 2011 May 1;21(9):2725-31. doi: 10.1016/j.bmcl.2010.11.103. Epub 2010 Nov 26.

PMID:
21183342
4.

Characterization of digoxin uptake in sandwich-cultured human hepatocytes.

Kimoto E, Chupka J, Xiao Y, Bi YA, Duignan DB.

Drug Metab Dispos. 2011 Jan;39(1):47-53. doi: 10.1124/dmd.110.034298. Epub 2010 Oct 6.

PMID:
20926619
5.

Physicochemical determinants of human renal clearance.

Varma MV, Feng B, Obach RS, Troutman MD, Chupka J, Miller HR, El-Kattan A.

J Med Chem. 2009 Aug 13;52(15):4844-52. doi: 10.1021/jm900403j.

PMID:
19445515
6.

N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat.

Kalgutkar AS, Frederick KS, Chupka J, Feng B, Kempshall S, Mireles RJ, Fenner KS, Troutman MD.

J Pharm Sci. 2009 Dec;98(12):4914-27. doi: 10.1002/jps.21756.

PMID:
19373887
7.

Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril.

Yuan H, Feng B, Yu Y, Chupka J, Zheng JY, Heath TG, Bond BR.

J Pharmacol Exp Ther. 2009 Jul;330(1):191-7. doi: 10.1124/jpet.108.149476. Epub 2009 Apr 6.

PMID:
19349522
8.

A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine.

Yasuda K, Ranade A, Venkataramanan R, Strom S, Chupka J, Ekins S, Schuetz E, Bachmann K.

Drug Metab Dispos. 2008 Aug;36(8):1689-97. doi: 10.1124/dmd.108.020701. Epub 2008 May 27.

9.

Application of simple mathematical expressions to relate half-lives of drugs in mice to those in humans.

Bachmann K, Chupka J, Erhardt P, White D.

Drug Metab Lett. 2007 Apr;1(2):127-9.

PMID:
19356031
10.

Detection of cytokine protein expression in mouse lung homogenates using suspension bead array.

McDuffie E, Obert L, Chupka J, Sigler R.

J Inflamm (Lond). 2006 Nov 29;3:15. doi: 10.1186/1476-9255-3-15.

11.

Acute coronary artery injury in dogs following administration of CI-1034, an endothelin A receptor antagonist.

McDuffie JE, Yu X, Sobocinski G, Song Y, Chupka J, Albassam M.

Cardiovasc Toxicol. 2006;6(1):25-38.

PMID:
16845180
12.

Comparative methods for multiplex analysis of cytokine protein expression in plasma of lipopolysaccharide-treated mice.

Bobrowski WF, McDuffie JE, Sobocinski G, Chupka J, Olle E, Bowman A, Albassam M.

Cytokine. 2005 Dec 7;32(5):194-8. Epub 2005 Oct 28.

PMID:
16257531

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