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Items: 1 to 50 of 257

1.

Automation of the kidney function prediction and classification through ultrasound-based kidney imaging using deep learning.

Kuo CC, Chang CM, Liu KT, Lin WK, Chiang HY, Chung CW, Ho MR, Sun PR, Yang RL, Chen KT.

NPJ Digit Med. 2019 Apr 26;2:29. doi: 10.1038/s41746-019-0104-2. eCollection 2019.

2.

RASA1 mosaic mutations in patients with capillary malformation-arteriovenous malformation.

Revencu N, Fastre E, Ravoet M, Helaers R, Brouillard P, Bisdorff-Bresson A, Chung CWT, Gerard M, Dvorakova V, Irvine AD, Boon LM, Vikkula M.

J Med Genet. 2019 Jul 12. pii: jmedgenet-2019-106024. doi: 10.1136/jmedgenet-2019-106024. [Epub ahead of print]

PMID:
31300548
3.

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors.

Schlott AC, Mayclin S, Reers AR, Coburn-Flynn O, Bell AS, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Lyons-Abbott S, Staker BL, Chung CW, Myler PJ, Fidock DA, Tate EW, Holder AA.

Cell Chem Biol. 2019 Jul 18;26(7):991-1000.e7. doi: 10.1016/j.chembiol.2019.03.015. Epub 2019 May 9.

4.

Etch Characteristics of Micrometer-Scale Masked Cu Thin Films Using Inductively Coupled Plasma of H₂/Ar.

Choi JS, Cho DH, Lim ET, Chung CW.

J Nanosci Nanotechnol. 2019 Oct 1;19(10):6506-6511. doi: 10.1166/jnn.2019.17064.

PMID:
31026985
5.

Fe in biosynthesis, translocation, and signal transduction of NO: toward bioinorganic engineering of dinitrosyl iron complexes into NO-delivery scaffolds for tissue engineering.

Hsiao HY, Chung CW, Santos JH, Villaflores OB, Lu TT.

Dalton Trans. 2019 Jul 2;48(26):9431-9453. doi: 10.1039/c9dt00777f.

PMID:
30990502
6.

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.

Wyllie S, Brand S, Thomas M, De Rycker M, Chung CW, Pena I, Bingham RP, Bueren-Calabuig JA, Cantizani J, Cebrian D, Craggs PD, Ferguson L, Goswami P, Hobrath J, Howe J, Jeacock L, Ko EJ, Korczynska J, MacLean L, Manthri S, Martinez MS, Mata-Cantero L, Moniz S, Nühs A, Osuna-Cabello M, Pinto E, Riley J, Robinson S, Rowland P, Simeons FRC, Shishikura Y, Spinks D, Stojanovski L, Thomas J, Thompson S, Viayna Gaza E, Wall RJ, Zuccotto F, Horn D, Ferguson MAJ, Fairlamb AH, Fiandor JM, Martin J, Gray DW, Miles TJ, Gilbert IH, Read KD, Marco M, Wyatt PG.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9318-9323. doi: 10.1073/pnas.1820175116. Epub 2019 Apr 8.

7.

Correction: Cryo-EM in drug discovery.

Ceska T, Chung CW, Cooke R, Phillips C, Williams PA.

Biochem Soc Trans. 2019 Feb 28;47(1):487. doi: 10.1042/BST-2018-0267C_COR. No abstract available.

PMID:
30819927
8.

Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP.

Johansson H, Isabella Tsai YC, Fantom K, Chung CW, Kümper S, Martino L, Thomas DA, Eberl HC, Muelbaier M, House D, Rittinger K.

J Am Chem Soc. 2019 Feb 13;141(6):2703-2712. doi: 10.1021/jacs.8b13193. Epub 2019 Feb 4.

9.

Cryo-EM in drug discovery.

Ceska T, Chung CW, Cooke R, Phillips C, Williams PA.

Biochem Soc Trans. 2019 Feb 28;47(1):281-293. doi: 10.1042/BST20180267. Epub 2019 Jan 15. Review. Erratum in: Biochem Soc Trans. 2019 Feb 28;47(1):487.

PMID:
30647139
10.

Longitudinal lipid trends and adverse outcomes in patients with CKD: a 13-year observational cohort study.

Tsai CW, Huang HC, Chiang HY, Chung CW, Chang SN, Chu PL, Kuo CC.

J Lipid Res. 2019 Mar;60(3):648-660. doi: 10.1194/jlr.P084590. Epub 2019 Jan 14.

PMID:
30642880
11.

Longitudinal progression trajectory of random urine creatinine as a novel predictor of ESRD among patients with CKD.

Tsai CW, Huang HC, Tien N, Chung CW, Chiu HT, Yeh HC, Kuo CC.

Clin Chim Acta. 2019 Feb;489:144-153. doi: 10.1016/j.cca.2018.12.002. Epub 2018 Dec 8.

PMID:
30529604
12.
13.

Revisiting the Effect of Slag in Reducing Heat of Hydration in Concrete in Comparison to Other Supplementary Cementitious Materials.

Moon H, Ramanathan S, Suraneni P, Shon CS, Lee CJ, Chung CW.

Materials (Basel). 2018 Sep 27;11(10). pii: E1847. doi: 10.3390/ma11101847.

14.

Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors.

Bamborough P, Chung CW, Furze RC, Grandi P, Michon AM, Watson RJ, Mitchell DJ, Barnett H, Prinjha RK, Rau C, Sheppard RJ, Werner T, Demont EH.

J Med Chem. 2018 Sep 27;61(18):8321-8336. doi: 10.1021/acs.jmedchem.8b00862. Epub 2018 Sep 18.

PMID:
30226378
15.

Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.

Richter A, Rudolph I, Möllmann U, Voigt K, Chung CW, Singh OMP, Rees M, Mendoza-Losana A, Bates R, Ballell L, Batt S, Veerapen N, Fütterer K, Besra G, Imming P, Argyrou A.

Sci Rep. 2018 Sep 7;8(1):13473. doi: 10.1038/s41598-018-31316-6.

16.

First-year estimated glomerular filtration rate variability after pre-end-stage renal disease program enrollment and adverse outcomes of chronic kidney disease.

Tsai CW, Huang HC, Chiang HY, Chung CW, Chiu HT, Liang CC, Yu T, Kuo CC.

Nephrol Dial Transplant. 2018 Jul 5. doi: 10.1093/ndt/gfy200. [Epub ahead of print]

PMID:
29982714
17.

A natural compound, aristoyagonine, is identified as a potent bromodomain inhibitor by mid-throughput screening.

Kim YH, Kim M, Yoo M, Kim JE, Lee HK, Heo JN, Lee CO, Yoo M, Jung KY, Yun CS, Moon SW, Chang HK, Chung CW, Pyo S, Choi SU, Park CH.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):882-887. doi: 10.1016/j.bbrc.2018.06.091. Epub 2018 Jun 20.

PMID:
29928885
18.

Integration of Lead Discovery Tactics and the Evolution of the Lead Discovery Toolbox.

Leveridge M, Chung CW, Gross JW, Phelps CB, Green D.

SLAS Discov. 2018 Oct;23(9):881-897. doi: 10.1177/2472555218778503. Epub 2018 Jun 6.

PMID:
29874524
19.

Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain.

Law RP, Atkinson SJ, Bamborough P, Chung CW, Demont EH, Gordon LJ, Lindon M, Prinjha RK, Watson AJB, Hirst DJ.

J Med Chem. 2018 May 24;61(10):4317-4334. doi: 10.1021/acs.jmedchem.7b01666. Epub 2018 May 3.

PMID:
29656650
20.

Enhanced Photosensing and Photodynamic Treatment of Colon Cancer Cells Using Methoxy Poly(ethylene glycol)-Conjugated Chlorin e6.

Ryu JH, Jeong YI, Kim HY, Son GM, Lee HL, Chung CW, Chu CW, Kang DH.

J Nanosci Nanotechnol. 2018 Feb 1;18(2):1131-1136. doi: 10.1166/jnn.2018.14872.

PMID:
29448545
21.

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.

Prati F, Zuccotto F, Fletcher D, Convery MA, Fernandez-Menendez R, Bates R, Encinas L, Zeng J, Chung CW, De Dios Anton P, Mendoza-Losana A, Mackenzie C, Green SR, Huggett M, Barros D, Wyatt PG, Ray PC.

ChemMedChem. 2018 Apr 6;13(7):672-677. doi: 10.1002/cmdc.201700774. Epub 2018 Feb 19.

22.

The New Approach for Establishing the Cellular Response Guideline for Medical Applications of Polydiacetylene as Innovative Parameters.

Nam MK, Lee HC, Hong YJ, Jang JY, Choi EH, Chung CW, Jeon S, Kim JM, Kang S, Rhim H.

J Biomed Nanotechnol. 2017 Jan;13(1):77-83.

PMID:
29372998
23.

Prognostic significance of microvascular invasion in tumor stage for hepatocellular carcinoma.

Park YK, Song SK, Kim BW, Park SK, Chung CW, Wang HJ.

World J Surg Oncol. 2017 Dec 19;15(1):225. doi: 10.1186/s12957-017-1292-3.

24.

Analysis of Medium-Chain-Length Polyhydroxyalkanoate-Producing Bacteria in Activated Sludge Samples Enriched by Aerobic Periodic Feeding.

Lee SH, Kim JH, Chung CW, Kim DY, Rhee YH.

Microb Ecol. 2018 Apr;75(3):720-728. doi: 10.1007/s00248-017-1084-x. Epub 2017 Oct 10.

PMID:
28993853
25.

Early Detection of Tuberous Sclerosis Complex: An Opportunity for Improved Neurodevelopmental Outcome.

Chung CWT, Lawson JA, Sarkozy V, Riney K, Wargon O, Shand AW, Cooper S, King H, Kennedy SE, Mowat D.

Pediatr Neurol. 2017 Nov;76:20-26. doi: 10.1016/j.pediatrneurol.2017.05.014. Epub 2017 May 26.

PMID:
28811058
26.

Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3'-Deoxy Nucleoside of Pacidamycins.

Michailidou F, Chung CW, Brown MJB, Bent AF, Naismith JH, Leavens WJ, Lynn SM, Sharma SV, Goss RJM.

Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12492-12497. doi: 10.1002/anie.201705639. Epub 2017 Aug 30.

27.

Development of the Korean Pregnancy Stress Scale.

Kim Y, Chung CW.

Jpn J Nurs Sci. 2018 Apr;15(2):113-124. doi: 10.1111/jjns.12175. Epub 2017 Jul 4.

PMID:
28675692
28.

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.

Hutchinson JP, Rowland P, Taylor MRD, Christodoulou EM, Haslam C, Hobbs CI, Holmes DS, Homes P, Liddle J, Mole DJ, Uings I, Walker AL, Webster SP, Mowat CG, Chung CW.

Nat Commun. 2017 Jun 12;8:15827. doi: 10.1038/ncomms15827.

29.

The Impact of Hepaticojejunostomy Leaks After Pancreatoduodenectomy: a Devastating Source of Morbidity and Mortality.

Jester AL, Chung CW, Becerra DC, Molly Kilbane E, House MG, Zyromski NJ, Max Schmidt C, Nakeeb A, Ceppa EP.

J Gastrointest Surg. 2017 Jun;21(6):1017-1024. doi: 10.1007/s11605-017-3406-1. Epub 2017 Mar 24.

PMID:
28342120
30.

Impact of Fellow Versus Resident Assistance on Outcomes Following Pancreatoduodenectomy.

Carr RA, Chung CW, Schmidt CM 2nd, Jester A, Kilbane ME, House MG, Zyromski NJ, Nakeeb A, Schmidt CM, Ceppa EP.

J Gastrointest Surg. 2017 Jun;21(6):1025-1030. doi: 10.1007/s11605-017-3383-4. Epub 2017 Feb 13.

PMID:
28194616
31.

Enhancement of thermal neutron shielding of cement mortar by using borosilicate glass powder.

Jang BK, Lee JC, Kim JH, Chung CW.

Appl Radiat Isot. 2017 May;123:1-5. doi: 10.1016/j.apradiso.2017.01.047. Epub 2017 Feb 6.

PMID:
28189090
32.

Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry.

Bax B, Chung CW, Edge C.

Acta Crystallogr D Struct Biol. 2017 Feb 1;73(Pt 2):131-140. doi: 10.1107/S2059798316020283. Epub 2017 Feb 1.

33.

Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.

Humphreys PG, Bamborough P, Chung CW, Craggs PD, Gordon L, Grandi P, Hayhow TG, Hussain J, Jones KL, Lindon M, Michon AM, Renaux JF, Suckling CJ, Tough DF, Prinjha RK.

J Med Chem. 2017 Jan 26;60(2):695-709. doi: 10.1021/acs.jmedchem.6b01566. Epub 2017 Jan 9.

PMID:
28002667
34.

Biocatalytic characterization of an endo-β-1,4-mannanase produced by Paenibacillus sp. strain HY-8.

Kim DY, Chung CW, Cho HY, Rhee YH, Shin DH, Son KH, Park HY.

Biotechnol Lett. 2017 Jan;39(1):149-155. doi: 10.1007/s10529-016-2228-7. Epub 2016 Oct 6.

PMID:
27714555
35.

Enhancement of Corneal Visibility in Optical Coherence Tomography Images with Corneal Opacification.

Chung CW, Ang M, Farook M, Strouthidis NG, Mehta JS, Mari JM, Girard MJ.

Transl Vis Sci Technol. 2016 Sep 8;5(5):3. eCollection 2016 Sep.

36.

Identification of KasA as the cellular target of an anti-tubercular scaffold.

Abrahams KA, Chung CW, Ghidelli-Disse S, Rullas J, Rebollo-López MJ, Gurcha SS, Cox JA, Mendoza A, Jiménez-Navarro E, Martínez-Martínez MS, Neu M, Shillings A, Homes P, Argyrou A, Casanueva R, Loman NJ, Moynihan PJ, Lelièvre J, Selenski C, Axtman M, Kremer L, Bantscheff M, Angulo-Barturen I, Izquierdo MC, Cammack NC, Drewes G, Ballell L, Barros D, Besra GS, Bates RH.

Nat Commun. 2016 Sep 1;7:12581. doi: 10.1038/ncomms12581.

37.

A Chemical Probe for the ATAD2 Bromodomain.

Bamborough P, Chung CW, Demont EH, Furze RC, Bannister AJ, Che KH, Diallo H, Douault C, Grandi P, Kouzarides T, Michon AM, Mitchell DJ, Prinjha RK, Rau C, Robson S, Sheppard RJ, Upton R, Watson RJ.

Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11382-6. doi: 10.1002/anie.201603928. Epub 2016 Aug 17.

PMID:
27530368
38.

Biophysics in drug discovery: impact, challenges and opportunities.

Renaud JP, Chung CW, Danielson UH, Egner U, Hennig M, Hubbard RE, Nar H.

Nat Rev Drug Discov. 2016 Oct;15(10):679-98. doi: 10.1038/nrd.2016.123. Epub 2016 Aug 12. Review.

39.

Characterization of Zn(O,S) Buffer Layers for Cu(In,Ga)Se2 Solar Cells.

Choi JH, Jung SH, Chung CW.

J Nanosci Nanotechnol. 2016 May;16(5):5378-83.

PMID:
27483934
40.
41.

Mucosa-associated lymphoid tissue (MALT) lymphoma as an unusual cause of malignant hilar biliary stricture: a case report with literature review.

Park YK, Choi JE, Jung WY, Song SK, Lee JI, Chung CW.

World J Surg Oncol. 2016 Jun 24;14(1):167. doi: 10.1186/s12957-016-0928-z. Review.

42.

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain.

Bamborough P, Barnett HA, Becher I, Bird MJ, Chung CW, Craggs PD, Demont EH, Diallo H, Fallon DJ, Gordon LJ, Grandi P, Hobbs CI, Hooper-Greenhill E, Jones EJ, Law RP, Le Gall A, Lugo D, Michon AM, Mitchell DJ, Prinjha RK, Sheppard RJ, Watson AJ, Watson RJ.

ACS Med Chem Lett. 2016 May 9;7(6):552-7. doi: 10.1021/acsmedchemlett.6b00092. eCollection 2016 Jun 9.

43.

Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis.

Tudor JC, Davis EJ, Peixoto L, Wimmer ME, van Tilborg E, Park AJ, Poplawski SG, Chung CW, Havekes R, Huang J, Gatti E, Pierre P, Abel T.

Sci Signal. 2016 Apr 26;9(425):ra41. doi: 10.1126/scisignal.aad4949.

44.

Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors.

Deng H, Zhou J, Sundersingh F, Messer JA, Somers DO, Ajakane M, Arico-Muendel CC, Beljean A, Belyanskaya SL, Bingham R, Blazensky E, Boullay AB, Boursier E, Chai J, Carter P, Chung CW, Daugan A, Ding Y, Herry K, Hobbs C, Humphries E, Kollmann C, Nguyen VL, Nicodeme E, Smith SE, Dodic N, Ancellin N.

ACS Med Chem Lett. 2016 Feb 8;7(4):379-84. doi: 10.1021/acsmedchemlett.5b00389. eCollection 2016 Apr 14.

45.

Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening.

Borthwick JA, Ancellin N, Bertrand SM, Bingham RP, Carter PS, Chung CW, Churcher I, Dodic N, Fournier C, Francis PL, Hobbs A, Jamieson C, Pickett SD, Smith SE, Somers DO, Spitzfaden C, Suckling CJ, Young RJ.

J Med Chem. 2016 Mar 24;59(6):2452-67. doi: 10.1021/acs.jmedchem.5b01607. Epub 2016 Mar 16.

46.

New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.

Pajk S, Živec M, Šink R, Sosič I, Neu M, Chung CW, Martínez-Hoyos M, Pérez-Herrán E, Álvarez-Gómez D, Álvarez-Ruíz E, Mendoza-Losana A, Castro-Pichel J, Barros D, Ballell-Pages L, Young RJ, Convery MA, Encinas L, Gobec S.

Eur J Med Chem. 2016 Apr 13;112:252-257. doi: 10.1016/j.ejmech.2016.02.008. Epub 2016 Feb 8.

PMID:
26900657
47.

Use and Misuse of Laplace's Law in Ophthalmology.

Chung CW, Girard MJ, Jan NJ, Sigal IA.

Invest Ophthalmol Vis Sci. 2016 Jan 1;57(1):236-45. doi: 10.1167/iovs.15-18053. Review.

48.

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.

Westaway SM, Preston AG, Barker MD, Brown F, Brown JA, Campbell M, Chung CW, Drewes G, Eagle R, Garton N, Gordon L, Haslam C, Hayhow TG, Humphreys PG, Joberty G, Katso R, Kruidenier L, Leveridge M, Pemberton M, Rioja I, Seal GA, Shipley T, Singh O, Suckling CJ, Taylor J, Thomas P, Wilson DM, Lee K, Prinjha RK.

J Med Chem. 2016 Feb 25;59(4):1370-87. doi: 10.1021/acs.jmedchem.5b01538. Epub 2016 Jan 15.

PMID:
26771203
49.

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives.

Westaway SM, Preston AG, Barker MD, Brown F, Brown JA, Campbell M, Chung CW, Diallo H, Douault C, Drewes G, Eagle R, Gordon L, Haslam C, Hayhow TG, Humphreys PG, Joberty G, Katso R, Kruidenier L, Leveridge M, Liddle J, Mosley J, Muelbaier M, Randle R, Rioja I, Rueger A, Seal GA, Sheppard RJ, Singh O, Taylor J, Thomas P, Thomson D, Wilson DM, Lee K, Prinjha RK.

J Med Chem. 2016 Feb 25;59(4):1357-69. doi: 10.1021/acs.jmedchem.5b01537. Epub 2016 Jan 15.

PMID:
26771107
50.

Novel Interaction Mechanism of a Domain Antibody-based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency than Ranibizumab and Bevacizumab and Improved Capacity over Aflibercept.

Walker A, Chung CW, Neu M, Burman M, Batuwangala T, Jones G, Tang CM, Steward M, Mullin M, Tournier N, Lewis A, Korczynska J, Chung V, Catchpole I.

J Biol Chem. 2016 Mar 11;291(11):5500-11. doi: 10.1074/jbc.M115.691162. Epub 2016 Jan 4.

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